CS199527B2 - Manufacturing process of the steady antibiotic agent - Google Patents

Manufacturing process of the steady antibiotic agent Download PDF

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Publication number
CS199527B2
CS199527B2 CS782444A CS244478A CS199527B2 CS 199527 B2 CS199527 B2 CS 199527B2 CS 782444 A CS782444 A CS 782444A CS 244478 A CS244478 A CS 244478A CS 199527 B2 CS199527 B2 CS 199527B2
Authority
CS
Czechoslovakia
Prior art keywords
solution
doxycycline
magnesium
oxytetracycline
caprolactam
Prior art date
Application number
CS782444A
Other languages
Czech (cs)
English (en)
Inventor
William W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS199527B2 publication Critical patent/CS199527B2/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
CS782444A 1977-04-27 1978-04-14 Manufacturing process of the steady antibiotic agent CS199527B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
CS199527B2 true CS199527B2 (en) 1980-07-31

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
CS782444A CS199527B2 (en) 1977-04-27 1978-04-14 Manufacturing process of the steady antibiotic agent

Country Status (38)

Country Link
US (1) US4126680A (de)
JP (1) JPS53136514A (de)
AR (1) AR217844A1 (de)
AT (1) AT360148B (de)
AU (1) AU503139B1 (de)
BE (1) BE866419A (de)
BG (1) BG47943A3 (de)
CA (1) CA1100875A (de)
CH (1) CH630260A5 (de)
CS (1) CS199527B2 (de)
DD (1) DD135445A5 (de)
DE (1) DE2817335C3 (de)
DK (1) DK155977C (de)
EG (1) EG14348A (de)
ES (1) ES468749A1 (de)
FI (3) FI781300A7 (de)
FR (1) FR2388561A1 (de)
GB (1) GB1563478A (de)
GR (1) GR70062B (de)
HU (1) HU179050B (de)
IE (1) IE47049B1 (de)
IL (1) IL54581A0 (de)
IN (1) IN148197B (de)
IT (1) IT1094557B (de)
LU (1) LU79547A1 (de)
MX (1) MX6087E (de)
NL (1) NL7804455A (de)
NO (1) NO148280C (de)
NZ (1) NZ187046A (de)
OA (1) OA05949A (de)
PH (1) PH12962A (de)
PL (1) PL110459B1 (de)
PT (1) PT67895B (de)
RO (2) RO75099A (de)
SE (1) SE443507B (de)
YU (1) YU87178A (de)
ZA (1) ZA782400B (de)
ZM (1) ZM3878A1 (de)

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US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (de) * 1993-04-20 1994-10-26 Nostras S.A. Oxytetracycline und Glycofurol enthaltendes antibiotisches Präparat
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CN1399627A (zh) 1999-09-14 2003-02-26 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
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WO2002004404A2 (en) 2000-07-07 2002-01-17 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
BR0112265A (pt) 2000-07-07 2003-06-24 Tufts College Compostos de tetraciclina substituìda, e de sanciclina 7-substituìda, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
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US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
PL2109602T3 (pl) 2006-12-21 2014-09-30 Paratek Pharm Innc Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych
SI2120963T1 (sl) 2006-12-21 2019-02-28 Paratek Pharmaceuticals, Inc. Substituirane spojine tetraciklina za zdravljenje vnetnih kožnih motenj
AU2008231033B2 (en) * 2007-03-23 2012-08-30 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
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Family Cites Families (9)

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US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
LU79547A1 (fr) 1979-11-07
EG14348A (en) 1984-09-30
IN148197B (de) 1980-11-29
PL110459B1 (en) 1980-07-31
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
PT67895B (en) 1979-11-14
JPS5632290B2 (de) 1981-07-27
AT360148B (de) 1980-12-29
NL7804455A (nl) 1978-10-31
IT1094557B (it) 1985-08-02
DE2817335A1 (de) 1978-11-16
FI781300A7 (fi) 1978-10-28
FI801196A7 (fi) 1981-01-01
MX6087E (es) 1984-11-08
DD135445A5 (de) 1979-05-09
FR2388561A1 (fr) 1978-11-24
BG47943A3 (bg) 1990-10-15
OA05949A (fr) 1981-06-30
PT67895A (en) 1978-05-01
ES468749A1 (es) 1979-01-01
CA1100875A (en) 1981-05-12
IT7822720A0 (it) 1978-04-26
DE2817335C3 (de) 1982-04-22
DE2817335B2 (de) 1981-06-11
US4126680A (en) 1978-11-21
FI801197A7 (fi) 1981-01-01
GB1563478A (en) 1980-03-26
GR70062B (de) 1982-07-26
RO75099A (ro) 1980-12-30
YU87178A (en) 1984-04-30
NO148280C (no) 1983-09-21
BE866419A (fr) 1978-10-26
FR2388561B1 (de) 1980-07-18
ZM3878A1 (en) 1978-11-21
CH630260A5 (fr) 1982-06-15
DK182578A (da) 1978-10-28
HU179050B (en) 1982-08-28
AU503139B1 (en) 1979-08-23
AR217844A1 (es) 1980-04-30
RO77953A (ro) 1981-12-25
NO148280B (no) 1983-06-06
ZA782400B (en) 1979-04-25
IE47049B1 (en) 1983-12-14
DK155977C (da) 1989-10-30
DK155977B (da) 1989-06-12
IL54581A0 (en) 1978-07-31
NO781457L (no) 1978-10-30
NZ187046A (en) 1980-03-05
ATA300478A (de) 1980-05-15
SE443507B (sv) 1986-03-03
JPS53136514A (en) 1978-11-29
PH12962A (en) 1979-10-19
IE780828L (en) 1978-10-27

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