PE20010030A1 - Compuesto heteroaromatico biciclico - Google Patents

Compuesto heteroaromatico biciclico

Info

Publication number
PE20010030A1
PE20010030A1 PE2000000312A PE0003122000A PE20010030A1 PE 20010030 A1 PE20010030 A1 PE 20010030A1 PE 2000000312 A PE2000000312 A PE 2000000312A PE 0003122000 A PE0003122000 A PE 0003122000A PE 20010030 A1 PE20010030 A1 PE 20010030A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
heteroaromatic
compound
alkinyl
Prior art date
Application number
PE2000000312A
Other languages
English (en)
Spanish (es)
Inventor
Gerritdina Geziena Gerritsma
Straten Nicole Corine Renee Van
Anton Egbert Peter Adang
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20010030A1 publication Critical patent/PE20010030A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PE2000000312A 1999-04-08 2000-04-06 Compuesto heteroaromatico biciclico PE20010030A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
PE20010030A1 true PE20010030A1 (es) 2001-01-27

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000312A PE20010030A1 (es) 1999-04-08 2000-04-06 Compuesto heteroaromatico biciclico

Country Status (30)

Country Link
US (2) US6569863B1 (https=)
EP (1) EP1171443B1 (https=)
JP (1) JP4854856B2 (https=)
KR (1) KR100691546B1 (https=)
CN (1) CN1177848C (https=)
AR (1) AR028474A1 (https=)
AT (1) ATE299507T1 (https=)
AU (1) AU772258B2 (https=)
BR (1) BRPI0009558B1 (https=)
CA (1) CA2368834C (https=)
CO (1) CO5160348A1 (https=)
CZ (1) CZ300832B6 (https=)
DE (1) DE60021262T2 (https=)
DK (1) DK1171443T3 (https=)
ES (1) ES2245304T3 (https=)
HK (1) HK1041266B (https=)
HU (1) HU229002B1 (https=)
ID (1) ID30502A (https=)
IL (2) IL145483A0 (https=)
MX (1) MXPA01010144A (https=)
NO (1) NO328826B1 (https=)
NZ (1) NZ514445A (https=)
PE (1) PE20010030A1 (https=)
PL (1) PL219316B1 (https=)
PT (1) PT1171443E (https=)
RU (1) RU2248979C2 (https=)
TR (1) TR200102839T2 (https=)
TW (1) TW564247B (https=)
WO (1) WO2000061586A1 (https=)
ZA (1) ZA200107917B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287554B6 (sk) * 2000-09-22 2011-01-04 N.V. Organon Bicyklické heteroaromatické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
DE10108481A1 (de) * 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
HUP0401443A3 (en) * 2001-09-04 2008-05-28 Organon Nv Glycine-substituted thieno[2,3-d]pyrimidines with lh and fsh agonistic activity, use of the compounds and pharmaceutical compositions containing same
DK1513516T3 (da) 2002-06-06 2009-10-19 Boehringer Ingelheim Pharma Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (ja) * 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
WO2007062222A2 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
EP2018384A2 (en) * 2006-05-17 2009-01-28 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
JP2009539865A (ja) 2006-06-06 2009-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
PL2203439T3 (pl) 2007-09-14 2011-06-30 Addex Pharmaceuticals Sa 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
US8722894B2 (en) * 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
US8252937B2 (en) 2007-09-14 2012-08-28 Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
US8653282B2 (en) * 2007-10-18 2014-02-18 Boehringer Ingelheim International Gmbh Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
RU2492170C9 (ru) 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153912A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
KR20140053991A (ko) 2011-07-18 2014-05-08 아츠 바이올로직스 에이/에스 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물
ES2575143T3 (es) 2011-11-23 2016-06-24 Cancer Research Technology Limited Inhibidores de tienopiridina de la proteína quinasa C atípica
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
HUE053734T2 (hu) 2014-01-21 2021-07-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
BR102019022529A2 (pt) * 2019-10-25 2021-05-04 Anhanguera Educacional Ltda. Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013664A2 (en) * 1992-01-11 1993-07-22 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
JP3854648B2 (ja) * 1994-04-19 2006-12-06 武田薬品工業株式会社 縮合チオフェン誘導体、その製造法及び用途
EP0791000B1 (en) 1994-11-08 2002-10-02 Takeda Chemical Industries, Ltd. Thienopyridine or thienopyrimidine derivatives and their use
JPH09169766A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd チエノピリジン誘導体，その製造法および用途
EP0862573A1 (en) 1995-10-19 1998-09-09 Takeda Chemical Industries, Ltd. Thienopyridine derivatives as gonadotropin releasing hormone antagonists
JPH09169767A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd 複素環化合物、その製造法および用途
CA2250895A1 (en) * 1996-04-26 1997-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their production and use

Also Published As

Publication number Publication date
NO20014824D0 (no) 2001-10-04
PL219316B1 (pl) 2015-04-30
CN1177848C (zh) 2004-12-01
IL145483A0 (en) 2002-06-30
DK1171443T3 (da) 2005-11-07
EP1171443A1 (en) 2002-01-16
ZA200107917B (en) 2003-09-23
HK1041266B (en) 2005-09-16
TW564247B (en) 2003-12-01
NO328826B1 (no) 2010-05-25
PL350964A1 (en) 2003-02-24
AR028474A1 (es) 2003-05-14
CA2368834C (en) 2009-11-03
ATE299507T1 (de) 2005-07-15
US6841553B2 (en) 2005-01-11
CN1349535A (zh) 2002-05-15
ID30502A (id) 2001-12-13
US6569863B1 (en) 2003-05-27
IL145483A (en) 2007-06-03
ES2245304T3 (es) 2006-01-01
NZ514445A (en) 2003-07-25
CZ20013605A3 (cs) 2002-03-13
HK1041266A1 (en) 2002-07-05
MXPA01010144A (es) 2002-04-24
RU2248979C2 (ru) 2005-03-27
HUP0200653A3 (en) 2004-07-28
BR0009558A (pt) 2002-02-19
CA2368834A1 (en) 2000-10-19
EP1171443B1 (en) 2005-07-13
CO5160348A1 (es) 2002-05-30
US20030212081A1 (en) 2003-11-13
KR20010103801A (ko) 2001-11-23
NO20014824L (no) 2001-10-04
BRPI0009558B1 (pt) 2016-10-25
AU772258B2 (en) 2004-04-22
KR100691546B1 (ko) 2007-03-12
WO2000061586A1 (en) 2000-10-19
JP4854856B2 (ja) 2012-01-18
HUP0200653A2 (en) 2002-06-29
AU3816600A (en) 2000-11-14
PT1171443E (pt) 2005-11-30
CZ300832B6 (cs) 2009-08-19
DE60021262T2 (de) 2006-01-05
HU229002B1 (en) 2013-07-29
DE60021262D1 (de) 2005-08-18
TR200102839T2 (tr) 2002-04-22
JP2002541259A (ja) 2002-12-03

Similar Documents

Publication Publication Date Title
PE20010030A1 (es) Compuesto heteroaromatico biciclico
PE20050131A1 (es) Derivados de benzoimidazol como agentes antiproliferativos
PE20050087A1 (es) Derivados de 2-oxodihidropiridina n-sustituidos
PE20130647A1 (es) Indoles
CO5040071A1 (es) Derivados de aminas biciclicas, procesos para su prepara- cion, y composiciones insecticidas que los comprenden
PE20040934A1 (es) Derivados de pirimidina como inhibidores selectivos de tirosina quinasas
PE20090705A1 (es) Derivados de uracilo en el tratamiento de hepatitis c
PE20071171A1 (es) Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropicos
PE20090601A1 (es) Derivados de piridin-il-oxi-piridinas como inhibidores de alk5
PE20091236A1 (es) Derivados de pirimidina como immunomoduladores de tlr7
CO6190609A2 (es) Compuestos de urea policiclicos antibacterianos
PE20080608A1 (es) Compuestos quimicos
GT200200197A (es) Derivados de quinolina
EP1006122A4 (en) PHENYLETHYLENAMIN DERIVATIVES
PE20011030A1 (es) Combinaciones farmaceuticas que comprenden tegaserod y omeprazol
PE20040772A1 (es) Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos
CA2304204A1 (en) Quinoline-containing .alpha.-ketoamide cysteine and serine protease inhibitors
PE20070007A1 (es) Metodos para sintetizar derivados de 6-alquilaminoquinolina
PE20060625A1 (es) Derivados de benzazepina como antagonistas y/o agonistas del receptor h3 de histamina
AR039111A1 (es) Tiopirimidinas e isotiazolpirimidinas inhibidoras de quinasas
CO5040063A1 (es) Compuestos de dihidropiridina utilies como abridores de los canales del potasio
GB1177840A (en) 2-Thiopyrimidine Nucleosides
DK1222160T3 (da) Fremgangsmåde til fremstilling af substituerede allylaminderivater og salte deraf
PE20020537A1 (es) Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh)
MXPA04003884A (es) Metodo y aparato para preparar hudrazo-dicarbonamida utilizando urea como materia inicial.

Legal Events

Date Code Title Description
FC Refusal