TR200102839T2 - LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler. - Google Patents

LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler.

Info

Publication number
TR200102839T2
TR200102839T2 TR2001/02839T TR200102839T TR200102839T2 TR 200102839 T2 TR200102839 T2 TR 200102839T2 TR 2001/02839 T TR2001/02839 T TR 2001/02839T TR 200102839 T TR200102839 T TR 200102839T TR 200102839 T2 TR200102839 T2 TR 200102839T2
Authority
TR
Turkey
Prior art keywords
agonists
bicyclic heteroaromatic
compounds useful
heteroaromatic compounds
bicyclic
Prior art date
Application number
TR2001/02839T
Other languages
English (en)
Turkish (tr)
Inventor
Geziena Gerritsma Gerrildina
Corine Ren�E Van Straten Nicole
Egbert Peter Adang Anton
Original Assignee
Akzo Nobel N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N. V. filed Critical Akzo Nobel N. V.
Publication of TR200102839T2 publication Critical patent/TR200102839T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
TR2001/02839T 1999-04-08 2000-04-03 LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler. TR200102839T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
TR200102839T2 true TR200102839T2 (tr) 2002-04-22

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02839T TR200102839T2 (tr) 1999-04-08 2000-04-03 LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler.

Country Status (30)

Country Link
US (2) US6569863B1 (https=)
EP (1) EP1171443B1 (https=)
JP (1) JP4854856B2 (https=)
KR (1) KR100691546B1 (https=)
CN (1) CN1177848C (https=)
AR (1) AR028474A1 (https=)
AT (1) ATE299507T1 (https=)
AU (1) AU772258B2 (https=)
BR (1) BRPI0009558B1 (https=)
CA (1) CA2368834C (https=)
CO (1) CO5160348A1 (https=)
CZ (1) CZ300832B6 (https=)
DE (1) DE60021262T2 (https=)
DK (1) DK1171443T3 (https=)
ES (1) ES2245304T3 (https=)
HK (1) HK1041266B (https=)
HU (1) HU229002B1 (https=)
ID (1) ID30502A (https=)
IL (2) IL145483A0 (https=)
MX (1) MXPA01010144A (https=)
NO (1) NO328826B1 (https=)
NZ (1) NZ514445A (https=)
PE (1) PE20010030A1 (https=)
PL (1) PL219316B1 (https=)
PT (1) PT1171443E (https=)
RU (1) RU2248979C2 (https=)
TR (1) TR200102839T2 (https=)
TW (1) TW564247B (https=)
WO (1) WO2000061586A1 (https=)
ZA (1) ZA200107917B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2422054C (en) * 2000-09-22 2011-01-11 Akzo Nobel Nv Bicyclic heteroaromatic compounds
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
DE10108481A1 (de) 2001-02-22 2002-10-24 Bayer Ag Pyridylpyrimidine
CN1261437C (zh) * 2001-09-04 2006-06-28 阿克佐诺贝尔公司 具有LH与FSH联合激动活性的甘氨酸－取代的噻吩并[2,3－d]嘧啶
TWI228508B (en) * 2001-09-04 2005-03-01 Akzo Nobel Nv Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
DE60325051D1 (de) 2002-06-06 2009-01-15 Boehringer Ingelheim Pharma SUBSTITUIERTE 3-AMINO-THIENO(2,3-b)PYRIDINE-2-AMIDE UND HERSTELLUNGSVERFAHREN SOWIE DEREN VERWENDUNG
WO2004092170A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
WO2004092177A1 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2005019225A1 (ja) * 2003-08-21 2005-03-03 Kyorin Pharmaceutical Co., Ltd. Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
CA2630920A1 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
WO2007136776A2 (en) * 2006-05-17 2007-11-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
CA2653654A1 (en) 2006-06-06 2007-12-21 Boehringer Ingelheim International Gmbh Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
PL2200985T3 (pl) 2007-09-14 2011-12-30 Ortho Mcneil Janssen Pharmaceuticals Inc 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony
CN101801930B (zh) * 2007-09-14 2013-01-30 奥梅-杨森制药有限公司 1,3-二取代的-4-苯基-1h-吡啶-2-酮
SI2203439T1 (sl) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
CA2702500A1 (en) * 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein
CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
BR112014001274A2 (pt) 2011-07-18 2017-04-18 Arts Biologics As composto de hormônio luteinizante, e, composição farmacêutica
WO2013078126A1 (en) 2011-11-23 2013-05-30 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase c
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
MX386697B (es) 2014-01-21 2025-03-19 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
BR102019022529A2 (pt) * 2019-10-25 2021-05-04 Anhanguera Educacional Ltda. Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3262593A (en) 1992-01-11 1993-08-03 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
JP3854648B2 (ja) * 1994-04-19 2006-12-06 武田薬品工業株式会社 縮合チオフェン誘導体、その製造法及び用途
WO1996014319A1 (en) * 1994-11-08 1996-05-17 Takeda Chemical Industries, Ltd. Thienopyridine or thienopyrimidine derivatives and their use
JPH09169767A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd 複素環化合物、その製造法および用途
JPH09169766A (ja) * 1995-10-19 1997-06-30 Takeda Chem Ind Ltd チエノピリジン誘導体，その製造法および用途
CN1063446C (zh) 1995-10-19 2001-03-21 武田药品工业株式会社 作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物
ID17260A (id) * 1996-04-26 1997-12-11 Takeda Chemical Industries Ltd Turunan tieno piridina dan produksi serta gunanya

Also Published As

Publication number Publication date
HU229002B1 (en) 2013-07-29
ES2245304T3 (es) 2006-01-01
AU3816600A (en) 2000-11-14
KR20010103801A (ko) 2001-11-23
KR100691546B1 (ko) 2007-03-12
JP4854856B2 (ja) 2012-01-18
IL145483A0 (en) 2002-06-30
PE20010030A1 (es) 2001-01-27
NO20014824L (no) 2001-10-04
ZA200107917B (en) 2003-09-23
CA2368834A1 (en) 2000-10-19
HUP0200653A2 (en) 2002-06-29
PL350964A1 (en) 2003-02-24
CA2368834C (en) 2009-11-03
EP1171443B1 (en) 2005-07-13
ID30502A (id) 2001-12-13
JP2002541259A (ja) 2002-12-03
IL145483A (en) 2007-06-03
WO2000061586A1 (en) 2000-10-19
CN1177848C (zh) 2004-12-01
NZ514445A (en) 2003-07-25
ATE299507T1 (de) 2005-07-15
DE60021262D1 (de) 2005-08-18
HK1041266B (en) 2005-09-16
BRPI0009558B1 (pt) 2016-10-25
NO20014824D0 (no) 2001-10-04
US20030212081A1 (en) 2003-11-13
HK1041266A1 (en) 2002-07-05
CZ300832B6 (cs) 2009-08-19
MXPA01010144A (es) 2002-04-24
AU772258B2 (en) 2004-04-22
CO5160348A1 (es) 2002-05-30
DK1171443T3 (da) 2005-11-07
CN1349535A (zh) 2002-05-15
US6569863B1 (en) 2003-05-27
BR0009558A (pt) 2002-02-19
DE60021262T2 (de) 2006-01-05
PT1171443E (pt) 2005-11-30
PL219316B1 (pl) 2015-04-30
HUP0200653A3 (en) 2004-07-28
TW564247B (en) 2003-12-01
RU2248979C2 (ru) 2005-03-27
US6841553B2 (en) 2005-01-11
AR028474A1 (es) 2003-05-14
EP1171443A1 (en) 2002-01-16
NO328826B1 (no) 2010-05-25
CZ20013605A3 (cs) 2002-03-13

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