PT1171443E - Compostos heteroaromaticos biciclicos uteis como agonistas de lh - Google Patents

Compostos heteroaromaticos biciclicos uteis como agonistas de lh

Info

Publication number
PT1171443E
PT1171443E PT00917026T PT00917026T PT1171443E PT 1171443 E PT1171443 E PT 1171443E PT 00917026 T PT00917026 T PT 00917026T PT 00917026 T PT00917026 T PT 00917026T PT 1171443 E PT1171443 E PT 1171443E
Authority
PT
Portugal
Prior art keywords
uht
agonists
heteroaromatic compounds
bicyclic heteroaromatic
bicyclic
Prior art date
Application number
PT00917026T
Other languages
English (en)
Portuguese (pt)
Inventor
Anton Egbert Peter Adang
Gerritsma Gerrildina Geziena
Straten Nicole Corine Va Renee
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PT1171443E publication Critical patent/PT1171443E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT00917026T 1999-04-08 2000-04-03 Compostos heteroaromaticos biciclicos uteis como agonistas de lh PT1171443E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
PT1171443E true PT1171443E (pt) 2005-11-30

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00917026T PT1171443E (pt) 1999-04-08 2000-04-03 Compostos heteroaromaticos biciclicos uteis como agonistas de lh

Country Status (30)

Country Link
US (2) US6569863B1 (https=)
EP (1) EP1171443B1 (https=)
JP (1) JP4854856B2 (https=)
KR (1) KR100691546B1 (https=)
CN (1) CN1177848C (https=)
AR (1) AR028474A1 (https=)
AT (1) ATE299507T1 (https=)
AU (1) AU772258B2 (https=)
BR (1) BRPI0009558B1 (https=)
CA (1) CA2368834C (https=)
CO (1) CO5160348A1 (https=)
CZ (1) CZ300832B6 (https=)
DE (1) DE60021262T2 (https=)
DK (1) DK1171443T3 (https=)
ES (1) ES2245304T3 (https=)
HK (1) HK1041266B (https=)
HU (1) HU229002B1 (https=)
ID (1) ID30502A (https=)
IL (2) IL145483A0 (https=)
MX (1) MXPA01010144A (https=)
NO (1) NO328826B1 (https=)
NZ (1) NZ514445A (https=)
PE (1) PE20010030A1 (https=)
PL (1) PL219316B1 (https=)
PT (1) PT1171443E (https=)
RU (1) RU2248979C2 (https=)
TR (1) TR200102839T2 (https=)
TW (1) TW564247B (https=)
WO (1) WO2000061586A1 (https=)
ZA (1) ZA200107917B (https=)

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HUP0401443A3 (en) * 2001-09-04 2008-05-28 Organon Nv Glycine-substituted thieno[2,3-d]pyrimidines with lh and fsh agonistic activity, use of the compounds and pharmaceutical compositions containing same
DK1513516T3 (da) 2002-06-06 2009-10-19 Boehringer Ingelheim Pharma Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
JPWO2005019225A1 (ja) * 2003-08-21 2007-11-01 杏林製薬株式会社 Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (ja) * 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
WO2007062222A2 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
EP2018384A2 (en) * 2006-05-17 2009-01-28 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
JP2009539865A (ja) 2006-06-06 2009-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換３−アミノ−チエノ［２，３−ｂ］ピリジン２−カルボン酸アミド化合物及び製造方法及びそれらの使用
RU2444524C2 (ru) * 2006-08-21 2012-03-10 Дженентек, Инк. Азабензотиофенильные соединения и способы применения
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
PL2203439T3 (pl) 2007-09-14 2011-06-30 Addex Pharmaceuticals Sa 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
US8722894B2 (en) * 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
US8252937B2 (en) 2007-09-14 2012-08-28 Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
US8653282B2 (en) * 2007-10-18 2014-02-18 Boehringer Ingelheim International Gmbh Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
RU2492170C9 (ru) 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153912A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
KR20140053991A (ko) 2011-07-18 2014-05-08 아츠 바이올로직스 에이/에스 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물
ES2575143T3 (es) 2011-11-23 2016-06-24 Cancer Research Technology Limited Inhibidores de tienopiridina de la proteína quinasa C atípica
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JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
HUE053734T2 (hu) 2014-01-21 2021-07-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
CN107602585A (zh) * 2017-10-23 2018-01-19 遵义医学院 噻吩并吡啶双杂环化合物的制备工艺
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Also Published As

Publication number Publication date
NO20014824D0 (no) 2001-10-04
PL219316B1 (pl) 2015-04-30
PE20010030A1 (es) 2001-01-27
CN1177848C (zh) 2004-12-01
IL145483A0 (en) 2002-06-30
DK1171443T3 (da) 2005-11-07
EP1171443A1 (en) 2002-01-16
ZA200107917B (en) 2003-09-23
HK1041266B (en) 2005-09-16
TW564247B (en) 2003-12-01
NO328826B1 (no) 2010-05-25
PL350964A1 (en) 2003-02-24
AR028474A1 (es) 2003-05-14
CA2368834C (en) 2009-11-03
ATE299507T1 (de) 2005-07-15
US6841553B2 (en) 2005-01-11
CN1349535A (zh) 2002-05-15
ID30502A (id) 2001-12-13
US6569863B1 (en) 2003-05-27
IL145483A (en) 2007-06-03
ES2245304T3 (es) 2006-01-01
NZ514445A (en) 2003-07-25
CZ20013605A3 (cs) 2002-03-13
HK1041266A1 (en) 2002-07-05
MXPA01010144A (es) 2002-04-24
RU2248979C2 (ru) 2005-03-27
HUP0200653A3 (en) 2004-07-28
BR0009558A (pt) 2002-02-19
CA2368834A1 (en) 2000-10-19
EP1171443B1 (en) 2005-07-13
CO5160348A1 (es) 2002-05-30
US20030212081A1 (en) 2003-11-13
KR20010103801A (ko) 2001-11-23
NO20014824L (no) 2001-10-04
BRPI0009558B1 (pt) 2016-10-25
AU772258B2 (en) 2004-04-22
KR100691546B1 (ko) 2007-03-12
WO2000061586A1 (en) 2000-10-19
JP4854856B2 (ja) 2012-01-18
HUP0200653A2 (en) 2002-06-29
AU3816600A (en) 2000-11-14
CZ300832B6 (cs) 2009-08-19
DE60021262T2 (de) 2006-01-05
HU229002B1 (en) 2013-07-29
DE60021262D1 (de) 2005-08-18
TR200102839T2 (tr) 2002-04-22
JP2002541259A (ja) 2002-12-03

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