PE20050087A1 - Derivados de 2-oxodihidropiridina n-sustituidos - Google Patents
Derivados de 2-oxodihidropiridina n-sustituidosInfo
- Publication number
- PE20050087A1 PE20050087A1 PE2003000968A PE2003000968A PE20050087A1 PE 20050087 A1 PE20050087 A1 PE 20050087A1 PE 2003000968 A PE2003000968 A PE 2003000968A PE 2003000968 A PE2003000968 A PE 2003000968A PE 20050087 A1 PE20050087 A1 PE 20050087A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- imidazolin
- pyridone
- fluorophenyl
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I DONDE Ar1 Y Ar2 SON CADA UNO ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON CIANO, HALOGENO, NITRO, ENTRE OTROS; R1 Y R2 SON CADA UNO HETEROARILOXI, CARBOXILO, FORMILO, ENTRE OTROS; R3, R4 Y R5 SON CADA UNO H, CIANO, HALOGENO, ENTRE OTROS. TAMBIEN REFERIDA A UN PROCEDIMIENTO PARA PREPARAR DICHO COMPUESTO DONDE SON COMPUESTOS PREFERIDOS: 5-[(4S, 5S)-4-(4-FLUOROFENIL)-4-(6-FLUORO-3-PIRIDIL)-5-METIL-2-IMIDAZOLIN-2-IL]-1-METIL-2-PIRIDONA; 1-(2,2-DIFLUOROETIL)-5-[(4R, 5S)]-4-(4-FLUOROFENIL)-5-METIL-4-(6-TRIFLUOROMETIL-3-PIRIDIL)-2-IMIDAZOLIN-2-IL]-2-PIRIDONA Y 1-DIFLUOROMETIL-3-ETIL-5-[(4S, 5S)-4-(4-FLUOROFENIL)-4-(6-FLUORO-3-PIRIDIL)-5-METIL-2-IMIDAZOLIN-2-IL]-2-PIRIDONA; ENTRE OTROS. ESTOS SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DEL NEUROPEPTIDO Y, ASI COMO EN EL TRATAMIENTO DE BULIMIA, OBESIDAD O DIABETES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002287015 | 2002-09-30 | ||
JP2002353202 | 2002-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050087A1 true PE20050087A1 (es) | 2005-02-22 |
Family
ID=32072466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000968A PE20050087A1 (es) | 2002-09-30 | 2003-09-22 | Derivados de 2-oxodihidropiridina n-sustituidos |
Country Status (17)
Country | Link |
---|---|
US (2) | US6869966B2 (es) |
EP (1) | EP1546133B1 (es) |
KR (1) | KR20050059217A (es) |
CN (1) | CN100528864C (es) |
AR (1) | AR041374A1 (es) |
AT (1) | ATE461191T1 (es) |
AU (1) | AU2003273522B2 (es) |
BR (1) | BR0314965A (es) |
CA (2) | CA2497237C (es) |
DE (1) | DE60331751D1 (es) |
MX (1) | MXPA05003293A (es) |
NO (1) | NO20052106L (es) |
PE (1) | PE20050087A1 (es) |
PL (1) | PL376475A1 (es) |
RU (1) | RU2005113310A (es) |
TW (1) | TW200407138A (es) |
WO (1) | WO2004031175A2 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1608317B1 (en) * | 2003-03-25 | 2012-09-26 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7470700B2 (en) * | 2003-08-13 | 2008-12-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
JP2007505121A (ja) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
FR2861302A1 (fr) * | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique. |
FR2861301B1 (fr) * | 2003-10-24 | 2008-07-11 | Sanofi Synthelabo | Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique. |
FR2861303A1 (fr) * | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
FR2861300B1 (fr) * | 2003-10-24 | 2008-07-11 | Sanofi Synthelabo | Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
AU2004318013B8 (en) * | 2004-03-15 | 2011-10-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
JP2008501714A (ja) * | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
JP4675586B2 (ja) * | 2004-06-23 | 2011-04-27 | 壽製薬株式会社 | 高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤 |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
JP2008524331A (ja) * | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
CA2622472C (en) * | 2005-09-14 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
US20070060528A1 (en) * | 2005-09-14 | 2007-03-15 | Christopher Ronald J | Administration of dipeptidyl peptidase inhibitors |
CN101360723A (zh) * | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
CA2624030A1 (en) | 2005-09-29 | 2007-04-12 | Tianying Jian | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2007112368A1 (en) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
WO2007115967A1 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Crystalline isopropanol solvate of glucokinase activator |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
EP2946778A1 (en) | 2006-09-22 | 2015-11-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
CA2741644C (en) | 2008-10-30 | 2013-05-07 | Merck Sharp & Dohme Corp. | Isonicotinamide orexin receptor antagonists |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
CA2945098C (en) * | 2014-04-09 | 2022-10-04 | Genentech, Inc. | Process for the manufacturing of medicaments |
CN112194634B (zh) * | 2018-11-30 | 2022-08-12 | 华南农业大学 | 一种n-二氟甲基咪唑硫(硒)脲衍生物的制备方法 |
TW202045476A (zh) | 2019-02-13 | 2020-12-16 | 美商默沙東藥廠 | 5-烷基吡咯啶食慾素受體促效劑 |
US20230018413A1 (en) | 2019-08-08 | 2023-01-19 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
CA3189908A1 (en) | 2020-08-18 | 2022-02-24 | Stephane L. Bogen | Bicycloheptane pyrrolidine orexin receptor agonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH234887A (de) * | 1942-12-11 | 1944-10-31 | Ag J R Geigy | Verfahren zur Herstellung von N-Cyclohexyl-6-pyridon-3-carbonsäurediäthylamid. |
CZ403592A3 (en) * | 1992-02-20 | 1993-12-15 | Hoechst Ag | Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use |
EP1066279A4 (en) * | 1998-03-25 | 2004-09-08 | Bristol Myers Squibb Co | ANOREECTIC IMIDAZOLONE COMPOUNDS: II. phenyl derivatives |
AU2001234128B2 (en) | 2000-02-22 | 2004-11-11 | Banyu Pharmaceutical Co., Ltd. | Novel imidazoline compounds |
-
2003
- 2003-08-15 US US10/641,017 patent/US6869966B2/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125570A patent/TW200407138A/zh unknown
- 2003-09-22 PE PE2003000968A patent/PE20050087A1/es not_active Application Discontinuation
- 2003-09-24 AR ARP030103473A patent/AR041374A1/es unknown
- 2003-09-25 EP EP03755682A patent/EP1546133B1/en not_active Expired - Lifetime
- 2003-09-25 CA CA2497237A patent/CA2497237C/en not_active Expired - Fee Related
- 2003-09-25 PL PL03376475A patent/PL376475A1/xx not_active Application Discontinuation
- 2003-09-25 DE DE60331751T patent/DE60331751D1/de not_active Expired - Lifetime
- 2003-09-25 CN CNB038233398A patent/CN100528864C/zh not_active Expired - Fee Related
- 2003-09-25 KR KR1020057005511A patent/KR20050059217A/ko not_active Application Discontinuation
- 2003-09-25 MX MXPA05003293A patent/MXPA05003293A/es unknown
- 2003-09-25 WO PCT/JP2003/012290 patent/WO2004031175A2/en active Application Filing
- 2003-09-25 CA CA2726754A patent/CA2726754C/en not_active Expired - Fee Related
- 2003-09-25 AT AT03755682T patent/ATE461191T1/de not_active IP Right Cessation
- 2003-09-25 AU AU2003273522A patent/AU2003273522B2/en not_active Ceased
- 2003-09-25 RU RU2005113310/04A patent/RU2005113310A/ru not_active Application Discontinuation
- 2003-09-25 BR BR0314965-0A patent/BR0314965A/pt not_active Application Discontinuation
-
2004
- 2004-07-27 US US10/899,162 patent/US7138525B2/en not_active Expired - Fee Related
-
2005
- 2005-04-29 NO NO20052106A patent/NO20052106L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO20052106L (no) | 2005-04-29 |
AR041374A1 (es) | 2005-05-11 |
US7138525B2 (en) | 2006-11-21 |
CA2497237A1 (en) | 2004-04-15 |
CA2726754A1 (en) | 2004-04-15 |
WO2004031175A2 (en) | 2004-04-15 |
EP1546133A2 (en) | 2005-06-29 |
DE60331751D1 (de) | 2010-04-29 |
AU2003273522A1 (en) | 2004-04-23 |
WO2004031175A3 (en) | 2005-02-24 |
CA2497237C (en) | 2011-03-29 |
MXPA05003293A (es) | 2005-10-18 |
AU2003273522B2 (en) | 2009-05-21 |
CN100528864C (zh) | 2009-08-19 |
ATE461191T1 (de) | 2010-04-15 |
CA2726754C (en) | 2013-04-02 |
US6869966B2 (en) | 2005-03-22 |
RU2005113310A (ru) | 2005-11-10 |
KR20050059217A (ko) | 2005-06-17 |
TW200407138A (en) | 2004-05-16 |
CN1684954A (zh) | 2005-10-19 |
US20050009879A1 (en) | 2005-01-13 |
BR0314965A (pt) | 2005-08-02 |
US20040072874A1 (en) | 2004-04-15 |
EP1546133B1 (en) | 2010-03-17 |
PL376475A1 (en) | 2005-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20050087A1 (es) | Derivados de 2-oxodihidropiridina n-sustituidos | |
PE20060361A1 (es) | Compuestos heterociclicos como inhibidores de la cinesina mitotica | |
PE20060197A1 (es) | Heterociclos biciclicos como inhibidores de cinasa | |
PE20080677A1 (es) | Inhibidores de pirrolotriazina cinaza | |
PE20090709A1 (es) | Compuestos heterociclico de 5 miembros | |
PE20091466A1 (es) | Derivados de 4,5-dihidro-oxazol-2-il-amina | |
PE20081530A1 (es) | Nuevos compuestos 617 | |
PE20070359A1 (es) | Inhibidores de pirimidinilpirazol de aurora quinasas | |
PE20060625A1 (es) | Derivados de benzazepina como antagonistas y/o agonistas del receptor h3 de histamina | |
PE20090610A1 (es) | Derivados de pirazol sustituidos | |
PE20070189A1 (es) | COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA | |
EA200301073A1 (ru) | N-(2-арилэтил)бензиламины в качестве антагонистов 5-ht-рецептора | |
PE20060374A1 (es) | Inhibidores de cinasa heterociclicos fusionados | |
DE60217147D1 (de) | Lactamderivaten zur verwendung als humane 11cby rezeptorantagonisten | |
PE20060770A1 (es) | Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina como antagonistas de los receptores cannabinoides cb1 | |
PE20040935A1 (es) | Analogos de 2-quinazolina sustituida-4-ilamina como moduladores de los receptores de capsaicina | |
PE20011066A1 (es) | PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS | |
ATE468853T1 (de) | Substituierte pyrazole, derartige verbindungen enthaltende zusammensetzungen und verfahren zu ihrer verwendung | |
ATE541839T1 (de) | Pyrrolidiniumderivate als m3-muskarinische rezeptoren | |
PE20110410A1 (es) | Derivado de 7-piperidinoalquil-3,4-dihidroquinolona | |
PE20001590A1 (es) | Compuestos heterociclicos, aromaticos utiles como secretagogos de la hormona del crecimiento | |
PE20090601A1 (es) | Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 | |
PE20060273A1 (es) | Derivados de tetrahidroisoquinolilsulfonamidas como moduladores del receptor h3 | |
PE20121050A1 (es) | Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog | |
PE20081314A1 (es) | COMPUESTOS TRICICLICOS FUSIONADOS NO ESTEROIDALES COMO MODULADORES DEL RECEPTOR GLUCOCORTICOIDE, AP-1 Y/O ACTIVIDAD NF-kB |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |