PE20050087A1 - Derivados de 2-oxodihidropiridina n-sustituidos - Google Patents

Derivados de 2-oxodihidropiridina n-sustituidos

Info

Publication number
PE20050087A1
PE20050087A1 PE2003000968A PE2003000968A PE20050087A1 PE 20050087 A1 PE20050087 A1 PE 20050087A1 PE 2003000968 A PE2003000968 A PE 2003000968A PE 2003000968 A PE2003000968 A PE 2003000968A PE 20050087 A1 PE20050087 A1 PE 20050087A1
Authority
PE
Peru
Prior art keywords
methyl
imidazolin
pyridone
fluorophenyl
pyridyl
Prior art date
Application number
PE2003000968A
Other languages
English (en)
Inventor
Nagaaki Sato
Makoto Ando
Shiho Ishikawa
Tsuyoshi Nagase
Keita Nagai
Akio Kanatani
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of PE20050087A1 publication Critical patent/PE20050087A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE Ar1 Y Ar2 SON CADA UNO ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON CIANO, HALOGENO, NITRO, ENTRE OTROS; R1 Y R2 SON CADA UNO HETEROARILOXI, CARBOXILO, FORMILO, ENTRE OTROS; R3, R4 Y R5 SON CADA UNO H, CIANO, HALOGENO, ENTRE OTROS. TAMBIEN REFERIDA A UN PROCEDIMIENTO PARA PREPARAR DICHO COMPUESTO DONDE SON COMPUESTOS PREFERIDOS: 5-[(4S, 5S)-4-(4-FLUOROFENIL)-4-(6-FLUORO-3-PIRIDIL)-5-METIL-2-IMIDAZOLIN-2-IL]-1-METIL-2-PIRIDONA; 1-(2,2-DIFLUOROETIL)-5-[(4R, 5S)]-4-(4-FLUOROFENIL)-5-METIL-4-(6-TRIFLUOROMETIL-3-PIRIDIL)-2-IMIDAZOLIN-2-IL]-2-PIRIDONA Y 1-DIFLUOROMETIL-3-ETIL-5-[(4S, 5S)-4-(4-FLUOROFENIL)-4-(6-FLUORO-3-PIRIDIL)-5-METIL-2-IMIDAZOLIN-2-IL]-2-PIRIDONA; ENTRE OTROS. ESTOS SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DEL NEUROPEPTIDO Y, ASI COMO EN EL TRATAMIENTO DE BULIMIA, OBESIDAD O DIABETES
PE2003000968A 2002-09-30 2003-09-22 Derivados de 2-oxodihidropiridina n-sustituidos PE20050087A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002287015 2002-09-30
JP2002353202 2002-12-05

Publications (1)

Publication Number Publication Date
PE20050087A1 true PE20050087A1 (es) 2005-02-22

Family

ID=32072466

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000968A PE20050087A1 (es) 2002-09-30 2003-09-22 Derivados de 2-oxodihidropiridina n-sustituidos

Country Status (17)

Country Link
US (2) US6869966B2 (es)
EP (1) EP1546133B1 (es)
KR (1) KR20050059217A (es)
CN (1) CN100528864C (es)
AR (1) AR041374A1 (es)
AT (1) ATE461191T1 (es)
AU (1) AU2003273522B2 (es)
BR (1) BR0314965A (es)
CA (2) CA2497237C (es)
DE (1) DE60331751D1 (es)
MX (1) MXPA05003293A (es)
NO (1) NO20052106L (es)
PE (1) PE20050087A1 (es)
PL (1) PL376475A1 (es)
RU (1) RU2005113310A (es)
TW (1) TW200407138A (es)
WO (1) WO2004031175A2 (es)

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EP1608317B1 (en) * 2003-03-25 2012-09-26 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7470700B2 (en) * 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007505121A (ja) * 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
WO2005030751A2 (en) * 2003-09-08 2005-04-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
FR2861302A1 (fr) * 2003-10-24 2005-04-29 Sanofi Synthelabo Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861301B1 (fr) * 2003-10-24 2008-07-11 Sanofi Synthelabo Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861303A1 (fr) * 2003-10-24 2005-04-29 Sanofi Synthelabo Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
FR2861300B1 (fr) * 2003-10-24 2008-07-11 Sanofi Synthelabo Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
AU2004318013B8 (en) * 2004-03-15 2011-10-06 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
JP2008501714A (ja) * 2004-06-04 2008-01-24 武田薬品工業株式会社 ジペプチジルペプチダーゼインヒビター
JP4675586B2 (ja) * 2004-06-23 2011-04-27 壽製薬株式会社 高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2008524331A (ja) * 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
CA2622472C (en) * 2005-09-14 2013-11-19 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
US20070060528A1 (en) * 2005-09-14 2007-03-15 Christopher Ronald J Administration of dipeptidyl peptidase inhibitors
CN101360723A (zh) * 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
CA2624030A1 (en) 2005-09-29 2007-04-12 Tianying Jian Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2007112368A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Preparation of (r)-3-aminopiperidine dihydrochloride
WO2007115967A1 (en) * 2006-04-12 2007-10-18 F. Hoffmann-La Roche Ag Crystalline isopropanol solvate of glucokinase activator
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
EP2946778A1 (en) 2006-09-22 2015-11-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
AU2008233662B2 (en) 2007-04-02 2012-08-23 Msd K.K. Indoledione derivative
CA2741644C (en) 2008-10-30 2013-05-07 Merck Sharp & Dohme Corp. Isonicotinamide orexin receptor antagonists
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
CA2945098C (en) * 2014-04-09 2022-10-04 Genentech, Inc. Process for the manufacturing of medicaments
CN112194634B (zh) * 2018-11-30 2022-08-12 华南农业大学 一种n-二氟甲基咪唑硫(硒)脲衍生物的制备方法
TW202045476A (zh) 2019-02-13 2020-12-16 美商默沙東藥廠 5-烷基吡咯啶食慾素受體促效劑
US20230018413A1 (en) 2019-08-08 2023-01-19 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
CA3189908A1 (en) 2020-08-18 2022-02-24 Stephane L. Bogen Bicycloheptane pyrrolidine orexin receptor agonists

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CH234887A (de) * 1942-12-11 1944-10-31 Ag J R Geigy Verfahren zur Herstellung von N-Cyclohexyl-6-pyridon-3-carbonsäurediäthylamid.
CZ403592A3 (en) * 1992-02-20 1993-12-15 Hoechst Ag Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
EP1066279A4 (en) * 1998-03-25 2004-09-08 Bristol Myers Squibb Co ANOREECTIC IMIDAZOLONE COMPOUNDS: II. phenyl derivatives
AU2001234128B2 (en) 2000-02-22 2004-11-11 Banyu Pharmaceutical Co., Ltd. Novel imidazoline compounds

Also Published As

Publication number Publication date
NO20052106L (no) 2005-04-29
AR041374A1 (es) 2005-05-11
US7138525B2 (en) 2006-11-21
CA2497237A1 (en) 2004-04-15
CA2726754A1 (en) 2004-04-15
WO2004031175A2 (en) 2004-04-15
EP1546133A2 (en) 2005-06-29
DE60331751D1 (de) 2010-04-29
AU2003273522A1 (en) 2004-04-23
WO2004031175A3 (en) 2005-02-24
CA2497237C (en) 2011-03-29
MXPA05003293A (es) 2005-10-18
AU2003273522B2 (en) 2009-05-21
CN100528864C (zh) 2009-08-19
ATE461191T1 (de) 2010-04-15
CA2726754C (en) 2013-04-02
US6869966B2 (en) 2005-03-22
RU2005113310A (ru) 2005-11-10
KR20050059217A (ko) 2005-06-17
TW200407138A (en) 2004-05-16
CN1684954A (zh) 2005-10-19
US20050009879A1 (en) 2005-01-13
BR0314965A (pt) 2005-08-02
US20040072874A1 (en) 2004-04-15
EP1546133B1 (en) 2010-03-17
PL376475A1 (en) 2005-12-27

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