MXPA05003293A - Derivados de 2-oxohidropiridina n-sustituidos. - Google Patents
Derivados de 2-oxohidropiridina n-sustituidos.Info
- Publication number
- MXPA05003293A MXPA05003293A MXPA05003293A MXPA05003293A MXPA05003293A MX PA05003293 A MXPA05003293 A MX PA05003293A MX PA05003293 A MXPA05003293 A MX PA05003293A MX PA05003293 A MXPA05003293 A MX PA05003293A MX PA05003293 A MXPA05003293 A MX PA05003293A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- alkylcarbamoyl
- alkylamino
- lower alkyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se proporciona un compuesto de la formula (I): en donde Ar1 y Ar2 son independientemente arilo o heteroarilo, cualquiera de los cuales esta opcionalmente sustituido por un sustituyente que se selecciona del grupo que consiste de ciano, halogeno, nitro, alquilo inferior, haloalquilo inferior, hidroxialquilo inferior, cicloalquilo inferior, ciclo(alquil inferior) °alquilo inferior, alquenilo inferior, alquilamino inferior, dialquilamino inferior, alcanoilamino inferior, alquisulfonilamino inferior, arilsulfonilamino, hidroxi, alcoxi inferior, haloalcoxi inferior, ariloxi, heteroariloxi, alquiltio inferior, carboxilo, formilo, alcanoilo inferior, alcoxicarbonilo inferior, carbamoilo, alquilcarbamoilo inferior, dialquilcarbamoilo inferior, alquilsulfonilo inferior, arilsulfonilo, arilo y heteroarilo; R1 y R2 son independientemente alquilo inferior, cicloalquilo inferior, ciclo (alquil inferior) °alquilo inferior o alcoxi inferior, cualquiera de los cuales esta opcionalmente sustituido por un sustituyente que se selecciona del grupo que consiste de halogeno, alquilamino inferior, dialquilamino inferior, alcanoilamino inferior, hidroxi, alcoxi inferior, formilo, alcoxicarbanilo inferior, alquil carbamoilo inferior y dialquilcarbamoilo inferior; R1, R4 y R5 son independientemente hidrogeno, ciano, halogeno, hidroxi o alquilo inferior, alcoxi inferior o alquiltio inferior, los ultimos tres grupos estan opcionalmente sustituidos por un sustituyente que se selecciona del grupo que consiste de halogeno, alquilamino inferior, dialquilamino inferior, alcanoilamino inferior, hidroxi, alcoxi inferior, formilo, alcoxicarbonilo inferior, alquilcarbamoilo inferior y dialquilcarbamoilo inferio), o una sal o ester del mismo que es util como un agente antagonista del receptor de neuropeptido y tambien es util como un agente para el tratamiento de bulimia, obesidad o diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002287015 | 2002-09-30 | ||
JP2002353202 | 2002-12-05 | ||
PCT/JP2003/012290 WO2004031175A2 (en) | 2002-09-30 | 2003-09-25 | N-substituted-2-oxodihydropyridine derivatives as npy antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05003293A true MXPA05003293A (es) | 2005-10-18 |
Family
ID=32072466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05003293A MXPA05003293A (es) | 2002-09-30 | 2003-09-25 | Derivados de 2-oxohidropiridina n-sustituidos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US6869966B2 (es) |
EP (1) | EP1546133B1 (es) |
KR (1) | KR20050059217A (es) |
CN (1) | CN100528864C (es) |
AR (1) | AR041374A1 (es) |
AT (1) | ATE461191T1 (es) |
AU (1) | AU2003273522B2 (es) |
BR (1) | BR0314965A (es) |
CA (2) | CA2497237C (es) |
DE (1) | DE60331751D1 (es) |
MX (1) | MXPA05003293A (es) |
NO (1) | NO20052106L (es) |
PE (1) | PE20050087A1 (es) |
PL (1) | PL376475A1 (es) |
RU (1) | RU2005113310A (es) |
TW (1) | TW200407138A (es) |
WO (1) | WO2004031175A2 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7687625B2 (en) * | 2003-03-25 | 2010-03-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN1867560A (zh) * | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
JP2007505121A (ja) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
EP1697342A2 (en) * | 2003-09-08 | 2006-09-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
FR2861301B1 (fr) * | 2003-10-24 | 2008-07-11 | Sanofi Synthelabo | Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique. |
FR2861300B1 (fr) * | 2003-10-24 | 2008-07-11 | Sanofi Synthelabo | Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
FR2861302A1 (fr) * | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique. |
FR2861303A1 (fr) * | 2003-10-24 | 2005-04-29 | Sanofi Synthelabo | Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102079743B (zh) * | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
JP2008501714A (ja) * | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
JP4675586B2 (ja) * | 2004-06-23 | 2011-04-27 | 壽製薬株式会社 | 高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤 |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006068978A2 (en) * | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
MY159522A (en) * | 2005-09-14 | 2017-01-13 | Takeda Pharmaceuticals Co | Administration of dipeptidyl peptidase inhibitors |
DK1942898T4 (da) * | 2005-09-14 | 2014-06-02 | Takeda Pharmaceutical | Dipeptidylpeptidase-inhibitorer til behandling af diabetes |
KR101368988B1 (ko) * | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
JP2009531456A (ja) * | 2006-03-28 | 2009-09-03 | 武田薬品工業株式会社 | (r)−3−アミノピペリジン二塩酸塩の調製 |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2007115967A1 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Crystalline isopropanol solvate of glucokinase activator |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
EP2083831B1 (en) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
EP2145884B1 (en) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledione derivative |
JP5635991B2 (ja) | 2008-10-30 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | イソニコチンアミドオレキシン受容体アンタゴニスト |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
MY188526A (en) * | 2014-04-09 | 2021-12-18 | Genentech Inc | Process for the manufacturing of medicaments |
CN112194634B (zh) * | 2018-11-30 | 2022-08-12 | 华南农业大学 | 一种n-二氟甲基咪唑硫(硒)脲衍生物的制备方法 |
EP3924058A1 (en) | 2019-02-13 | 2021-12-22 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
EP4010314B1 (en) | 2019-08-08 | 2024-02-28 | Merck Sharp & Dohme LLC | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
JP7443625B2 (ja) | 2020-08-18 | 2024-03-05 | メルク・シャープ・アンド・ドーム・エルエルシー | ビシクロヘプタンピロリジンオレキシン受容体アゴニスト |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH234887A (de) * | 1942-12-11 | 1944-10-31 | Ag J R Geigy | Verfahren zur Herstellung von N-Cyclohexyl-6-pyridon-3-carbonsäurediäthylamid. |
CZ403592A3 (en) * | 1992-02-20 | 1993-12-15 | Hoechst Ag | Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use |
CA2325472A1 (en) * | 1998-03-25 | 1999-09-30 | Graham S. Poindexter | Imidazolone anorectic agents: iii. heteroaryl derivatives |
WO2001062738A1 (fr) | 2000-02-22 | 2001-08-30 | Banyu Pharmaceutical Co., Ltd. | Composes a base d'imidazoline |
-
2003
- 2003-08-15 US US10/641,017 patent/US6869966B2/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125570A patent/TW200407138A/zh unknown
- 2003-09-22 PE PE2003000968A patent/PE20050087A1/es not_active Application Discontinuation
- 2003-09-24 AR ARP030103473A patent/AR041374A1/es unknown
- 2003-09-25 EP EP03755682A patent/EP1546133B1/en not_active Expired - Lifetime
- 2003-09-25 CN CNB038233398A patent/CN100528864C/zh not_active Expired - Fee Related
- 2003-09-25 CA CA2497237A patent/CA2497237C/en not_active Expired - Fee Related
- 2003-09-25 BR BR0314965-0A patent/BR0314965A/pt not_active Application Discontinuation
- 2003-09-25 AT AT03755682T patent/ATE461191T1/de not_active IP Right Cessation
- 2003-09-25 MX MXPA05003293A patent/MXPA05003293A/es unknown
- 2003-09-25 KR KR1020057005511A patent/KR20050059217A/ko not_active Application Discontinuation
- 2003-09-25 CA CA2726754A patent/CA2726754C/en not_active Expired - Fee Related
- 2003-09-25 AU AU2003273522A patent/AU2003273522B2/en not_active Ceased
- 2003-09-25 DE DE60331751T patent/DE60331751D1/de not_active Expired - Lifetime
- 2003-09-25 WO PCT/JP2003/012290 patent/WO2004031175A2/en active Application Filing
- 2003-09-25 RU RU2005113310/04A patent/RU2005113310A/ru not_active Application Discontinuation
- 2003-09-25 PL PL03376475A patent/PL376475A1/xx not_active Application Discontinuation
-
2004
- 2004-07-27 US US10/899,162 patent/US7138525B2/en not_active Expired - Fee Related
-
2005
- 2005-04-29 NO NO20052106A patent/NO20052106L/no unknown
Also Published As
Publication number | Publication date |
---|---|
US20040072874A1 (en) | 2004-04-15 |
RU2005113310A (ru) | 2005-11-10 |
BR0314965A (pt) | 2005-08-02 |
CN1684954A (zh) | 2005-10-19 |
CA2497237C (en) | 2011-03-29 |
EP1546133A2 (en) | 2005-06-29 |
CA2726754A1 (en) | 2004-04-15 |
ATE461191T1 (de) | 2010-04-15 |
CA2726754C (en) | 2013-04-02 |
DE60331751D1 (de) | 2010-04-29 |
AU2003273522A1 (en) | 2004-04-23 |
CN100528864C (zh) | 2009-08-19 |
PE20050087A1 (es) | 2005-02-22 |
WO2004031175A2 (en) | 2004-04-15 |
AU2003273522B2 (en) | 2009-05-21 |
PL376475A1 (en) | 2005-12-27 |
KR20050059217A (ko) | 2005-06-17 |
TW200407138A (en) | 2004-05-16 |
WO2004031175A3 (en) | 2005-02-24 |
EP1546133B1 (en) | 2010-03-17 |
US7138525B2 (en) | 2006-11-21 |
US6869966B2 (en) | 2005-03-22 |
CA2497237A1 (en) | 2004-04-15 |
NO20052106L (no) | 2005-04-29 |
AR041374A1 (es) | 2005-05-11 |
US20050009879A1 (en) | 2005-01-13 |
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