OA13151A - Aminoheteroaryl compounds as protein kinase inhibitors. - Google Patents
Aminoheteroaryl compounds as protein kinase inhibitors. Download PDFInfo
- Publication number
- OA13151A OA13151A OA1200500243A OA1200500243A OA13151A OA 13151 A OA13151 A OA 13151A OA 1200500243 A OA1200500243 A OA 1200500243A OA 1200500243 A OA1200500243 A OA 1200500243A OA 13151 A OA13151 A OA 13151A
- Authority
- OA
- OAPI
- Prior art keywords
- phenyl
- amino
- pyridin
- ethoxy
- dichloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44958803P | 2003-02-26 | 2003-02-26 | |
US54022904P | 2004-01-29 | 2004-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA13151A true OA13151A (en) | 2006-12-13 |
Family
ID=32930516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200500243A OA13151A (en) | 2003-02-26 | 2004-02-26 | Aminoheteroaryl compounds as protein kinase inhibitors. |
Country Status (29)
Country | Link |
---|---|
US (2) | US7230098B2 (fr) |
EP (2) | EP1603570B9 (fr) |
JP (1) | JP4695588B2 (fr) |
KR (1) | KR101106905B1 (fr) |
CN (1) | CN103265477B (fr) |
AP (1) | AP2114A (fr) |
AU (1) | AU2004215428B2 (fr) |
BR (1) | BRPI0407827B8 (fr) |
CA (1) | CA2517256C (fr) |
CY (2) | CY1113837T1 (fr) |
DK (2) | DK1603570T5 (fr) |
EA (1) | EA010727B1 (fr) |
EC (1) | ECSP055988A (fr) |
ES (2) | ES2401330T3 (fr) |
GE (1) | GEP20084341B (fr) |
HR (1) | HRP20050714B1 (fr) |
IL (1) | IL170291A (fr) |
IS (1) | IS2910B (fr) |
MA (1) | MA27713A1 (fr) |
ME (1) | MEP52808A (fr) |
MX (1) | MXPA05009063A (fr) |
NO (1) | NO332188B1 (fr) |
NZ (1) | NZ541861A (fr) |
OA (1) | OA13151A (fr) |
PL (1) | PL216368B1 (fr) |
PT (2) | PT1603570E (fr) |
RS (1) | RS53118B (fr) |
TN (1) | TNSN05208A1 (fr) |
WO (1) | WO2004076412A2 (fr) |
Families Citing this family (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1603570T5 (da) * | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
WO2005082411A1 (fr) * | 2004-02-23 | 2005-09-09 | Sugen, Inc. | Methode de traitement d'une croissance cellulaire anormale au moyen d'inhibiteurs c-met et m-tor |
RU2330021C2 (ru) * | 2004-02-27 | 2008-07-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Новые пиридиновое производное и пиримидиновое производное (1) |
RU2006138036A (ru) * | 2004-03-30 | 2008-05-10 | Чирон Корпорейшн (Us) | Производные замещенного тиофена в качестве противораковых средств |
CN1960969B (zh) * | 2004-04-01 | 2012-03-28 | 伊莱利利公司 | 组胺h3受体药物、其制备方法及治疗用途 |
US8008301B2 (en) | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
MX2007002274A (es) | 2004-08-23 | 2007-05-07 | Lilly Co Eli | Agentes del receptor de histamina h3. preparacion y usos terapeuticos. |
ES2341351T3 (es) * | 2004-08-26 | 2010-06-18 | Pfizer, Inc. | Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas. |
JP2008510792A (ja) * | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
CN101027404A (zh) * | 2004-08-26 | 2007-08-29 | 辉瑞大药厂 | 对映选择性生物转化制备蛋白酪氨酸激酶抑制剂中间体 |
ES2355923T3 (es) * | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
GT200600042A (es) * | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
CA2599989A1 (fr) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Derives de n-phenylbenzamide en tant qu'agents regulant la sirtuine |
BRPI0611439A2 (pt) * | 2005-05-13 | 2010-09-08 | Lexicon Pharmaceuticals Inc | compostos multicìclicos e métodos para uso dos mesmos |
ES2396913T3 (es) | 2005-08-04 | 2013-03-01 | Sirtris Pharmaceuticals, Inc. | Compuestos moduladores de sirtuina |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
NZ566793A (en) * | 2005-08-24 | 2010-03-26 | Eisai R&D Man Co Ltd | Novel pyridine derivative and pyrimidine derivative |
PL1959955T3 (pl) * | 2005-12-05 | 2011-04-29 | Pfizer Prod Inc | Sposób traktowania nieprawidłowego wzrostu komórek |
AU2006323025B2 (en) * | 2005-12-05 | 2012-07-05 | Pfizer Products Inc. | Polymorphs of a c-Met/HGFR inhibitor |
PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
RU2008139599A (ru) | 2006-03-07 | 2010-04-20 | Эррэй Биофарма Инк. (Us) | Гетеробициклические производные пиразола и способы их применения |
RU2008141761A (ru) * | 2006-03-22 | 2010-04-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | ИНГИБИТОРЫ с-МЕТ ПРОТЕИНКИНАЗЫ |
US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
SI2450437T1 (sl) | 2006-04-14 | 2017-12-29 | Cell Signaling Technology Inc. | Okvarjenost genov in mutantna ALK kinaza v človeških solidnih tumorjih |
US7601716B2 (en) | 2006-05-01 | 2009-10-13 | Cephalon, Inc. | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors |
EP2094268A2 (fr) * | 2006-05-26 | 2009-09-02 | Bayer HealthCare, LLC | Associations de médicaments comportant des urées de diaryle substituées pour le traitement du cancer |
JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
CA2660836A1 (fr) | 2006-08-07 | 2008-02-21 | Incyte Corporation | Utilisation de triazolotriazines en tant qu'inhibiteurs des kinases |
KR101380444B1 (ko) | 2006-08-23 | 2014-04-01 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 페녹시피리딘 유도체의 염 또는 그 결정 및 이들의 제조 방법 |
US7790885B2 (en) * | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
WO2008042867A2 (fr) * | 2006-09-29 | 2008-04-10 | Emiliem Inc. | Modulateurs de kinases multiples |
ES2633318T3 (es) | 2006-10-23 | 2017-09-20 | Cephalon, Inc. | Derivados bicíclicos fusionados de 2,4-diaminopirimidina como inhibidores de ALK y c-Met |
GB0621607D0 (en) * | 2006-10-31 | 2006-12-06 | Chroma Therapeutics Ltd | Inhibitors of c-Met |
EA026126B1 (ru) | 2006-11-22 | 2017-03-31 | Инсайт Холдингс Корпорейшн | Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы |
SG177200A1 (en) | 2006-12-14 | 2012-01-30 | Bayer Schering Pharma Ag | Dihydropyridine derivatives useful as protein kinase inhibitors |
JP2010516680A (ja) * | 2007-01-19 | 2010-05-20 | エックスカバリー,インコーポレイテッド | キナーゼ阻害薬化合物 |
WO2008087736A1 (fr) * | 2007-01-19 | 2008-07-24 | Ube Industries, Ltd. | Procédé de production d'amine aromatique ayant un groupe aralkyloxy ou hétéroaralkyloxy |
US8715665B2 (en) | 2007-04-13 | 2014-05-06 | The General Hospital Corporation | Methods for treating cancer resistant to ErbB therapeutics |
DK2134685T3 (en) * | 2007-04-16 | 2015-12-07 | Abbvie Inc | 7-unsubstituted indole derivatives as MCL-1 inhibitors |
US8263585B2 (en) | 2007-05-04 | 2012-09-11 | Novartis Ag | Organic compounds |
TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
EP2170830B1 (fr) * | 2007-07-17 | 2014-10-15 | Plexxikon, Inc. | COMPOSÉS DE 2-FLUORO-BENZÈNESULFONAMIDE COMME MODULATEURS DE LA KINASE Raf |
CA2694275A1 (fr) * | 2007-07-26 | 2009-01-29 | Novartis Ag | Composes organiques |
US8748143B2 (en) | 2007-09-13 | 2014-06-10 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
CA2703479C (fr) * | 2007-10-23 | 2017-08-22 | Allergan, Inc. | Lactames gamma 1,5-substitues |
AU2008319267A1 (en) * | 2007-11-01 | 2009-05-07 | Sirtris Pharmaceuticals, Inc. | Amide derivatives as sirtuin modulators |
CN101910184A (zh) * | 2007-11-08 | 2010-12-08 | 西特里斯药业公司 | 可溶性噻唑并吡啶 |
JP2009132660A (ja) | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
WO2009073224A1 (fr) * | 2007-12-07 | 2009-06-11 | Ambit Biosciences Corp. | Procédés de traitement de certaines maladies à l'aide de dérivés de la pyrimidine |
US20090227556A1 (en) * | 2008-01-31 | 2009-09-10 | Eisai R&D Management Co., Ltd. | Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives |
WO2009096198A1 (fr) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | Nouveau derive de biaryle |
WO2009099982A1 (fr) * | 2008-02-04 | 2009-08-13 | Osi Pharmaceuticals, Inc. | Inhibiteurs de 2-aminopyridine kinases |
AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
EP2248810A4 (fr) * | 2008-02-18 | 2011-05-25 | Eisai R&D Man Co Ltd | Procédé de fabrication d'un dérivé de phénoxypyridine |
US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
US8268834B2 (en) * | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
FR2928923B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
FR2928922B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
FR2928924B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
US20110039860A1 (en) * | 2008-05-07 | 2011-02-17 | Cangming Yang | Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
WO2009143211A2 (fr) | 2008-05-21 | 2009-11-26 | Incyte Corporation | Sels de 2-fluoro-n-méthyl-4-[7-(quinoléin-6-yl-méthyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide et procédés associés à leur préparation |
MX2010014171A (es) * | 2008-06-19 | 2011-07-04 | Xcovery Holding Co Llc | Compuestos de piridazin-carboxamida sustituida como compuestos inhibidores de cinasa. |
KR20110068987A (ko) * | 2008-08-29 | 2011-06-22 | 제넨테크, 인크. | Vegf-비의존적 종양의 진단 및 치료 |
WO2010046780A2 (fr) * | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Composés antiviraux |
JP2012509342A (ja) | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ[2,3−b]−ピリジンおよび−ピラジン |
EP2375904B1 (fr) * | 2008-12-09 | 2014-05-28 | Merck Sharp & Dohme Corp. | Biaryl carboxamides |
CN102300862B (zh) | 2008-12-19 | 2016-11-23 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
BRPI0922435A2 (pt) | 2008-12-19 | 2018-09-11 | Sirtris Pharmaceuticals Inc | "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso." |
JP2012102018A (ja) * | 2009-03-03 | 2012-05-31 | Astellas Pharma Inc | アミド化合物 |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
DE102009056886A1 (de) | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
BR112012019302B1 (pt) | 2010-02-03 | 2022-06-21 | Incyte Holdings Corporation | Imidazo[1,2-b] [1,2,4]triazinas como inibidores de c-met, composição que as compreende e métodos in vitro de inibir a atividade de c-met cinase, de inibir a via de sinalização da hgf/c-met cinase em uma célula e de inibir a atividade proliferativa de uma célula |
JP2013525476A (ja) * | 2010-05-04 | 2013-06-20 | ファイザー・インク | Alk阻害剤としての複素環式誘導体 |
EP2569286B1 (fr) * | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Composés utilisables en tant qu'inhibiteurs de la kinase atr |
NZ603477A (en) | 2010-05-12 | 2014-09-26 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
EP2569287B1 (fr) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Composés utilisables en tant qu'inhibiteurs de la kinase atr |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
JP2013526570A (ja) | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 縮合二環式キナーゼ阻害剤 |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
KR101677790B1 (ko) | 2010-06-25 | 2016-11-18 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제 |
US9120752B2 (en) | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
WO2012042421A1 (fr) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Procédé de traitement de la croissance cellulaire anormale |
AU2011311814B2 (en) | 2010-10-08 | 2016-12-22 | Xcovery Holdings, Inc. | Substituted pyridazine carboxamide compounds |
JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 大環状キナーゼ阻害剤 |
GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
PL2672847T3 (pl) | 2011-02-11 | 2015-10-30 | Batmark Ltd | Część składowa inhalatora |
JP5965923B2 (ja) * | 2011-02-24 | 2016-08-10 | ジエンス ハンセン ファーマセウティカル カンパニー リミテッド | プロテインキナーゼ阻害剤としてのリン含有化合物 |
US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
BR112013028895A2 (pt) | 2011-05-10 | 2016-08-09 | Bayer Ip Gmbh | (tio)carbonilamidinas bicíclicas |
EP2710003A1 (fr) | 2011-05-16 | 2014-03-26 | OSI Pharmaceuticals, LLC | Inhibiteurs de kinases bicycliques fusionnés |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
CA2842841C (fr) * | 2011-07-27 | 2016-04-19 | Nanjing Allgen Pharma Co. Ltd. | Molecules spirocycliques convenant comme inhibiteurs de proteines kinases |
KR20140041906A (ko) | 2011-08-02 | 2014-04-04 | 화이자 인코포레이티드 | 암의 치료에 사용하기 위한 크리조티닙 |
EP2940017B1 (fr) | 2011-09-30 | 2019-08-28 | Vertex Pharmaceuticals Incorporated | Procédé de préparation de composés utiles en tant qu'inhibiteurs de kinase d'ATR |
MX2014003785A (es) | 2011-09-30 | 2014-07-24 | Vertex Phamaceuticals Inc | Tratamiento del cancer de pancreas y del cancer de pulmon de celulas no pequeñas con inhibidores de atr. |
JP5823066B2 (ja) | 2012-03-06 | 2015-11-25 | ファイザー・インク | 増殖性疾患の治療のための大環状誘導体 |
AU2013203824A1 (en) | 2012-03-16 | 2013-10-03 | Purdue Pharma L.P. | Substituted pyridines and pryimidines as sodium channel blockers |
NZ720511A (en) | 2012-04-05 | 2016-12-23 | Vertex Pharma | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
WO2013152252A1 (fr) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Polythérapie antinéoplasique |
JP6340361B2 (ja) | 2012-04-13 | 2018-06-06 | エピザイム,インコーポレイティド | がんを処置するための組合せ治療 |
CN103387535B (zh) * | 2012-05-10 | 2016-06-01 | 广东东阳光药业有限公司 | 取代的炔基吡啶化合物及其使用方法和用途 |
WO2013177092A1 (fr) * | 2012-05-23 | 2013-11-28 | Sunshine Lake Pharma Co., Ltd. | Composés d'alcynylpyridine substitués et procédés d'utilisation |
GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
MX367055B (es) | 2012-06-26 | 2019-08-02 | Del Mar Pharmaceuticals | El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa. |
US9651555B2 (en) | 2012-09-24 | 2017-05-16 | Ventana Medical Systems, Inc. | Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker |
DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
WO2014081816A1 (fr) * | 2012-11-21 | 2014-05-30 | Concert Pharmaceuticals, Inc. | Dérivés fluorés de composés amino-hétéroaryle substitués par pyrazole |
HUE037371T2 (hu) | 2012-12-07 | 2018-08-28 | Vertex Pharma | 2-Amino-6-fluor-N-(5-fluor-4-(4-(4-(oxetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il) pirazolo[1,5alfa]pirimidin-3-karboxamid mint ATR kináz inhibitor |
US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
JP6200520B2 (ja) * | 2013-02-02 | 2017-09-20 | 正大天晴薬業集団股▲ふん▼有限公司 | 置換2−アミノピリジンプロテインキナーゼ阻害剤 |
JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物 |
SG11201509278XA (en) | 2013-05-14 | 2015-12-30 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
WO2015034729A1 (fr) * | 2013-09-05 | 2015-03-12 | Calitor Sciences, Llc | Composés de pyridine substituée et leurs méthodes d'utilisation |
WO2015036898A2 (fr) * | 2013-09-10 | 2015-03-19 | Shilpa Medicare Limited | Nouveaux sels de crizotinib et leur préparation |
RU2550346C2 (ru) | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
MX368311B (es) | 2013-09-30 | 2019-09-27 | Korea Res Inst Chemical Tech | Nuevos derivados de triazolopirazina y usos de los mismos. |
US20160280798A1 (en) | 2013-11-06 | 2016-09-29 | The United States Of America, As Represented By The Secretary Department Of Health & Human Service | Alk antibodies, conjugates, and chimeric antigen receptors, and their use |
AU2014360380B2 (en) | 2013-12-06 | 2019-03-21 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
ES2841137T3 (es) | 2013-12-20 | 2021-07-07 | Sagimet Biosciences Inc | Moduladores heterocíclicos de la síntesis de lípidos y combinaciones de los mismos |
CN103755627B (zh) * | 2014-01-09 | 2016-02-17 | 定陶县友帮化工有限公司 | 2-氨基-3-羟基-5-氯吡啶的合成方法 |
TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ros1突變癌細胞之分子 |
MA39776A (fr) | 2014-03-24 | 2017-02-01 | Hoffmann La Roche | Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
WO2015167825A1 (fr) | 2014-04-29 | 2015-11-05 | Emory University | Antagonistes du récepteur ep2 des prostaglandines, dérivés, compositions et utilisations associés |
WO2015172747A1 (fr) * | 2014-05-16 | 2015-11-19 | Zhaoyin Wang | Molécules spirocycliques servant d'inhibiteurs de mth1 |
SG11201610197XA (en) | 2014-06-05 | 2017-01-27 | Vertex Pharma | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
PL3157566T3 (pl) | 2014-06-17 | 2019-10-31 | Vertex Pharma | Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr |
WO2016019909A1 (fr) * | 2014-08-07 | 2016-02-11 | 江苏豪森药业股份有限公司 | Nouvelle forme cristalline de composé anticancéreux, procédé de préparation et utilisation correspondants |
CN107108581B (zh) | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
SI3524595T1 (sl) | 2014-08-28 | 2022-10-28 | Eisai R&D Management Co., Ltd. | Derivat kinolina visoke čistosti in postopek njegove proizvodnje |
MX2017004515A (es) | 2014-10-13 | 2017-10-31 | Atrin Pharmaceuticals LLC | Inhibidores de proteína-cinasas relacionados a ataxia-telengiectasia y rad3 (atr). |
GB2535427A (en) | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
WO2016073847A2 (fr) * | 2014-11-07 | 2016-05-12 | The Regents Of The University Of Michigan | Inhibiteurs de la transcription de gènes médiée par le facteur apparenté à la myocardine et le facteur de réponse sérique (mrtf/srf) et procédés pour les utiliser |
KR102595599B1 (ko) | 2014-12-02 | 2023-11-02 | 이그니타, 인코포레이티드 | 신경모세포종의 치료를 위한 병용 |
WO2016114322A1 (fr) | 2015-01-13 | 2016-07-21 | 国立大学法人京都大学 | Agent pour la prévention et/ou le traitement de la sclérose latérale amyotrophique |
WO2016136745A1 (fr) | 2015-02-25 | 2016-09-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Procédé de suppression de l'amertume d'un dérivé de quinoléine |
MA41598A (fr) * | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | Composés thérapeutiques de pyridazine et leurs utilisations |
KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
US10464896B2 (en) | 2015-06-11 | 2019-11-05 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
CA2988707C (fr) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combinaison de proteine se liant au cre/inhibiteur de catenine et d'un inhibiteur de point de controle immunitaire servant au traitement du cancer |
US10405627B2 (en) * | 2015-07-14 | 2019-09-10 | Michael Charles Boland, III | Luggage with fold out table |
WO2017059357A1 (fr) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Méthode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr |
WO2017106492A1 (fr) | 2015-12-18 | 2017-06-22 | Ignyta, Inc. | Combinaisons pour le traitement du cancer |
WO2017161004A1 (fr) * | 2016-03-15 | 2017-09-21 | University Of South Florida | Formulations d'inhibiteurs de pkcδ et utilisations associées |
WO2017180723A1 (fr) | 2016-04-12 | 2017-10-19 | Atrin Pharmaceuticals LLC | Inhibiteurs de l'atr (ataxia telangiectasia and rad3 related) et leurs méthodes d'utilisation |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
WO2017201585A1 (fr) * | 2016-05-26 | 2017-11-30 | Genea Ip Holdings Pty Ltd | Modulateurs de dux4 pour la régulation de la fonction musculaire |
TWI646094B (zh) | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
EP3558992A4 (fr) * | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | Activateur de canaux trek (canaux k+ associés à twik) |
CN106866627B (zh) * | 2017-01-24 | 2021-09-14 | 南方医科大学 | 3-(1-(氨基吡啶氧基)乙基)苯甲酰胺衍生物及其合成方法和应用 |
SG11202000431PA (en) | 2017-07-18 | 2020-02-27 | Nuvation Bio Inc | 1,8-naphthyridinone compounds and uses thereof |
AU2018302179A1 (en) | 2017-07-18 | 2020-02-13 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
US10398693B2 (en) | 2017-07-19 | 2019-09-03 | Ignyta, Inc. | Pharmaceutical compositions and dosage forms |
CN111225662B (zh) | 2017-10-17 | 2022-11-22 | 伊尼塔公司 | 药物组合物和剂型 |
CN107794282B (zh) * | 2017-11-20 | 2020-12-25 | 浙江工业大学 | 一种克唑替尼手性中间体的制备方法及菌株 |
WO2019154665A1 (fr) * | 2018-02-07 | 2019-08-15 | Basf Se | Nouveaux pyridine carboxamides |
US11767296B2 (en) | 2018-03-15 | 2023-09-26 | Fujian Haixi Pharmaceuticals Co., Ltd | Heteroaryl compounds as kinase inhibitor |
CN110372664A (zh) * | 2018-04-13 | 2019-10-25 | 华东理工大学 | 选择性jak2抑制剂及其应用 |
WO2019206049A1 (fr) * | 2018-04-25 | 2019-10-31 | Zhuhai Yufan Biotechnologies Co., Ltd | Inhibiteurs d'hpk1, procédé de préparation et utilisation associés |
CN110396088B (zh) * | 2018-04-25 | 2024-03-12 | 珠海宇繁生物科技有限责任公司 | Hpk1激酶抑制剂、制备方法及其应用 |
CN108947895B (zh) * | 2018-08-22 | 2021-09-24 | 肇庆中彩机电技术研发有限公司 | 一种抗癌活性的化合物 |
CN113939291A (zh) | 2019-01-18 | 2022-01-14 | 诺维逊生物股份有限公司 | 1,8-萘啶酮化合物及其用途 |
AU2020207952A1 (en) * | 2019-01-18 | 2021-08-26 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
AU2020208644A1 (en) * | 2019-01-18 | 2021-08-26 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
KR20220004206A (ko) | 2019-05-14 | 2022-01-11 | 텔리진 엘티디. | 키네이스 억제제로 유용한 치환된 거대고리화합물 |
KR102426921B1 (ko) * | 2019-09-24 | 2022-07-29 | 주식회사 이노보테라퓨틱스 | 헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물 |
CN112552293A (zh) * | 2019-09-25 | 2021-03-26 | 珠海宇繁生物科技有限责任公司 | 一种protac小分子化合物及其应用 |
KR102344185B1 (ko) * | 2020-02-26 | 2021-12-27 | 계명대학교 산학협력단 | 신규한 Pim 키나아제 억제제 및 이의 용도 |
CN113493437B (zh) * | 2020-04-03 | 2022-07-26 | 中国药科大学 | 含苯并咪唑结构的化合物及其制备方法和用途 |
WO2021196655A1 (fr) * | 2020-04-03 | 2021-10-07 | 中国药科大学 | Composé contenant une structure benzimidazole, son procédé de préparation et application de celui-ci |
WO2023086671A1 (fr) * | 2021-11-15 | 2023-05-19 | The Broad Institute, Inc. | Composés, compositions et méthodes pour induire une activité intracellulaire antimicrobienne et pour prévenir et traiter des infections microbiennes |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
US4966849A (en) | 1985-09-20 | 1990-10-30 | President And Fellows Of Harvard College | CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression |
US5217999A (en) | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5326905A (en) | 1990-04-02 | 1994-07-05 | Pfizer Inc. | Benzylphosphonic acid tyrosine kinase inhibitors |
US5302606A (en) | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
US5409930A (en) * | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US6194439B1 (en) | 1991-05-29 | 2001-02-27 | Pfizer Inc. | Tricyclic polyhydroxylic tyrosine kinase inhibitors |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
GB9201693D0 (en) | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
CA2372813A1 (fr) | 1992-02-06 | 1993-08-19 | L.L. Houston | Proteine fixatrice biosynthetique pour marqueur du cancer |
RU2155187C2 (ru) | 1992-08-06 | 2000-08-27 | Варнер-Ламберт Компани | Производные индола, их таутомеры, смеси их изомеров или отдельные изомеры и фармацевтически приемлемые соли, фармацевтическая композиция с антиопухолевой или ингибирующей протеин-тирозинкиназу активностью и способ торможения зависящего от протеин-тирозинкиназы заболевания или борьбы с аберрантным ростом клеток млекопитающего или человека. |
US5330992A (en) | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
DK0666868T4 (da) | 1992-10-28 | 2006-09-18 | Genentech Inc | Anvendelse af anti-VEGF-antistoffer til behandling af cancer |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5521190A (en) * | 1993-05-27 | 1996-05-28 | Fmc Corporation | Insecticidal pterdines and 8-deazapteridines |
JPH07109260A (ja) * | 1993-10-12 | 1995-04-25 | Fuji Photo Film Co Ltd | 5−アミノ−2−ニトロピリジン誘導体及び2,5−ジアミノ−3−ヒドロキシピリジン誘導体の製造方法 |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
US5861510A (en) | 1995-04-20 | 1999-01-19 | Pfizer Inc | Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
ES2183905T3 (es) | 1995-12-20 | 2003-04-01 | Hoffmann La Roche | Inhibidores de metaloproteasa de matriz. |
IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
BR9710362A (pt) | 1996-07-13 | 1999-08-17 | Glaxo Group Ltd | Composto formula-ao farmaceutica utiliza-ao de um composto processos de tratamento de um ser humano ou animal sofrendo de uma mediada por atividade anormal de cinase de proteina tirosina e para a prepara-ao de um composto |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
JP4386967B2 (ja) | 1996-07-13 | 2009-12-16 | グラクソ、グループ、リミテッド | プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物 |
EP0923585B1 (fr) | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Composes a base de phosphinate inhibiteurs des metalloproteases matricielles |
CN1228083A (zh) | 1996-08-23 | 1999-09-08 | 美国辉瑞有限公司 | 芳基磺酰氨基异羟肟酸衍生物 |
ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
WO1998030566A1 (fr) | 1997-01-06 | 1998-07-16 | Pfizer Inc. | Derives de sulfone cyclique |
NZ336840A (en) | 1997-02-03 | 2001-01-26 | Pfizer Prod Inc | Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases |
JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
IL131123A0 (en) | 1997-02-11 | 2001-01-28 | Pfizer | Arylsulfonyl hydroxamic acid derivatives |
SE9700661D0 (sv) * | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
EP0984930B1 (fr) | 1997-05-07 | 2005-04-06 | Sugen, Inc. | Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase |
CA2291709A1 (fr) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Nouveaux inhibiteurs d'angiogenese |
DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
JP2001518470A (ja) | 1997-09-26 | 2001-10-16 | メルク エンド カムパニー インコーポレーテッド | 新規な血管形成阻害剤 |
PL340589A1 (en) | 1997-11-11 | 2001-02-12 | Pfizer Prod Inc | Derivatives of thienepyrimidine and thienepyridine useful as anticarcinogenic agents |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
SK287132B6 (sk) | 1998-05-29 | 2009-12-07 | Sugen, Inc. | Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu |
US20010002396A1 (en) * | 1998-07-16 | 2001-05-31 | Charles Achkar | Compositions and methods of treating skin conditions |
AU2124800A (en) | 1999-02-11 | 2000-08-29 | Pfizer Products Inc. | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents |
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
AU5636900A (en) * | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
DE122010000004I1 (de) | 2000-02-15 | 2010-04-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
KR20030031886A (ko) | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
US6818635B2 (en) | 2000-07-07 | 2004-11-16 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
WO2002024681A2 (fr) * | 2000-09-20 | 2002-03-28 | Ortho-Mcneil Pharmaceutical, Inc. | Derives de pyrazine tenant lieu de modulateurs de tyrosine kinase |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
JP4064818B2 (ja) * | 2001-02-12 | 2008-03-19 | エフ.ホフマン−ラ ロシュ アーゲー | 6−置換ピリド−ピリミジン類 |
US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
MXPA04004714A (es) | 2001-11-21 | 2004-08-19 | Upjohn Co | Derivados de aril 1,4-pirazina sustituidos. |
DK1603570T5 (da) * | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
ES2355923T3 (es) * | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
ES2341351T3 (es) * | 2004-08-26 | 2010-06-18 | Pfizer, Inc. | Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas. |
US10181126B2 (en) | 2012-03-13 | 2019-01-15 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
JP6943759B2 (ja) | 2017-12-28 | 2021-10-06 | 株式会社東海理化電機製作所 | シフト装置 |
-
2004
- 2004-02-26 DK DK04715001.6T patent/DK1603570T5/da active
- 2004-02-26 ES ES04715001T patent/ES2401330T3/es not_active Expired - Lifetime
- 2004-02-26 PT PT47150016T patent/PT1603570E/pt unknown
- 2004-02-26 CN CN201310167961.7A patent/CN103265477B/zh not_active Expired - Lifetime
- 2004-02-26 AU AU2004215428A patent/AU2004215428B2/en active Active
- 2004-02-26 MX MXPA05009063A patent/MXPA05009063A/es active IP Right Grant
- 2004-02-26 KR KR1020057015999A patent/KR101106905B1/ko active IP Right Grant
- 2004-02-26 DK DK12163855.5T patent/DK2476667T3/da active
- 2004-02-26 EA EA200501236A patent/EA010727B1/ru active Protection Beyond IP Right Term
- 2004-02-26 GE GEAP20048993A patent/GEP20084341B/en unknown
- 2004-02-26 CA CA2517256A patent/CA2517256C/fr not_active Expired - Lifetime
- 2004-02-26 US US10/786,610 patent/US7230098B2/en active Active
- 2004-02-26 RS YU20050708A patent/RS53118B/en unknown
- 2004-02-26 WO PCT/US2004/005495 patent/WO2004076412A2/fr active Application Filing
- 2004-02-26 PT PT121638555T patent/PT2476667E/pt unknown
- 2004-02-26 NZ NZ541861A patent/NZ541861A/en not_active IP Right Cessation
- 2004-02-26 EP EP04715001.6A patent/EP1603570B9/fr not_active Expired - Lifetime
- 2004-02-26 EP EP12163855.5A patent/EP2476667B1/fr not_active Expired - Lifetime
- 2004-02-26 BR BRPI0407827A patent/BRPI0407827B8/pt active IP Right Grant
- 2004-02-26 AP AP2005003383A patent/AP2114A/xx active
- 2004-02-26 OA OA1200500243A patent/OA13151A/en unknown
- 2004-02-26 ES ES12163855.5T patent/ES2502490T3/es not_active Expired - Lifetime
- 2004-02-26 ME MEP-528/08A patent/MEP52808A/xx unknown
- 2004-02-26 JP JP2006503845A patent/JP4695588B2/ja not_active Expired - Lifetime
- 2004-02-26 PL PL378759A patent/PL216368B1/pl unknown
-
2005
- 2005-08-15 IL IL170291A patent/IL170291A/en active Protection Beyond IP Right Term
- 2005-08-16 HR HRP20050714AA patent/HRP20050714B1/hr not_active IP Right Cessation
- 2005-08-18 IS IS7990A patent/IS2910B/is unknown
- 2005-08-26 TN TNP2005000208A patent/TNSN05208A1/fr unknown
- 2005-08-26 EC EC2005005988A patent/ECSP055988A/es unknown
- 2005-08-26 MA MA28457A patent/MA27713A1/fr unknown
- 2005-09-01 NO NO20054080A patent/NO332188B1/no unknown
-
2006
- 2006-11-14 US US11/598,765 patent/US8106197B2/en active Active
-
2013
- 2013-03-19 CY CY20131100229T patent/CY1113837T1/el unknown
-
2014
- 2014-08-20 CY CY20141100664T patent/CY1115472T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
OA13151A (en) | Aminoheteroaryl compounds as protein kinase inhibitors. | |
JP2021152064A (ja) | 乳酸脱水素酵素の小分子阻害剤及びその使用方法 | |
EP3094325B1 (fr) | Hétéroaryles et utilisations de ceux-ci | |
TWI552752B (zh) | 雜芳基化合物及其用途 | |
CN103124730B (zh) | 杂环炔苯类化合物及其药用组合物和应用 | |
JP2017165788A (ja) | Dna−pk阻害剤 | |
JP2011528026A (ja) | 新規化学化合物 | |
JP2011528026A6 (ja) | 新規化学化合物 | |
HUE026315T2 (en) | Preparations and methods for inhibiting the JAK pathway | |
BRPI0617150A2 (pt) | pirazolopirimidinas como inibidores de protéina cinase | |
US20070238737A1 (en) | Novel compounds | |
CN116041320A (zh) | 吡啶胺-吡啶酮化合物和嘧啶胺-吡啶酮化合物 | |
AU2004221812A1 (en) | Tie-2 modulators and methods of use | |
KR20210095621A (ko) | 키나아제 억제 활성을 가진 방향족 헤테로고리 화합물 | |
EP1683798B1 (fr) | Composés polycycliques condensés comprenant un heterocycle et ses applications medicales | |
TW201605832A (zh) | 作為p97錯合物之抑制劑之單環嘧啶/吡啶化合物 | |
CN110938071A (zh) | 一类具有激酶抑制活性的芳香杂环类化合物 | |
CN114269742B (zh) | 作为治疗剂的4-(咪唑并[1,2-a]吡啶-3-基)-N-(吡啶基)嘧啶-2-胺的衍生物 | |
CN111247144B (zh) | 氮杂吲哚基吡啶酮化合物和二氮杂吲哚基吡啶酮化合物 | |
CN116063324A (zh) | 具有大环结构的btk和/或ret抑制剂 |