NO994397L - FremgangsmÕte ved integrering av gener ved spesifikke seter i pattedyrceller via homolog rekombinasjon samt vektorer for utförelse av fremgangsmÕten - Google Patents
FremgangsmÕte ved integrering av gener ved spesifikke seter i pattedyrceller via homolog rekombinasjon samt vektorer for utförelse av fremgangsmÕtenInfo
- Publication number
- NO994397L NO994397L NO994397A NO994397A NO994397L NO 994397 L NO994397 L NO 994397L NO 994397 A NO994397 A NO 994397A NO 994397 A NO994397 A NO 994397A NO 994397 L NO994397 L NO 994397L
- Authority
- NO
- Norway
- Prior art keywords
- homologous recombination
- via homologous
- vectors
- mammalian cells
- cells via
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/819,866 US5830698A (en) | 1997-03-14 | 1997-03-14 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
US09/023,715 US5998144A (en) | 1997-03-14 | 1998-02-13 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
PCT/US1998/003935 WO1998041645A1 (fr) | 1997-03-14 | 1998-03-09 | Procede pour integrer des genes a des sites specifiques dans des cellules de mammifere par recombinaison homologue et vecteurs utilises pour la mise en oeuvre de ce procede |
Publications (2)
Publication Number | Publication Date |
---|---|
NO994397D0 NO994397D0 (no) | 1999-09-10 |
NO994397L true NO994397L (no) | 1999-11-09 |
Family
ID=26697516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO994397A NO994397L (no) | 1997-03-14 | 1999-09-10 | FremgangsmÕte ved integrering av gener ved spesifikke seter i pattedyrceller via homolog rekombinasjon samt vektorer for utförelse av fremgangsmÕten |
Country Status (21)
Country | Link |
---|---|
US (3) | US6413777B1 (fr) |
EP (1) | EP0981637B1 (fr) |
JP (1) | JP4128227B2 (fr) |
CN (1) | CN1175111C (fr) |
AT (1) | ATE296356T1 (fr) |
AU (1) | AU737155B2 (fr) |
BR (1) | BR9808584A (fr) |
CA (1) | CA2283740C (fr) |
CZ (1) | CZ293355B6 (fr) |
DE (1) | DE69830312T2 (fr) |
ES (1) | ES2242997T3 (fr) |
ID (1) | ID24565A (fr) |
IL (1) | IL131746A0 (fr) |
IN (1) | IN189732B (fr) |
NO (1) | NO994397L (fr) |
PL (1) | PL191251B1 (fr) |
PT (1) | PT981637E (fr) |
RO (1) | RO120148B1 (fr) |
RU (1) | RU2004107694A (fr) |
TW (1) | TWI232239B (fr) |
WO (1) | WO1998041645A1 (fr) |
Families Citing this family (98)
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PT981637E (pt) * | 1997-03-14 | 2005-09-30 | Biogen Idec Inc | Metodo para integrar genes em sitios especificos em celulas de mamifero atraves de recombinacao homologa e vectores para a realizacao do mesmo |
US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
CA2313380C (fr) | 1997-12-08 | 2008-12-30 | California Institute Of Technology | Procede servant a creer des sequences de polynucleotides et de polypeptides |
CA2358385C (fr) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides codant pour des polypeptides antigeniques du type c du vih; polypeptides et leurs utilisations |
GB9912965D0 (en) * | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
US6316253B1 (en) | 1999-11-01 | 2001-11-13 | Chiron Corporation | Expression vectors, transfection systems, and method of use thereof |
DK1297170T3 (en) * | 2000-06-23 | 2016-03-14 | Novozymes As | A process for stable chromosomal integration of multiple copies of the genes |
EP1411770A4 (fr) | 2001-07-05 | 2006-05-10 | Chiron Corp | Polynucleotides codant des polypeptides de type c du vih antigeniques, polypeptides et leurs utilisations |
EA007905B1 (ru) | 2001-11-16 | 2007-02-27 | Байоджен Айдек Инк. | Полицистронная экспрессия антител |
US7164056B2 (en) * | 2002-05-03 | 2007-01-16 | Pioneer Hi-Bred International, Inc. | Gene targeting using replicating DNA molecules |
ATE514717T1 (de) | 2002-07-18 | 2011-07-15 | Merus B V | Rekombinante produktion von antikörpermischungen |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
AU2003286684A1 (en) * | 2002-10-30 | 2004-06-07 | Gail Bishop | Somatic cell gene targeting vectors and methods of use thereof |
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DE10303937A1 (de) * | 2003-01-31 | 2004-08-12 | Icon Genetics Ag | Pflanzentransformation mit Assemblierung einer gewünschten Sequenz in Vivo |
BRPI0408501A (pt) * | 2003-03-19 | 2006-03-14 | Biogen Idec Inc | proteìna de ligação ao receptor nogo |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
NZ568403A (en) * | 2003-05-09 | 2009-10-30 | Univ Duke | CD20-specific antibodies and methods of employing same |
WO2004106375A1 (fr) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Banque de fab pour la preparation de fab anti-vegf et antirabique |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
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JP4751326B2 (ja) * | 2003-09-04 | 2011-08-17 | メダレックス インコーポレイテッド | 発現ベクター |
US8030833B2 (en) * | 2003-09-19 | 2011-10-04 | The Board Of Trustees Of The University Of Illinois | Electron emission device incorporating free standing monocrystalline nanowires |
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US7935862B2 (en) * | 2003-12-02 | 2011-05-03 | Syngenta Participations Ag | Targeted integration and stacking of DNA through homologous recombination |
CA2554054C (fr) | 2004-01-20 | 2013-06-04 | Merus B.V. | Melanges de proteines de liaison |
PL1776136T3 (pl) | 2004-06-24 | 2013-03-29 | Biogen Ma Inc | Leczenie stanów związanych z demielinizacją |
ATE443870T1 (de) | 2004-07-20 | 2009-10-15 | Symphogen As | Verfahren zur charakterisierung einer polyklonalen zellinie |
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EP2436696B8 (fr) | 2007-01-05 | 2017-12-13 | University of Zurich | Anticorps anti-amyloide et son utilisation |
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KR20210010942A (ko) | 2010-03-31 | 2021-01-28 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
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EP3548066A1 (fr) | 2016-12-02 | 2019-10-09 | Bioverativ Therapeutics Inc. | Méthodes de traitement de l'arthropathie hémophilique à l'aide de facteurs de coagulation chimériques |
TW201831521A (zh) | 2017-01-31 | 2018-09-01 | 美商生物化學醫療公司 | 因子ix融合蛋白以及其製備方法及使用方法 |
TW202003551A (zh) | 2018-03-28 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 介白素-2/介白素-2受體阿法融合蛋白及其使用方法 |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
WO2019236417A1 (fr) | 2018-06-04 | 2019-12-12 | Biogen Ma Inc. | Anticorps anti-vla-4 ayant une fonction effectrice réduite |
CN110607326B (zh) * | 2018-06-15 | 2022-11-29 | 江苏省农业科学院 | 非强启动式的外源基因表达法及其在具有毒性的目标蛋白表达中的应用 |
WO2020072480A1 (fr) * | 2018-10-01 | 2020-04-09 | Lonza Ltd | Cellules ssi à expression transgénique prévisible et stable et procédés de formation |
SG11202108560RA (en) | 2019-02-13 | 2021-09-29 | Brigham & Womens Hospital Inc | Anti-peripheral lymph node addressin antibodies and uses thereof |
AU2022332276A1 (en) | 2021-08-23 | 2024-04-04 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
IL310963A (en) | 2021-08-23 | 2024-04-01 | Bioverativ Therapeutics Inc | Production of closed DNA with inverted repeat sequences |
WO2023056331A1 (fr) | 2021-09-30 | 2023-04-06 | Bioverativ Therapeutics Inc. | Acides nucléiques codant pour des polypeptides du facteur viii à immunogénicité réduite |
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US5202238A (en) * | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
WO1991006666A1 (fr) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production de proteines par recombinaison homologue |
PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
AU4401993A (en) * | 1992-06-04 | 1993-12-30 | Exemplar Corporation | Insertion of heterologous dna outside of known chromosomal genes |
MX9305183A (es) * | 1992-08-27 | 1994-05-31 | Us Agriculture | Intron portatil, molecula de adn genomico viral, virus vivo y vacuna que los contiene y metodo para su obtencion. |
US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
PT981637E (pt) * | 1997-03-14 | 2005-09-30 | Biogen Idec Inc | Metodo para integrar genes em sitios especificos em celulas de mamifero atraves de recombinacao homologa e vectores para a realizacao do mesmo |
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1998
- 1998-03-09 PT PT98910109T patent/PT981637E/pt unknown
- 1998-03-09 CZ CZ19993162A patent/CZ293355B6/cs not_active IP Right Cessation
- 1998-03-09 AT AT98910109T patent/ATE296356T1/de not_active IP Right Cessation
- 1998-03-09 CN CNB988049880A patent/CN1175111C/zh not_active Expired - Fee Related
- 1998-03-09 ID IDW991196A patent/ID24565A/id unknown
- 1998-03-09 DE DE69830312T patent/DE69830312T2/de not_active Revoked
- 1998-03-09 WO PCT/US1998/003935 patent/WO1998041645A1/fr active IP Right Grant
- 1998-03-09 RO RO99-00972A patent/RO120148B1/ro unknown
- 1998-03-09 AU AU64435/98A patent/AU737155B2/en not_active Ceased
- 1998-03-09 EP EP98910109A patent/EP0981637B1/fr not_active Revoked
- 1998-03-09 PL PL335695A patent/PL191251B1/pl not_active IP Right Cessation
- 1998-03-09 CA CA002283740A patent/CA2283740C/fr not_active Expired - Fee Related
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- 1998-03-09 BR BR9808584-0A patent/BR9808584A/pt not_active Application Discontinuation
- 1998-03-10 IN IN616DE1998 patent/IN189732B/en unknown
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Also Published As
Publication number | Publication date |
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WO1998041645A1 (fr) | 1998-09-24 |
DE69830312T2 (de) | 2006-02-02 |
JP4128227B2 (ja) | 2008-07-30 |
RO120148B1 (ro) | 2005-09-30 |
US6841383B2 (en) | 2005-01-11 |
US20020192820A1 (en) | 2002-12-19 |
CZ293355B6 (cs) | 2004-04-14 |
BR9808584A (pt) | 2000-05-23 |
JP2001516221A (ja) | 2001-09-25 |
NO994397D0 (no) | 1999-09-10 |
DE69830312D1 (de) | 2005-06-30 |
PL191251B1 (pl) | 2006-04-28 |
CN1175111C (zh) | 2004-11-10 |
CN1255166A (zh) | 2000-05-31 |
ES2242997T3 (es) | 2005-11-16 |
TWI232239B (en) | 2005-05-11 |
AU6443598A (en) | 1998-10-12 |
EP0981637A1 (fr) | 2000-03-01 |
IN189732B (fr) | 2003-04-19 |
PL335695A1 (en) | 2000-05-08 |
ATE296356T1 (de) | 2005-06-15 |
ID24565A (id) | 2000-07-27 |
AU737155B2 (en) | 2001-08-09 |
PT981637E (pt) | 2005-09-30 |
EP0981637B1 (fr) | 2005-05-25 |
CA2283740A1 (fr) | 1998-09-24 |
RU2004107694A (ru) | 2005-08-27 |
CA2283740C (fr) | 2006-06-27 |
CZ316299A3 (cs) | 2000-02-16 |
IL131746A0 (en) | 2001-03-19 |
US6413777B1 (en) | 2002-07-02 |
US20040166528A1 (en) | 2004-08-26 |
US7235360B2 (en) | 2007-06-26 |
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