NO325672B1 - Kinazolinderivater, medikamenter inneholdende disse forbindelser, deres anvendelse for fremstilling av legemidler og fremgangsmate for fremstilling derav - Google Patents
Kinazolinderivater, medikamenter inneholdende disse forbindelser, deres anvendelse for fremstilling av legemidler og fremgangsmate for fremstilling derav Download PDFInfo
- Publication number
- NO325672B1 NO325672B1 NO20032726A NO20032726A NO325672B1 NO 325672 B1 NO325672 B1 NO 325672B1 NO 20032726 A NO20032726 A NO 20032726A NO 20032726 A NO20032726 A NO 20032726A NO 325672 B1 NO325672 B1 NO 325672B1
- Authority
- NO
- Norway
- Prior art keywords
- amino
- tetrahydrofuran
- general formula
- chloro
- fluorophenyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title description 7
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- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10063435A DE10063435A1 (de) | 2000-12-20 | 2000-12-20 | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| PCT/EP2001/014569 WO2002050043A1 (de) | 2000-12-20 | 2001-12-12 | Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20032726D0 NO20032726D0 (no) | 2003-06-16 |
| NO20032726L NO20032726L (no) | 2003-06-16 |
| NO325672B1 true NO325672B1 (no) | 2008-07-07 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20032726A NO325672B1 (no) | 2000-12-20 | 2003-06-16 | Kinazolinderivater, medikamenter inneholdende disse forbindelser, deres anvendelse for fremstilling av legemidler og fremgangsmate for fremstilling derav |
| NO2014003C NO2014003I2 (no) | 2000-12-20 | 2014-02-11 | Afatinib - tautomerer, stereoisomerer og salter derav, fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, fortrinnsvis et maleatsalt derav, mer fortrinnsvis et dimaletsalt derav (patentkravene 3, 4 og 5) |
| NO2022028C NO2022028I1 (no) | 2000-12-20 | 2022-07-01 | Afatinib - tautomers, stereoisomers og salts thereof - forlengelse SPC |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2014003C NO2014003I2 (no) | 2000-12-20 | 2014-02-11 | Afatinib - tautomerer, stereoisomerer og salter derav, fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, fortrinnsvis et maleatsalt derav, mer fortrinnsvis et dimaletsalt derav (patentkravene 3, 4 og 5) |
| NO2022028C NO2022028I1 (no) | 2000-12-20 | 2022-07-01 | Afatinib - tautomers, stereoisomers og salts thereof - forlengelse SPC |
Country Status (40)
| Country | Link |
|---|---|
| EP (2) | EP1345910B9 (sh) |
| JP (1) | JP3827641B2 (sh) |
| KR (1) | KR100852102B1 (sh) |
| CN (1) | CN1277822C (sh) |
| AR (1) | AR040524A1 (sh) |
| AT (1) | ATE430136T1 (sh) |
| AU (2) | AU2002219174B2 (sh) |
| BE (1) | BE2014C009I2 (sh) |
| BG (1) | BG66139B1 (sh) |
| BR (1) | BRPI0116266B8 (sh) |
| CA (1) | CA2432428C (sh) |
| CY (2) | CY1109290T1 (sh) |
| CZ (1) | CZ302721B6 (sh) |
| DE (2) | DE10063435A1 (sh) |
| DK (1) | DK1345910T3 (sh) |
| EA (1) | EA006317B1 (sh) |
| EE (1) | EE05244B1 (sh) |
| ES (1) | ES2326617T3 (sh) |
| FR (1) | FR14C0009I2 (sh) |
| HK (1) | HK1060571A1 (sh) |
| HR (1) | HRP20030504B1 (sh) |
| HU (2) | HU228874B1 (sh) |
| IL (2) | IL156277A0 (sh) |
| LT (1) | LTC1345910I2 (sh) |
| LU (1) | LU92370I2 (sh) |
| ME (1) | ME02777B (sh) |
| MX (1) | MXPA03005559A (sh) |
| MY (1) | MY136086A (sh) |
| NO (3) | NO325672B1 (sh) |
| NZ (1) | NZ526918A (sh) |
| PL (1) | PL214798B1 (sh) |
| PT (1) | PT1345910E (sh) |
| RS (1) | RS50860B (sh) |
| SI (1) | SI1345910T1 (sh) |
| SK (1) | SK287573B6 (sh) |
| TW (1) | TWI295992B (sh) |
| UA (1) | UA74614C2 (sh) |
| UY (1) | UY27078A1 (sh) |
| WO (1) | WO2002050043A1 (sh) |
| ZA (1) | ZA200304141B (sh) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71976C2 (en) | 1999-06-21 | 2005-01-17 | Boehringer Ingelheim Pharma | Bicyclic heterocycles and a medicament based thereon |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| US20040044014A1 (en) | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10221018A1 (de) | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| DE10307165A1 (de) * | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10334226A1 (de) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| UA85706C2 (en) * | 2004-05-06 | 2009-02-25 | Уорнер-Ламберт Компани Ллси | 4-phenylaminoquinazolin-6-yl amides |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2006081741A1 (fr) * | 2005-02-05 | 2006-08-10 | Piaoyang Sun | Dérivés de quinazoline ou leurs sels de qualité pharmaceutique, synthèse et applications médicales desdites substances |
| KR100832594B1 (ko) * | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| DK1948180T3 (da) | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
| EP3173084B1 (en) * | 2005-11-11 | 2019-10-23 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
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| IL126351A0 (en) * | 1996-04-12 | 1999-05-09 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
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| DE19908567A1 (de) * | 1999-02-27 | 2000-08-31 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| AU3281600A (en) * | 1999-02-27 | 2000-09-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| UA71976C2 (en) * | 1999-06-21 | 2005-01-17 | Boehringer Ingelheim Pharma | Bicyclic heterocycles and a medicament based thereon |
| ES2280375T3 (es) * | 2000-04-08 | 2007-09-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparacion. |
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