NO324256B1 - Nye multicykliske forbindelser, farmasoytiske preparater inneholdende disse og anvendelser av disse for fremstilling av farmasoytiske preparater for behandling av sykdommer - Google Patents
Nye multicykliske forbindelser, farmasoytiske preparater inneholdende disse og anvendelser av disse for fremstilling av farmasoytiske preparater for behandling av sykdommer Download PDFInfo
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- NO324256B1 NO324256B1 NO20025376A NO20025376A NO324256B1 NO 324256 B1 NO324256 B1 NO 324256B1 NO 20025376 A NO20025376 A NO 20025376A NO 20025376 A NO20025376 A NO 20025376A NO 324256 B1 NO324256 B1 NO 324256B1
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- BZCHKHCGOVKYIY-JTQLQIEISA-N tert-butyl (2s)-5-(carbamothioylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate Chemical compound CC(C)(C)OC(=O)N[C@H](C(=O)OC(C)(C)C)CCCNC(N)=S BZCHKHCGOVKYIY-JTQLQIEISA-N 0.000 description 1
- XJJBXZIKXFOMLP-ZETCQYMHSA-N tert-butyl (2s)-pyrrolidine-2-carboxylate Chemical compound CC(C)(C)OC(=O)[C@@H]1CCCN1 XJJBXZIKXFOMLP-ZETCQYMHSA-N 0.000 description 1
- MRXPDEOWDKBHHK-UHFFFAOYSA-N tert-butyl 3-amino-3-sulfanylidenepropanoate Chemical compound CC(C)(C)OC(=O)CC(N)=S MRXPDEOWDKBHHK-UHFFFAOYSA-N 0.000 description 1
- ZGDKXUIASJWQPP-UHFFFAOYSA-N tert-butyl-[4-(chloromethyl)phenoxy]-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)OC1=CC=C(CCl)C=C1 ZGDKXUIASJWQPP-UHFFFAOYSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- VXKWYPOMXBVZSJ-UHFFFAOYSA-N tetramethyltin Chemical compound C[Sn](C)(C)C VXKWYPOMXBVZSJ-UHFFFAOYSA-N 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 238000001685 time-resolved fluorescence spectroscopy Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
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- UNEPXPMBVGDXGH-UHFFFAOYSA-N tributyl(pyridin-4-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=NC=C1 UNEPXPMBVGDXGH-UHFFFAOYSA-N 0.000 description 1
- UKTDFYOZPFNQOQ-UHFFFAOYSA-N tributyl(thiophen-2-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CS1 UKTDFYOZPFNQOQ-UHFFFAOYSA-N 0.000 description 1
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000003039 volatile agent Substances 0.000 description 1
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- QNLXXQBCQYDKHD-UHFFFAOYSA-K ytterbium(iii) bromide Chemical compound Br[Yb](Br)Br QNLXXQBCQYDKHD-UHFFFAOYSA-K 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
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US20294700P | 2000-05-09 | 2000-05-09 | |
US09/850,858 US7122679B2 (en) | 2000-05-09 | 2001-05-08 | Multicyclic compounds and the use thereof |
PCT/US2001/014996 WO2001085686A2 (en) | 2000-05-09 | 2001-05-09 | Multicyclic compounds and the use as inhibitors of parp, vegfr2 and mlk3 enzymes |
Publications (3)
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NO20025376D0 NO20025376D0 (no) | 2002-11-08 |
NO20025376L NO20025376L (no) | 2003-01-08 |
NO324256B1 true NO324256B1 (no) | 2007-09-17 |
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NO20025376A NO324256B1 (no) | 2000-05-09 | 2002-11-08 | Nye multicykliske forbindelser, farmasoytiske preparater inneholdende disse og anvendelser av disse for fremstilling av farmasoytiske preparater for behandling av sykdommer |
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US (1) | US7122679B2 (de) |
EP (3) | EP2050750B1 (de) |
JP (1) | JP5156150B2 (de) |
KR (1) | KR100832602B1 (de) |
CN (2) | CN101560213B (de) |
AT (3) | ATE411997T1 (de) |
AU (1) | AU6132701A (de) |
BG (1) | BG66036B1 (de) |
BR (1) | BR0110993A (de) |
CA (1) | CA2409758A1 (de) |
CY (1) | CY1108722T1 (de) |
CZ (2) | CZ305350B6 (de) |
DE (3) | DE60143140D1 (de) |
DK (1) | DK1754707T3 (de) |
EA (1) | EA007868B1 (de) |
ES (2) | ES2256238T3 (de) |
HK (3) | HK1051369A1 (de) |
HU (1) | HU229448B1 (de) |
IL (1) | IL152663A0 (de) |
MX (1) | MXPA02010977A (de) |
NO (1) | NO324256B1 (de) |
NZ (1) | NZ522539A (de) |
PL (1) | PL226805B1 (de) |
PT (1) | PT1754707E (de) |
SK (1) | SK287591B6 (de) |
UA (1) | UA73773C2 (de) |
WO (1) | WO2001085686A2 (de) |
ZA (1) | ZA200209065B (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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US6811992B1 (en) * | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
US6531464B1 (en) | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
US6476048B1 (en) | 1999-12-07 | 2002-11-05 | Inotek Pharamaceuticals Corporation | Substituted phenanthridinones and methods of use thereof |
US20060276497A1 (en) * | 2000-05-09 | 2006-12-07 | Cephalon, Inc. | Novel multicyclic compounds and the use thereof |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
EP1464645A1 (de) * | 2001-12-18 | 2004-10-06 | Kyowa Hakko Kogyo Co., Ltd. | Indolderivat |
EP1501831A1 (de) * | 2002-04-26 | 2005-02-02 | Warner-Lambert Company Llc | Kontrollpunktkinase (wee1 und chk1) inhibitoren |
US7094798B1 (en) | 2002-04-26 | 2006-08-22 | Pfizer Inc | Inhibitors of checkpoint kinases (Wee1 and Chk1) |
CA2482806A1 (en) | 2002-04-30 | 2003-11-13 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
US7511065B2 (en) | 2003-11-12 | 2009-03-31 | Eli Lilly And Company | Mixed lineage kinase modulators |
SG150548A1 (en) | 2003-12-01 | 2009-03-30 | Kudos Pharm Ltd | Dna damage repair inhibitors for treatment of cancer |
CN1905864B (zh) * | 2003-12-01 | 2011-04-06 | 库多斯药物有限公司 | 用于治疗癌症的dna损伤修复抑制剂 |
PE20060285A1 (es) * | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
JP5070042B2 (ja) * | 2004-05-03 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター(sarms)としての新規インドール化合物 |
AU2006206512B2 (en) | 2005-01-19 | 2012-09-13 | Eisai Inc. | Diazabenzo(de)anthracen-3-one compounds and methods for inhibiting PARP |
SG164368A1 (en) * | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
DK2251319T3 (da) * | 2005-09-02 | 2012-03-05 | Otsuka Pharma Co Ltd | Fremgangsmåde til fremstilling af derivater af benzoesyre |
EP1957477B1 (de) * | 2005-09-29 | 2011-12-07 | Abbott Laboratories | In der 2-stellung durch phenyl substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
CA2662517A1 (en) * | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
US20080076778A1 (en) * | 2006-09-05 | 2008-03-27 | Bipar Sciences, Inc. | Methods for designing parp inhibitors and uses thereof |
WO2008030891A2 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
CA2671517C (en) * | 2006-11-20 | 2015-01-27 | Cephalon, Inc. | Method of radio-sensitizing tumors using a radio-sensitizing agent |
EP2167075A4 (de) * | 2007-06-08 | 2012-07-11 | Univ Massachusetts | Mixed-lineage-kinasen und stoffwechselstörungen |
MX2010002749A (es) | 2007-09-14 | 2010-06-25 | Astrazeneca Ab | Derivados de ftalazinona. |
DK2209375T3 (da) | 2007-10-03 | 2014-10-06 | Eisai Inc | Parp-inhibitorforbindelser, præparater og fremgangsmåder til anvendelse deraf |
JP2011500684A (ja) * | 2007-10-19 | 2011-01-06 | バイパー サイエンシズ,インコーポレイティド | ベンゾピロン系parp阻害剤を用いる癌の処置方法および組成物 |
CN101918003A (zh) * | 2007-11-12 | 2010-12-15 | 彼帕科学公司 | 单独使用parp抑制剂或与抗肿瘤剂组合治疗子宫癌和卵巢癌 |
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