NO324035B1 - Antracyklin-analoger samt blandinger og anvendelser derav - Google Patents
Antracyklin-analoger samt blandinger og anvendelser derav Download PDFInfo
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- NO324035B1 NO324035B1 NO19982252A NO982252A NO324035B1 NO 324035 B1 NO324035 B1 NO 324035B1 NO 19982252 A NO19982252 A NO 19982252A NO 982252 A NO982252 A NO 982252A NO 324035 B1 NO324035 B1 NO 324035B1
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- compound according
- doxorubicin
- pyrrolin
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
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- USISRUCGEISZIB-UHFFFAOYSA-N piperidin-3-one Chemical compound O=C1CCCNC1 USISRUCGEISZIB-UHFFFAOYSA-N 0.000 description 1
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- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
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- VXBQABNTEOKEGM-UHFFFAOYSA-N triazolidine-4-carboxylic acid Chemical compound OC(=O)C1CNNN1 VXBQABNTEOKEGM-UHFFFAOYSA-N 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/562,652 US5843903A (en) | 1995-11-27 | 1995-11-27 | Targeted cytotoxic anthracycline analogs |
| PCT/EP1996/005029 WO1997019954A1 (en) | 1995-11-27 | 1996-11-14 | Targeted cytotoxic anthracycline analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982252L NO982252L (no) | 1998-05-15 |
| NO982252D0 NO982252D0 (no) | 1998-05-15 |
| NO324035B1 true NO324035B1 (no) | 2007-07-30 |
Family
ID=24247176
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982252A NO324035B1 (no) | 1995-11-27 | 1998-05-15 | Antracyklin-analoger samt blandinger og anvendelser derav |
| NO20051111A NO20051111L (no) | 1995-11-27 | 2005-03-01 | Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051111A NO20051111L (no) | 1995-11-27 | 2005-03-01 | Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US5843903A (2) |
| EP (2) | EP1384710B1 (2) |
| JP (2) | JP3987575B2 (2) |
| KR (2) | KR100445754B1 (2) |
| CN (2) | CN1137136C (2) |
| AT (2) | ATE251179T1 (2) |
| AU (1) | AU709539B2 (2) |
| BR (1) | BR9611647B1 (2) |
| CA (2) | CA2238574C (2) |
| CZ (1) | CZ297297B6 (2) |
| DE (2) | DE69637604D1 (2) |
| DK (2) | DK0863917T3 (2) |
| EA (1) | EA001372B1 (2) |
| ES (2) | ES2310222T3 (2) |
| HK (1) | HK1052920B (2) |
| HU (1) | HU229870B1 (2) |
| IL (3) | IL119691A (2) |
| IS (2) | IS2178B (2) |
| MX (1) | MX9804119A (2) |
| NO (2) | NO324035B1 (2) |
| NZ (1) | NZ322054A (2) |
| PL (3) | PL188786B1 (2) |
| PT (2) | PT1384710E (2) |
| SK (2) | SK284672B6 (2) |
| UA (1) | UA67722C2 (2) |
| WO (1) | WO1997019954A1 (2) |
| ZA (1) | ZA969709B (2) |
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| US6576239B1 (en) | 1996-09-10 | 2003-06-10 | The Burnham Institute | Angiogenic homing molecules and conjugates derived therefrom |
| US6180084B1 (en) | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| IL142869A0 (en) | 1998-11-13 | 2002-03-10 | Cyclacel Ltd | Transport vectors |
| FR2786397B1 (fr) * | 1998-11-30 | 2003-01-10 | Synt Em | Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc |
| FR2786398B1 (fr) * | 1998-11-30 | 2002-12-27 | Synt Em | Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6528481B1 (en) | 1999-02-16 | 2003-03-04 | The Burnam Institute | NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods |
| US6380161B1 (en) | 1999-06-21 | 2002-04-30 | Inkine Pharmaceutical Company, Inc. | Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions |
| JP2003513756A (ja) * | 1999-11-12 | 2003-04-15 | アンジオテック ファーマシューティカルズ，インコーポレイテッド | 放射性治療と細胞周期インヒビターとの組合せの組成物 |
| ATE344801T1 (de) | 1999-12-29 | 2006-11-15 | Immunogen Inc | Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung |
| AU4267700A (en) * | 2000-01-13 | 2001-07-19 | Academia Sinica | Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells |
| JP2004517034A (ja) * | 2000-04-26 | 2004-06-10 | バイオシンセマ インコーポレーテッド | （神経）ペプチド結合ｒｇｄ（ａｒｇ−ｇｌｙ−ａｓｐ） |
| US20040170955A1 (en) | 2000-09-08 | 2004-09-02 | Wadih Arap | Human and mouse targeting peptides identified by phage display |
| US7420030B2 (en) | 2000-09-08 | 2008-09-02 | The Board Of Regents Of The University Of Texas System | Aminopeptidase A (APA) targeting peptides for the treatment of cancer |
| US7452964B2 (en) | 2001-09-07 | 2008-11-18 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides against placenta and adipose tissues |
| KR100420007B1 (ko) * | 2001-04-25 | 2004-03-02 | 노영쇠 | 안트라사이클린 유도체 및 이를 포함하는 항암제 |
| BR0212897A (pt) | 2001-09-21 | 2004-08-24 | Univ Tulane | Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos |
| EP1531846A4 (en) * | 2002-02-27 | 2006-04-19 | Us Gov Health & Human Serv | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| EP1487493B1 (en) | 2002-03-01 | 2010-01-20 | The Administrators of The Tulane Educational Fund | Conjugates of cytotoxic agents and biologically active peptides |
| US7544767B2 (en) | 2002-04-05 | 2009-06-09 | Burnham Institute For Medical Research | HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells |
| WO2003097083A1 (en) * | 2002-05-21 | 2003-11-27 | Daiichi Suntory Pharma Co.,Ltd. | Medicinal compositions containing ghrelin |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| EP2075014B9 (en) | 2002-05-24 | 2012-02-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| KR20050084599A (ko) | 2002-09-26 | 2005-08-26 | 안지오테크 인터내셔날 아게 | 혈관주위 랩 |
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US20040202666A1 (en) * | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
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| NZ564694A (en) * | 2003-04-22 | 2009-11-27 | Sod Conseils Rech Applic | Peptide vectors |
| AU2007221964B2 (en) * | 2003-04-22 | 2008-12-11 | Ipsen Pharma S.A.S. | Peptide vectors |
| US7097993B2 (en) | 2003-06-25 | 2006-08-29 | Wisconsin Alumni Research Foundation | Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity |
| WO2005086951A2 (en) * | 2004-03-10 | 2005-09-22 | Threshold Pharmaceuticals, Inc. | Hypoxia-activated anti-cancer agents |
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| JP5340155B2 (ja) * | 2006-09-06 | 2013-11-13 | エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 細胞結合分子を有するジソラゾールのコンジュゲート及びそれらの誘導体、新規ジソラゾール誘導体、それらの製法ならびに使用 |
| EP1900742A1 (en) | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
| WO2008100591A2 (en) * | 2007-02-14 | 2008-08-21 | The General Hospital Corporation | Modulation of nitric oxide signaling to normalize tumor vasculature |
| RU2377247C2 (ru) * | 2007-12-27 | 2009-12-27 | Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет | Молекулярный конъюгат на основе синтетических аналогов люлиберина и его применение в качестве средства доставки днк в клетки гормон-чувствительных опухолей (варианты) |
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| CN102050856B (zh) * | 2009-11-03 | 2014-04-30 | 天津和美生物技术有限公司 | 具有高活性的表阿霉素的衍生物及其制备和应用 |
| ES2533710T3 (es) | 2010-12-02 | 2015-04-14 | Nerviano Medical Sciences S.R.L. | Proceso para la preparación de derivados de morfolinil antraciclina |
| CN105198966B (zh) * | 2014-06-26 | 2019-06-21 | 中国人民解放军军事医学科学院毒物药物研究所 | GnRH类似物-细胞毒分子缀合物、其制备方法及用途 |
| CA2953371C (en) * | 2014-06-30 | 2021-08-24 | Tarveda Therapeutics, Inc. | Targeted conjugates and particles and formulations thereof |
| EP3045540A1 (en) | 2015-01-19 | 2016-07-20 | Æterna Zentaris GmbH | Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters |
| JP7057278B2 (ja) | 2015-10-28 | 2022-04-19 | ターベダ セラピューティクス インコーポレイテッド | Ｓｓｔｒ標的化コンジュゲート及び粒子並びにその製剤 |
| US10450340B2 (en) | 2017-02-16 | 2019-10-22 | Monopar Therapeutics Inc. | 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation |
| WO2021068051A1 (en) * | 2018-11-13 | 2021-04-15 | Provincial Health Services Authority | Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders |
| CA3246188A1 (en) | 2022-03-25 | 2023-09-28 | The University Of British Columbia | Radiolabeled compounds for in vivo imaging of the gastrin-releasing peptide (GRPR) receptor and treatment of GRPR-related disorders |
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| US3725350A (en) * | 1972-04-26 | 1973-04-03 | Commercial Soluents Corp | Polymeric substances comprising the reaction product of melamine, aldehyde and oxazolidines |
| US4299822A (en) * | 1980-06-09 | 1981-11-10 | Sidney Farber Cancer Institute, Inc. | N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same |
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| US5217955A (en) * | 1989-09-15 | 1993-06-08 | Biomeasure, Inc. | Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin |
| DK0434960T3 (da) * | 1989-12-19 | 1996-10-14 | Pharmacia Spa | Chirale 1,5-diiod-2-methoxy- eller benzyloxymellemprodukter |
| US5304687A (en) * | 1989-12-19 | 1994-04-19 | Farmitalia Carlo Erba S.R.L. | Morpholinyl derivatives of doxorubicin and process for their preparation |
| ATE124054T1 (de) * | 1990-04-06 | 1995-07-15 | Univ Tulane | Somatostatinanaloge. |
| DK0450461T3 (da) * | 1990-04-06 | 1995-10-23 | Univ Tulane | LHRH-analoger |
| JP3169425B2 (ja) * | 1992-03-27 | 2001-05-28 | 三共株式会社 | アジドペンタンサイクリトール |
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
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1995
- 1995-11-27 US US08/562,652 patent/US5843903A/en not_active Expired - Lifetime
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1996
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- 1996-11-14 JP JP52012397A patent/JP3987575B2/ja not_active Expired - Lifetime
- 1996-11-14 PT PT03010988T patent/PT1384710E/pt unknown
- 1996-11-14 KR KR10-1998-0703948A patent/KR100445754B1/ko not_active Expired - Lifetime
- 1996-11-14 DE DE69637604T patent/DE69637604D1/de not_active Expired - Lifetime
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- 1996-11-14 WO PCT/EP1996/005029 patent/WO1997019954A1/en not_active Ceased
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- 1996-11-14 AT AT03010988T patent/ATE401305T1/de active
- 1996-11-14 CN CNB021439192A patent/CN1166597C/zh not_active Expired - Lifetime
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1998
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2000
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2003
- 2003-07-09 HK HK03104934.8A patent/HK1052920B/zh not_active IP Right Cessation
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2005
- 2005-03-01 NO NO20051111A patent/NO20051111L/no not_active Application Discontinuation
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2006
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