DK1384710T3 - Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe - Google Patents

Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe

Info

Publication number
DK1384710T3
DK1384710T3 DK03010988T DK03010988T DK1384710T3 DK 1384710 T3 DK1384710 T3 DK 1384710T3 DK 03010988 T DK03010988 T DK 03010988T DK 03010988 T DK03010988 T DK 03010988T DK 1384710 T3 DK1384710 T3 DK 1384710T3
Authority
DK
Denmark
Prior art keywords
nitrogen
halo
carbon
och2
excess
Prior art date
Application number
DK03010988T
Other languages
English (en)
Inventor
Andrew V Schally
Nagy Attila
Zhi Cai Ren
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1384710(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Tulane filed Critical Univ Tulane
Application granted granted Critical
Publication of DK1384710T3 publication Critical patent/DK1384710T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK03010988T 1995-11-27 1996-11-14 Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe DK1384710T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number Publication Date
DK1384710T3 true DK1384710T3 (da) 2008-11-17

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03010988T DK1384710T3 (da) 1995-11-27 1996-11-14 Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe
DK96938216T DK0863917T3 (da) 1995-11-27 1996-11-14 Målrettede cytotoksiske anthracyclin-analoger

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96938216T DK0863917T3 (da) 1995-11-27 1996-11-14 Målrettede cytotoksiske anthracyclin-analoger

Country Status (27)

Country Link
US (2) US5843903A (da)
EP (2) EP0863917B1 (da)
JP (2) JP3987575B2 (da)
KR (2) KR100445754B1 (da)
CN (2) CN1137136C (da)
AT (2) ATE401305T1 (da)
AU (1) AU709539B2 (da)
BR (1) BR9611647B1 (da)
CA (2) CA2238574C (da)
CZ (1) CZ297297B6 (da)
DE (2) DE69630233T2 (da)
DK (2) DK1384710T3 (da)
EA (1) EA001372B1 (da)
ES (2) ES2310222T3 (da)
HK (2) HK1017363A1 (da)
HU (1) HU229870B1 (da)
IL (3) IL134685A (da)
IS (2) IS2178B (da)
MX (1) MX9804119A (da)
NO (2) NO324035B1 (da)
NZ (1) NZ322054A (da)
PL (3) PL188786B1 (da)
PT (2) PT863917E (da)
SK (2) SK284392B6 (da)
UA (1) UA67722C2 (da)
WO (1) WO1997019954A1 (da)
ZA (1) ZA969709B (da)

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FR2786398B1 (fr) * 1998-11-30 2002-12-27 Synt Em Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide
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US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
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WO2003074551A2 (en) 2002-03-01 2003-09-12 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
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CA2497349C (en) 2002-09-26 2008-07-08 Angiotech International Ag Perivascular wraps
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
AU2007221964B2 (en) * 2003-04-22 2008-12-11 Ipsen Pharma S.A.S. Peptide vectors
CN1777439A (zh) * 2003-04-22 2006-05-24 研究及应用科学协会股份有限公司 生长抑素的载体
US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
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CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用
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CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
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EP3045540A1 (en) 2015-01-19 2016-07-20 Æterna Zentaris GmbH Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters
AU2016343817B2 (en) 2015-10-28 2021-05-27 Tva (Abc), Llc SSTR-targeted conjugates and particles and formulations thereof
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Also Published As

Publication number Publication date
HK1052920A1 (en) 2003-10-03
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30
JP3987575B2 (ja) 2007-10-10
EP0863917B1 (en) 2003-10-01
EA199800492A1 (ru) 1998-12-24
HK1017363A1 (en) 1999-11-19
PT863917E (pt) 2004-02-27
DE69637604D1 (de) 2008-08-28
SK62898A3 (en) 1999-06-11
US5843903A (en) 1998-12-01
CN1202903A (zh) 1998-12-23
CN1166597C (zh) 2004-09-15
PT1384710E (pt) 2008-10-08
IS8567A (is) 2006-11-09
CZ297297B6 (cs) 2006-11-15
IL134685A0 (en) 2001-04-30
DE69630233D1 (de) 2003-11-06
EP0863917A1 (en) 1998-09-16
CZ135798A3 (cs) 1998-10-14
HK1052920B (zh) 2005-03-04
KR20040037176A (ko) 2004-05-04
EP1384710A1 (en) 2004-01-28
CN1137136C (zh) 2004-02-04
IS2178B (is) 2006-12-15
SK284672B6 (sk) 2005-08-04
NO324035B1 (no) 2007-07-30
UA67722C2 (en) 2004-07-15
DK0863917T3 (da) 2004-01-19
ES2205067T3 (es) 2004-05-01
CA2238574A1 (en) 1997-06-05
ATE251179T1 (de) 2003-10-15
AU7572296A (en) 1997-06-19
IS4734A (is) 1998-05-05
CA2238574C (en) 2004-10-19
NO982252D0 (no) 1998-05-15
HU229870B1 (en) 2014-10-28
EA001372B1 (ru) 2001-02-26
EP1384710B1 (en) 2008-07-16
PL187230B1 (pl) 2004-06-30
IL119691A0 (en) 1997-02-18
PL188786B1 (pl) 2005-04-29
CA2471775A1 (en) 1997-06-05
ES2310222T3 (es) 2009-01-01
BR9611647A (pt) 1999-02-23
JP4778405B2 (ja) 2011-09-21
BR9611647B1 (pt) 2010-03-09
AU709539B2 (en) 1999-09-02
ATE401305T1 (de) 2008-08-15
PL191781B1 (pl) 2006-07-31
JP2007045845A (ja) 2007-02-22
PL326865A1 (en) 1998-10-26
WO1997019954A1 (en) 1997-06-05
NZ322054A (en) 1999-04-29
HUP9903771A2 (hu) 2000-02-28
KR19990071672A (ko) 1999-09-27
DE69630233T2 (de) 2004-08-05
HUP9903771A3 (en) 2000-07-28
SK284392B6 (sk) 2005-03-04
US6184374B1 (en) 2001-02-06
CA2471775C (en) 2008-01-29
CN1405127A (zh) 2003-03-26
JP2000502055A (ja) 2000-02-22
ZA969709B (en) 1997-08-25
IL119691A (en) 2002-02-10
IS2634B (is) 2010-06-15
NO20051111L (no) 2005-03-01
KR100445754B1 (ko) 2004-12-08
IL134685A (en) 2002-12-01
NO982252L (no) 1998-05-15

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