DK0932597T3 - Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme - Google Patents
Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholismeInfo
- Publication number
- DK0932597T3 DK0932597T3 DK97941921T DK97941921T DK0932597T3 DK 0932597 T3 DK0932597 T3 DK 0932597T3 DK 97941921 T DK97941921 T DK 97941921T DK 97941921 T DK97941921 T DK 97941921T DK 0932597 T3 DK0932597 T3 DK 0932597T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- treatment
- hydroxybutyric acid
- alcoholism
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Addiction (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001732A IT1283782B1 (it) | 1996-08-09 | 1996-08-09 | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
PCT/EP1997/004309 WO1998006690A1 (en) | 1996-08-09 | 1997-08-07 | USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0932597T3 true DK0932597T3 (da) | 2002-06-24 |
Family
ID=11374795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97941921T DK0932597T3 (da) | 1996-08-09 | 1997-08-07 | Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme |
Country Status (13)
Country | Link |
---|---|
US (2) | US6436998B1 (da) |
EP (1) | EP0932597B1 (da) |
JP (1) | JP4259615B2 (da) |
AT (1) | ATE215065T1 (da) |
AU (1) | AU4379097A (da) |
CA (1) | CA2263328C (da) |
DE (1) | DE69711411T2 (da) |
DK (1) | DK0932597T3 (da) |
ES (1) | ES2174287T3 (da) |
HU (1) | HU228595B1 (da) |
IT (1) | IT1283782B1 (da) |
PT (1) | PT932597E (da) |
WO (1) | WO1998006690A1 (da) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU779354B2 (en) * | 1998-12-23 | 2005-01-20 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
WO2004041207A2 (en) * | 2002-11-01 | 2004-05-21 | Baylor Research Institute | Ghb treatment methods |
US7838556B2 (en) * | 2006-02-21 | 2010-11-23 | University Of Maryland, Baltimore | Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands |
EP2062875A1 (en) | 2007-11-13 | 2009-05-27 | LABORATORIO FARMACEUTICO C.T. S.r.l. | New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide |
US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
US8771735B2 (en) * | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
ITMI20132041A1 (it) * | 2013-12-06 | 2015-06-07 | Ct Lab Farm Srl | Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico. |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
ITUB20152860A1 (it) * | 2015-08-04 | 2017-02-04 | Laboratorio Farm C T S R L | Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool |
ITUA20164040A1 (it) * | 2016-06-01 | 2017-12-01 | Laboratorio Farm C T S R L | Procedimento per la preparazione di polimorfo a |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
JP7472116B2 (ja) | 2018-11-19 | 2024-04-22 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 耐アルコール性製剤 |
CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
WO2023126076A1 (en) | 2022-01-03 | 2023-07-06 | Laboratorio Farmaceutico C.T. S.R.L. | Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3940258A (en) * | 1971-11-26 | 1976-02-24 | Gaf Corporation | Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide |
JPS6016432B2 (ja) * | 1977-07-26 | 1985-04-25 | グレラン製薬株式会社 | 複素環式化合物類およびその製造法 |
ES2103287T3 (es) * | 1987-02-23 | 1997-09-16 | Ono Pharmaceutical Co | Nuevos derivados de tiazolidina. |
IT1217783B (it) * | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
IT1248588B (it) * | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
WO1995032945A1 (en) * | 1994-06-01 | 1995-12-07 | Arris Pharmaceutical Corporation | Compositions and methods for treating mast-cell mediated conditions |
HUP9602538A3 (en) * | 1995-09-18 | 1997-08-28 | Sankyo Co | New urea and amide derivatives having acat inhibitory activity, their preparation and their use |
CA2306811A1 (en) * | 1997-10-14 | 1999-04-22 | Yoshiyuki Aoki | Piperazine compounds and medicinal use thereof |
-
1996
- 1996-08-09 IT IT96MI001732A patent/IT1283782B1/it active IP Right Grant
-
1997
- 1997-08-07 HU HU9902437A patent/HU228595B1/hu unknown
- 1997-08-07 AT AT97941921T patent/ATE215065T1/de active
- 1997-08-07 ES ES97941921T patent/ES2174287T3/es not_active Expired - Lifetime
- 1997-08-07 AU AU43790/97A patent/AU4379097A/en not_active Abandoned
- 1997-08-07 EP EP97941921A patent/EP0932597B1/en not_active Expired - Lifetime
- 1997-08-07 CA CA002263328A patent/CA2263328C/en not_active Expired - Lifetime
- 1997-08-07 WO PCT/EP1997/004309 patent/WO1998006690A1/en active IP Right Grant
- 1997-08-07 DK DK97941921T patent/DK0932597T3/da active
- 1997-08-07 DE DE69711411T patent/DE69711411T2/de not_active Expired - Lifetime
- 1997-08-07 US US09/242,048 patent/US6436998B1/en not_active Expired - Lifetime
- 1997-08-07 PT PT97941921T patent/PT932597E/pt unknown
- 1997-08-07 JP JP50937298A patent/JP4259615B2/ja not_active Expired - Lifetime
-
2001
- 2001-12-11 US US10/013,971 patent/US6770784B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4379097A (en) | 1998-03-06 |
ITMI961732A0 (da) | 1996-08-09 |
CA2263328C (en) | 2006-07-25 |
ITMI961732A1 (it) | 1998-02-09 |
ES2174287T3 (es) | 2002-11-01 |
DE69711411T2 (de) | 2002-11-07 |
PT932597E (pt) | 2002-09-30 |
EP0932597A1 (en) | 1999-08-04 |
US6770784B2 (en) | 2004-08-03 |
IT1283782B1 (it) | 1998-04-30 |
DE69711411D1 (de) | 2002-05-02 |
US20020165224A1 (en) | 2002-11-07 |
EP0932597B1 (en) | 2002-03-27 |
JP2000516225A (ja) | 2000-12-05 |
ATE215065T1 (de) | 2002-04-15 |
CA2263328A1 (en) | 1998-02-19 |
HUP9902437A2 (hu) | 1999-12-28 |
JP4259615B2 (ja) | 2009-04-30 |
WO1998006690A1 (en) | 1998-02-19 |
HUP9902437A3 (en) | 2001-07-30 |
HU228595B1 (en) | 2013-04-29 |
US6436998B1 (en) | 2002-08-20 |
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