ES2174287T3 - Empleo de las amidas del acido gamma-hidroxibutarico en el tratamiento de drogadicciones y en particular del alcoholismo. - Google Patents

Empleo de las amidas del acido gamma-hidroxibutarico en el tratamiento de drogadicciones y en particular del alcoholismo.

Info

Publication number
ES2174287T3
ES2174287T3 ES97941921T ES97941921T ES2174287T3 ES 2174287 T3 ES2174287 T3 ES 2174287T3 ES 97941921 T ES97941921 T ES 97941921T ES 97941921 T ES97941921 T ES 97941921T ES 2174287 T3 ES2174287 T3 ES 2174287T3
Authority
ES
Spain
Prior art keywords
treatment
amidas
acid
alcoholism
hydroxibutaric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97941921T
Other languages
English (en)
Inventor
Roberto Cacciaglia
Antonella Loche
Vincenzo Perlini
Lorenza Guano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ct Lab Farm Srl
Laboratorio Farmaceutico CT SRL
Original Assignee
Ct Lab Farm Srl
Laboratorio Farmaceutico CT SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Lab Farm Srl, Laboratorio Farmaceutico CT SRL filed Critical Ct Lab Farm Srl
Application granted granted Critical
Publication of ES2174287T3 publication Critical patent/ES2174287T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA UTILIZACION DE AMIDAS DE ACIDO GA - HIDROXIBUTIRICO, DENOMINADAS AQUI GHB, EN EL TRATAMIENTO DE LA ADICCION A DROGAS COMO LA HEROINA, LA MORFINA Y A SUSTANCIAS PSICOACTIVAS, Y EN EL TRATAMIENTO DEL ALCOHOLISMO, MAS ESPECIALMENTE PARA DISMINUIR EL DESEO CRONICO DE LOS ALCOHOLICOS Y SU HABITO DE CONSUMO DE BEBIDAS ALCOHOLICAS, Y EN EL TRATAMIENTO DEL SINDROME DE ABSTINENCIA DEL ALCOHOL.
ES97941921T 1996-08-09 1997-08-07 Empleo de las amidas del acido gamma-hidroxibutarico en el tratamiento de drogadicciones y en particular del alcoholismo. Expired - Lifetime ES2174287T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo

Publications (1)

Publication Number Publication Date
ES2174287T3 true ES2174287T3 (es) 2002-11-01

Family

ID=11374795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97941921T Expired - Lifetime ES2174287T3 (es) 1996-08-09 1997-08-07 Empleo de las amidas del acido gamma-hidroxibutarico en el tratamiento de drogadicciones y en particular del alcoholismo.

Country Status (13)

Country Link
US (2) US6436998B1 (es)
EP (1) EP0932597B1 (es)
JP (1) JP4259615B2 (es)
AT (1) ATE215065T1 (es)
AU (1) AU4379097A (es)
CA (1) CA2263328C (es)
DE (1) DE69711411T2 (es)
DK (1) DK0932597T3 (es)
ES (1) ES2174287T3 (es)
HU (1) HU228595B1 (es)
IT (1) IT1283782B1 (es)
PT (1) PT932597E (es)
WO (1) WO1998006690A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038672A2 (en) 1998-12-23 2000-07-06 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
AU2003295393A1 (en) * 2002-11-01 2004-06-07 Baylor Research Institute Ghb treatment methods
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2062875A1 (en) * 2007-11-13 2009-05-27 LABORATORIO FARMACEUTICO C.T. S.r.l. New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
US8778398B2 (en) * 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
AU2011232408B2 (en) 2010-03-24 2015-07-30 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
ITUB20152860A1 (it) * 2015-08-04 2017-02-04 Laboratorio Farm C T S R L Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
CA3115122A1 (en) 2018-11-19 2020-05-28 Jazz Pharmaceuticals Ireland Limited Alcohol-resistant drug formulations
JP2022522270A (ja) 2019-03-01 2022-04-15 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
WO2023126076A1 (en) 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940258A (en) * 1971-11-26 1976-02-24 Gaf Corporation Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide
JPS6016432B2 (ja) * 1977-07-26 1985-04-25 グレラン製薬株式会社 複素環式化合物類およびその製造法
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) * 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
JPH10501238A (ja) * 1994-06-01 1998-02-03 アリス ファーマシューティカル コーポレイション 肥満細胞媒介症状を治療するための組成物及び方法
AU712467B2 (en) * 1995-09-18 1999-11-04 Sankyo Company Limited New urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use
US6455528B1 (en) * 1997-10-14 2002-09-24 Mitsubishi Pharma Corporation Piperazine compounds and medicinal use thereof

Also Published As

Publication number Publication date
EP0932597A1 (en) 1999-08-04
HUP9902437A2 (hu) 1999-12-28
DK0932597T3 (da) 2002-06-24
US6770784B2 (en) 2004-08-03
WO1998006690A1 (en) 1998-02-19
ATE215065T1 (de) 2002-04-15
JP2000516225A (ja) 2000-12-05
HU228595B1 (en) 2013-04-29
DE69711411D1 (de) 2002-05-02
JP4259615B2 (ja) 2009-04-30
US20020165224A1 (en) 2002-11-07
EP0932597B1 (en) 2002-03-27
US6436998B1 (en) 2002-08-20
HUP9902437A3 (en) 2001-07-30
ITMI961732A0 (es) 1996-08-09
ITMI961732A1 (it) 1998-02-09
PT932597E (pt) 2002-09-30
CA2263328C (en) 2006-07-25
CA2263328A1 (en) 1998-02-19
DE69711411T2 (de) 2002-11-07
IT1283782B1 (it) 1998-04-30
AU4379097A (en) 1998-03-06

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