HK1017363A1 - Targeted cytotoxic anthracycline analogs - Google Patents

Targeted cytotoxic anthracycline analogs

Info

Publication number
HK1017363A1
HK1017363A1 HK99102273A HK99102273A HK1017363A1 HK 1017363 A1 HK1017363 A1 HK 1017363A1 HK 99102273 A HK99102273 A HK 99102273A HK 99102273 A HK99102273 A HK 99102273A HK 1017363 A1 HK1017363 A1 HK 1017363A1
Authority
HK
Hong Kong
Prior art keywords
nitrogen
halo
carbon
och2
excess
Prior art date
Application number
HK99102273A
Other languages
English (en)
Inventor
Andrew V Schally
Attila A Nagy
Ren-Zhi Cai
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1017363(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of HK1017363A1 publication Critical patent/HK1017363A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK99102273A 1995-11-27 1999-05-24 Targeted cytotoxic anthracycline analogs HK1017363A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number Publication Date
HK1017363A1 true HK1017363A1 (en) 1999-11-19

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
HK99102273A HK1017363A1 (en) 1995-11-27 1999-05-24 Targeted cytotoxic anthracycline analogs
HK03104934.8A HK1052920B (zh) 1995-11-27 2003-07-09 含氮基團的轉化方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK03104934.8A HK1052920B (zh) 1995-11-27 2003-07-09 含氮基團的轉化方法

Country Status (27)

Country Link
US (2) US5843903A (xx)
EP (2) EP0863917B1 (xx)
JP (2) JP3987575B2 (xx)
KR (2) KR100467899B1 (xx)
CN (2) CN1137136C (xx)
AT (2) ATE251179T1 (xx)
AU (1) AU709539B2 (xx)
BR (1) BR9611647B1 (xx)
CA (2) CA2238574C (xx)
CZ (1) CZ297297B6 (xx)
DE (2) DE69630233T2 (xx)
DK (2) DK1384710T3 (xx)
EA (1) EA001372B1 (xx)
ES (2) ES2205067T3 (xx)
HK (2) HK1017363A1 (xx)
HU (1) HU229870B1 (xx)
IL (3) IL119691A (xx)
IS (2) IS2178B (xx)
MX (1) MX9804119A (xx)
NO (2) NO324035B1 (xx)
NZ (1) NZ322054A (xx)
PL (3) PL187230B1 (xx)
PT (2) PT1384710E (xx)
SK (2) SK284672B6 (xx)
UA (1) UA67722C2 (xx)
WO (1) WO1997019954A1 (xx)
ZA (1) ZA969709B (xx)

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FR2786397B1 (fr) * 1998-11-30 2003-01-10 Synt Em Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6528481B1 (en) 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
EP1235598A2 (en) * 1999-11-12 2002-09-04 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
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US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
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MXPA04002621A (es) 2001-09-21 2004-07-08 Univ Tulane Conjugados de analogos de somatostatina o bombesina para diagnostico o terapeuticos y usos de los mismos.
WO2003072754A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
DE60331049D1 (de) 2002-03-01 2010-03-11 Univ Tulane Konjugate von zytotoxischen mitteln und biologisch aktiven peptiden
US7544767B2 (en) 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
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US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
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US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
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Also Published As

Publication number Publication date
JP2007045845A (ja) 2007-02-22
IS2634B (is) 2010-06-15
CN1202903A (zh) 1998-12-23
IL134685A0 (en) 2001-04-30
JP2000502055A (ja) 2000-02-22
CA2238574C (en) 2004-10-19
CN1405127A (zh) 2003-03-26
SK284392B6 (sk) 2005-03-04
CZ297297B6 (cs) 2006-11-15
HK1052920A1 (en) 2003-10-03
IL134685A (en) 2002-12-01
EA001372B1 (ru) 2001-02-26
NO982252L (no) 1998-05-15
PL191781B1 (pl) 2006-07-31
KR100445754B1 (ko) 2004-12-08
NO324035B1 (no) 2007-07-30
PL188786B1 (pl) 2005-04-29
IS2178B (is) 2006-12-15
CN1137136C (zh) 2004-02-04
SK284672B6 (sk) 2005-08-04
EA199800492A1 (ru) 1998-12-24
IL119691A (en) 2002-02-10
PL187230B1 (pl) 2004-06-30
US6184374B1 (en) 2001-02-06
BR9611647A (pt) 1999-02-23
SK62898A3 (en) 1999-06-11
BR9611647B1 (pt) 2010-03-09
AU709539B2 (en) 1999-09-02
KR19990071672A (ko) 1999-09-27
KR20040037176A (ko) 2004-05-04
DE69630233D1 (de) 2003-11-06
PT1384710E (pt) 2008-10-08
EP1384710B1 (en) 2008-07-16
HK1052920B (zh) 2005-03-04
PT863917E (pt) 2004-02-27
NO982252D0 (no) 1998-05-15
NO20051111L (no) 2005-03-01
ES2310222T3 (es) 2009-01-01
HUP9903771A3 (en) 2000-07-28
AU7572296A (en) 1997-06-19
ATE401305T1 (de) 2008-08-15
ATE251179T1 (de) 2003-10-15
CN1166597C (zh) 2004-09-15
NZ322054A (en) 1999-04-29
UA67722C2 (en) 2004-07-15
DK1384710T3 (da) 2008-11-17
WO1997019954A1 (en) 1997-06-05
CA2471775C (en) 2008-01-29
IL119691A0 (en) 1997-02-18
JP4778405B2 (ja) 2011-09-21
HUP9903771A2 (hu) 2000-02-28
EP0863917B1 (en) 2003-10-01
PL326865A1 (en) 1998-10-26
DE69630233T2 (de) 2004-08-05
US5843903A (en) 1998-12-01
DK0863917T3 (da) 2004-01-19
EP1384710A1 (en) 2004-01-28
CA2238574A1 (en) 1997-06-05
JP3987575B2 (ja) 2007-10-10
EP0863917A1 (en) 1998-09-16
IS4734A (is) 1998-05-05
ZA969709B (en) 1997-08-25
ES2205067T3 (es) 2004-05-01
CA2471775A1 (en) 1997-06-05
DE69637604D1 (de) 2008-08-28
HU229870B1 (en) 2014-10-28
CZ135798A3 (cs) 1998-10-14
IS8567A (is) 2006-11-09
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30

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Effective date: 20161113