JPS55111419A - Antitumorigenic agent - Google Patents
Antitumorigenic agentInfo
- Publication number
- JPS55111419A JPS55111419A JP1786979A JP1786979A JPS55111419A JP S55111419 A JPS55111419 A JP S55111419A JP 1786979 A JP1786979 A JP 1786979A JP 1786979 A JP1786979 A JP 1786979A JP S55111419 A JPS55111419 A JP S55111419A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- agent
- geldanamycin
- effective component
- antitumorigenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: An antitumorigenic agent that contains a geldanamycin derivative as an effective component.
CONSTITUTION: Said agent contains a geldanamycin derivative of formula I (R is amino, methylamino, dimethylamino) as an effective component. It shows great activity of inhibiting the growth of experimental tumor cells, W-2K-11. It is administered orally or parenterally. The compound of formula I is obtained by treating geldanamycin of formula II with ammonia, methylamine or dimethylamine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1786979A JPS55111419A (en) | 1979-02-20 | 1979-02-20 | Antitumorigenic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1786979A JPS55111419A (en) | 1979-02-20 | 1979-02-20 | Antitumorigenic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55111419A true JPS55111419A (en) | 1980-08-28 |
JPS6341885B2 JPS6341885B2 (en) | 1988-08-19 |
Family
ID=11955670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1786979A Granted JPS55111419A (en) | 1979-02-20 | 1979-02-20 | Antitumorigenic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55111419A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US6890917B2 (en) | 2001-03-30 | 2005-05-10 | The United States Of America As Represented By The Department Of Health And Human Services | Geldanamycin derivative and method of treating cancer using same |
US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
EP1420747A4 (en) * | 2001-08-06 | 2010-06-02 | Kosan Biosciences Inc | Benzoquinone ansamycins |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55111469A (en) * | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
-
1979
- 1979-02-20 JP JP1786979A patent/JPS55111419A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55111469A (en) * | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890917B2 (en) | 2001-03-30 | 2005-05-10 | The United States Of America As Represented By The Department Of Health And Human Services | Geldanamycin derivative and method of treating cancer using same |
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US7405208B2 (en) | 2001-08-06 | 2008-07-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
EP1420747A4 (en) * | 2001-08-06 | 2010-06-02 | Kosan Biosciences Inc | Benzoquinone ansamycins |
US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
US7378407B2 (en) | 2004-05-20 | 2008-05-27 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
Also Published As
Publication number | Publication date |
---|---|
JPS6341885B2 (en) | 1988-08-19 |
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