NO322588B1 - Fremgangsmate for oppkonsentrering og fremstilling av epotiloner og dyrkningsmedium. - Google Patents
Fremgangsmate for oppkonsentrering og fremstilling av epotiloner og dyrkningsmedium. Download PDFInfo
- Publication number
- NO322588B1 NO322588B1 NO20004114A NO20004114A NO322588B1 NO 322588 B1 NO322588 B1 NO 322588B1 NO 20004114 A NO20004114 A NO 20004114A NO 20004114 A NO20004114 A NO 20004114A NO 322588 B1 NO322588 B1 NO 322588B1
- Authority
- NO
- Norway
- Prior art keywords
- cyclodextrin
- epothilones
- epothilone
- medium
- production
- Prior art date
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- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title claims abstract description 108
- 229930013356 epothilone Natural products 0.000 title claims abstract description 93
- 238000000034 method Methods 0.000 title claims abstract description 41
- 239000001963 growth medium Substances 0.000 title claims abstract description 36
- 230000008569 process Effects 0.000 title claims abstract description 10
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims abstract description 90
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims abstract description 60
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims abstract description 59
- 238000004519 manufacturing process Methods 0.000 claims abstract description 36
- 229920000858 Cyclodextrin Polymers 0.000 claims description 139
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 71
- -1 morpholino, piperidino, pyrrolidino Chemical group 0.000 claims description 56
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH39698 | 1998-02-19 | ||
| CH100798 | 1998-05-05 | ||
| PCT/EP1999/001025 WO1999042602A2 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004114D0 NO20004114D0 (no) | 2000-08-17 |
| NO20004114L NO20004114L (no) | 2000-10-17 |
| NO322588B1 true NO322588B1 (no) | 2006-10-30 |
Family
ID=25684443
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004114A NO322588B1 (no) | 1998-02-19 | 2000-08-17 | Fremgangsmate for oppkonsentrering og fremstilling av epotiloner og dyrkningsmedium. |
| NO20052034A NO321596B1 (no) | 1998-02-19 | 2005-04-26 | Fremgangsmate for separasjon av epotiloner |
| NO20061735A NO329063B1 (no) | 1998-02-19 | 2006-04-20 | Stamme av sorangium cellulosum |
| NO20061736A NO20061736L (no) | 1998-02-19 | 2006-04-20 | Krystallform av epotilon B |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052034A NO321596B1 (no) | 1998-02-19 | 2005-04-26 | Fremgangsmate for separasjon av epotiloner |
| NO20061735A NO329063B1 (no) | 1998-02-19 | 2006-04-20 | Stamme av sorangium cellulosum |
| NO20061736A NO20061736L (no) | 1998-02-19 | 2006-04-20 | Krystallform av epotilon B |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US6194181B1 (xx) |
| EP (2) | EP1054994B1 (xx) |
| JP (3) | JP3681109B2 (xx) |
| KR (4) | KR100595774B1 (xx) |
| CN (2) | CN1229502C (xx) |
| AT (1) | ATE282710T1 (xx) |
| AU (1) | AU746294B2 (xx) |
| BR (1) | BR9908119A (xx) |
| CA (1) | CA2318818A1 (xx) |
| CZ (1) | CZ301517B6 (xx) |
| DE (1) | DE69921966T2 (xx) |
| DK (1) | DK1054994T3 (xx) |
| ES (1) | ES2233028T3 (xx) |
| HK (1) | HK1034100A1 (xx) |
| HU (1) | HU225851B1 (xx) |
| IL (4) | IL159631A0 (xx) |
| NO (4) | NO322588B1 (xx) |
| NZ (2) | NZ525622A (xx) |
| PL (2) | PL404926A1 (xx) |
| PT (1) | PT1054994E (xx) |
| RU (1) | RU2268306C2 (xx) |
| SI (1) | SI1054994T1 (xx) |
| SK (3) | SK286517B6 (xx) |
| TR (2) | TR200101634T2 (xx) |
| WO (1) | WO1999042602A2 (xx) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1186606T4 (da) | 1995-11-17 | 2011-12-05 | Biotechnolog Forschung Gmbh | Epothilonderivater, deres fremstilling og anvendelse |
| ATE408612T1 (de) * | 1996-11-18 | 2008-10-15 | Biotechnolog Forschung Gmbh | Epothilone e und f |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| US6399638B1 (en) | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| EP1135470A2 (en) | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
| US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
| US6998256B2 (en) | 2000-04-28 | 2006-02-14 | Kosan Biosciences, Inc. | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate |
| AU2001295195B2 (en) * | 2000-04-28 | 2007-02-01 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| US6589968B2 (en) | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
| UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
| EP1414384A4 (en) | 2000-10-13 | 2005-07-27 | Univ Mississippi | SYNTHESIS OF EPOTHILONES AND RELATED ANALOGS |
| GB0029895D0 (en) * | 2000-12-07 | 2001-01-24 | Novartis Ag | Organic compounds |
| BR0206511A (pt) * | 2001-01-25 | 2003-10-21 | Bristol Myeres Squibb Company | Formulação parenteral para análogos de epotilona |
| NZ526871A (en) * | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
| CZ20032021A3 (cs) | 2001-01-25 | 2004-05-12 | Bristol@Myersásquibbácompany | Způsoby podávání analogů epothilonu při léčbě rakoviny |
| US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| IL156988A0 (en) | 2001-02-20 | 2004-02-08 | Bristol Myers Squibb Co | Pharmaceutical compositions containing epothilone derivatives |
| CA2438598A1 (en) | 2001-02-20 | 2002-08-29 | Francis Y. F. Lee | Epothilone derivatives for the treatment of refractory tumors |
| CA2440555A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| JP2004532888A (ja) * | 2001-06-01 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン誘導体 |
| TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
| RU2346686C2 (ru) | 2002-01-14 | 2009-02-20 | Новартис Аг | Комбинации, включающие эпотилоны и антиметаболиты |
| TW200303202A (en) * | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
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- 1999-02-17 PL PL404926A patent/PL404926A1/pl unknown
- 1999-02-17 BR BR9908119-9A patent/BR9908119A/pt active Search and Examination
- 1999-02-17 IL IL15963199A patent/IL159631A0/xx active IP Right Grant
- 1999-02-17 AT AT99911678T patent/ATE282710T1/de active
- 1999-02-17 EP EP99911678A patent/EP1054994B1/en not_active Expired - Lifetime
- 1999-02-17 KR KR1020077011230A patent/KR20070058021A/ko not_active Application Discontinuation
- 1999-02-17 DK DK99911678T patent/DK1054994T3/da active
- 1999-02-17 EP EP04002632A patent/EP1428826A3/en not_active Withdrawn
- 1999-02-17 NZ NZ506138A patent/NZ506138A/en not_active IP Right Cessation
- 1999-02-17 ES ES99911678T patent/ES2233028T3/es not_active Expired - Lifetime
- 1999-02-17 IL IL13769199A patent/IL137691A0/xx active IP Right Grant
- 1999-02-17 AU AU30287/99A patent/AU746294B2/en not_active Ceased
- 1999-02-17 PT PT99911678T patent/PT1054994E/pt unknown
- 1999-02-17 KR KR1020087017482A patent/KR20080070781A/ko not_active Application Discontinuation
- 1999-02-17 PL PL342423A patent/PL196787B1/pl not_active IP Right Cessation
- 1999-02-17 SK SK5029-2009A patent/SK288058B6/sk not_active IP Right Cessation
- 1999-02-17 KR KR1020067004228A patent/KR100873526B1/ko not_active IP Right Cessation
- 1999-02-17 HU HU0100855A patent/HU225851B1/hu not_active IP Right Cessation
- 1999-02-17 SK SK5014-2008A patent/SK287677B6/sk not_active IP Right Cessation
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2000
- 2000-08-03 IL IL137691A patent/IL137691A/en not_active IP Right Cessation
- 2000-08-17 NO NO20004114A patent/NO322588B1/no not_active IP Right Cessation
- 2000-09-07 US US09/656,954 patent/US6380227B1/en not_active Expired - Fee Related
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2001
- 2001-04-25 HK HK01102978A patent/HK1034100A1/xx not_active IP Right Cessation
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2002
- 2002-01-29 US US10/059,587 patent/US6656711B2/en not_active Expired - Fee Related
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2003
- 2003-01-08 US US10/338,336 patent/US20030194787A1/en not_active Abandoned
- 2003-06-12 US US10/459,762 patent/US7101702B2/en not_active Expired - Fee Related
- 2003-12-29 IL IL159631A patent/IL159631A/en not_active IP Right Cessation
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2004
- 2004-01-08 US US10/754,661 patent/US20040142990A1/en not_active Abandoned
- 2004-09-30 JP JP2004287797A patent/JP2005068156A/ja active Pending
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2005
- 2005-04-26 NO NO20052034A patent/NO321596B1/no not_active IP Right Cessation
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2006
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- 2006-04-20 NO NO20061736A patent/NO20061736L/no unknown
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2007
- 2007-02-05 US US11/671,357 patent/US20070197611A1/en not_active Abandoned
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2009
- 2009-03-04 US US12/397,620 patent/US20090326239A1/en not_active Abandoned
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2010
- 2010-01-27 JP JP2010015022A patent/JP2010099089A/ja active Pending
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