NO320394B1 - Legemiddel- avgivelsesanordning for to eller flere aktive forbindelser - Google Patents
Legemiddel- avgivelsesanordning for to eller flere aktive forbindelser Download PDFInfo
- Publication number
- NO320394B1 NO320394B1 NO19981638A NO981638A NO320394B1 NO 320394 B1 NO320394 B1 NO 320394B1 NO 19981638 A NO19981638 A NO 19981638A NO 981638 A NO981638 A NO 981638A NO 320394 B1 NO320394 B1 NO 320394B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- delivery device
- drug delivery
- core
- progestogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 42
- 238000012377 drug delivery Methods 0.000 title claims description 19
- 239000011162 core material Substances 0.000 claims description 40
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims description 26
- 229960002941 etonogestrel Drugs 0.000 claims description 25
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 21
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 21
- 229960002568 ethinylestradiol Drugs 0.000 claims description 21
- 239000000583 progesterone congener Substances 0.000 claims description 21
- 229920001169 thermoplastic Polymers 0.000 claims description 21
- 239000000262 estrogen Substances 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 18
- 229940011871 estrogen Drugs 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 12
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 12
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 230000003637 steroidlike Effects 0.000 claims description 10
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 7
- 239000004416 thermosoftening plastic Substances 0.000 claims description 6
- 239000006213 vaginal ring Substances 0.000 description 27
- 150000003431 steroids Chemical class 0.000 description 25
- 229940044953 vaginal ring Drugs 0.000 description 24
- 239000013543 active substance Substances 0.000 description 20
- 239000000835 fiber Substances 0.000 description 18
- 230000000757 progestagenic effect Effects 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 230000001076 estrogenic effect Effects 0.000 description 7
- MXDOOIVQXATHKU-RYVPXURESA-N (8s,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 MXDOOIVQXATHKU-RYVPXURESA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000004700 high-density polyethylene Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920002379 silicone rubber Polymers 0.000 description 3
- -1 steroid compound Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003433 contraceptive agent Substances 0.000 description 2
- 230000002254 contraceptive effect Effects 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000009256 replacement therapy Methods 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- 229920003345 Elvax® Polymers 0.000 description 1
- 229920003351 Ultrathene® Polymers 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229960004976 desogestrel Drugs 0.000 description 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
- 229960001348 estriol Drugs 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 description 1
- 229960005352 gestodene Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960004400 levonorgestrel Drugs 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 229960000417 norgestimate Drugs 0.000 description 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003918 potentiometric titration Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 230000009677 vaginal delivery Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201098 | 1997-04-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981638D0 NO981638D0 (no) | 1998-04-08 |
| NO981638L NO981638L (no) | 1998-10-12 |
| NO320394B1 true NO320394B1 (no) | 2005-11-28 |
Family
ID=8228203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981638A NO320394B1 (no) | 1997-04-11 | 1998-04-08 | Legemiddel- avgivelsesanordning for to eller flere aktive forbindelser |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5989581A (cs) |
| EP (1) | EP0876815B1 (cs) |
| JP (2) | JP4982670B2 (cs) |
| KR (1) | KR100492676B1 (cs) |
| CN (1) | CN1163222C (cs) |
| AR (1) | AR011709A1 (cs) |
| AT (1) | ATE211646T1 (cs) |
| AU (1) | AU726934B2 (cs) |
| BR (1) | BR9801027B1 (cs) |
| CA (1) | CA2233753C (cs) |
| CZ (1) | CZ294099B6 (cs) |
| DE (1) | DE69803112T2 (cs) |
| DK (1) | DK0876815T3 (cs) |
| ES (1) | ES2171283T3 (cs) |
| HK (1) | HK1016886A1 (cs) |
| HU (1) | HU222343B1 (cs) |
| ID (1) | ID21259A (cs) |
| IL (2) | IL123813A0 (cs) |
| NO (1) | NO320394B1 (cs) |
| NZ (1) | NZ330145A (cs) |
| PL (1) | PL192449B1 (cs) |
| PT (1) | PT876815E (cs) |
| RU (1) | RU2206325C2 (cs) |
| SG (1) | SG65061A1 (cs) |
| TR (1) | TR199800648A1 (cs) |
| TW (1) | TW358031B (cs) |
| ZA (1) | ZA982911B (cs) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123813A0 (en) * | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| US6039968A (en) † | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US6361780B1 (en) * | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
| US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6371970B1 (en) | 1999-07-30 | 2002-04-16 | Incept Llc | Vascular filter having articulation region and methods of use in the ascending aorta |
| US7369463B1 (en) | 2000-02-21 | 2008-05-06 | N.V. Organon | Electronic alarm timer for use with a medical regimen |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| US6671562B2 (en) | 2001-11-09 | 2003-12-30 | Oscor Inc. | High impedance drug eluting cardiac lead |
| TWI297685B (en) | 2002-04-04 | 2008-06-11 | Organon Nv | Non-steroidal progesterone receptor modulators |
| CA2484632C (en) * | 2002-05-07 | 2012-12-11 | Control Delivery Systems, Inc. | Processes for forming a drug delivery device |
| US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| KR20050072812A (ko) | 2002-11-07 | 2005-07-12 | 악조 노벨 엔.브이. | 안드로겐-수용체와 관련된 질병의 치료에 효과적인 인돌 |
| US7357046B2 (en) * | 2002-12-16 | 2008-04-15 | N. V. Organon | Method for dissolution testing of a pharmaceutical delivery device |
| DE60316344T2 (de) * | 2002-12-16 | 2008-06-12 | N.V. Organon | Behälter ,vorrichtung und verfahren zur prüfung des auflösens von pharmazeutischen zusammensetzungen |
| EP1620060B1 (en) | 2003-04-29 | 2010-03-24 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| TWI336627B (en) | 2003-05-23 | 2011-02-01 | Organon Nv | Drug delivery system,and use and manufacturing method thereof |
| WO2005070949A1 (en) * | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of estradiol |
| US7067504B2 (en) * | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| WO2005089723A1 (en) | 2004-03-24 | 2005-09-29 | N.V. Organon | Drug delivery system based on polyethylene vinylacetate copolymers |
| TW200531977A (en) | 2004-03-25 | 2005-10-01 | Akzo Nobel Nv | Progesterone receptor modulators |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| JP2008520783A (ja) * | 2004-11-16 | 2008-06-19 | ユニベルシテ・ド・リエージュ | ヒドロゲルマトリックスおよびマイクロキャリアを含む活性物質供給システム |
| CN100366242C (zh) * | 2005-01-13 | 2008-02-06 | 杭州容立医药科技有限公司 | 防滑脱阴道药物释放体系及其制造工艺和在制药中的应用 |
| EP1904147A4 (en) * | 2005-06-20 | 2009-05-27 | Abbeymoor Medical Inc | MEDICATION DISPOSABLE ARTICLES, ACCESSORIES AND SYSTEM |
| TW200727920A (en) * | 2005-06-21 | 2007-08-01 | Organon Nv | New regimens for oral monophasic contraceptives |
| CN101218245B (zh) | 2005-07-12 | 2011-08-17 | 沃纳奇尔科特有限责任公司 | 炔雌醇的3-酯前药 |
| EP1910402A2 (en) * | 2005-07-12 | 2008-04-16 | Warner Chilcott Company, Inc. | 3-ester prodrugs of estradiol |
| CN1899643B (zh) * | 2005-07-20 | 2010-12-29 | 上海市计划生育科学研究所 | 含有抗雌激素和抗孕激素复合制剂的阴道环或宫内释药装置及其制药用途 |
| ES2400091T3 (es) | 2005-08-11 | 2013-04-05 | Massachusetts Institute Of Technology | Dispositivo de suministro de fármacos intravesical y método |
| US20070077269A1 (en) * | 2005-10-04 | 2007-04-05 | Woodward John R | Method of birth control and hormone regulation |
| US7989442B2 (en) | 2006-09-27 | 2011-08-02 | N.V. Organon | Progesterone receptor modulators |
| AU2007324467A1 (en) * | 2006-11-22 | 2008-05-29 | N.V. Organon | Vaginal delivery system for mirtazapine |
| TW200840595A (en) * | 2006-12-12 | 2008-10-16 | Organon Nv | Oral contraceptive spray |
| US8063037B2 (en) | 2007-05-07 | 2011-11-22 | N. V. Organon | Progesterone receptor modulators |
| TW200930343A (en) * | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
| BRPI0820800B8 (pt) * | 2007-12-11 | 2021-06-22 | Massachusetts Inst Technology | dispositivo médico implantável para liberação controlada de droga |
| BRPI0917135A2 (pt) * | 2008-08-09 | 2015-11-10 | Massachusetts Inst Technology | dispositivo médico para extensão e retenção em uma vesícula seminal, duto ejaculatório, próstata ou vaso deferente de um paciente, uso de um elastômero reabsorvível, e, dispositivo de bomba osmótica. |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| WO2010054296A2 (en) * | 2008-11-07 | 2010-05-14 | Combinent Biomedical Systems, Inc. | Devices and methods for treating and/or preventing diseases |
| FI121000B (fi) * | 2008-11-19 | 2010-06-15 | Bayer Schering Pharma Oy | Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi |
| WO2010105995A2 (en) | 2009-03-17 | 2010-09-23 | Intervet International B.V. | Zoo-technical drug delivery device |
| CN102481450B (zh) | 2009-04-07 | 2015-09-16 | 威斯特天主教保健中心 | 子宫电刺激系统及方法 |
| US8568374B2 (en) * | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
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1998
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