NO317743B1 - Enteriske fluoksetinpellet samt fremgangsmate til fremstilling derav, formulering som omfatter slik pellet, gelatinkapsel inneholdende nevnte formulering og anvendelse av slik pellet til fremstilling av et medikament for fremstilling av mennesker - Google Patents
Enteriske fluoksetinpellet samt fremgangsmate til fremstilling derav, formulering som omfatter slik pellet, gelatinkapsel inneholdende nevnte formulering og anvendelse av slik pellet til fremstilling av et medikament for fremstilling av mennesker Download PDFInfo
- Publication number
- NO317743B1 NO317743B1 NO19982197A NO982197A NO317743B1 NO 317743 B1 NO317743 B1 NO 317743B1 NO 19982197 A NO19982197 A NO 19982197A NO 982197 A NO982197 A NO 982197A NO 317743 B1 NO317743 B1 NO 317743B1
- Authority
- NO
- Norway
- Prior art keywords
- fluoxetine
- pellet
- enteric
- layer
- pharmaceutically acceptable
- Prior art date
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000009496 sugar coating process Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 229940033134 talc Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/867,196 US5910319A (en) | 1997-05-29 | 1997-05-29 | Fluoxetine enteric pellets and methods for their preparation and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982197D0 NO982197D0 (no) | 1998-05-14 |
| NO982197L NO982197L (no) | 1998-11-30 |
| NO317743B1 true NO317743B1 (no) | 2004-12-13 |
Family
ID=25349313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982197A NO317743B1 (no) | 1997-05-29 | 1998-05-14 | Enteriske fluoksetinpellet samt fremgangsmate til fremstilling derav, formulering som omfatter slik pellet, gelatinkapsel inneholdende nevnte formulering og anvendelse av slik pellet til fremstilling av et medikament for fremstilling av mennesker |
Country Status (46)
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| IE990406A1 (en) | 1999-05-20 | 2000-12-27 | Elan Corp Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
| EP1178780B1 (fr) * | 1999-05-20 | 2007-07-18 | ELAN CORPORATION, Plc | Preparations d'inhibiteurs specifiques du recaptage de la serotonine a liberation multiparticulaire regulee |
| ES2162560B1 (es) * | 1999-06-25 | 2002-07-16 | Rodriguez Concepcion Pena | Uso de fluoxetina, paroxetina y otros isrs para la fabricacion de medicamentos con el fin de aumentar la capacidad de abstenerse de substancias o actividades que crean dependencia. |
| ES2393582T3 (es) | 1999-09-03 | 2012-12-26 | Apbi Holdings, Llc | Procedimiento de utilización de inhibidores de la recaptación de serotonina selectivos de inicio rápido de acción para el tratamiento de las disfunciones sexuales |
| CN1094347C (zh) * | 1999-11-15 | 2002-11-20 | 广东药学院药物研究所 | 一种治疗前列腺良性增生症的控释微丸及其制备方法 |
| US6273260B1 (en) | 2000-03-08 | 2001-08-14 | Eli Lilly And Company | Pharmaceutical packaging system |
| ES2185452B2 (es) * | 2000-08-01 | 2004-03-16 | Cinfa S A Lab | Composicion farmaceutica de fluoxetina en comprimido dispersable recubierto y su proceso de fabricacion. |
| JP4181738B2 (ja) * | 2000-08-25 | 2008-11-19 | 信越化学工業株式会社 | 腸溶性コーティング製剤の製造方法 |
| US6482440B2 (en) * | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| WO2002038126A2 (fr) * | 2000-11-08 | 2002-05-16 | Aeromatic-Fielder Ag | Procede de production de particules pour preparations pharmaceutiques presentant une biodisponibilite accrue |
| US20040170688A1 (en) * | 2001-08-06 | 2004-09-02 | Deshmukh Abhijit Mukund | Enteric formulation of fluoxetin |
| WO2003013480A1 (fr) | 2001-08-06 | 2003-02-20 | Dr. Reddy's Laboratories Ltd. | Preparation enterique de fluoxetine |
| US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| WO2004058228A1 (fr) * | 2002-12-24 | 2004-07-15 | Lupin Limited | Composition de fluoxetine a enrobage enterique |
| US8614247B2 (en) * | 2003-04-10 | 2013-12-24 | Institut National De La Sante Et De La Recherche Medicale | Methods for preventing, attenuating or treating pulmonary hypertension using a serotonin transporter inhibitor, and pharmaceutical compositions for the treatment thereof |
| CN101967117A (zh) | 2003-05-30 | 2011-02-09 | 兰贝克赛实验室有限公司 | 取代的吡咯衍生物及其作为hmg-co抑制剂的用途 |
| US20050176693A1 (en) * | 2003-08-12 | 2005-08-11 | Boissonneault Roger M. | Method of intermittent administration of a pharmaceutical for the treatment of conditions associated with a female's menstrual cycle |
| US20070141150A1 (en) * | 2003-12-30 | 2007-06-21 | Raghupathi Kandarapu | Pharmaceutical composition |
| CA2579767A1 (fr) * | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | Composition pharmaceutique orale sous forme particulaire a liberation chronocontrolee et comprimes a dissolution rapide ainsi constitues |
| KR100920856B1 (ko) * | 2004-11-30 | 2009-10-09 | (주)아모레퍼시픽 | 선택적 세로토닌 재흡수 억제제의 연장방출 제제 및 그제조방법 |
| US20060194869A1 (en) * | 2004-12-23 | 2006-08-31 | Santiago Ini | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
| WO2007015270A2 (fr) * | 2005-08-02 | 2007-02-08 | Lupin Limited | Nouvelles compositions a liberation controlee a base d'inhibiteurs selectifs de la recapture de la serotonine |
| BRPI0618379A2 (pt) | 2005-11-08 | 2011-08-30 | Ranbaxy Lab Ltd | processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico |
| EP1951643A1 (fr) * | 2005-11-23 | 2008-08-06 | Auspex Pharmaceuticals Inc. | Aryloxypropylamines substituées possédant une activité sérotoninergique et/ou norépinephrinergique |
| EP2100888A3 (fr) * | 2005-12-05 | 2011-01-19 | Teva Pharmaceutical Industries Ltd. | Procédé de préparation d'hydrochlorure de duloxétine |
| US20080033030A1 (en) * | 2006-02-24 | 2008-02-07 | Capua Simona D | Fluvastatin sodium pharmaceutical compositions |
| CN101057837B (zh) * | 2006-04-20 | 2010-12-22 | 湖南九典制药有限公司 | 一种右旋酮洛芬肠溶微丸及制备方法 |
| WO2007134168A2 (fr) * | 2006-05-10 | 2007-11-22 | Dr. Reddy's Laboratories Ltd. | Procédé de préparation de duloxétine |
| JP2009538315A (ja) * | 2006-05-22 | 2009-11-05 | テバ ファーマシューティカル インダストリーズ リミティド | 塩酸デュロキセチン遅延放出型製剤 |
| CA2654402A1 (fr) * | 2006-06-01 | 2007-12-06 | Adel Penhasi | Formulation pharmaceutique comprenant des unites multiples |
| JP5052051B2 (ja) * | 2006-06-16 | 2012-10-17 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
| BRPI0714915A2 (pt) * | 2006-07-28 | 2013-05-28 | Reddys Lab Ltd Dr | composiÇço farmacÊuticas; formas de dosagem farmacÊutica; e processo para o preparo de uma composiÇço farmacÊutica |
| US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| US20090175935A1 (en) * | 2006-08-14 | 2009-07-09 | Torrent Research Ltd. | Pharmaceutical compositions of duloxetine |
| US20080103105A1 (en) * | 2006-09-22 | 2008-05-01 | Braincells, Inc. | HMG CoA REDUCTASE MEDIATED MODULATION OF NEUROGENESIS |
| US20080226711A1 (en) * | 2007-03-12 | 2008-09-18 | Torrent Pharmaceuticals Ltd. | Pharmaceutical compositions of duloxetine |
| US20090226517A1 (en) * | 2008-02-06 | 2009-09-10 | Vinita Umashankar Vyas | Pharmaceutical formulations comprising duloxetine |
| AU2009270823B2 (en) | 2008-07-16 | 2014-07-17 | Richter Gedeon Nyrt. | Pharmaceutical formulations containing dopamine receptor ligands |
| EP2329823A4 (fr) * | 2008-09-03 | 2013-04-03 | Takeda Pharmaceutical | Procédé pour améliorer la capacité d'une préparation à être absorbée et préparation dont la capacité à être absorbée est améliorée |
| CN101804145B (zh) * | 2009-02-12 | 2012-11-14 | 杭州赛利药物研究所有限公司 | 一种大蒜油肠溶微丸胶囊及其制备方法 |
| WO2011039768A2 (fr) * | 2009-09-17 | 2011-04-07 | Cadila Healthcare Limited | Compositions pharmaceutiques pour réduire une libération massive induite par l'alcool |
| WO2011102504A1 (fr) * | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | Préparation solide à libération prolongée pour utilisation orale |
| JP6626712B2 (ja) * | 2012-05-02 | 2019-12-25 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 放出制御ポリマーの水性分散液並びにそのシェル及びカプセル |
| CN102716084B (zh) * | 2012-06-29 | 2013-09-25 | 海南美大制药有限公司 | 盐酸氟西汀脂质体固体制剂 |
| CA2883077C (fr) | 2012-09-03 | 2017-03-07 | Daiichi Sankyo Company, Limited | Composition pharmaceutique a liberation prolongee administree par voie orale contenant du chlorhydrate d'hydromorphone |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| KR20170005833A (ko) | 2014-05-20 | 2017-01-16 | 다우 글로벌 테크놀로지스 엘엘씨 | 부분적으로 중화된 에스테르화 셀룰로오스 에테르를 포함하는 분산물 |
| WO2015179073A1 (fr) * | 2014-05-20 | 2015-11-26 | Dow Global Technologies Llc | Enveloppes de capsule comprenant un éther de cellulose estérifié |
| WO2015187874A1 (fr) * | 2014-06-07 | 2015-12-10 | Structure-Ase, Inc. | Procédé de détection et/ou de diagnostic de troubles alimentaires et de malnutrition à l'aide de diffraction aux rayons x |
| US10471152B2 (en) | 2014-08-29 | 2019-11-12 | Capsugel Belgium Nv | Colloidal dispersion comprising HPMCAS |
| WO2016174664A1 (fr) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Compositions à désintégration par voie orale |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| EP3609578A4 (fr) * | 2017-04-13 | 2021-03-10 | Chase Therapeutics Corporation | Combinaison pharmaceutique et son utilisation pour le traitement de synucléinopathies |
| HUP1700253A1 (hu) | 2017-06-13 | 2019-01-28 | Richter Gedeon Nyrt | Szilárd orális gyógyszerkészítmények |
| CN107898942B (zh) * | 2017-11-24 | 2021-01-26 | 一力制药(罗定)有限公司 | 一种感冒清热胶囊及其制备方法 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| WO2022115054A1 (fr) * | 2020-11-27 | 2022-06-02 | Santa Farma Ilac Sanayii A.S. | Compositions de duloxétine à enrobage entérique |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018895A (en) | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| US4626549A (en) * | 1974-01-10 | 1986-12-02 | Eli Lilly And Company | Treatment of obesity with aryloxyphenylpropylamines |
| US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| US4194009A (en) | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| JPS517116A (en) | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
| CH649216A5 (de) | 1979-08-16 | 1985-05-15 | Sandoz Ag | Verfahren zur auftragung eines magensaftresistenten filmes auf einen heilmittelkern und feste einheitsdosierungsform mit magensaftresistentem film. |
| JPS5855125B2 (ja) * | 1980-03-10 | 1983-12-08 | 信越化学工業株式会社 | 固形薬剤用腸溶性コ−テイング剤組成物 |
| US4444778A (en) * | 1981-08-27 | 1984-04-24 | Coughlin Shaun R | Method and composition for treating atherosclerosis |
| US4847092A (en) * | 1985-11-12 | 1989-07-11 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulations |
| US4797286A (en) | 1985-11-12 | 1989-01-10 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulations |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| US4918242A (en) | 1988-03-30 | 1990-04-17 | Aldrich Chemical Company, Inc. | Novel optically 1,3-phenoxypropylhalides |
| CA1337955C (fr) * | 1988-09-26 | 1996-01-23 | Thomas A. Almquist | Recouvrement de couches stereolithographiques |
| US4999382A (en) * | 1988-10-26 | 1991-03-12 | Massachusetts Institute Of Technology | Compositions for treating tobacco withdrawal symptoms and methods for their use |
| US5356934A (en) * | 1990-03-29 | 1994-10-18 | Eli Lilly And Company | Selected serotonin subtype receptor agonist to treat sleep apnea |
| US5104899A (en) * | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
| US5589511A (en) * | 1990-08-13 | 1996-12-31 | Sepracor Inc. | Method for treating migraine headaches using optically pure S(+) fluoxetine |
| JPH04202124A (ja) * | 1990-11-29 | 1992-07-22 | Fuji Kagaku Kogyo Kk | 噴霧乾燥造粒法による薬物放出の制御された製剤の製造法 |
| AU1429092A (en) * | 1991-02-04 | 1992-09-07 | Timothy J Barberich | Methods of use and compositions of r(-) fluoxetine |
| JPH06507416A (ja) * | 1991-05-07 | 1994-08-25 | ダイナジェン・インコーポレーテッド | 禁煙のための調節された持続的放出伝達システム |
| WO1993018755A1 (fr) * | 1992-03-25 | 1993-09-30 | Depomed Systems, Incorporated | Formes galeniques de medicament oral a liberation prolongee a base de cellulose a substitution alkyle |
| US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| JPH06293633A (ja) * | 1993-04-05 | 1994-10-21 | Shin Etsu Chem Co Ltd | 水性腸溶性エマルジョンの製造方法 |
| US5362886A (en) | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| CA2175494C (fr) * | 1993-11-03 | 2000-09-19 | Young W. Cho | Compositions pharmaceutiques microparticulaires sous forme micellaire |
| CA2134038C (fr) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentialisation des effets de medicaments |
| US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
| JPH08109126A (ja) * | 1994-10-07 | 1996-04-30 | Amano Pharmaceut Co Ltd | 耐衝撃性腸溶性顆粒剤およびこれを含有する錠剤 |
| JPH08245423A (ja) * | 1995-03-06 | 1996-09-24 | Shionogi & Co Ltd | 水系腸溶性コーティング液 |
| GB9514842D0 (en) * | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
-
1997
- 1997-05-29 US US08/867,196 patent/US5910319A/en not_active Ceased
-
1998
- 1998-04-13 IL IL12407398A patent/IL124073A/en not_active IP Right Cessation
- 1998-04-14 RU RU98106998/14A patent/RU2164405C2/ru active
- 1998-04-14 RO RO98-00869A patent/RO120043B1/ro unknown
- 1998-04-14 CA CA002234826A patent/CA2234826C/fr not_active Expired - Lifetime
- 1998-04-15 NZ NZ330192A patent/NZ330192A/xx not_active IP Right Cessation
- 1998-04-15 CZ CZ19981143A patent/CZ290582B6/cs not_active IP Right Cessation
- 1998-04-15 ZA ZA9803173A patent/ZA983173B/xx unknown
- 1998-04-15 HU HU9800882A patent/HUP9800882A3/hu not_active Application Discontinuation
- 1998-04-15 GB GB9807939A patent/GB2325623B/en not_active Expired - Lifetime
- 1998-04-15 RS YUP-165/98A patent/RS49827B/sr unknown
- 1998-04-15 UA UA98041929A patent/UA48193C2/uk unknown
- 1998-04-16 MY MYPI98001702A patent/MY118139A/en unknown
- 1998-04-16 FI FI980846A patent/FI119971B/fi active IP Right Grant
- 1998-04-17 SE SE9801336A patent/SE522914C2/sv not_active IP Right Cessation
- 1998-04-17 SG SG1998000871A patent/SG72805A1/en unknown
- 1998-04-20 KR KR1019980014014A patent/KR100549473B1/ko not_active IP Right Cessation
- 1998-04-22 LT LT98-058A patent/LT4477B/lt not_active IP Right Cessation
- 1998-04-24 JP JP15350198A patent/JP3210288B2/ja not_active Expired - Lifetime
- 1998-04-24 CN CNB981087787A patent/CN1161109C/zh not_active Expired - Lifetime
- 1998-04-28 ES ES009800899A patent/ES2161574B1/es not_active Expired - Fee Related
- 1998-04-28 IT IT98MI000908A patent/ITMI980908A1/it unknown
- 1998-04-28 SV SV1998000052A patent/SV1998000052A/es unknown
- 1998-04-29 SI SI9800128A patent/SI9800128B/sl unknown
- 1998-05-01 PL PL326134A patent/PL192293B1/pl unknown
- 1998-05-07 AR ARP980102130A patent/AR011728A1/es not_active Application Discontinuation
- 1998-05-08 PT PT102152A patent/PT102152B/pt active IP Right Grant
- 1998-05-11 TW TW087107241A patent/TWI239838B/zh not_active IP Right Cessation
- 1998-05-12 CO CO98026349A patent/CO4940407A1/es unknown
- 1998-05-13 FR FR9806040A patent/FR2763846B1/fr not_active Expired - Lifetime
- 1998-05-14 NO NO19982197A patent/NO317743B1/no not_active IP Right Cessation
- 1998-05-19 BR BR9801989-9A patent/BR9801989A/pt not_active Application Discontinuation
- 1998-05-20 LU LU90245A patent/LU90245B1/fr active
- 1998-05-20 BE BE9800383A patent/BE1011925A3/fr not_active IP Right Cessation
- 1998-05-25 LV LVP-98-121A patent/LV12176B/xx unknown
- 1998-05-26 CH CH01157/98A patent/CH693018A5/de not_active IP Right Cessation
- 1998-05-26 NL NL1009259A patent/NL1009259C2/nl not_active IP Right Cessation
- 1998-05-27 TR TR1998/00937A patent/TR199800937A2/xx unknown
- 1998-05-28 ID IDP980791A patent/ID20343A/id unknown
- 1998-05-28 PE PE1998000430A patent/PE75399A1/es not_active Application Discontinuation
- 1998-05-28 DK DK199800728A patent/DK176776B1/da not_active IP Right Cessation
- 1998-05-28 DE DE19823940A patent/DE19823940B4/de not_active Expired - Lifetime
- 1998-05-28 AU AU69048/98A patent/AU726690B2/en not_active Expired
- 1998-05-28 GR GR980100188A patent/GR980100188A/el unknown
- 1998-05-29 AT AT0093198A patent/AT408068B/de not_active IP Right Cessation
-
1999
- 1999-03-10 US US09/265,610 patent/US5985322A/en not_active Expired - Lifetime
-
2000
- 2000-07-25 CN CNB001222090A patent/CN1212834C/zh not_active Expired - Lifetime
-
2001
- 2001-08-10 HK HK01105581A patent/HK1034902A1/xx not_active IP Right Cessation
-
2002
- 2002-01-28 US US10/058,891 patent/USRE39030E1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |