NO315802B1 - Biologisk fremgangsmåte for fremstilling av 7-ACA og 7-ADAC - Google Patents
Biologisk fremgangsmåte for fremstilling av 7-ACA og 7-ADAC Download PDFInfo
- Publication number
- NO315802B1 NO315802B1 NO19941345A NO941345A NO315802B1 NO 315802 B1 NO315802 B1 NO 315802B1 NO 19941345 A NO19941345 A NO 19941345A NO 941345 A NO941345 A NO 941345A NO 315802 B1 NO315802 B1 NO 315802B1
- Authority
- NO
- Norway
- Prior art keywords
- adipoyl
- expandase
- gene
- strain
- enzyme
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77783391A | 1991-10-15 | 1991-10-15 | |
| US95349292A | 1992-10-06 | 1992-10-06 | |
| PCT/US1992/008585 WO1993008287A1 (fr) | 1991-10-15 | 1992-10-08 | Nouveaux procedes biologiques de preparation de 7-aca et de 7-adac |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941345D0 NO941345D0 (no) | 1994-04-14 |
| NO941345L NO941345L (no) | 1994-06-15 |
| NO315802B1 true NO315802B1 (no) | 2003-10-27 |
Family
ID=27119363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19941345A NO315802B1 (no) | 1991-10-15 | 1994-04-14 | Biologisk fremgangsmåte for fremstilling av 7-ACA og 7-ADAC |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US5559005A (fr) |
| EP (2) | EP0856516B1 (fr) |
| JP (1) | JP2655790B2 (fr) |
| KR (1) | KR100227711B1 (fr) |
| CN (1) | CN1074484A (fr) |
| AT (2) | ATE216700T1 (fr) |
| AU (1) | AU657800B2 (fr) |
| BG (1) | BG62261B1 (fr) |
| CA (1) | CA2080573C (fr) |
| CZ (1) | CZ288721B6 (fr) |
| DE (2) | DE69232581T2 (fr) |
| DK (2) | DK0540210T3 (fr) |
| ES (2) | ES2127205T3 (fr) |
| FI (1) | FI106965B (fr) |
| GR (1) | GR3029343T3 (fr) |
| HU (1) | HU219370B (fr) |
| IL (3) | IL103419A (fr) |
| MX (1) | MX9205902A (fr) |
| NO (1) | NO315802B1 (fr) |
| NZ (1) | NZ244714A (fr) |
| RO (1) | RO116648B1 (fr) |
| RU (1) | RU2002130702A (fr) |
| SK (1) | SK280569B6 (fr) |
| TW (1) | TW272233B (fr) |
| UA (1) | UA47385C2 (fr) |
| WO (1) | WO1993008287A1 (fr) |
| YU (1) | YU48930B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6709859B1 (en) | 1986-01-31 | 2004-03-23 | Beecham Group P.L.C. | Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression |
| DE3789880T2 (de) * | 1986-01-31 | 1994-09-08 | Beecham Group Plc | Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen. |
| KR0171897B1 (ko) * | 1989-12-27 | 1999-02-01 | 후지사와 도모끼찌로 | 7-아미노세펨 화합물 또는 그 염류의 제조 방법 |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| HU219265B (en) * | 1993-07-30 | 2001-03-28 | Gist Brocades Bv | Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca, recombinant dna vectors and host cells |
| CA2168431A1 (fr) * | 1993-07-30 | 1995-02-09 | Roelof Ary Lans Bovenberg | Methode pour la preparation efficace de 7-adca par l'intermediaire de 2-(carboxyethylthio)acetyl-7-adca et de 3-(carboxymethylthio)propionyl-7-adca |
| US5882883A (en) * | 1994-09-28 | 1999-03-16 | Novo Nordisk A/S | Process for the production of secondary metabolites |
| DE4437420A1 (de) * | 1994-10-19 | 1996-04-25 | Hoechst Ag | Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase |
| CN1084791C (zh) * | 1995-06-02 | 2002-05-15 | 吉斯特·布罗卡迪斯股份有限公司 | 通过扩环酶活性作用于青霉素g生产7－adca的方法 |
| US5731165A (en) * | 1995-06-02 | 1998-03-24 | Gist-Brocades, B.V. | Process for the production of 7-ADCA via expandase activity on penicillin G |
| AU2508897A (en) * | 1996-04-04 | 1997-10-29 | Gist-Brocades B.V. | An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof |
| AU4201897A (en) | 1996-07-16 | 1998-02-09 | Gist-Brocades B.V. | Novel process for the preparation of cephalosporins using (acremonium chrysogenum) |
| ES2237840T3 (es) | 1997-04-22 | 2005-08-01 | Dsm Ip Assets B.V. | Proceso mejorado para la produccion fermentativa de cefalosporina. |
| WO1998048037A1 (fr) * | 1997-04-22 | 1998-10-29 | Dsm N.V. | Procede de regulation de la solubilite d'une betalactamine |
| JP2000512511A (ja) * | 1997-04-22 | 2000-09-26 | ギスト ブロカデス ベスローテン フェンノートシャップ | 脱アシル化セファロスポリンの発酵による製造方法 |
| PT915988E (pt) * | 1997-04-22 | 2003-06-30 | Dsm Nv | Processo para a producao fermentativa de cefalosporinas desaciladas |
| WO1999010499A1 (fr) * | 1997-08-22 | 1999-03-04 | Dsm N.V. | Production de statine par fermentation |
| SI1066294T1 (en) | 1998-03-27 | 2003-04-30 | Dsm N.V. | Novel process for the fermentative production of cephalosporin |
| US6383773B2 (en) | 1998-04-23 | 2002-05-07 | Massachusetts Institute Of Technology | Penicillin conversion |
| AU3042600A (en) * | 1998-12-22 | 2000-07-12 | Dsm N.V. | Improved (in vivo) production of cephalosporins |
| ES2165276B1 (es) * | 1999-06-18 | 2003-03-01 | Antibioticos Sau | Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc) |
| US7767823B2 (en) | 2000-05-13 | 2010-08-03 | Smithkline Beecham Limited | Process for the purification of a salt of clavulanic acid |
| US6699699B2 (en) | 2002-03-26 | 2004-03-02 | Synmax Biochemical Co., Ltd. | Mutated penicillin expandases |
| US20070093465A1 (en) * | 2003-05-28 | 2007-04-26 | Van Den Berg Marco A | Cephem compound |
| ES2423454T3 (es) * | 2006-02-23 | 2013-09-20 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Producción mejorada de cefalosporina |
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-
1992
- 1992-10-08 KR KR1019940701210A patent/KR100227711B1/ko not_active IP Right Cessation
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- 1992-10-08 UA UA94005496A patent/UA47385C2/uk unknown
- 1992-10-08 WO PCT/US1992/008585 patent/WO1993008287A1/fr active IP Right Grant
- 1992-10-13 NZ NZ244714A patent/NZ244714A/en not_active IP Right Cessation
- 1992-10-14 CN CN92113331A patent/CN1074484A/zh active Pending
- 1992-10-14 AU AU27016/92A patent/AU657800B2/en not_active Ceased
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- 1992-10-14 CA CA002080573A patent/CA2080573C/fr not_active Expired - Fee Related
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- 1992-10-14 DK DK92309351T patent/DK0540210T3/da active
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- 1994-04-14 NO NO19941345A patent/NO315802B1/no unknown
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1995
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