NO313752B1 - Arylsulfonylaminohydroksamsyre-derivater, anvendelse derav samt farmasöytisk blanding - Google Patents
Arylsulfonylaminohydroksamsyre-derivater, anvendelse derav samt farmasöytisk blanding Download PDFInfo
- Publication number
- NO313752B1 NO313752B1 NO19974103A NO974103A NO313752B1 NO 313752 B1 NO313752 B1 NO 313752B1 NO 19974103 A NO19974103 A NO 19974103A NO 974103 A NO974103 A NO 974103A NO 313752 B1 NO313752 B1 NO 313752B1
- Authority
- NO
- Norway
- Prior art keywords
- amino
- methoxybenzenesulfonyl
- hydroxy
- methylbutyramide
- compound
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000002253 acid Substances 0.000 title description 19
- 150000001875 compounds Chemical class 0.000 claims description 63
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 61
- -1 carboxypiperazinyl ring Chemical group 0.000 claims description 56
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- 239000000203 mixture Substances 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 19
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 17
- 230000005764 inhibitory process Effects 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 11
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 9
- 208000025865 Ulcer Diseases 0.000 claims description 7
- 230000036269 ulceration Effects 0.000 claims description 7
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 206010040047 Sepsis Diseases 0.000 claims description 6
- 206010040070 Septic Shock Diseases 0.000 claims description 6
- 206010003246 arthritis Diseases 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 230000036303 septic shock Effects 0.000 claims description 6
- 208000030507 AIDS Diseases 0.000 claims description 5
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims description 5
- 206010039705 Scleritis Diseases 0.000 claims description 5
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- 238000002360 preparation method Methods 0.000 claims description 5
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- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 claims description 4
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims description 3
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
- WXDHEKCNKUOATG-UHFFFAOYSA-N 3-[(3,4-dimethoxyphenyl)sulfonyl-[2-(hydroxyamino)-2-oxoethyl]amino]propanoic acid Chemical compound COC1=CC=C(S(=O)(=O)N(CCC(O)=O)CC(=O)NO)C=C1OC WXDHEKCNKUOATG-UHFFFAOYSA-N 0.000 claims description 2
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- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 26
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- 238000000034 method Methods 0.000 description 14
- 125000006239 protecting group Chemical group 0.000 description 14
- 239000007787 solid Substances 0.000 description 14
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- 239000012267 brine Substances 0.000 description 13
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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US40104995A | 1995-03-08 | 1995-03-08 | |
PCT/US1996/002679 WO1996027583A1 (en) | 1995-03-08 | 1996-03-07 | Arylsulfonylamino hydroxamic acid derivatives |
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NO19974103A NO313752B1 (no) | 1995-03-08 | 1997-09-05 | Arylsulfonylaminohydroksamsyre-derivater, anvendelse derav samt farmasöytisk blanding |
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MY (1) | MY113586A (pt) |
NO (1) | NO313752B1 (pt) |
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