BR112018068702A2 - inibidores bicíclicos em ponte de menin-mll e métodos de uso - Google Patents

inibidores bicíclicos em ponte de menin-mll e métodos de uso

Info

Publication number
BR112018068702A2
BR112018068702A2 BR112018068702A BR112018068702A BR112018068702A2 BR 112018068702 A2 BR112018068702 A2 BR 112018068702A2 BR 112018068702 A BR112018068702 A BR 112018068702A BR 112018068702 A BR112018068702 A BR 112018068702A BR 112018068702 A2 BR112018068702 A2 BR 112018068702A2
Authority
BR
Brazil
Prior art keywords
methods
menin
mll
bridged bicyclic
bicyclic inhibitors
Prior art date
Application number
BR112018068702A
Other languages
English (en)
Inventor
Dmitry Borkin
Tomasz Cierpicki
Jolanta Grembecka
Szymon Klossowski
Liansheng Li
Jonathan Pollock
Pingda Ren
Yi Wang
Tao Wu
Original Assignee
Kura Oncology Inc
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kura Oncology Inc, Univ Michigan Regents filed Critical Kura Oncology Inc
Publication of BR112018068702A2 publication Critical patent/BR112018068702A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

o presente relatório provê métodos para a inibição da interação de menin com mll1, mll2 e oncoproteínas de fusão de mll. os métodos são úteis para o tratamento de leucemia, cânceres sólidos, diabetes e outras doenças dependentes da atividade de mll1, mll2, proteínas de fusão de mll e/ou menin. são também providas composições para uso nestes métodos.
BR112018068702A 2016-03-16 2017-03-15 inibidores bicíclicos em ponte de menin-mll e métodos de uso BR112018068702A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662309362P 2016-03-16 2016-03-16
US201662431387P 2016-12-07 2016-12-07
PCT/US2017/022535 WO2017161002A1 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use

Publications (1)

Publication Number Publication Date
BR112018068702A2 true BR112018068702A2 (pt) 2019-01-15

Family

ID=59851929

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018068702A BR112018068702A2 (pt) 2016-03-16 2017-03-15 inibidores bicíclicos em ponte de menin-mll e métodos de uso

Country Status (17)

Country Link
US (2) US10752639B2 (pt)
EP (1) EP3429585B1 (pt)
JP (1) JP7000333B2 (pt)
KR (1) KR102419524B1 (pt)
CN (1) CN109640987B (pt)
AU (1) AU2017235462B2 (pt)
BR (1) BR112018068702A2 (pt)
CA (1) CA3015845A1 (pt)
HK (1) HK1258821A1 (pt)
IL (1) IL261625B (pt)
MA (1) MA43823A (pt)
MX (1) MX2018011092A (pt)
PH (1) PH12018501955A1 (pt)
SG (1) SG11201807834WA (pt)
TW (1) TWI743096B (pt)
WO (1) WO2017161002A1 (pt)
ZA (1) ZA201805845B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
ES2947636T3 (es) 2016-03-16 2023-08-14 Kura Oncology Inc Derivados de tieno[2,3-d]pirimidina sustituida como inhibidores de menina-MLL y métodos de uso
TWI743096B (zh) 2016-03-16 2021-10-21 美商庫拉腫瘤技術股份有限公司 Menin-mll之橋聯雙環抑制劑及使用方法
KR20190015275A (ko) 2016-05-02 2019-02-13 더 리젠츠 오브 더 유니버시티 오브 미시간 메닌 억제제로서의 피페리딘
WO2018050684A1 (en) 2016-09-14 2018-03-22 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-mll interaction
SI3512857T1 (sl) 2016-09-14 2021-07-30 Janssen Pharmaceutica Nv Spiro biciklični zaviralci interakcije menin-MLL
ES2901227T3 (es) 2016-12-15 2022-03-21 Janssen Pharmaceutica Nv Inhibidores de azepano de la interacción menina-MLL
EA201991448A1 (ru) 2017-01-06 2019-12-30 Янссен Фармацевтика Нв Азепановые ингибиторы взаимодействия менин-mll
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
US11045448B2 (en) 2017-03-31 2021-06-29 The Regents Of The University Of Michigan Piperidines as covalent menin inhibitors
WO2018226976A1 (en) 2017-06-08 2018-12-13 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
US11649251B2 (en) 2017-09-20 2023-05-16 Kura Oncology, Inc. Substituted inhibitors of menin-MLL and methods of use
US11396517B1 (en) 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction
CN110204552B (zh) * 2018-02-28 2021-08-17 中国科学院上海药物研究所 一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途
CN112105621B (zh) 2018-03-30 2024-02-20 住友制药株式会社 光学活性桥型环状仲胺衍生物
JP2022503792A (ja) * 2018-09-26 2022-01-12 クラ オンコロジー，インク． メニン阻害剤を用いた血液悪性腫瘍の処置
CN110964016B (zh) * 2018-09-29 2021-05-28 南京药捷安康生物科技有限公司 氨基降茨烷衍生物及其制备方法与应用
AU2019395201A1 (en) 2018-12-06 2021-05-20 Daiichi Sankyo Company, Limited Cycloalkane-1,3-diamine derivative
TW202043205A (zh) * 2018-12-31 2020-12-01 美商拜歐米富士恩有限公司 Menin-mll相互作用之抑制劑
CN111297863B (zh) * 2020-03-30 2021-06-25 四川大学华西医院 menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用
AU2021252552A1 (en) * 2020-04-07 2022-10-27 Syndax Pharmaceuticals, Inc. Combinations of menin inhibitors and CYP3A4 inhibitors and methods of use thereof
BR112023021040A2 (pt) 2021-05-08 2024-02-06 Janssen Pharmaceutica Nv Derivados espiro substituídos
CN117321049A (zh) 2021-05-08 2023-12-29 詹森药业有限公司 取代的螺环衍生物
US11919901B2 (en) 2021-05-14 2024-03-05 Syndax Pharmaceuticals, Inc. Inhibitors of the menin-MLL interaction
KR20240016324A (ko) 2021-06-01 2024-02-06 얀센 파마슈티카 엔브이 치환된 페닐-1H-피롤로[2,3-c]피리딘 유도체
CN117425659A (zh) 2021-06-03 2024-01-19 詹森药业有限公司 哒嗪或被螺环胺取代的1,2,4-三嗪
CA3220099A1 (en) 2021-06-17 2022-12-22 Wei Cai (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cance
WO2023220098A1 (en) * 2022-05-09 2023-11-16 Syndax Pharmaceuticals, Inc. Menin-mll inhibitors for the treatment of cancer

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861A (en) 1848-10-17 Locking umbrella and parasol
US510A (en) 1837-12-07 soeel
US949A (en) 1838-09-27 Improvement in roller cotton-gins for ginning long-staple and other kinds of cotton
US5863A (en) 1848-10-17 Matthias p
US1007727A (en) 1908-02-17 1911-11-07 Oscar F Onken Auxiliary table-top.
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
DE4239169A1 (de) 1992-11-21 1994-05-26 Merck Patent Gmbh Cyclobutan - Benzol - Derivate
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
CA2218503C (en) 1995-04-20 2001-07-24 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
ATE225343T1 (de) 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
JP3195756B2 (ja) 1996-07-04 2001-08-06 公子 吉水 潤滑補助体
JP3299975B2 (ja) 1996-07-18 2002-07-08 ファイザー・インク マトリックスメタロプロテアーゼのホスフィン酸塩ベース阻害薬
JP3333870B2 (ja) 1996-07-26 2002-10-15 国土交通省北陸地方整備局長 草刈機
US6153609A (en) 1996-08-23 2000-11-28 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
US5866562A (en) 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
ATE272640T1 (de) 1997-01-06 2004-08-15 Pfizer Cyclische sulfonderivate
IL131042A (en) 1997-02-03 2004-07-25 Pfizer Prod Inc Derivatives of arylsulfonamic acid hydroxyamic acid and medicinal preparations containing them
AU5493598A (en) 1997-02-07 1998-08-26 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
TR199901926T2 (xx) 1997-02-11 1999-12-21 Pfizer Inc. Arils�lfonil hidroksamik asit t�revleri
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
US6479487B1 (en) 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
WO2002088107A1 (en) 2001-04-26 2002-11-07 Eisai Co., Ltd. Nitrogenous fused-ring compound having pyrazolyl group as substituent and medicinal composition thereof
JP2005503345A (ja) 2001-04-30 2005-02-03 バイエル・コーポレーシヨン 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン
US7115741B2 (en) 2001-09-06 2006-10-03 Levy Daniel E 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds
AU2003258662A1 (en) 2002-10-02 2004-04-23 Merck Patent Gmbh Use of 4-amino-quinazolines as anti cancer agents
AU2003255482A1 (en) 2002-10-02 2004-04-23 Merck Patent Gmbh Use of 4 amino-quinazolines as anti cancer agents
US20050222175A1 (en) 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
CN1777612A (zh) 2003-03-31 2006-05-24 普雷迪克医药品控股公司 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
US7612078B2 (en) 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
WO2005020897A2 (en) 2003-08-22 2005-03-10 Dendreon Corporation Compositions and methods for the treatment of disease associated with trp-p8 expression
US20050123906A1 (en) 2003-11-06 2005-06-09 Rana Tariq M. Protein modulation
AU2005269974A1 (en) 2004-07-06 2006-02-09 Angion Biomedica Corporation Quinazoline modulators of hepatocyte growth factor / c-Met activity for the treatment of cancer
CA2610655A1 (en) * 2005-06-03 2006-12-14 Abbott Laboratories Cyclobutyl amine derivatives
US20060281771A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators
US20060281769A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
RU2008112661A (ru) 2005-09-02 2009-10-10 Тиботек Фармасьютикалз Лтд. (Ie) Бензодиазепины в качестве ингибиторов hcv
JP5456315B2 (ja) 2005-09-19 2014-03-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロブタンおよびスピロ［３．３］ヘプタン化合物類
FR2891829A1 (fr) 2005-10-12 2007-04-13 Sanofi Aventis Sa Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique
AU2006330924B2 (en) 2005-12-21 2012-03-15 Abbvie Inc. Anti-viral compounds
US8633201B2 (en) 2006-04-07 2014-01-21 Boehringer Ingelheim International Gmbh Thienopyrimidines having Mnk1/Mnk2 inhibiting activity for pharmaceutical compositions
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
WO2008070303A2 (en) 2006-10-19 2008-06-12 The University Of Chicago Therapeutics to inhibit mll-menin interaction for treating leukemia
EP1947103A1 (en) 2007-01-22 2008-07-23 4Sc Ag Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
WO2008099019A1 (en) 2007-02-16 2008-08-21 Tibotec Pharmaceuticals Ltd. 6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors
FR2913017A1 (fr) 2007-02-23 2008-08-29 Cerep Sa Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
US8309726B2 (en) 2007-03-19 2012-11-13 Council Of Scientific & Industrial Research Substituted piperazine compounds of formula 8
WO2008135232A1 (en) 2007-05-02 2008-11-13 Riccardo Cortese Use and compositions of purine derivatives for the treatment of proliferative disorders
JP2010530736A (ja) 2007-05-25 2010-09-16 バーンハム インスティトゥート フォー メディカル リサーチ タプシガルジンにより誘導される細胞死の阻害剤
WO2009017838A2 (en) 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
WO2009064388A2 (en) 2007-11-09 2009-05-22 Liu Jun O Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
RU2010152290A (ru) 2008-05-22 2012-06-27 Аллерган, Инк. (Us) Бициклические соединения, обладающие активностью при рецепторе сxcr4
DE102008027574A1 (de) * 2008-06-10 2009-12-17 Merck Patent Gmbh Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
EA018721B1 (ru) 2008-08-25 2013-10-30 Айрм Ллк Модуляторы сигнального пути hedgehog
WO2010030757A2 (en) 2008-09-10 2010-03-18 Kalypsys Inc. Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
JP5690823B2 (ja) 2009-07-08 2015-03-25 レオ ファーマ アクティーゼルスカブ Ｊａｋ受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物
US8742100B2 (en) 2009-07-30 2014-06-03 National University Of Singapore Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
AU2010289321A1 (en) 2009-09-04 2012-04-05 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
BR112012019561A2 (pt) 2010-02-22 2019-09-24 Merck Patent Gmbh hetarilamino naftiridinas
RU2563644C2 (ru) 2010-08-20 2015-09-20 Хатчисон Медифарма Лимитед Пирролопиримидиновые соединения и их применения
WO2013019966A1 (en) * 2011-08-04 2013-02-07 Allergan, Inc. Aromatic bycyclic derivatives as cxcr4 receptor modulators
GB201114212D0 (en) 2011-08-18 2011-10-05 Ucb Pharma Sa Therapeutic agents
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
CN103833759A (zh) * 2012-11-23 2014-06-04 华东理工大学 作为blk、flt3抑制剂的蝶啶酮衍生物及其应用
US9771327B2 (en) 2013-03-13 2017-09-26 Flatley Discovery Lab, Llc Compounds and methods for the treatment of cystic fibrosis
JP2016512514A (ja) * 2013-03-13 2016-04-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン チエノピリミジン及びチエノピリジン化合物を含有する組成物並びにそれらの使用方法
US9212180B2 (en) * 2013-06-12 2015-12-15 The Regents Of The University Of Michigan Menin-MLL inhibitors and methods of use thereof
CA2944669A1 (en) * 2014-04-04 2015-10-08 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US20170119769A1 (en) * 2014-06-10 2017-05-04 The Trustees Of The University Of Pennsylvania Scaffolds for inhibitors of menin-mll interactions
WO2016040330A1 (en) * 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
BR112018012707A2 (pt) 2015-12-22 2019-01-29 Vitae Pharmaceuticals Inc inibidores da interação de menin-mll
WO2017132398A1 (en) 2016-01-26 2017-08-03 Memorial Sloan-Kettering Cancer Center Targeting chromatin regulators inhibits leukemogenic gene expression in npm1 mutant leukemia
ES2947636T3 (es) 2016-03-16 2023-08-14 Kura Oncology Inc Derivados de tieno[2,3-d]pirimidina sustituida como inhibidores de menina-MLL y métodos de uso
TWI743096B (zh) 2016-03-16 2021-10-21 美商庫拉腫瘤技術股份有限公司 Menin-mll之橋聯雙環抑制劑及使用方法
KR20190015275A (ko) 2016-05-02 2019-02-13 더 리젠츠 오브 더 유니버시티 오브 미시간 메닌 억제제로서의 피페리딘
WO2017207387A1 (en) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction
IL298381A (en) 2016-06-10 2023-01-01 Vitae Pharmaceuticals Llc Inhibitors of menin–mll interaction
WO2018024602A1 (en) 2016-08-04 2018-02-08 Bayer Aktiengesellschaft 2,7-diazaspiro[4.4]nonanes
WO2018050684A1 (en) 2016-09-14 2018-03-22 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-mll interaction
TWI738864B (zh) 2016-09-14 2021-09-11 比利時商健生藥品公司 Ｍｅｎｉｎ-ｍｌｌ相互作用之螺二環抑制劑
AR109658A1 (es) 2016-09-16 2019-01-09 Vitae Pharmaceuticals Inc Inhibidores de la interacción de menina-mll

Also Published As

Publication number Publication date
PH12018501955A1 (en) 2019-06-17
EP3429585A1 (en) 2019-01-23
EP3429585B1 (en) 2021-11-24
TW201742870A (zh) 2017-12-16
ZA201805845B (en) 2023-03-29
AU2017235462A1 (en) 2018-09-27
IL261625B (en) 2021-08-31
KR20180127406A (ko) 2018-11-28
US20210107917A1 (en) 2021-04-15
KR102419524B1 (ko) 2022-07-08
CA3015845A1 (en) 2017-09-21
HK1258821A1 (zh) 2019-11-22
MX2018011092A (es) 2018-11-22
CN109640987A (zh) 2019-04-16
IL261625A (en) 2018-10-31
SG11201807834WA (en) 2018-10-30
MA43823A (fr) 2018-11-28
JP2019508426A (ja) 2019-03-28
CN109640987B (zh) 2022-12-02
US10752639B2 (en) 2020-08-25
AU2017235462B2 (en) 2021-07-01
TWI743096B (zh) 2021-10-21
EP3429585A4 (en) 2019-10-09
US20190092783A1 (en) 2019-03-28
JP7000333B2 (ja) 2022-02-10
WO2017161002A1 (en) 2017-09-21
US11555041B2 (en) 2023-01-17

Similar Documents

Publication Publication Date Title
BR112018068702A2 (pt) inibidores bicíclicos em ponte de menin-mll e métodos de uso
BR112018068703A2 (pt) inibidores substituídos de menin-mll e métodos de uso
EP4006030A3 (en) Methods and compositions for inhibiting the interaction of menin with mll proteins
MX2021010482A (es) Compuestos y metodos para la degradacion mejorada de proteinas especificas.
BR112015022602A2 (pt) composições compreendendo compostos de tienopirimidina e tienopiridina e métodos de uso dos mesmos
CO2018011668A2 (es) Neoantígenos y métodos de su uso
BR112019007369A2 (pt) anticorpos anti-lag-3 e métodos de uso dos mesmos
WO2018119441A8 (en) Egfr proteolysis targeting chimeric molecules and associated methods of use
MX2021012926A (es) Moduladores de la proteolisis basados en imida y metodos de uso asociados.
BR112016027722A8 (pt) compostos contendo grupo autoimulativo e seu uso
BR112018000768A2 (pt) anticorpos anti-pd-1, anticorpos anti-pd-1 ativáveis e métodos de uso dos mesmos
MX2017012805A (es) Complejo de unión a antígenos con actividad agonista y métodos de uso.
MX2018000360A (es) Moduladores basados en mdm2 de proteolisis y metodos de uso asociados.
MX2017015605A (es) Moduladores de proteolisis basados en imida y metodos de uso asociados.
CL2021001735A1 (es) Inhibidores irreversibles de la interacción menina-mll.
BR112017007170A2 (pt) anticorpos anti-ox40 humanizados e suas utilizações
MX2017003478A (es) Anticuerpos anti-fgfr2/3 y metodos para su uso.
MX2022009478A (es) Compuestos y metodos para degradacion mejorada de proteinas y otros polipeptidos elegidos como blanco mediante una ubiquitina ligasa e3.
TR201909887T4 (tr) ERK inhibitörleri olarak tieno[2,3-c]pirol-4-on türevleri.
BR112016016916A8 (pt) uso de um anticorpo que se liga à calicreína plasmática ativa para tratamento de angiodema hereditário (hae)
BR112019017403A2 (pt) composições e métodos para o tratamento de câncer
MX2018005399A (es) Nuevo polipeptido con afinidad por pd-l1.
BR112019000693A2 (pt) composições de muc1- car e métodos para uso
MX2017000083A (es) Compuestos de platino, composiciones y usos de estos.
BR112018072699A2 (pt) determinados inibidores de proteína cinase

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements