BR112018072699A2 - determinados inibidores de proteína cinase - Google Patents
determinados inibidores de proteína cinaseInfo
- Publication number
- BR112018072699A2 BR112018072699A2 BR112018072699-0A BR112018072699A BR112018072699A2 BR 112018072699 A2 BR112018072699 A2 BR 112018072699A2 BR 112018072699 A BR112018072699 A BR 112018072699A BR 112018072699 A2 BR112018072699 A2 BR 112018072699A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein kinase
- kinase inhibitors
- certain protein
- certain
- inhibitors
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
são fornecidos determinados inibidores de cdk4/6, composições farmacêuticas dos mesmos, e métodos de uso dos mesmos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662333165P | 2016-05-07 | 2016-05-07 | |
| US62/333,165 | 2016-05-07 | ||
| PCT/CN2017/083162 WO2017193872A1 (en) | 2016-05-07 | 2017-05-05 | Certain protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018072699A2 true BR112018072699A2 (pt) | 2019-02-19 |
| BR112018072699B1 BR112018072699B1 (pt) | 2024-05-14 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| KR102374033B1 (ko) | 2022-03-14 |
| EP3452484A4 (en) | 2019-10-09 |
| MX2018013573A (es) | 2019-08-01 |
| EP3452484A1 (en) | 2019-03-13 |
| AU2017262155A1 (en) | 2018-12-06 |
| RU2018143284A3 (pt) | 2020-07-31 |
| AU2017262155B2 (en) | 2021-03-11 |
| JP2019516790A (ja) | 2019-06-20 |
| CA3023460A1 (en) | 2017-11-16 |
| CN109153686A (zh) | 2019-01-04 |
| ES2954148T3 (es) | 2023-11-20 |
| EP3452484B1 (en) | 2023-07-05 |
| ZA201808238B (en) | 2022-10-26 |
| TWI752026B (zh) | 2022-01-11 |
| KR20190025545A (ko) | 2019-03-11 |
| TW201805290A (zh) | 2018-02-16 |
| JP6927548B2 (ja) | 2021-09-01 |
| RU2738837C2 (ru) | 2020-12-17 |
| US10835535B2 (en) | 2020-11-17 |
| US20190209566A1 (en) | 2019-07-11 |
| DK3452484T3 (da) | 2023-09-25 |
| CN109153686B (zh) | 2021-04-30 |
| WO2017193872A1 (en) | 2017-11-16 |
| RU2018143284A (ru) | 2020-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) ; FOCHON PHARMACEUTICALS, LTD. (CN) |
|
| B25A | Requested transfer of rights approved |
Owner name: SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) ; FOCHON PHARMACEUTICALS, LTD. (CN) |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) Free format text: ANULADA A PUBLICACAO CODIGO 25.1 NA RPI NO 2755 DE 24/10/2023 POR TER SIDO INDEVIDA. |
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| B25A | Requested transfer of rights approved |
Owner name: FOCHON PHARMACEUTICALS, LTD. (CN) |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/05/2017, OBSERVADAS AS CONDICOES LEGAIS |