NO313668B1 - Prostaglandin-agonister, anvendelse derav samt farmasöytisk blanding og sett - Google Patents
Prostaglandin-agonister, anvendelse derav samt farmasöytisk blanding og sett Download PDFInfo
- Publication number
- NO313668B1 NO313668B1 NO19992996A NO992996A NO313668B1 NO 313668 B1 NO313668 B1 NO 313668B1 NO 19992996 A NO19992996 A NO 19992996A NO 992996 A NO992996 A NO 992996A NO 313668 B1 NO313668 B1 NO 313668B1
- Authority
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- Norway
- Prior art keywords
- phenyl
- compound according
- acid
- alkylene
- amino
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
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- CBWMWTPDCPHQHS-UHFFFAOYSA-N methyl 2-[3-[[2,1,3-benzoxadiazol-4-ylsulfonyl-[(4-butylphenyl)methyl]amino]methyl]phenyl]acetate Chemical compound C1=CC(CCCC)=CC=C1CN(S(=O)(=O)C=1C2=NON=C2C=CC=1)CC1=CC=CC(CC(=O)OC)=C1 CBWMWTPDCPHQHS-UHFFFAOYSA-N 0.000 description 1
- MHPHSWBZVCWVQE-UHFFFAOYSA-N methyl 2-[4-[2-(methanesulfonamido)ethyl]phenyl]acetate Chemical compound COC(=O)CC1=CC=C(CCNS(C)(=O)=O)C=C1 MHPHSWBZVCWVQE-UHFFFAOYSA-N 0.000 description 1
- YDCHPLOFQATIDS-UHFFFAOYSA-N methyl 2-bromoacetate Chemical compound COC(=O)CBr YDCHPLOFQATIDS-UHFFFAOYSA-N 0.000 description 1
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- HNVIHAZFYCQJJB-UHFFFAOYSA-N methyl 4-[2-(2,2-dimethylpropanoylamino)ethoxy]benzoate Chemical compound COC(=O)C1=CC=C(OCCNC(=O)C(C)(C)C)C=C1 HNVIHAZFYCQJJB-UHFFFAOYSA-N 0.000 description 1
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- CZDMNFXKKRHQOO-UHFFFAOYSA-N methyl 5-(3-aminopropyl)thiophene-2-carboxylate;hydrochloride Chemical compound Cl.COC(=O)C1=CC=C(CCCN)S1 CZDMNFXKKRHQOO-UHFFFAOYSA-N 0.000 description 1
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- SSJGUZWCCXVZHO-UHFFFAOYSA-N methyl 5-[6-(3-chlorophenyl)hexyl]thiophene-2-carboxylate Chemical compound S1C(C(=O)OC)=CC=C1CCCCCCC1=CC=CC(Cl)=C1 SSJGUZWCCXVZHO-UHFFFAOYSA-N 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- UKRDPEFKFJNXQM-UHFFFAOYSA-N vinylsilane Chemical class [SiH3]C=C UKRDPEFKFJNXQM-UHFFFAOYSA-N 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US3345196P | 1996-12-20 | 1996-12-20 | |
PCT/IB1997/001417 WO1998028264A1 (fr) | 1996-12-20 | 1997-11-10 | Prevention de la perte de masse osseuse et reconstitution de celle-ci au moyen de certains agonistes de la prostaglandine |
Publications (3)
Publication Number | Publication Date |
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NO992996D0 NO992996D0 (no) | 1999-06-18 |
NO992996L NO992996L (no) | 1999-08-18 |
NO313668B1 true NO313668B1 (no) | 2002-11-11 |
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NO19992996A NO313668B1 (no) | 1996-12-20 | 1999-06-18 | Prostaglandin-agonister, anvendelse derav samt farmasöytisk blanding og sett |
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1997
- 1997-10-11 UA UA99063443A patent/UA59384C2/uk unknown
- 1997-11-10 IL IL13030697A patent/IL130306A0/xx unknown
- 1997-11-10 BR BR9714155-0A patent/BR9714155A/pt not_active IP Right Cessation
- 1997-11-10 SK SK782-99A patent/SK78299A3/sk unknown
- 1997-11-10 AU AU47200/97A patent/AU721260B2/en not_active Ceased
- 1997-11-10 YU YU32799A patent/YU32799A/sh unknown
- 1997-11-10 US US09/331,081 patent/US6288120B1/en not_active Expired - Fee Related
- 1997-11-10 EA EA199900474A patent/EA003529B1/ru not_active IP Right Cessation
- 1997-11-10 ES ES97909544T patent/ES2267133T3/es not_active Expired - Lifetime
- 1997-11-10 WO PCT/IB1997/001417 patent/WO1998028264A1/fr active IP Right Grant
- 1997-11-10 SI SI9730746T patent/SI0946501T1/sl unknown
- 1997-11-10 PL PL334343A patent/PL192670B1/pl not_active IP Right Cessation
- 1997-11-10 EP EP97909544A patent/EP0946501B1/fr not_active Expired - Lifetime
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- 1997-11-10 NZ NZ335736A patent/NZ335736A/xx unknown
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- 1997-11-10 DK DK97909544T patent/DK0946501T3/da active
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- 1997-12-16 TW TW091124115A patent/TWI242560B/zh not_active IP Right Cessation
- 1997-12-16 PE PE1997001123A patent/PE47499A1/es not_active Application Discontinuation
- 1997-12-16 TW TW086119005A patent/TW541310B/zh not_active IP Right Cessation
- 1997-12-17 DZ DZ970225A patent/DZ2375A1/fr active
- 1997-12-17 MA MA24901A patent/MA24425A1/fr unknown
- 1997-12-17 TN TNTNSN97208A patent/TNSN97208A1/fr unknown
- 1997-12-17 PA PA19978443001A patent/PA8443001A1/es unknown
- 1997-12-18 AP APAP/P/1997/001166A patent/AP1041A/en active
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- 1997-12-19 AR ARP970106085A patent/AR010843A1/es active IP Right Grant
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- 1997-12-19 ZA ZA9711437A patent/ZA9711437B/xx unknown
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- 1997-12-21 SA SA5260204A patent/SA05260204B1/ar unknown
- 1997-12-21 SA SA97180721A patent/SA97180721B1/ar unknown
- 1997-12-29 GT GT199700141A patent/GT199700141A/es unknown
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1999
- 1999-05-21 IS IS5055A patent/IS2389B/is unknown
- 1999-06-03 IL IL130306A patent/IL130306A/en not_active IP Right Cessation
- 1999-06-16 OA OA9900128A patent/OA11065A/en unknown
- 1999-06-18 NO NO19992996A patent/NO313668B1/no not_active IP Right Cessation
- 1999-06-18 KR KR1019997005537A patent/KR100311566B1/ko not_active IP Right Cessation
- 1999-07-19 BG BG103593A patent/BG64893B1/bg unknown
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2001
- 2001-06-29 US US09/897,824 patent/US6492412B2/en not_active Expired - Fee Related
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2002
- 2002-09-26 US US10/256,985 patent/US6649657B2/en not_active Expired - Fee Related
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2003
- 2003-08-29 US US10/652,188 patent/US6998423B2/en not_active Expired - Fee Related
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2004
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