PE47499A1 - Agonistas de prostaglandinas utiles en la prevencion de la perdida y restauracion de la masa osea - Google Patents
Agonistas de prostaglandinas utiles en la prevencion de la perdida y restauracion de la masa oseaInfo
- Publication number
- PE47499A1 PE47499A1 PE1997001123A PE00112397A PE47499A1 PE 47499 A1 PE47499 A1 PE 47499A1 PE 1997001123 A PE1997001123 A PE 1997001123A PE 00112397 A PE00112397 A PE 00112397A PE 47499 A1 PE47499 A1 PE 47499A1
- Authority
- PE
- Peru
- Prior art keywords
- alkylene
- restoration
- prevention
- loss
- agonists
- Prior art date
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES (ALQUILO C1-C6) SULFONILO, ALCANOILO C1-C6, ENTRE OTROS, DE PREFERENCIA ES METILSULFONILO; "B" ES N o C(H); "K" ES ALQUILENO C1-C8, OXI(ALQUILENO C1-C4), ENTRE OTROS; "M" ES Ar, Ar1-O-Ar2, EN DONDE: Ar, Ar1 Y Ar2 SON UN ANILLO SATURADO O NO SATURADO DE 5-8 MIEMBROS CON 1-4 HETEROATOMOS, DE PREFERENCIA "M" ES 3,5-DICLOROFENILO; "Q" ES (ALQUILENO C2-C6)-W-(ALQUILENO C1-C3), X-(ALQUILENO C1-C5), ENTRE OTROS, EN DONDE: "W" ES O, S, ENTRE OTROS, "X" ES UN ANILLO AROMATICO DE 5-6 MIEMBROS OPCIONALMENTE CON 1-2 HETEROATOMOS, DE PREFERENCIA "Q" ES n-HEXILENO; "Z" ES CARBOXILO, ALCOXICARBONILO C1-C6, ENTRE OTROS; A CONDICION DE QUE: CUANDO "K" ES ALQUILENO C2-C4, ENTONCES SI "M" ES CICLOALQUILO C5-C8, NO ESTA SUSTITUIDO EN LA POSICION 1 CON OH; Y DE QUE "A-B(K-M)(Q-Z)" NO ES EL ACIDO 6-[(3-FENIL-PROPIL)-(2-PROPIL-PENTANOIL)AMINO]HEXANOICO Y SU ESTER ETILICO. ESTOS COMPUESTOS ACTUAN COMO AGONISTAS DE PROSTAGLANDINAS, SIENDO UTILES EN EL TRATAMIENTO DE LA OSTEOPOROSIS, EN COMBINACION CON: AGENTES ANTIRESORCION, COMO LOS AGONISTAS/ANTAGONISTAS DE ESTROGENOS O BIFOSFONATOS (RISEDRONATO); o CON UN SEGUNDO AGENTE ANABOLICO OSEO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE1997001123A PE47499A1 (es) | 1996-12-20 | 1997-12-16 | Agonistas de prostaglandinas utiles en la prevencion de la perdida y restauracion de la masa osea |
Country Status (44)
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
ATE390917T1 (de) | 1996-12-20 | 2008-04-15 | Pfizer | Prävention und behandlung von skeletterkrankungen mit ep2 subtyp selektiven prostaglandin e2 agonisten |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
UA67754C2 (uk) * | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
EP1000619A3 (en) * | 1998-06-23 | 2002-07-24 | Pfizer Products Inc. | Method for treating glaucoma |
JP4474773B2 (ja) * | 1998-12-11 | 2010-06-09 | 日産化学工業株式会社 | (p−クロロフェニル)プロパノール誘導体の製造法 |
NZ513825A (en) | 1999-03-05 | 2001-09-28 | Procter & Gamble | C 16 unsaturated FP-selective prostaglandins analogs |
EP1108426A3 (en) * | 1999-12-02 | 2002-10-02 | Pfizer Products Inc. | Use of prostaglandin agonists to treat erectile dysfunction or impotence |
PT1132086E (pt) | 2000-01-31 | 2006-09-29 | Pfizer Prod Inc | Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica |
US6911476B2 (en) * | 2000-03-13 | 2005-06-28 | Eli Lilly And Company | Sulfonamide derivatives |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
EP1149583A3 (en) * | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues |
US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
CA2347330C (en) * | 2001-05-10 | 2002-03-12 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
CA2460947A1 (en) | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
HUP0402135A3 (en) * | 2001-11-30 | 2008-04-28 | Pfizer | Controlled release implant forming polymeric compositions of bone growth promoting compounds and process for their preparation |
PL370914A1 (en) * | 2001-11-30 | 2005-06-13 | Pfizer Products Inc. | Pharmaceutical compositions and methods for administering ep2 receptor selective agonists |
US7163952B2 (en) | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
WO2003050132A1 (en) | 2001-12-05 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials |
WO2003053923A2 (en) | 2001-12-20 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Pyrrolidine derivatives as prostaglandin modulators |
JP4754820B2 (ja) * | 2002-06-10 | 2011-08-24 | メルク セローノ ソシエテ アノニム | プロスタグランジン作動薬としてのγラクタムおよびその使用 |
JP2006021998A (ja) * | 2002-07-18 | 2006-01-26 | Ono Pharmaceut Co Ltd | Ep2アゴニストを有効成分とする月経困難症治療剤 |
US6986884B2 (en) * | 2002-09-04 | 2006-01-17 | Rosenberg E William | Composition and method for treating soft nails |
HUE029417T2 (en) | 2002-10-10 | 2017-02-28 | Ono Pharmaceutical Co | Microspheres containing ONO-1301 |
EP2422814A1 (en) | 2003-07-25 | 2012-02-29 | Ono Pharmaceutical Co., Ltd. | Remedy for cartilage-related diseases |
CN1838968A (zh) | 2003-08-08 | 2006-09-27 | 艾伯吉尼斯公司 | 针对甲状旁腺激素(pth)之抗体和其用途 |
US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
WO2005027931A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
US20050203086A1 (en) * | 2004-03-04 | 2005-09-15 | Pfizer Inc. | Methods of treatment using an EP2 selective receptor agonist |
CA2571482A1 (en) * | 2004-06-21 | 2005-12-29 | Pharmacia & Upjohn Company Llc | Pyk2 inhibitors for stimulation of osteoblast function |
US7906552B2 (en) | 2004-08-10 | 2011-03-15 | Allergan, Inc. | Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US7183310B2 (en) * | 2004-08-10 | 2007-02-27 | Allergan, Inc. | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US7645755B2 (en) | 2004-10-22 | 2010-01-12 | Janssen Pharmaceutical N.V. | Inhibitors of c-fms kinase |
US7662837B2 (en) | 2004-10-22 | 2010-02-16 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
US7858650B2 (en) | 2004-10-22 | 2010-12-28 | Ono Pharmaceutical Co., Ltd. | Medicinal composition for inhalation |
AU2005313380A1 (en) | 2004-12-06 | 2006-06-15 | Merck Serono Sa | Pyrrolidin-2-one derivatives for use as DP1 receptor agonists |
RU2420316C2 (ru) | 2005-06-03 | 2011-06-10 | Оно Фармасьютикал Ко., Лтд. | Агент для регенерации и/или защиты нервов |
US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
US7915316B2 (en) | 2005-08-22 | 2011-03-29 | Allergan, Inc | Sulfonamides |
EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | C-fms 키나제의 저해제로서의 복소환식 화합물 |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
EA200970067A1 (ru) | 2006-07-28 | 2009-08-28 | Пфайзер Продактс Инк. | Агонисты ep2 |
GB0711463D0 (en) * | 2007-06-14 | 2007-07-25 | Opal Drug Discovery Ltd | Trimethylsilylbeneylsulphamates as treatments for diseases of bone loss |
JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
ES2718813T3 (es) | 2008-03-12 | 2019-07-04 | Ube Industries | Compuesto de ácido piridilaminoacético |
DK2415763T3 (en) | 2009-03-30 | 2016-03-07 | Ube Industries | A pharmaceutical composition for the treatment or prevention of glaucoma |
WO2010116270A1 (en) | 2009-04-10 | 2010-10-14 | Pfizer Inc. | Ep2/4 agonists |
AU2010336248A1 (en) | 2009-12-25 | 2012-08-02 | Ube Industries, Ltd. | Aminopyridine compound |
US9090584B2 (en) | 2010-01-26 | 2015-07-28 | Allergan, Inc. | Therapeutic agents for treatment of ocular hypertension |
US8772541B2 (en) * | 2011-12-15 | 2014-07-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Cannabinoid receptor 2 (CB2) inverse agonists and therapeutic potential for multiple myeloma and osteoporosis bone diseases |
JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
EP2882757B1 (en) | 2012-08-07 | 2016-10-05 | Janssen Pharmaceutica, N.V. | Process for the preparation of heterocyclic ester derivatives |
US20150272874A1 (en) | 2012-10-29 | 2015-10-01 | Cardio Incorporated | Pulmonary disease-specific therapeutic agent |
US9676720B2 (en) | 2013-03-28 | 2017-06-13 | Ube Industries, Ltd. | Substituted biaryl compound |
JP6449166B2 (ja) | 2013-10-15 | 2019-01-09 | 小野薬品工業株式会社 | 薬剤溶出性ステントグラフト |
KR102006862B1 (ko) * | 2019-01-07 | 2019-08-02 | 주식회사 하이센스바이오 | 신규한 펩타이드 |
CN114805120A (zh) * | 2022-05-23 | 2022-07-29 | 江苏瑞达环保科技有限公司 | 一种间氰甲基苯甲酸甲酯的合成工艺 |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE51251C (de) | W. LANGENBRUCH in Düren, Rheinl., Kölnstr. 68 b | Sicherheitslampe für Bergwerke | ||
DE512251C (de) | 1930-01-24 | 1930-11-07 | Koch & Sterzel Akt Ges | Verfahren zum Einstellen der Kapazitaet eines auf Induktionswirkung beruhenden elektrischen Apparates, insbesondere Stromwandlers |
FR897566A (fr) * | 1942-08-28 | 1945-03-26 | Bopp & Reuther Gmbh | Machine à rotors |
US3442890A (en) | 1965-06-15 | 1969-05-06 | Mead Johnson & Co | Substituted 3-benzazocin-16-ones |
DE1917006B2 (de) | 1969-04-02 | 1971-09-23 | Siemens AG, 1000 Berlin u. 8000 München | Elektrooptischer regelkreis zum regeln der lichtpunktinten sitaet einer kathodenstrahlroehre |
CH549555A (de) | 1969-04-02 | 1974-06-14 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung von cylierten anilinocarbonsaeuren oder deren salze. |
US3780095A (en) | 1970-04-08 | 1973-12-18 | Byk Gulden Lomberg Chem Fab | Acylated anilino-carboxylic acids and their salts |
US4066692A (en) | 1972-10-30 | 1978-01-03 | Merck & Co., Inc. | 11,12-secoprostaglandins |
US4092356A (en) | 1972-10-30 | 1978-05-30 | Merck & Co., Inc. | 11,12-Secoprostaglandins |
US4055597A (en) | 1973-01-26 | 1977-10-25 | Merck & Co., Inc. | 10-Aza-11,12-secoprostaglandins |
US3987091A (en) | 1973-04-12 | 1976-10-19 | Merck & Co., Inc. | 11,12-secoprostaglandins |
US4091107A (en) | 1973-04-25 | 1978-05-23 | Merck & Co., Inc. | 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins |
US4033996A (en) * | 1973-04-25 | 1977-07-05 | Merck & Co., Inc. | 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins |
US3894065A (en) | 1973-04-27 | 1975-07-08 | Merck & Co Inc | Aryl-oxo-alkanoic acids |
JPS5019756A (es) | 1973-06-25 | 1975-03-01 | ||
US3989749A (en) | 1973-10-17 | 1976-11-02 | Merck & Co., Inc. | 11,12-Secoprostaglandins |
US3991087A (en) | 1973-12-13 | 1976-11-09 | Merck & Co., Inc. | 8-Halo-11,12-secoprostaglandins |
SE7414770L (es) * | 1973-12-13 | 1975-06-16 | Merck & Co Inc | |
DK366475A (da) | 1974-08-30 | 1976-03-01 | Merck & Co Inc | Fremgangsmade til fremstilling af aryloxy- eller arylthioholdige secoprostaglandiner |
US4020177A (en) | 1974-08-30 | 1977-04-26 | Merck & Co., Inc. | Substituted phenoxy-tridecanoic acids |
US4055596A (en) * | 1974-09-13 | 1977-10-25 | Merck & Co., Inc. | 11,12-Seco-prostaglandins |
US3991106A (en) | 1974-09-13 | 1976-11-09 | Merck & Co., Inc. | 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins |
US4210749A (en) | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
GB1479158A (en) | 1974-12-18 | 1977-07-06 | Basford A | Furniture |
US4018802A (en) | 1975-04-09 | 1977-04-19 | Merck & Co., Inc. | 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes |
US4097504A (en) | 1975-04-23 | 1978-06-27 | Merck & Co., Inc. | 11,12-Secoprostaglandins |
US4150235A (en) | 1976-12-17 | 1979-04-17 | Merck & Co., Inc. | Interphenylene 11,12-secoprostaglandins |
US4175203A (en) | 1976-12-17 | 1979-11-20 | Merck & Co., Inc. | Interphenylene 11,12-secoprostaglandins |
US4087435A (en) | 1977-02-17 | 1978-05-02 | Merck & Co., Inc. | 8-Aza-9-dioxothiaprostanoic acids |
US4112236A (en) | 1977-04-04 | 1978-09-05 | Merck & Co., Inc. | Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins |
AT368358B (de) | 1977-12-24 | 1982-10-11 | Fisons Ltd | Schaedlingsbekaempfungs- und pflanzenwachstumsregulierungsmittel |
GB2012170B (en) * | 1977-12-24 | 1982-09-02 | Fisons Ltd | Pesticidal and platn growth regulant compounds and composiions |
US4243678A (en) | 1977-12-30 | 1981-01-06 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Acylhydrocarbylaminoalkanoic acids, compositions and uses |
FI832935A (fi) | 1982-08-20 | 1984-02-21 | Midit | Derivat av w-aminosyror, deras framstaellning samt dessa derivat innehaollande blandningar |
US4803197A (en) | 1987-01-12 | 1989-02-07 | Ciba-Geigy Corporation | 2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives |
DE3719046A1 (de) | 1987-06-06 | 1988-12-15 | Basf Ag | Verwendung von salzen von sulfonamidcarbonsaeuren als korrosionsinhibitoren in waessrigen systemen |
DE3829455A1 (de) | 1988-08-31 | 1990-03-15 | Boehringer Mannheim Gmbh | Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel |
US5084466A (en) | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5081152A (en) | 1989-07-05 | 1992-01-14 | Kotobuki Seiyaku Co., Ltd. | Azulene derivatives as thromboxane a2 and prostaglandin endoperoxide receptor antagonist |
WO1991008737A2 (en) | 1989-12-16 | 1991-06-27 | Fisons Plc | Pharmacologically active amide carboxylate derivatives |
ES2036926B1 (es) | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
US6743929B1 (en) * | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
DE69326321T2 (de) | 1992-10-15 | 2000-01-13 | Kanegafuchi Kagaku Kogyo K.K., Osaka | Neues aminosäurederivat |
US5332730A (en) | 1992-10-16 | 1994-07-26 | Allergan, Inc. | Azido derivatives of cyclopentane heptanoic or heptenoic acid |
SK282166B6 (sk) | 1992-12-11 | 2001-11-06 | Merck & Co., Inc. | Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom |
US5578593A (en) | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
TW383306B (en) | 1992-12-22 | 2000-03-01 | Lilly Co Eli | New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5605814A (en) | 1993-08-31 | 1997-02-25 | Merck Frosst Canada Inc. | DNA encoding human prostaglandin receptor EP2 |
SK56296A3 (en) | 1993-11-09 | 1997-02-05 | Merck & Co Inc | Piperidinal, pyrrolidinal and hexahydro-1h-azepinal derivatives, manufacturing process thereof and pharmaceutical compositions containing them |
WO1995014666A1 (en) | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
JPH07334432A (ja) * | 1994-06-07 | 1995-12-22 | Hitachi Ltd | メモリ制御回路 |
WO1995034311A1 (en) | 1994-06-13 | 1995-12-21 | Merck & Co., Inc. | Piperazine compounds promote release of growth hormone |
WO1996036595A1 (en) | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
EP0871710A4 (en) | 1995-08-08 | 2001-03-07 | Univ Jefferson | RECOMBINANT PROTEINASE C AND PROCESSES, METHODS AND USES |
JP3843145B2 (ja) * | 1995-12-25 | 2006-11-08 | 株式会社ルネサステクノロジ | 同期型半導体記憶装置 |
DE19603033A1 (de) | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
CA2242416C (en) | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
ES2284180T3 (es) * | 1996-01-23 | 2007-11-01 | SHIONOGI & CO., LTD. | Derivados de aminoacidos sulfonados e inhibidores de metaloproteinasas que contienen los mismos. |
US5658897A (en) | 1996-04-08 | 1997-08-19 | Allergan | Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents |
JP2001508404A (ja) * | 1996-10-11 | 2001-06-26 | ワーナー―ランバート・コンパニー | スルホンアミドインターロイキン―1β変換酵素阻害剤 |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
ATE390917T1 (de) | 1996-12-20 | 2008-04-15 | Pfizer | Prävention und behandlung von skeletterkrankungen mit ep2 subtyp selektiven prostaglandin e2 agonisten |
CZ300754B6 (cs) * | 1997-02-21 | 2009-08-05 | Bayer Aktiengesellschaft | Arylsulfonamidy a jejich analogy, zpusob jejich výroby, meziprodukty pro jejich výrobu, farmaceutické prostredky tyto látky obsahující a jejich použití |
TW378330B (en) * | 1997-06-03 | 2000-01-01 | Fujitsu Ltd | Semiconductor memory device |
US5910923A (en) * | 1997-10-23 | 1999-06-08 | Texas Instruments Incorporated | Memory access circuits for test time reduction |
US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
EP1000619A3 (en) * | 1998-06-23 | 2002-07-24 | Pfizer Products Inc. | Method for treating glaucoma |
US6436914B1 (en) * | 1998-06-30 | 2002-08-20 | Bristol-Myers Squibb Company | 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists |
US6069829A (en) * | 1998-09-29 | 2000-05-30 | Texas Instruments Incorporated | Internal clock multiplication for test time reduction |
US6246619B1 (en) * | 2000-02-07 | 2001-06-12 | Vanguard International Semiconductor Corp. | Self-refresh test time reduction scheme |
AU2001262936A1 (en) * | 2000-05-19 | 2001-12-03 | Eli Lilly And Company | Sulfonamide derivatives |
US6822001B2 (en) * | 2000-11-03 | 2004-11-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
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1997
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