NO310239B1 - Substituerte liposakkarider anvendelige ved behandling og forebygging av endotoksemi - Google Patents
Substituerte liposakkarider anvendelige ved behandling og forebygging av endotoksemi Download PDFInfo
- Publication number
- NO310239B1 NO310239B1 NO19975644A NO975644A NO310239B1 NO 310239 B1 NO310239 B1 NO 310239B1 NO 19975644 A NO19975644 A NO 19975644A NO 975644 A NO975644 A NO 975644A NO 310239 B1 NO310239 B1 NO 310239B1
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- Norway
- Prior art keywords
- mixture
- added
- solution
- compound
- methylene chloride
- Prior art date
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- 241000712461 unidentified influenza virus Species 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
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- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/461,675 US5750664A (en) | 1995-06-05 | 1995-06-05 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| PCT/US1996/009578 WO1996039411A1 (en) | 1995-06-05 | 1996-06-05 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975644D0 NO975644D0 (no) | 1997-12-04 |
| NO975644L NO975644L (no) | 1998-02-04 |
| NO310239B1 true NO310239B1 (no) | 2001-06-11 |
Family
ID=23833509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975644A NO310239B1 (no) | 1995-06-05 | 1997-12-04 | Substituerte liposakkarider anvendelige ved behandling og forebygging av endotoksemi |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US5750664A (hu) |
| EP (1) | EP0853627B1 (hu) |
| JP (3) | JP4009318B2 (hu) |
| KR (1) | KR100416335B1 (hu) |
| CN (1) | CN1067082C (hu) |
| AT (1) | ATE258185T1 (hu) |
| AU (1) | AU707779C (hu) |
| CA (1) | CA2223140C (hu) |
| DE (1) | DE69631376T2 (hu) |
| DK (1) | DK0853627T3 (hu) |
| ES (1) | ES2214543T3 (hu) |
| HU (1) | HU221342B1 (hu) |
| IL (2) | IL122251A0 (hu) |
| MX (1) | MX9709502A (hu) |
| NO (1) | NO310239B1 (hu) |
| NZ (1) | NZ312299A (hu) |
| PT (1) | PT853627E (hu) |
| RU (1) | RU2170738C2 (hu) |
| TW (1) | TW366345B (hu) |
| WO (1) | WO1996039411A1 (hu) |
| ZA (1) | ZA964666B (hu) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750664A (en) * | 1995-06-05 | 1998-05-12 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| US6417172B1 (en) * | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
| DE69733651T2 (de) * | 1996-07-03 | 2006-05-18 | Eisai Co., Ltd. | Lipid a-analoge enthaltende injektionen und verfahren zu deren herstellung |
| JP3943334B2 (ja) * | 1998-09-01 | 2007-07-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リピッドａ類縁体含有注射剤の評価方法 |
| US20030130212A1 (en) * | 1999-01-14 | 2003-07-10 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by intravenous infusion |
| DE60045750D1 (de) * | 1999-01-14 | 2011-04-28 | Eisai R&D Man Co Ltd | E5564 zur Verwendung in der Behandlung von Allograft-Abstossung oder Host-versus-Graft-Erkrankungen |
| US20040006242A1 (en) * | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| US7915238B2 (en) * | 1999-02-01 | 2011-03-29 | Eisai R & D Management Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| US6835721B2 (en) | 1999-02-01 | 2004-12-28 | Eisai Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| CN1346361A (zh) | 1999-02-10 | 2002-04-24 | 三共株式会社 | 醚型类酯a1－位羧酸类似物 |
| JP2003524638A (ja) * | 2000-01-14 | 2003-08-19 | エーザイ株式会社 | 手術に伴う内毒素血症及び関連する合併症の予防及び治療 |
| US20050101549A1 (en) * | 2000-01-14 | 2005-05-12 | Melvyn Lynn | Prevention and treatment of endotoxemia and related complications associated with surgery |
| EP2452684B1 (en) * | 2000-02-18 | 2018-01-24 | Eisai R&D Management Co., Ltd. | Micelles |
| US6861512B2 (en) * | 2000-03-01 | 2005-03-01 | Eisai Co., Ltd. | Separation of olefinic isomers |
| US20030105033A1 (en) * | 2000-06-09 | 2003-06-05 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion |
| JP2004503472A (ja) * | 2000-06-09 | 2004-02-05 | エーザイ株式会社 | ボーラスまたは間欠的な静脈内注入による、抗内毒素薬の投与 |
| JPWO2002088072A1 (ja) * | 2001-04-23 | 2004-08-12 | エーザイ株式会社 | アルキレン化合物の製造方法 |
| WO2002088062A1 (fr) * | 2001-04-23 | 2002-11-07 | Eisai Co., Ltd. | Procede de preparation de derives d'alcool |
| WO2002085117A1 (en) * | 2001-04-24 | 2002-10-31 | Eisai Co., Ltd. | Methods and compositions for preventing and treating septic shock and endotoxemia |
| WO2002094019A1 (en) * | 2001-05-22 | 2002-11-28 | Eisai Co., Ltd | Highly purified antiendotoxin compound |
| DE10125179A1 (de) * | 2001-05-23 | 2002-12-05 | Laves Ralph Georg | Verwendung von LPS zur Behandlung intestinaler Entzündungsprozesse |
| US7727974B2 (en) * | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
| WO2003013440A2 (en) * | 2001-08-10 | 2003-02-20 | Eisai Co., Ltd. | Treatment and prevention of heat shock protein-associated diseases and conditions |
| US6913888B2 (en) * | 2001-12-11 | 2005-07-05 | Duke University | Toll-like receptor 4 mutations |
| AU2002950657A0 (en) * | 2002-08-08 | 2002-09-12 | Alchemia Limited | Derivatives of monosaccharides for drug discovery |
| AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| WO2004058788A1 (ja) * | 2002-12-24 | 2004-07-15 | Sankyo Company, Limited | 右糖グルコースリピドa類縁体 |
| RU2389732C2 (ru) * | 2003-01-06 | 2010-05-20 | Корикса Корпорейшн | Некоторые аминоалкилглюкозаминидфосфатные производные и их применение |
| US7906633B2 (en) | 2003-02-20 | 2011-03-15 | Eisai R&D Management Co., Ltd. | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof |
| RU2005130771A (ru) * | 2003-03-05 | 2006-01-27 | Эйсай Ко., Лтд. (JP) | Композиции и способы профилактики и лечения эндотоксин-связанных заболеваний и состояний |
| WO2005027826A2 (en) * | 2003-07-14 | 2005-03-31 | Eisai, Co, Ltd. | Methods and treating severe acute respiratory syndrome |
| WO2005072097A2 (en) | 2003-12-16 | 2005-08-11 | University Of Massachusetts | Toll-like receptor 9 modulators |
| CN1930180B (zh) * | 2004-01-08 | 2010-05-26 | 三共株式会社 | 左侧葡萄糖脂a类似物 |
| US20070292418A1 (en) * | 2005-04-26 | 2007-12-20 | Eisai Co., Ltd. | Compositions and methods for immunotherapy |
| WO2006116423A2 (en) | 2005-04-26 | 2006-11-02 | Eisai Co., Ltd | Compositions and methods for cancer immunotherapy |
| WO2006138681A2 (en) * | 2005-06-17 | 2006-12-28 | University Of Rochester | Methods and compositions for enhancing immune memory by blocking intrahepatic activated t cell deletion |
| JP5118968B2 (ja) * | 2005-08-31 | 2013-01-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リピッドａ類縁体の製造方法 |
| CA2620027A1 (en) * | 2005-08-31 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Process for production of lipid a analogue |
| US7943588B2 (en) | 2006-03-28 | 2011-05-17 | Trustees Of Dartmouth College | Method for preventing or treating neuropathic pain |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| ES2392890T3 (es) * | 2006-11-22 | 2012-12-14 | Eisai R&D Management Co., Ltd. | Sal sódica de un compuesto disacarídico, procedimiento para la producción de la misma y uso de la misma |
| CN101541820B (zh) | 2006-11-22 | 2013-05-08 | 卫材R&D管理有限公司 | 二糖类化合物的钠盐及其制造方法以及其使用 |
| CA2670124C (en) | 2006-11-23 | 2015-04-21 | Cadila Pharmaceuticals Limited | Poly-tlr antagonist |
| WO2011035026A1 (en) * | 2009-09-16 | 2011-03-24 | Heidi Ehrentraut | Methods for treating myocardial disorders |
| WO2011038537A1 (zh) * | 2009-09-29 | 2011-04-07 | 上海南方基因科技有限公司 | 败血症以及败血症休克的预测、预防和治疗方法及试剂盒 |
| GB201013785D0 (en) * | 2010-08-17 | 2010-09-29 | Ucl Business Plc | Treatment |
| JP2012246470A (ja) | 2011-05-31 | 2012-12-13 | Sharp Corp | 半導体ナノ粒子の製造方法、半導体ナノ粒子、ならびにこれを用いた蛍光体 |
| CN104245568B (zh) * | 2011-12-22 | 2017-10-03 | 纳米技术有限公司 | 表面改性的纳米粒子 |
| MX358470B (es) | 2012-03-28 | 2018-08-22 | Univ Maryland | Administracion de eritoran o sales farmaceuticamente aceptables del mismo para tratar infecciones para ortomixovirus. |
| WO2014113048A1 (en) * | 2013-01-18 | 2014-07-24 | Loma Linda University | Compositions and methods for diagnosing and treating sepsis |
| JP6702862B2 (ja) | 2013-07-11 | 2020-06-03 | アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法 |
| US9584991B1 (en) * | 2014-06-19 | 2017-02-28 | Isaac S. Daniel | Method of communicating and accessing social networks using interactive coded messages |
| CN114712383B (zh) * | 2016-03-30 | 2024-09-24 | 阿尤维斯研究有限公司 | 新组合物和治疗方法 |
| SI3795576T1 (sl) * | 2016-09-14 | 2023-08-31 | Genomatica, Inc. | 1,3-maščobne spojine diola in njihovi glikozilirani derivati |
| US11185554B2 (en) * | 2016-09-16 | 2021-11-30 | Eisai R&D Management Co., Ltd | Method of use of eritoran as a TLR4 antagonist for treatment of ebola and Marburg disease |
| AU2019400340A1 (en) * | 2018-12-17 | 2021-05-20 | Eisai R&D Management Co., Ltd. | Formulation comprising liposomes |
| WO2021207218A1 (en) | 2020-04-06 | 2021-10-14 | Eisai R&D Management Co., Ltd. | Treatment of nidovirales infection with eritoran |
| CN113527396B (zh) * | 2020-04-17 | 2024-02-02 | 上海医药工业研究院 | 一种疫苗佐剂mpla的中间体、合成及应用 |
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| US4495346A (en) * | 1981-03-30 | 1985-01-22 | Wisconsin Alumni Research Foundation | Method of preparing a disaccharide |
| US4987237A (en) * | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US5066794A (en) * | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| JPS6153295A (ja) * | 1984-08-24 | 1986-03-17 | Dai Ichi Seiyaku Co Ltd | ジサツカライド誘導体 |
| NL8601551A (nl) * | 1985-06-28 | 1987-01-16 | Sandoz Ag | Nieuwe saccharides, hun bereiding en farmaceutische samenstellingen, die hen bevatten. |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5158939A (en) * | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| JP2839916B2 (ja) * | 1989-10-20 | 1998-12-24 | 三共株式会社 | リピドａ３位エーテル類縁体 |
| DD295854A5 (de) | 1989-12-11 | 1991-11-14 | ��@���������@�������k�� | Lipid-a-austauschstoffe mit immunoaktivierender und antitumorwirkung |
| JP2847319B2 (ja) | 1990-05-18 | 1999-01-20 | イビデン株式会社 | 電子部品搭載用多層ボンディング基板 |
| JP3040847B2 (ja) | 1990-06-22 | 2000-05-15 | 三共株式会社 | リピドｘ類縁体 |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| JP3135990B2 (ja) | 1992-07-31 | 2001-02-19 | 沖電気工業株式会社 | パリティ付加回路 |
| US5413785A (en) * | 1993-01-27 | 1995-05-09 | New England Deaconess Hospital Corp. | Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo |
| US6417172B1 (en) * | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
| US5750664A (en) * | 1995-06-05 | 1998-05-12 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| JP4235193B2 (ja) | 2005-06-07 | 2009-03-11 | 日本電信電話株式会社 | イベント履歴蓄積装置、イベント情報検証装置、イベント履歴蓄積方法、イベント情報検証方法およびイベント情報処理システム |
-
1995
- 1995-06-05 US US08/461,675 patent/US5750664A/en not_active Expired - Lifetime
- 1995-06-05 US US08/461,677 patent/US5681824A/en not_active Expired - Lifetime
-
1996
- 1996-06-05 JP JP50186897A patent/JP4009318B2/ja not_active Expired - Lifetime
- 1996-06-05 EP EP96923234A patent/EP0853627B1/en not_active Expired - Lifetime
- 1996-06-05 HU HU9802662A patent/HU221342B1/hu unknown
- 1996-06-05 IL IL12225196A patent/IL122251A0/xx not_active IP Right Cessation
- 1996-06-05 NZ NZ312299A patent/NZ312299A/xx not_active IP Right Cessation
- 1996-06-05 AT AT96923234T patent/ATE258185T1/de active
- 1996-06-05 US US08/658,656 patent/US5935938A/en not_active Expired - Lifetime
- 1996-06-05 KR KR1019970708583A patent/KR100416335B1/ko not_active IP Right Cessation
- 1996-06-05 ZA ZA964666A patent/ZA964666B/xx unknown
- 1996-06-05 RU RU98100107/04A patent/RU2170738C2/ru active
- 1996-06-05 CA CA002223140A patent/CA2223140C/en not_active Expired - Lifetime
- 1996-06-05 DK DK96923234T patent/DK0853627T3/da active
- 1996-06-05 ES ES96923234T patent/ES2214543T3/es not_active Expired - Lifetime
- 1996-06-05 TW TW085106735A patent/TW366345B/zh not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/009578 patent/WO1996039411A1/en active IP Right Grant
- 1996-06-05 CN CN96195890A patent/CN1067082C/zh not_active Expired - Lifetime
- 1996-06-05 AU AU63802/96A patent/AU707779C/en not_active Expired
- 1996-06-05 PT PT96923234T patent/PT853627E/pt unknown
- 1996-06-05 DE DE69631376T patent/DE69631376T2/de not_active Expired - Lifetime
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1997
- 1997-12-04 NO NO19975644A patent/NO310239B1/no not_active IP Right Cessation
- 1997-12-04 MX MX9709502A patent/MX9709502A/es unknown
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1999
- 1999-04-16 US US09/293,856 patent/US6184366B1/en not_active Expired - Lifetime
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2001
- 2001-01-30 US US09/774,541 patent/US20020028927A1/en not_active Abandoned
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2002
- 2002-05-13 US US10/144,670 patent/US20030144503A1/en not_active Abandoned
- 2002-06-02 IL IL149971A patent/IL149971A/en not_active IP Right Cessation
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2007
- 2007-06-11 JP JP2007154127A patent/JP4712001B2/ja not_active Expired - Lifetime
- 2007-07-30 US US11/830,412 patent/US7737129B2/en not_active Expired - Fee Related
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2010
- 2010-05-17 US US12/781,166 patent/US7994154B2/en not_active Expired - Fee Related
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2011
- 2011-01-31 JP JP2011018401A patent/JP2011121970A/ja active Pending
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| MK1K | Patent expired |