NO300156B1 - Anvendelse av aromatasehemmeren 5-(p-cyanofenyl)-5,6,7,8-tetrahydroimidazo-£1,5-a|pyridin for fremstilling av farmasöytiske preparater for å hindre befruktning hos hunnlige primater - Google Patents
Anvendelse av aromatasehemmeren 5-(p-cyanofenyl)-5,6,7,8-tetrahydroimidazo-£1,5-a|pyridin for fremstilling av farmasöytiske preparater for å hindre befruktning hos hunnlige primater Download PDFInfo
- Publication number
- NO300156B1 NO300156B1 NO921575A NO921575A NO300156B1 NO 300156 B1 NO300156 B1 NO 300156B1 NO 921575 A NO921575 A NO 921575A NO 921575 A NO921575 A NO 921575A NO 300156 B1 NO300156 B1 NO 300156B1
- Authority
- NO
- Norway
- Prior art keywords
- cyanophenyl
- pyridine
- female
- tetrahydroimidazo
- aromatase inhibitor
- Prior art date
Links
- 239000003886 aromatase inhibitor Substances 0.000 title claims description 18
- 241000288906 Primates Species 0.000 title claims description 17
- 229940122815 Aromatase inhibitor Drugs 0.000 title claims description 8
- 230000004720 fertilization Effects 0.000 title claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 4
- -1 p-cyanophenyl Chemical group 0.000 title 1
- CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 claims description 12
- 230000027758 ovulation cycle Effects 0.000 claims description 9
- 230000001850 reproductive effect Effects 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 4
- UKCVAQGKEOJTSR-UHFFFAOYSA-N Fadrozole hydrochloride Chemical compound Cl.C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 UKCVAQGKEOJTSR-UHFFFAOYSA-N 0.000 claims description 2
- LENLQGBLVGGAMF-UHFFFAOYSA-N tributyl([1,2,4]triazolo[1,5-a]pyridin-6-yl)stannane Chemical compound C1=C([Sn](CCCC)(CCCC)CCCC)C=CC2=NC=NN21 LENLQGBLVGGAMF-UHFFFAOYSA-N 0.000 claims 1
- 102000014654 Aromatase Human genes 0.000 description 10
- 108010078554 Aromatase Proteins 0.000 description 10
- 229940046844 aromatase inhibitors Drugs 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 229950011548 fadrozole Drugs 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 7
- 230000016087 ovulation Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000003433 contraceptive agent Substances 0.000 description 5
- 230000002254 contraceptive effect Effects 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000005906 menstruation Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000035935 pregnancy Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 241000282693 Cercopithecidae Species 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 229960005471 androstenedione Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- 229960003387 progesterone Drugs 0.000 description 3
- 239000000583 progesterone congener Substances 0.000 description 3
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241001272567 Hominoidea Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 description 2
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000003756 cervix mucus Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000029849 luteinization Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 241000117261 Melicope radiata Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 206010046782 Uterine enlargement Diseases 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001109 blastomere Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 230000001456 gonadotroph Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 231100000546 inhibition of ovulation Toxicity 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 239000002395 mineralocorticoid Substances 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 229940037129 plain mineralocorticoids for systemic use Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1227/91A CH683151A5 (de) | 1991-04-24 | 1991-04-24 | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO921575D0 NO921575D0 (no) | 1992-04-23 |
| NO921575L NO921575L (no) | 1992-10-26 |
| NO300156B1 true NO300156B1 (no) | 1997-04-21 |
Family
ID=4205470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921575A NO300156B1 (no) | 1991-04-24 | 1992-04-23 | Anvendelse av aromatasehemmeren 5-(p-cyanofenyl)-5,6,7,8-tetrahydroimidazo-£1,5-a|pyridin for fremstilling av farmasöytiske preparater for å hindre befruktning hos hunnlige primater |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5583128A (zh) |
| JP (1) | JP3710830B2 (zh) |
| KR (1) | KR100219017B1 (zh) |
| AT (1) | AT401873B (zh) |
| AU (1) | AU654540B2 (zh) |
| BE (1) | BE1005781A3 (zh) |
| CA (1) | CA2066807C (zh) |
| CH (1) | CH683151A5 (zh) |
| DE (1) | DE4213005B4 (zh) |
| DK (1) | DK176332B1 (zh) |
| FR (1) | FR2675693B1 (zh) |
| GB (1) | GB2256137B (zh) |
| IE (1) | IE64875B1 (zh) |
| IL (1) | IL101688A (zh) |
| IT (1) | IT1257474B (zh) |
| LU (1) | LU88106A1 (zh) |
| MX (1) | MX9201908A (zh) |
| NL (1) | NL9200755A (zh) |
| NO (1) | NO300156B1 (zh) |
| NZ (1) | NZ242443A (zh) |
| PH (1) | PH30495A (zh) |
| PT (1) | PT100409B (zh) |
| SE (1) | SE512618C2 (zh) |
| TW (1) | TW201267B (zh) |
| ZA (1) | ZA922931B (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9510926B (en) | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
| IT1286866B1 (it) * | 1996-10-28 | 1998-07-17 | Menarini Farma Ind | Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi |
| WO1999007381A1 (en) * | 1997-08-11 | 1999-02-18 | Weider Nutrition International, Inc. | Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors |
| US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| US6245814B1 (en) | 1998-05-08 | 2001-06-12 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| US7105552B2 (en) | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6525093B1 (en) * | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US20020002200A1 (en) * | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| JP2005515207A (ja) * | 2001-12-11 | 2005-05-26 | エモリー ユニバーシティ | 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール |
| US8685950B2 (en) * | 2004-10-04 | 2014-04-01 | Wayne State University | Use of aromatase inhibitors for treatment of ectopic pregnancy |
| CA2619503A1 (en) * | 2005-06-28 | 2007-01-04 | Robert F. Casper | Aromatase inhibitors for emergency contraception |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| WO2008019048A1 (en) * | 2006-08-04 | 2008-02-14 | Meditrina Pharmaceuticals | Use of aromatase inhibitors for thining the endometrium or treating menorrhagia |
| US20100292150A1 (en) * | 2007-12-10 | 2010-11-18 | Meditrina Pharmaceuticals, Inc. | Treatment of Menorrhagia with Aromatase Inhibitor |
| GB0914767D0 (en) | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289762A (en) * | 1980-06-27 | 1981-09-15 | Merrell Dow Pharmaceuticals Inc. | 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors |
| US4322416A (en) * | 1980-06-27 | 1982-03-30 | Merrell Dow Pharmaceuticals Inc. | 10-Alkynyl steroids |
| DE3378208D1 (en) * | 1982-12-21 | 1988-11-17 | Ciba Geigy Ag | Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds |
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US4728645A (en) * | 1982-12-21 | 1988-03-01 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors |
| US4889861A (en) * | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
| DK23984A (da) * | 1983-02-11 | 1984-08-12 | Hoffmann La Roche | D-homosteroider |
| DE3422187A1 (de) * | 1984-06-12 | 1985-12-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1,2ss-methylen-4-androsten- und 4,6-androstadien-3,17-dione |
| DE3578608D1 (de) * | 1984-06-20 | 1990-08-16 | Ciba Geigy Ag | Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen. |
| US5002940A (en) * | 1984-11-06 | 1991-03-26 | Ciba-Geigy Corporation | Solid drug formulations and stable suspensions |
| GB8503940D0 (en) * | 1985-02-15 | 1985-03-20 | Erba Farmitalia | 4-substituted androstendione derivatives |
| GB8517360D0 (en) * | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| DE3525560C2 (de) * | 1985-07-15 | 1994-09-08 | Schering Ag | 10-Fluor-1-methyl-1,4-östradien-3,17-dion |
| DE3539244A1 (de) * | 1985-11-01 | 1987-05-07 | Schering Ag | 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| GB8531747D0 (en) * | 1985-12-24 | 1986-02-05 | Erba Farmitalia | 10beta-alkynylestrene derivatives |
| US4978672A (en) * | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
| US5071861A (en) * | 1986-03-07 | 1991-12-10 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US5352795A (en) * | 1986-03-07 | 1994-10-04 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US4937250A (en) * | 1988-03-07 | 1990-06-26 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US5112845A (en) * | 1986-03-07 | 1992-05-12 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| GB2191198B (en) * | 1986-06-02 | 1990-01-24 | Erba Farmitalia | 4-hydroxy derivatives of c-6 or c-7 substituted steroids and process for their preparation |
| GB8614712D0 (en) * | 1986-06-17 | 1986-07-23 | Ici Plc | Heterocyclic compounds |
| GB8615093D0 (en) * | 1986-06-20 | 1986-07-23 | Erba Farmitalia | Methylene derivatives of androst-4-ene-1317-diones |
| GB8615092D0 (en) * | 1986-06-20 | 1986-07-23 | Erba Farmitalia | Androst-4-ene-317-diones |
| GB8617107D0 (en) * | 1986-07-14 | 1986-08-20 | Erba Farmitalia | 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives |
| GB8624251D0 (en) * | 1986-10-09 | 1986-11-12 | Erba Farmitalia | "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives |
| DE3740125A1 (de) * | 1986-12-03 | 1988-06-16 | Sandoz Ag | Azolderivate |
| GB8701080D0 (en) * | 1987-01-19 | 1987-02-18 | Erba Farmitalia | Cycloalkyl-substituted 4-aminophenyl halo derivatives |
| GB8705174D0 (en) * | 1987-03-05 | 1987-04-08 | Ici Plc | Heterocyclic compounds |
| DE3711772A1 (de) * | 1987-04-08 | 1988-10-27 | Schering Ag | 4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung |
| DE3714965A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3714964A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 15-alkyl-19-thio-4-androsten-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| NZ224714A (en) * | 1987-06-01 | 1990-03-27 | Janssen Pharmaceutica Nv | Substituted benzotriazole derivatives and pharmaceutical compositions |
| DE3720234A1 (de) * | 1987-06-12 | 1988-12-22 | Schering Ag | 1,6(alpha)-dimethyl-15(alpha)-alkyl-1,4-androstadien-3,17 -dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| GB8714013D0 (en) * | 1987-06-16 | 1987-07-22 | Ici Plc | (substituted-aralkyl)heterocyclic compounds |
| GB8716651D0 (en) * | 1987-07-15 | 1987-08-19 | Ici Plc | 2-propanol derivatives |
| GB8716650D0 (en) * | 1987-07-15 | 1987-08-19 | Ici Plc | Use of olefinic compounds |
| GB8721384D0 (en) * | 1987-09-11 | 1987-10-21 | Erba Farmitalia | 17-substituted andro-sta-1 4-dien-3-one derivatives |
| GB8726505D0 (en) * | 1987-11-12 | 1987-12-16 | Ici Plc | Naphtho(2 1-b)furan derivatives |
| DE3811574A1 (de) * | 1988-03-31 | 1989-10-19 | Schering Ag | N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| GB8818561D0 (en) * | 1988-08-04 | 1988-09-07 | Ici Plc | Diphenylethane derivatives |
| GB8818791D0 (en) * | 1988-08-08 | 1988-09-07 | Ici Plc | Azole derivatives |
| GB8820730D0 (en) * | 1988-09-02 | 1988-10-05 | Erba Carlo Spa | Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation |
| GB2222401B (en) * | 1988-09-02 | 1991-11-06 | Erba Carlo Spa | 1,5-disubstituted imidazole derivatives and process for their preparation |
| GB2222589B (en) * | 1988-09-09 | 1991-03-06 | Erba Carlo Spa | Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation |
| US5057521A (en) * | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
| DE59010171D1 (de) * | 1989-07-14 | 1996-04-11 | Ciba Geigy Ag | Substituierte Benzonitrile |
| MTP1076B (en) * | 1990-01-12 | 1991-09-30 | Ciba Geigy Ag | Hemihydrate |
| AU7124691A (en) * | 1990-02-27 | 1991-08-29 | Ciba-Geigy Ag | Benzofurans |
| EP0457716A1 (de) * | 1990-04-20 | 1991-11-21 | Ciba-Geigy Ag | Naphthalinderivate |
| TW224461B (zh) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag |
-
1991
- 1991-04-24 CH CH1227/91A patent/CH683151A5/de not_active IP Right Cessation
-
1992
- 1992-04-20 JP JP09968792A patent/JP3710830B2/ja not_active Expired - Fee Related
- 1992-04-21 SE SE9201249A patent/SE512618C2/sv not_active IP Right Cessation
- 1992-04-21 DE DE4213005A patent/DE4213005B4/de not_active Expired - Fee Related
- 1992-04-22 LU LU88106A patent/LU88106A1/de unknown
- 1992-04-22 FR FR9204943A patent/FR2675693B1/fr not_active Expired - Fee Related
- 1992-04-22 PT PT100409A patent/PT100409B/pt not_active IP Right Cessation
- 1992-04-22 GB GB9208718A patent/GB2256137B/en not_active Expired - Fee Related
- 1992-04-22 CA CA002066807A patent/CA2066807C/en not_active Expired - Fee Related
- 1992-04-22 TW TW081103156A patent/TW201267B/zh not_active IP Right Cessation
- 1992-04-22 NZ NZ242443A patent/NZ242443A/en not_active IP Right Cessation
- 1992-04-22 PH PH44246A patent/PH30495A/en unknown
- 1992-04-23 AT AT0083692A patent/AT401873B/de not_active IP Right Cessation
- 1992-04-23 KR KR1019920006846A patent/KR100219017B1/ko not_active IP Right Cessation
- 1992-04-23 IL IL10168892A patent/IL101688A/xx active IP Right Grant
- 1992-04-23 BE BE9200367A patent/BE1005781A3/fr not_active IP Right Cessation
- 1992-04-23 IE IE921318A patent/IE64875B1/en not_active IP Right Cessation
- 1992-04-23 NO NO921575A patent/NO300156B1/no not_active IP Right Cessation
- 1992-04-23 AU AU15092/92A patent/AU654540B2/en not_active Ceased
- 1992-04-23 ZA ZA922931A patent/ZA922931B/xx unknown
- 1992-04-24 IT ITRM920310A patent/IT1257474B/it active IP Right Grant
- 1992-04-24 DK DK199200533A patent/DK176332B1/da not_active IP Right Cessation
- 1992-04-24 MX MX9201908A patent/MX9201908A/es unknown
- 1992-04-24 NL NL9200755A patent/NL9200755A/nl active Search and Examination
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1994
- 1994-09-02 US US08/300,668 patent/US5583128A/en not_active Expired - Lifetime
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