KR920019351A - 생리주기에 영향을 미치지 않는 영장류 암컷의 피임방법 - Google Patents

생리주기에 영향을 미치지 않는 영장류 암컷의 피임방법 Download PDF

Info

Publication number
KR920019351A
KR920019351A KR1019920006846A KR920006846A KR920019351A KR 920019351 A KR920019351 A KR 920019351A KR 1019920006846 A KR1019920006846 A KR 1019920006846A KR 920006846 A KR920006846 A KR 920006846A KR 920019351 A KR920019351 A KR 920019351A
Authority
KR
South Korea
Prior art keywords
aromatase
cyanophenyl
benzonitrile
inhibitor
primate
Prior art date
Application number
KR1019920006846A
Other languages
English (en)
Other versions
KR100219017B1 (ko
Inventor
브하트나자트 아야이
Original Assignee
원본미기재
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 시바-가이기 에이지 filed Critical 원본미기재
Publication of KR920019351A publication Critical patent/KR920019351A/ko
Application granted granted Critical
Publication of KR100219017B1 publication Critical patent/KR100219017B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

내용 없음

Description

생리주기에 영향을 미치지 않는 영장류 암컷의 피임방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 영장류 암컷의 생리주기가 실제적으로 영향받지 않고 유지되는 투여량으로 영장류 암컷에게 아로마타제 억제제를 투여함을 특징으로 하여 생식 연령기의 영장류 암컷에 있어서의 피임방법.
  2. 제1항에 있어서, 영장류가 인간인 방법.
  3. 제1항에 있어서, 시험관내 아로마타제 활성 억제시험의 경우, 아로마타제 억제제의 IC50값이 10-5M이하인 방법.
  4. 제1항에 있어서, 시험관내 아로마타제 활성 억제시험의 경우, 아로마타제 억제제의 IC50값이 10-7M이하인 방법.
  5. 제1항에 있어서, 생체내 아로마타제 억제 시험의 경우, 아로마타제 억제제가 10㎎/㎏이하의 투여량에서 효과적인 방법.
  6. 제1항에 있어서, 생체내 아로마타제 억제 시험의 경우, 아로마타제 억제제가 0.1㎎/㎏이하의 투여량에서 효과적인 방법.
  7. 제1항에 있어서, 아모마타제 억제제로서 명세서중에 정의된 (a) 내지 (z) 및 (aa) 내지 (ae)로 이루어진 그룹중에서 선택된 화합물을 사용하는 방법.
  8. 제1항에 있어서, 5-(p-시아노페닐)-5,6,7,8-테트라하이드로이미다조〔1,5-a〕피리딘, 또는 이의 약제학적으로 허용되는 산 부가염을 아로마타제 억제제로 사용하는 방법.
  9. 제1항에 있어서, (-)-5-(p-시아노페닐)-5,6,7,8-테트라하이드로이미다조〔1,5-a〕피리딘, 또는 이의 약제학적으로 허용되는 산부가염을 아로마타제 억제제로 사용되는 방법.
  10. 제1항에 있어서, 아로마타제 억제제를 -4-〔α-(4-시아노페닐)-5-이소티아졸릴메틸〕-벤조니트릴, -4-〔α-(4-시아노페닐)-α-플루오로-1-(1,2,4-트리아졸릴)메틸〕-벤조니트릴, -4-〔α-(4-시아노페닐)-1-(1,2,4-트리아졸릴)메틸〕-벤조니트릴, -4-〔α-(4-시아노페닐)-(1-테트라졸릴)메틸〕-벤조니트릴〕,-4-〔α-(4-시아노페닐)-1-(1,2,3-트리아졸릴)메틸〕-벤조니트릴, -4-〔α-(4-시아노페닐)-1-이미다졸릴메틸〕-벤조니트릴, 및 이의 약제학적으로 허용되는 산 부가염으로 이루어진 그룹중에서 선택된 화합물을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920006846A 1991-04-24 1992-04-23 생리주기에 영향을 미치지 않는 피임용 조성물 KR100219017B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1227/91-3 1991-04-24
CH01227/91-3 1991-04-24
CH1227/91A CH683151A5 (de) 1991-04-24 1991-04-24 Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.

Publications (2)

Publication Number Publication Date
KR920019351A true KR920019351A (ko) 1992-11-19
KR100219017B1 KR100219017B1 (ko) 1999-09-01

Family

ID=4205470

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920006846A KR100219017B1 (ko) 1991-04-24 1992-04-23 생리주기에 영향을 미치지 않는 피임용 조성물

Country Status (25)

Country Link
US (1) US5583128A (ko)
JP (1) JP3710830B2 (ko)
KR (1) KR100219017B1 (ko)
AT (1) AT401873B (ko)
AU (1) AU654540B2 (ko)
BE (1) BE1005781A3 (ko)
CA (1) CA2066807C (ko)
CH (1) CH683151A5 (ko)
DE (1) DE4213005B4 (ko)
DK (1) DK176332B1 (ko)
FR (1) FR2675693B1 (ko)
GB (1) GB2256137B (ko)
IE (1) IE64875B1 (ko)
IL (1) IL101688A (ko)
IT (1) IT1257474B (ko)
LU (1) LU88106A1 (ko)
MX (1) MX9201908A (ko)
NL (1) NL9200755A (ko)
NO (1) NO300156B1 (ko)
NZ (1) NZ242443A (ko)
PH (1) PH30495A (ko)
PT (1) PT100409B (ko)
SE (1) SE512618C2 (ko)
TW (1) TW201267B (ko)
ZA (1) ZA922931B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
WO1999007381A1 (en) * 1997-08-11 1999-02-18 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
US8685950B2 (en) * 2004-10-04 2014-04-01 Wayne State University Use of aromatase inhibitors for treatment of ectopic pregnancy
CA2619503A1 (en) * 2005-06-28 2007-01-04 Robert F. Casper Aromatase inhibitors for emergency contraception
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
WO2008019048A1 (en) * 2006-08-04 2008-02-14 Meditrina Pharmaceuticals Use of aromatase inhibitors for thining the endometrium or treating menorrhagia
US20100292150A1 (en) * 2007-12-10 2010-11-18 Meditrina Pharmaceuticals, Inc. Treatment of Menorrhagia with Aromatase Inhibitor
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
DE3378208D1 (en) * 1982-12-21 1988-11-17 Ciba Geigy Ag Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
DK23984A (da) * 1983-02-11 1984-08-12 Hoffmann La Roche D-homosteroider
DE3422187A1 (de) * 1984-06-12 1985-12-12 Schering AG, 1000 Berlin und 4709 Bergkamen 1,2ss-methylen-4-androsten- und 4,6-androstadien-3,17-dione
DE3578608D1 (de) * 1984-06-20 1990-08-16 Ciba Geigy Ag Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen.
US5002940A (en) * 1984-11-06 1991-03-26 Ciba-Geigy Corporation Solid drug formulations and stable suspensions
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
DE3525560C2 (de) * 1985-07-15 1994-09-08 Schering Ag 10-Fluor-1-methyl-1,4-östradien-3,17-dion
DE3539244A1 (de) * 1985-11-01 1987-05-07 Schering Ag 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US5071861A (en) * 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB2191198B (en) * 1986-06-02 1990-01-24 Erba Farmitalia 4-hydroxy derivatives of c-6 or c-7 substituted steroids and process for their preparation
GB8614712D0 (en) * 1986-06-17 1986-07-23 Ici Plc Heterocyclic compounds
GB8615093D0 (en) * 1986-06-20 1986-07-23 Erba Farmitalia Methylene derivatives of androst-4-ene-1317-diones
GB8615092D0 (en) * 1986-06-20 1986-07-23 Erba Farmitalia Androst-4-ene-317-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3740125A1 (de) * 1986-12-03 1988-06-16 Sandoz Ag Azolderivate
GB8701080D0 (en) * 1987-01-19 1987-02-18 Erba Farmitalia Cycloalkyl-substituted 4-aminophenyl halo derivatives
GB8705174D0 (en) * 1987-03-05 1987-04-08 Ici Plc Heterocyclic compounds
DE3711772A1 (de) * 1987-04-08 1988-10-27 Schering Ag 4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714964A1 (de) * 1987-04-30 1988-11-10 Schering Ag 15-alkyl-19-thio-4-androsten-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
DE3720234A1 (de) * 1987-06-12 1988-12-22 Schering Ag 1,6(alpha)-dimethyl-15(alpha)-alkyl-1,4-androstadien-3,17 -dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
GB8716651D0 (en) * 1987-07-15 1987-08-19 Ici Plc 2-propanol derivatives
GB8716650D0 (en) * 1987-07-15 1987-08-19 Ici Plc Use of olefinic compounds
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8726505D0 (en) * 1987-11-12 1987-12-16 Ici Plc Naphtho(2 1-b)furan derivatives
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
GB8818791D0 (en) * 1988-08-08 1988-09-07 Ici Plc Azole derivatives
GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
GB2222401B (en) * 1988-09-02 1991-11-06 Erba Carlo Spa 1,5-disubstituted imidazole derivatives and process for their preparation
GB2222589B (en) * 1988-09-09 1991-03-06 Erba Carlo Spa Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation
US5057521A (en) * 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate
AU7124691A (en) * 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (ko) * 1990-09-18 1994-06-01 Ciba Geigy Ag

Also Published As

Publication number Publication date
GB2256137B (en) 1995-01-11
PT100409B (pt) 1999-10-29
AU1509292A (en) 1992-10-29
JPH05112467A (ja) 1993-05-07
ITRM920310A1 (it) 1993-10-24
CH683151A5 (de) 1994-01-31
US5583128A (en) 1996-12-10
IL101688A (en) 1997-01-10
AU654540B2 (en) 1994-11-10
DK53392D0 (da) 1992-04-24
PT100409A (pt) 1993-08-31
ZA922931B (en) 1993-04-28
IT1257474B (it) 1996-01-25
SE9201249D0 (sv) 1992-04-21
NO921575D0 (no) 1992-04-23
DK176332B1 (da) 2007-08-20
NO300156B1 (no) 1997-04-21
IE64875B1 (en) 1995-09-20
DK53392A (da) 1992-10-25
SE9201249L (sv) 1992-10-25
SE512618C2 (sv) 2000-04-10
NL9200755A (nl) 1992-11-16
CA2066807A1 (en) 1992-10-25
DE4213005A1 (de) 1992-10-29
JP3710830B2 (ja) 2005-10-26
PH30495A (en) 1997-05-28
CA2066807C (en) 2003-09-23
IE921318A1 (en) 1992-11-04
IL101688A0 (en) 1992-12-30
BE1005781A3 (fr) 1994-01-25
FR2675693B1 (fr) 1995-06-30
AT401873B (de) 1996-12-27
DE4213005B4 (de) 2005-12-08
GB2256137A (en) 1992-12-02
KR100219017B1 (ko) 1999-09-01
NZ242443A (en) 1996-10-28
TW201267B (ko) 1993-03-01
MX9201908A (es) 1992-11-01
ATA83692A (de) 1996-05-15
LU88106A1 (de) 1993-12-06
NO921575L (no) 1992-10-26
GB9208718D0 (en) 1992-06-10
FR2675693A1 (fr) 1992-10-30
ITRM920310A0 (it) 1992-04-24

Similar Documents

Publication Publication Date Title
KR920019351A (ko) 생리주기에 영향을 미치지 않는 영장류 암컷의 피임방법
US4571400A (en) Dihydrocodeine/ibuprofen pharmaceutical compositions and method
Lester et al. Effect of pyrazoles and other compounds on alcohol metabolism
US5071655A (en) Pharmaceutical combination for treatment of bone-wasting diseases
US5312818A (en) Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromboxane A2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation
RU95122558A (ru) Производные гуанидина
JPH10500700A (ja) メトロニダゾールもしくはメトロニダゾールとクリンダマイシンとの相乗混合物を主成分とする薬剤
EP0371559A3 (en) Use of benzimidazoles in the treatment of epithelial disorders
US4263313A (en) Topical pharmaceutical formulations, carrier compositions therefor, and preparation thereof
AU740875B2 (en) Novel use of compounds for anti-pruritic activity
MD523G2 (ro) Derivaţi noi ai triazolpirimidinei, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
KR880007073A (ko) 의 약 품
US4661493A (en) Tioconazole and related compounds for control of Herpes simplex virus
HUT61540A (en) Process for producing new pharmaceutical compositions comprising diphenylimidazole derivatives and their active ingredients
CA2223435A1 (en) Use of benzimidazoles for the manufacture of a medicament for the treatment of leukemia
EP0561977B1 (en) Use of angiotensin ii receptor antagonists in the treatment of hemorragic stroke
Bechtel Pharmacokinetics and metabolism of brotizolam in humans.
IL92799A0 (en) Benzimidazole derivatives with gastric acid inhibition and process for its preparation
EP0660713B1 (en) Use of angiotensin ii antagonists in the treatment of left ventricular hypertrophy
Botter Further experiences with miconazole nitrate, a broad‐spectrum antimycotic with antibacterial activity
US3060090A (en) Pyrazolidine-quinazolone therapeutic composition
JPS5921615A (ja) 鎮痛剤組成物
JPH01199914A (ja) 妊娠毒血症の予防または治療用組成物
US5981538A (en) Methods of treating psoriasis employing substituted azaspiranes
IT1249686B (it) Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20090609

Year of fee payment: 11

LAPS Lapse due to unpaid annual fee