DK176332B1 - Anvendelse af aromatasehæmmeren 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridin eller dens optiske antipoder eller et farmaceutisk acceptabelt salt af disse forbindelser til fremstilling af farmaceutiske præparater... - Google Patents

Anvendelse af aromatasehæmmeren 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridin eller dens optiske antipoder eller et farmaceutisk acceptabelt salt af disse forbindelser til fremstilling af farmaceutiske præparater... Download PDF

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Publication number
DK176332B1
DK176332B1 DK199200533A DK53392A DK176332B1 DK 176332 B1 DK176332 B1 DK 176332B1 DK 199200533 A DK199200533 A DK 199200533A DK 53392 A DK53392 A DK 53392A DK 176332 B1 DK176332 B1 DK 176332B1
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DK
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Prior art keywords
cyanophenyl
pyridine
tetrahydroimidazo
acid
compounds
Prior art date
Application number
DK199200533A
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Danish (da)
English (en)
Other versions
DK53392D0 (da
DK53392A (da
Inventor
Ajay Bhatnagar
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of DK53392D0 publication Critical patent/DK53392D0/da
Publication of DK53392A publication Critical patent/DK53392A/da
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Publication of DK176332B1 publication Critical patent/DK176332B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK199200533A 1991-04-24 1992-04-24 Anvendelse af aromatasehæmmeren 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridin eller dens optiske antipoder eller et farmaceutisk acceptabelt salt af disse forbindelser til fremstilling af farmaceutiske præparater... DK176332B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH122791 1991-04-24
CH1227/91A CH683151A5 (de) 1991-04-24 1991-04-24 Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.

Publications (3)

Publication Number Publication Date
DK53392D0 DK53392D0 (da) 1992-04-24
DK53392A DK53392A (da) 1992-10-25
DK176332B1 true DK176332B1 (da) 2007-08-20

Family

ID=4205470

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199200533A DK176332B1 (da) 1991-04-24 1992-04-24 Anvendelse af aromatasehæmmeren 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridin eller dens optiske antipoder eller et farmaceutisk acceptabelt salt af disse forbindelser til fremstilling af farmaceutiske præparater...

Country Status (25)

Country Link
US (1) US5583128A (zh)
JP (1) JP3710830B2 (zh)
KR (1) KR100219017B1 (zh)
AT (1) AT401873B (zh)
AU (1) AU654540B2 (zh)
BE (1) BE1005781A3 (zh)
CA (1) CA2066807C (zh)
CH (1) CH683151A5 (zh)
DE (1) DE4213005B4 (zh)
DK (1) DK176332B1 (zh)
FR (1) FR2675693B1 (zh)
GB (1) GB2256137B (zh)
IE (1) IE64875B1 (zh)
IL (1) IL101688A (zh)
IT (1) IT1257474B (zh)
LU (1) LU88106A1 (zh)
MX (1) MX9201908A (zh)
NL (1) NL9200755A (zh)
NO (1) NO300156B1 (zh)
NZ (1) NZ242443A (zh)
PH (1) PH30495A (zh)
PT (1) PT100409B (zh)
SE (1) SE512618C2 (zh)
TW (1) TW201267B (zh)
ZA (1) ZA922931B (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
WO1999007381A1 (en) * 1997-08-11 1999-02-18 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6485972B1 (en) 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
US8685950B2 (en) * 2004-10-04 2014-04-01 Wayne State University Use of aromatase inhibitors for treatment of ectopic pregnancy
CA2619503A1 (en) * 2005-06-28 2007-01-04 Robert F. Casper Aromatase inhibitors for emergency contraception
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
WO2008019048A1 (en) * 2006-08-04 2008-02-14 Meditrina Pharmaceuticals Use of aromatase inhibitors for thining the endometrium or treating menorrhagia
US20100292150A1 (en) * 2007-12-10 2010-11-18 Meditrina Pharmaceuticals, Inc. Treatment of Menorrhagia with Aromatase Inhibitor
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
DE3378208D1 (en) * 1982-12-21 1988-11-17 Ciba Geigy Ag Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
DK23984A (da) * 1983-02-11 1984-08-12 Hoffmann La Roche D-homosteroider
DE3422187A1 (de) * 1984-06-12 1985-12-12 Schering AG, 1000 Berlin und 4709 Bergkamen 1,2ss-methylen-4-androsten- und 4,6-androstadien-3,17-dione
DE3578608D1 (de) * 1984-06-20 1990-08-16 Ciba Geigy Ag Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen.
US5002940A (en) * 1984-11-06 1991-03-26 Ciba-Geigy Corporation Solid drug formulations and stable suspensions
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
DE3525560C2 (de) * 1985-07-15 1994-09-08 Schering Ag 10-Fluor-1-methyl-1,4-östradien-3,17-dion
DE3539244A1 (de) * 1985-11-01 1987-05-07 Schering Ag 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US5071861A (en) * 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB2191198B (en) * 1986-06-02 1990-01-24 Erba Farmitalia 4-hydroxy derivatives of c-6 or c-7 substituted steroids and process for their preparation
GB8614712D0 (en) * 1986-06-17 1986-07-23 Ici Plc Heterocyclic compounds
GB8615093D0 (en) * 1986-06-20 1986-07-23 Erba Farmitalia Methylene derivatives of androst-4-ene-1317-diones
GB8615092D0 (en) * 1986-06-20 1986-07-23 Erba Farmitalia Androst-4-ene-317-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3740125A1 (de) * 1986-12-03 1988-06-16 Sandoz Ag Azolderivate
GB8701080D0 (en) * 1987-01-19 1987-02-18 Erba Farmitalia Cycloalkyl-substituted 4-aminophenyl halo derivatives
GB8705174D0 (en) * 1987-03-05 1987-04-08 Ici Plc Heterocyclic compounds
DE3711772A1 (de) * 1987-04-08 1988-10-27 Schering Ag 4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714964A1 (de) * 1987-04-30 1988-11-10 Schering Ag 15-alkyl-19-thio-4-androsten-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
DE3720234A1 (de) * 1987-06-12 1988-12-22 Schering Ag 1,6(alpha)-dimethyl-15(alpha)-alkyl-1,4-androstadien-3,17 -dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
GB8716651D0 (en) * 1987-07-15 1987-08-19 Ici Plc 2-propanol derivatives
GB8716650D0 (en) * 1987-07-15 1987-08-19 Ici Plc Use of olefinic compounds
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8726505D0 (en) * 1987-11-12 1987-12-16 Ici Plc Naphtho(2 1-b)furan derivatives
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
GB8818791D0 (en) * 1988-08-08 1988-09-07 Ici Plc Azole derivatives
GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
GB2222401B (en) * 1988-09-02 1991-11-06 Erba Carlo Spa 1,5-disubstituted imidazole derivatives and process for their preparation
GB2222589B (en) * 1988-09-09 1991-03-06 Erba Carlo Spa Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation
US5057521A (en) * 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate
AU7124691A (en) * 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (zh) * 1990-09-18 1994-06-01 Ciba Geigy Ag

Also Published As

Publication number Publication date
GB2256137B (en) 1995-01-11
PT100409B (pt) 1999-10-29
AU1509292A (en) 1992-10-29
JPH05112467A (ja) 1993-05-07
ITRM920310A1 (it) 1993-10-24
CH683151A5 (de) 1994-01-31
US5583128A (en) 1996-12-10
IL101688A (en) 1997-01-10
AU654540B2 (en) 1994-11-10
DK53392D0 (da) 1992-04-24
PT100409A (pt) 1993-08-31
ZA922931B (en) 1993-04-28
IT1257474B (it) 1996-01-25
SE9201249D0 (sv) 1992-04-21
NO921575D0 (no) 1992-04-23
NO300156B1 (no) 1997-04-21
IE64875B1 (en) 1995-09-20
DK53392A (da) 1992-10-25
SE9201249L (sv) 1992-10-25
SE512618C2 (sv) 2000-04-10
NL9200755A (nl) 1992-11-16
CA2066807A1 (en) 1992-10-25
DE4213005A1 (de) 1992-10-29
JP3710830B2 (ja) 2005-10-26
PH30495A (en) 1997-05-28
CA2066807C (en) 2003-09-23
IE921318A1 (en) 1992-11-04
KR920019351A (ko) 1992-11-19
IL101688A0 (en) 1992-12-30
BE1005781A3 (fr) 1994-01-25
FR2675693B1 (fr) 1995-06-30
AT401873B (de) 1996-12-27
DE4213005B4 (de) 2005-12-08
GB2256137A (en) 1992-12-02
KR100219017B1 (ko) 1999-09-01
NZ242443A (en) 1996-10-28
TW201267B (zh) 1993-03-01
MX9201908A (es) 1992-11-01
ATA83692A (de) 1996-05-15
LU88106A1 (de) 1993-12-06
NO921575L (no) 1992-10-26
GB9208718D0 (en) 1992-06-10
FR2675693A1 (fr) 1992-10-30
ITRM920310A0 (it) 1992-04-24

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