NO20026239L - Antistoffer med dobbel spesifisitet og fremgangsmåter for fremstilling og bruk - Google Patents
Antistoffer med dobbel spesifisitet og fremgangsmåter for fremstilling og brukInfo
- Publication number
- NO20026239L NO20026239L NO20026239A NO20026239A NO20026239L NO 20026239 L NO20026239 L NO 20026239L NO 20026239 A NO20026239 A NO 20026239A NO 20026239 A NO20026239 A NO 20026239A NO 20026239 L NO20026239 L NO 20026239L
- Authority
- NO
- Norway
- Prior art keywords
- antibodies
- methods
- alpha
- beta
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21537900P | 2000-06-29 | 2000-06-29 | |
PCT/US2001/020755 WO2002002773A2 (en) | 2000-06-29 | 2001-06-28 | Dual specificity antibodies and methods of making and using |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20026239D0 NO20026239D0 (no) | 2002-12-27 |
NO20026239L true NO20026239L (no) | 2003-02-27 |
Family
ID=22802758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20026239A NO20026239L (no) | 2000-06-29 | 2002-12-27 | Antistoffer med dobbel spesifisitet og fremgangsmåter for fremstilling og bruk |
Country Status (27)
Country | Link |
---|---|
US (5) | US7491516B2 (hu) |
EP (4) | EP2042518A3 (hu) |
JP (2) | JP4955185B2 (hu) |
KR (2) | KR20080074231A (hu) |
CN (3) | CN102120773B (hu) |
AT (1) | ATE420958T1 (hu) |
AU (1) | AU2001271636A1 (hu) |
BG (1) | BG66209B1 (hu) |
BR (1) | BR0112026A (hu) |
CA (1) | CA2411374C (hu) |
CZ (1) | CZ2003291A3 (hu) |
DE (1) | DE60137421D1 (hu) |
EC (1) | ECSP024409A (hu) |
ES (1) | ES2319866T3 (hu) |
HK (1) | HK1055316A1 (hu) |
HU (1) | HUP0301002A3 (hu) |
IL (3) | IL153567A0 (hu) |
MX (1) | MXPA02012867A (hu) |
NO (1) | NO20026239L (hu) |
NZ (1) | NZ523080A (hu) |
PE (1) | PE20020132A1 (hu) |
PL (1) | PL208069B1 (hu) |
SK (1) | SK1152003A3 (hu) |
TW (2) | TW200516083A (hu) |
UY (1) | UY26807A1 (hu) |
WO (1) | WO2002002773A2 (hu) |
ZA (1) | ZA200210109B (hu) |
Families Citing this family (172)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002510974A (ja) * | 1997-06-27 | 2002-04-09 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | ヒトnk−3関連前立腺特異的遺伝子−1 |
KR20080074231A (ko) | 2000-06-29 | 2008-08-12 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 및 사용 방법 |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
GB0115841D0 (en) | 2001-06-28 | 2001-08-22 | Medical Res Council | Ligand |
EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
ES2442615T5 (es) | 2002-07-18 | 2023-03-16 | Merus Nv | Producción recombinante de mezclas de anticuerpos |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
GB0230201D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
US20110223168A1 (en) * | 2002-12-27 | 2011-09-15 | Greg Winter | Ligand that has binding specificity for il-4 and/or il-13 |
EP1639009B1 (en) | 2003-05-30 | 2013-02-27 | Merus B.V. | Fab library for the preparation of a mixture of antibodies |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
CA2553692C (en) * | 2004-01-20 | 2014-10-07 | Kalobios, Inc. | Antibody specificity transfer using minimal essential binding determinants |
DK1737971T3 (da) | 2004-01-20 | 2017-11-13 | Merus Nv | Blandinger af bindingsproteiner |
TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
US7514539B2 (en) | 2004-04-26 | 2009-04-07 | Centocor, Inc. | Epitope directed selection of antibodies to murine tissue factor |
JP5017097B2 (ja) * | 2004-04-26 | 2012-09-05 | セントカー・インコーポレーテツド | 設計デコイタンパク質を用いる溶液相バイオパニング方法 |
US7790405B2 (en) | 2004-04-26 | 2010-09-07 | Centocor, Inc. | Solution phase biopanning method using engineered decoy proteins |
KR20120133403A (ko) | 2004-06-01 | 2012-12-10 | 도만티스 리미티드 | 증강된 혈청 반감기를 가지는 이특이성 융합 항체 |
AU2006208286A1 (en) | 2005-01-26 | 2006-08-03 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
KR100675791B1 (ko) * | 2005-02-04 | 2007-02-02 | 제주대학교 산학협력단 | 육상어류양식장용 자동먹이공급시스템 |
AU2006245734C1 (en) * | 2005-05-12 | 2012-05-24 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
EP1893645A1 (en) * | 2005-06-23 | 2008-03-05 | Crucell Holland B.V. | Optimization of west nile virus antibodies |
SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500353A3 (en) | 2005-08-19 | 2012-10-10 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
AU2006283532B2 (en) | 2005-08-19 | 2012-04-26 | Abbvie Inc. | Dual variable domain immunoglobin and uses thereof |
WO2007039256A2 (de) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
EP1940880A2 (en) * | 2005-10-14 | 2008-07-09 | Novo Nordisk A/S | Treating diabetes using inhibitors of il-1 |
WO2007120828A1 (en) * | 2006-04-14 | 2007-10-25 | Novartis Ag | Use of il-i antibodies for treating ophthalmic disorders |
CA2654712C (en) | 2006-06-06 | 2015-05-05 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
MX363905B (es) | 2006-06-12 | 2019-04-08 | Aptevo Res & Development Llc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
AU2007281479A1 (en) * | 2006-08-02 | 2008-02-07 | California Institute Of Technology | Methods and systems for detecting and/or sorting targets |
US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
EP3124045A3 (en) | 2006-12-20 | 2017-05-03 | Xoma (Us) Llc | Treatment of il-1 beta related diseases |
EP2114443A4 (en) * | 2006-12-29 | 2011-08-10 | Abbott Lab | IL-1A / IL-1B ANTIBODY WITH DOUBLE SPECIFICITY |
EP2165194A4 (en) | 2007-05-31 | 2010-09-08 | Abbott Lab | BIOMARKERS FOR PREDICTING RESPONSABILITY TO TNF ALPHA INHIBITORS IN AUTOIMMUNE DISEASES |
EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
AU2008338421A1 (en) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
WO2009111450A2 (en) | 2008-03-03 | 2009-09-11 | Dyax Corp. | Metalloproteinase 9 binding proteins |
US8013125B2 (en) * | 2008-03-03 | 2011-09-06 | Dyax Corp. | Metalloproteinase 9 and metalloproteinase 2 binding proteins |
EP2132228B1 (en) | 2008-04-11 | 2011-06-22 | Emergent Product Development Seattle, LLC | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
CA2722466A1 (en) * | 2008-04-29 | 2009-11-05 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
CA2725666A1 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
AU2009256250B2 (en) | 2008-06-03 | 2013-05-30 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
NZ590074A (en) * | 2008-07-08 | 2012-12-21 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
JP5796831B2 (ja) | 2008-09-03 | 2015-10-21 | ジェネンテック, インコーポレイテッド | 多重特異性抗体 |
EP2341935A4 (en) * | 2008-09-05 | 2012-07-25 | Xoma Technology Ltd | METHODS FOR IMPROVING BETA CELL FUNCTION |
JP5976319B2 (ja) * | 2008-09-12 | 2016-08-23 | エックスバイオテク,インコーポレイテッドXbiotech,Inc. | 病原性単球の標的化 |
DK2334705T3 (en) | 2008-09-26 | 2017-03-27 | Ucb Biopharma Sprl | BIOLOGICAL PRODUCTS |
EP2196476A1 (en) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
TW201031421A (en) * | 2009-01-29 | 2010-09-01 | Abbott Lab | IL-1 binding proteins |
NZ594514A (en) | 2009-03-05 | 2013-06-28 | Abbott Lab | Interleukin-17 BINDING PROTEINS |
JP5501439B2 (ja) * | 2009-04-02 | 2014-05-21 | ロシュ グリクアート アクチェンゲゼルシャフト | 完全長抗体と単鎖Fabフラグメントとを含む多重特異的抗体 |
CN101957365B (zh) * | 2009-07-21 | 2013-08-07 | 卫生部北京医院 | 检测抗环瓜氨酸肽和抗免疫球蛋白g双特异性抗体的试剂盒 |
UY32808A (es) * | 2009-07-29 | 2011-02-28 | Abbott Lab | Inmunoglobulinas como dominio variable dual y usos de las mismas |
TWI465250B (zh) | 2009-08-29 | 2014-12-21 | Abbvie Inc | 治療用之dll4結合蛋白質 |
IN2012DN02737A (hu) * | 2009-09-01 | 2015-09-11 | Abbott Lab | |
GB201005063D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
KR20140015139A (ko) | 2009-10-15 | 2014-02-06 | 애브비 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
TW201124427A (en) * | 2009-10-15 | 2011-07-16 | Abbott Lab | IL-1 binding proteins |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
CN102656190A (zh) | 2009-12-08 | 2012-09-05 | 雅培股份有限两合公司 | 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体 |
CA2786745A1 (en) * | 2010-01-12 | 2011-07-21 | Oncomed Pharmaceuticals, Inc. | Wnt-binding agents and uses thereof |
EP2542582A4 (en) | 2010-03-02 | 2013-12-04 | Abbvie Inc | THERAPEUTIC PROTEINS LINKING TO DLL4 |
RU2624027C2 (ru) * | 2010-04-23 | 2017-06-30 | Дженентек, Инк. | Получение гетеромультимерных белков |
EP2571532B1 (en) | 2010-05-14 | 2017-05-03 | Abbvie Inc. | Il-1 binding proteins |
WO2012006500A2 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
CA2807014A1 (en) | 2010-08-03 | 2012-02-09 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
RU2013110844A (ru) * | 2010-08-13 | 2014-09-20 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ |
TW201211252A (en) | 2010-08-26 | 2012-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
RU2627171C2 (ru) | 2010-12-21 | 2017-08-03 | Эббви Инк. | Il-1 альфа и бета биспецифические иммуноглобулины с двойными вариабельными доменами и их применение |
RU2015134562A (ru) | 2011-02-08 | 2018-12-24 | Эббви Инк. | Лечение остеоартрита и боли |
PL2726510T3 (pl) | 2011-05-27 | 2023-05-29 | F.Hoffmann-La Roche Ag | Kierowanie podwójne |
WO2012163521A1 (en) | 2011-05-27 | 2012-12-06 | Dutalys | Removal of monomeric targets |
CN103781800A (zh) | 2011-06-20 | 2014-05-07 | 协和发酵麒麟株式会社 | 抗erbB3抗体 |
WO2013059439A2 (en) | 2011-10-21 | 2013-04-25 | Dyax Corp. | Combination therapy comprising an mmp-14 binding protein |
MX2014004980A (es) | 2011-10-24 | 2014-09-11 | Abbvie Inc | Inmunoaglutinantes biespecificos dirigidos contra tnf e il-17. |
RU2014120981A (ru) | 2011-10-24 | 2015-12-10 | Эббви Инк. | Иммунные связывающие агенты против склеростина |
AU2012340878A1 (en) * | 2011-11-21 | 2014-06-12 | Abbvie Inc. | IL-1 binding proteins |
RU2482181C1 (ru) * | 2011-12-07 | 2013-05-20 | Учреждение Российской академии медицинских наук Российский онкологический научный центр имени Н.Н. Блохина РАМН | Клеточная линия d11 множественной миеломы человека, используемая для гибридомной технологии |
EP2791173B1 (en) | 2011-12-14 | 2020-07-29 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
US9636398B2 (en) | 2011-12-14 | 2017-05-02 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
KR101963230B1 (ko) | 2011-12-26 | 2019-03-29 | 삼성전자주식회사 | 복수개의 단일 항체를 포함하는 단백질 복합체 |
EP2915818A3 (en) | 2011-12-30 | 2015-11-11 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
UY34558A (es) | 2011-12-30 | 2013-07-31 | Abbvie Inc | Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17 |
IL305223A (en) | 2012-01-27 | 2023-10-01 | Abbvie Inc | The composition and method for the diagnosis and treatment of diseases related to the degeneration of nerve cells |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
NZ630551A (en) | 2012-04-20 | 2017-11-24 | Merus Nv | Methods and means for the production of ig-like molecules |
UY34905A (es) | 2012-07-12 | 2014-01-31 | Abbvie Inc | Proteínas de unión a il-1 |
KR101911438B1 (ko) | 2012-10-31 | 2018-10-24 | 삼성전자주식회사 | 이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법 |
SG11201503324WA (en) * | 2012-11-01 | 2015-05-28 | Abbvie Inc | Stable dual variable domain immunoglobulin protein formulations |
AU2013337775B2 (en) | 2012-11-01 | 2017-03-30 | Abbvie Inc. | Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof |
JP2016501881A (ja) | 2012-12-04 | 2016-01-21 | アッヴィ・インコーポレイテッド | 血液脳関門(bbb)を透過する二重特異性結合タンパク質 |
US9856319B2 (en) | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
EP2938637A2 (en) | 2012-12-28 | 2015-11-04 | AbbVie Inc. | Multivalent binding protein compositions |
EP2938634A2 (en) * | 2012-12-28 | 2015-11-04 | AbbVie Inc. | Dual specific binding proteins having a receptor sequence |
WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
US9469686B2 (en) | 2013-03-15 | 2016-10-18 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
EP2970457A2 (en) | 2013-03-15 | 2016-01-20 | AbbVie Inc. | Dual specific binding proteins directed against tnf |
US10183988B2 (en) | 2013-06-07 | 2019-01-22 | Duke University | Anti-Complement factor H antibodies |
CN103308697B (zh) * | 2013-06-09 | 2014-11-26 | 卫生部北京医院 | 检测抗丙型肝炎病毒编码的非结构蛋白ns3和ns5的天然双特异性抗体的试剂盒 |
US9879081B2 (en) | 2013-06-25 | 2018-01-30 | Samsung Electronics Co., Ltd. | Protein complex, bispecific antibody including the protein complex, and method of preparation thereof |
MX2016003525A (es) | 2013-09-17 | 2017-01-06 | Univ Health Network (Uhn) | Agentes dirigidos contra una interaccion cis de molecula de orientacion repulsiva a (rgma) /neogenina o balsas lipidicas y uso de los mismos en metodos de tratamiento. |
WO2015046554A1 (ja) * | 2013-09-30 | 2015-04-02 | 中外製薬株式会社 | 改変されたヘルパーファージを用いて抗原結合分子を作製する方法 |
EP3083682B1 (en) | 2013-12-20 | 2024-04-17 | F. Hoffmann-La Roche AG | Dual specific antibodies |
US20160000936A1 (en) | 2014-06-10 | 2016-01-07 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
US20160002343A1 (en) | 2014-06-11 | 2016-01-07 | Abbvie Inc. | Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases |
EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
JP6655302B2 (ja) * | 2015-05-29 | 2020-02-26 | デンカ生研株式会社 | 被検対象の検出方法並びにそのための免疫測定器具及びモノクローナル抗体 |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
CN108473576A (zh) | 2015-09-11 | 2018-08-31 | 艾伯维公司 | 用于治疗复发形式的多发性硬化的方法 |
WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
WO2017055404A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
CN108139394B (zh) * | 2015-10-02 | 2020-10-30 | 豪夫迈·罗氏有限公司 | 用于确定同时结合的基于细胞的fret测定法 |
US11219645B2 (en) | 2015-11-18 | 2022-01-11 | Duke University | Tumor infiltrating lymphocytes for treatment of cancer |
CN109071646A (zh) | 2016-03-11 | 2018-12-21 | 供石公司 | TGFβ1-结合免疫球蛋白及其用途 |
TW201803900A (zh) | 2016-06-01 | 2018-02-01 | 艾伯維有限公司 | 治療脊髓損傷及疼痛之方法 |
BR112019006710A2 (pt) | 2016-10-03 | 2019-06-25 | Abbott Lab | métodos aprimorados para avaliação do estado da uch-l1 em amostras de pacientes |
EP3551658A1 (en) | 2017-01-06 | 2019-10-16 | Scholar Rock, Inc. | Isoform-specific, context-permissive tgf 1 inhibitors and use thereof |
US11016092B2 (en) | 2017-03-23 | 2021-05-25 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase L1 |
KR102461885B1 (ko) | 2017-04-03 | 2022-11-03 | 에프. 호프만-라 로슈 아게 | 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체 |
KR102346336B1 (ko) | 2017-04-05 | 2022-01-04 | 에프. 호프만-라 로슈 아게 | Pd1 및 lag3에 특이적으로 결합하는 이중특이적 항체 |
WO2018191531A1 (en) | 2017-04-15 | 2018-10-18 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
BR112019022476A2 (pt) | 2017-04-28 | 2020-05-12 | Abbott Laboratories | Métodos para o auxílio no diagnóstico e determinação hiperagudos de lesão cerebral traumática usando biomarcadores iniciais em pelo menos duas amostras a partir do mesmo ser humano |
US10865238B1 (en) | 2017-05-05 | 2020-12-15 | Duke University | Complement factor H antibodies |
CA3078725A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
BR112019025313A2 (pt) | 2017-05-30 | 2020-06-23 | Abbott Laboratories | Métodos para auxílio no diagnóstico e avaliação de uma lesão cerebral traumática leve em um indivíduo humano usando troponina cardíaca i |
EP3649474A1 (en) | 2017-07-03 | 2020-05-13 | Abbott Laboratories | Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood |
GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
CN111344307A (zh) | 2017-11-08 | 2020-06-26 | 协和麒麟株式会社 | 与CD40和EpCAM结合的双特异性抗体 |
US11016105B2 (en) | 2017-12-09 | 2021-05-25 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1 |
EP3721233A2 (en) | 2017-12-09 | 2020-10-14 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
EP3732489A1 (en) | 2017-12-29 | 2020-11-04 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
SI3677278T1 (sl) | 2018-07-11 | 2022-01-31 | Scholar Rock, Inc. | Izoformno selektivni zaviralci TGFBETA1 in uporaba le-teh |
EP3820896A1 (en) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | TGFbeta1 INHIBITORS AND USE THEREOF |
CA3105988A1 (en) | 2018-07-11 | 2020-01-16 | Abhishek Datta | High-affinity, isoform-selective tgf.beta.1 inhibitors and use thereof |
KR20210108961A (ko) | 2018-12-28 | 2021-09-03 | 쿄와 기린 가부시키가이샤 | TfR에 결합하는 이중 특이적 항체 |
US11079395B2 (en) | 2019-03-01 | 2021-08-03 | Abbott Laboratories | Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease |
KR20220008820A (ko) | 2019-05-15 | 2022-01-21 | 쿄와 기린 가부시키가이샤 | Cd40과 fap에 결합하는 이중 특이적 항체 |
EP3971293A4 (en) | 2019-05-15 | 2023-02-08 | Kyowa Kirin Co., Ltd. | BISPECIFIC ANTIBODIES CAPABLE OF BINDING TO CD40 AND GPC3 |
CA3167427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgfb inhibitors and use thereof |
US20230050148A1 (en) | 2020-01-11 | 2023-02-16 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
EP4136459A1 (en) | 2020-04-13 | 2023-02-22 | Abbott Laboratories | Methods, complexes and kits for detecting or determining an amount of a ss-coronavirus antibody in a sample |
CN111793131A (zh) * | 2020-05-11 | 2020-10-20 | 廊坊天光生物技术有限公司 | 一种用于检测血清中pf4含量的抗体对及其用途 |
KR20230042301A (ko) | 2020-08-04 | 2023-03-28 | 애벗트 라보라토리이즈 | 샘플에서 sars-cov-2 단백질을 검출하기 위한 개선된 방법 및 키트 |
WO2022119841A1 (en) | 2020-12-01 | 2022-06-09 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2023102384A1 (en) | 2021-11-30 | 2023-06-08 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
EP4271998A1 (en) | 2020-12-30 | 2023-11-08 | Abbott Laboratories | Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample |
WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
US20220381796A1 (en) | 2021-05-18 | 2022-12-01 | Abbott Laboratories | Methods of evaluating brain injury in a pediatric subject |
WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
EP4356129A1 (en) | 2021-06-14 | 2024-04-24 | Abbott Laboratories | Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind |
WO2023288277A1 (en) | 2021-07-14 | 2023-01-19 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgfb1 and uses thereof |
WO2023019019A2 (en) * | 2021-08-13 | 2023-02-16 | Abwiz Bio, Inc. | Humanization, affinity maturation, and optimization methods for proteins and antibodies |
CA3230038A1 (en) | 2021-08-31 | 2023-03-09 | Hongwei Zhang | Methods and systems of diagnosing brain injury |
AU2022354059A1 (en) | 2021-09-30 | 2024-03-28 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023114978A1 (en) | 2021-12-17 | 2023-06-22 | Abbott Laboratories | Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples |
US20230213536A1 (en) | 2021-12-28 | 2023-07-06 | Abbott Laboratories | Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan |
WO2023150652A1 (en) | 2022-02-04 | 2023-08-10 | Abbott Laboratories | Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample |
WO2024006876A1 (en) | 2022-06-29 | 2024-01-04 | Abbott Laboratories | Magnetic point-of-care systems and assays for determining gfap in biological samples |
WO2024059708A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Biomarkers and methods for differentiating between mild and supermild traumatic brain injury |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US126603A (en) | 1872-05-07 | Improvement in machines for sawing staves | ||
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
FR2577377B1 (fr) * | 1985-02-21 | 1989-06-16 | Albaret Sa | Procede pour eviter le patinage d'un tracteur equipe d'un relevage hydraulique avec un outil enfoui dans le sol, et equipement de tracteur pour mettre en oeuvre ce procede |
US4772685A (en) * | 1985-10-02 | 1988-09-20 | Merck & Co., Inc. | Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies |
US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
JP3771253B2 (ja) | 1988-09-02 | 2006-04-26 | ダイアックス コープ. | 新規な結合タンパク質の生成と選択 |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
AU634186B2 (en) | 1988-11-11 | 1993-02-18 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
KR950701681A (ko) | 1992-05-22 | 1995-04-28 | 로저 엔, 플레어 | 다중 부착 분자에 특이성을 갖는 항체 |
US5622701A (en) * | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
AU698393B2 (en) * | 1994-06-24 | 1998-10-29 | Immunex Corporation | Controlled release polypeptide compositions and methods of treating inflammatory bowel disease |
CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
SI9720020B (en) | 1996-02-09 | 2001-12-31 | Basf Ag | Human antibodies that bind human TNF alpha |
US6300065B1 (en) | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
IL119587A (en) * | 1996-11-07 | 2000-12-06 | Univ Ramot | Method of preparing and for obtaining bimolecular interactions |
EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
ATE332368T1 (de) | 1997-01-21 | 2006-07-15 | Gen Hospital Corp | Selektion von proteinen mittels rns-protein fusionen |
JP2002514919A (ja) | 1997-04-04 | 2002-05-21 | バイオサイト ダイアグノスティックス,インコーポレイテッド | 多価ライブラリーおよびポリクローナルライブラリー |
WO1998049286A2 (en) | 1997-05-01 | 1998-11-05 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
US6680380B1 (en) | 1998-09-18 | 2004-01-20 | Schering Corporation | Nucleic acids encoding mammalian interleukin-1ζ, related reagents and methods |
IL145134A0 (en) | 1999-03-25 | 2002-06-30 | Knoll Gmbh | Human antibodies that bind human il-12 and methods for producing |
GB0001448D0 (en) | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
KR20080074231A (ko) | 2000-06-29 | 2008-08-12 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 및 사용 방법 |
WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
EP1399484B1 (en) | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
EP1957536A2 (en) | 2005-12-01 | 2008-08-20 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
EP2114443A4 (en) | 2006-12-29 | 2011-08-10 | Abbott Lab | IL-1A / IL-1B ANTIBODY WITH DOUBLE SPECIFICITY |
-
2001
- 2001-06-28 KR KR1020087018593A patent/KR20080074231A/ko not_active Application Discontinuation
- 2001-06-28 IL IL15356701A patent/IL153567A0/xx unknown
- 2001-06-28 HU HU0301002A patent/HUP0301002A3/hu unknown
- 2001-06-28 CN CN2010105838125A patent/CN102120773B/zh not_active Expired - Fee Related
- 2001-06-28 BR BR0112026-3A patent/BR0112026A/pt not_active IP Right Cessation
- 2001-06-28 CN CN01814818A patent/CN1451043A/zh active Pending
- 2001-06-28 PL PL359995A patent/PL208069B1/pl not_active IP Right Cessation
- 2001-06-28 WO PCT/US2001/020755 patent/WO2002002773A2/en active Application Filing
- 2001-06-28 US US09/894,550 patent/US7491516B2/en not_active Expired - Fee Related
- 2001-06-28 CA CA2411374A patent/CA2411374C/en not_active Expired - Fee Related
- 2001-06-28 CZ CZ2003291A patent/CZ2003291A3/cs unknown
- 2001-06-28 JP JP2002508013A patent/JP4955185B2/ja not_active Expired - Fee Related
- 2001-06-28 EP EP09150437A patent/EP2042518A3/en not_active Withdrawn
- 2001-06-28 UY UY26807A patent/UY26807A1/es not_active Application Discontinuation
- 2001-06-28 MX MXPA02012867A patent/MXPA02012867A/es active IP Right Grant
- 2001-06-28 AU AU2001271636A patent/AU2001271636A1/en not_active Abandoned
- 2001-06-28 PE PE2001000641A patent/PE20020132A1/es not_active Application Discontinuation
- 2001-06-28 EP EP15154039.0A patent/EP2899210A3/en not_active Withdrawn
- 2001-06-28 KR KR1020027017916A patent/KR100919593B1/ko not_active IP Right Cessation
- 2001-06-28 EP EP01950668A patent/EP1297142B1/en not_active Expired - Lifetime
- 2001-06-28 EP EP10182393A patent/EP2386575A3/en not_active Withdrawn
- 2001-06-28 NZ NZ523080A patent/NZ523080A/en not_active IP Right Cessation
- 2001-06-28 ES ES01950668T patent/ES2319866T3/es not_active Expired - Lifetime
- 2001-06-28 SK SK115-2003A patent/SK1152003A3/sk not_active Application Discontinuation
- 2001-06-28 AT AT01950668T patent/ATE420958T1/de not_active IP Right Cessation
- 2001-06-28 CN CNA2009101351381A patent/CN101525384A/zh active Pending
- 2001-06-28 DE DE60137421T patent/DE60137421D1/de not_active Expired - Lifetime
- 2001-06-29 TW TW094102248A patent/TW200516083A/zh unknown
- 2001-06-29 TW TW090115948A patent/TWI307716B/zh not_active IP Right Cessation
-
2002
- 2002-12-12 ZA ZA200210109A patent/ZA200210109B/en unknown
- 2002-12-20 IL IL153567A patent/IL153567A/en not_active IP Right Cessation
- 2002-12-27 NO NO20026239A patent/NO20026239L/no not_active Application Discontinuation
- 2002-12-27 EC EC2002004409A patent/ECSP024409A/es unknown
-
2003
- 2003-01-21 BG BG107483A patent/BG66209B1/bg unknown
- 2003-08-27 HK HK03106152.8A patent/HK1055316A1/xx unknown
-
2008
- 2008-12-11 US US12/316,340 patent/US8475766B2/en not_active Expired - Lifetime
-
2010
- 2010-02-14 IL IL203955A patent/IL203955A/en not_active IP Right Cessation
-
2011
- 2011-08-31 JP JP2011188635A patent/JP2012031178A/ja active Pending
-
2013
- 2013-05-23 US US13/900,841 patent/US20140155579A1/en not_active Abandoned
-
2014
- 2014-08-26 US US14/469,122 patent/US20140378666A1/en not_active Abandoned
-
2015
- 2015-03-05 US US14/639,985 patent/US20150175694A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20026239L (no) | Antistoffer med dobbel spesifisitet og fremgangsmåter for fremstilling og bruk | |
HUP0300423A2 (hu) | Emberi interleukin-18-at megkötni képes antitestek és ezek előállítására és alkalmazására szolgáló eljárások | |
LU92159I2 (fr) | Ustekinumab et ses dérivés pharmaceutiquement acceptables (STELARA®) | |
ATE555130T1 (de) | Il-18-bindende proteine | |
HUP0302589A2 (hu) | A béta-amiloid peptidet felismerő humanizált ellenanyagok | |
CR20130154A (es) | Proteínas de la unión a il-12/p40 (divisional exp. 9599) | |
ATE409047T1 (de) | Humanisierte antikörper | |
DK388384D0 (da) | Monoklone antistoffer med specifitet for membran-associerede antigene, deres fremstilling og anvendelse | |
DK1411962T3 (da) | Terapi for pancreacancer med monoklonalt stof | |
DE60045870D1 (de) | Monoklonaler antikörper, hybridoma, immuntestverfahren und diagnosekit | |
GR3025630T3 (en) | Monoclonal antibody against human IgE | |
NO173901C (no) | Fremgangsmaate, monoklonalt antistoff og sett for maaling av vevplasminogenaktivator-aktivitet | |
BR9702101A (pt) | Hibridoma e anticorpo monoclonal |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |