ECSP024409A - Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismos - Google Patents
Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismosInfo
- Publication number
- ECSP024409A ECSP024409A EC2002004409A ECSP024409A ECSP024409A EC SP024409 A ECSP024409 A EC SP024409A EC 2002004409 A EC2002004409 A EC 2002004409A EC SP024409 A ECSP024409 A EC SP024409A EC SP024409 A ECSP024409 A EC SP024409A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- methods
- double specificity
- activity
- elaboration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 abstract 3
- 102100039065 Interleukin-1 beta Human genes 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Se proveen anticuerpos que tienen especificidad doble por dos antígenos diferentes pero relacionados desde el punto de vista estructural. Los anticuerpos pueden ser, por ejemplo, anticuerpos humanos completos, anticuerpos recombinantes o anticuerpos monoclonales. Los anticuerpos preferidos tienen especificidad doble por IL - 1a e IL-1B y neutralizan la actividad de IL-1a e IL-1B in vitro e in vivo. Un anticuerpo de la invención puede ser un anticuerpo completo o una porción de unión a antígeno del mismo. Se proveen también métodos para preparar y métodos para usar los anticuerpos de la invención. Los anticuerpos o las porciones de anticuerpo de la invención son útiles para detectar dos antígenos diferentes pero relacionados desde el punto de vista estructural (por ejemplo IL-1a e Il1-b) y para inhibir la actividad de los antígenos, por ejemplo, en un sujeto humano que sufre de una afección en la cual es perjudicial la actividad de IL-1a y/o IL-1B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21537900P | 2000-06-29 | 2000-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP024409A true ECSP024409A (es) | 2003-02-06 |
Family
ID=22802758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2002004409A ECSP024409A (es) | 2000-06-29 | 2002-12-27 | Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismos |
Country Status (27)
Country | Link |
---|---|
US (5) | US7491516B2 (es) |
EP (4) | EP2386575A3 (es) |
JP (2) | JP4955185B2 (es) |
KR (2) | KR20080074231A (es) |
CN (3) | CN102120773B (es) |
AT (1) | ATE420958T1 (es) |
AU (1) | AU2001271636A1 (es) |
BG (1) | BG66209B1 (es) |
BR (1) | BR0112026A (es) |
CA (1) | CA2411374C (es) |
CZ (1) | CZ2003291A3 (es) |
DE (1) | DE60137421D1 (es) |
EC (1) | ECSP024409A (es) |
ES (1) | ES2319866T3 (es) |
HK (1) | HK1055316A1 (es) |
HU (1) | HUP0301002A3 (es) |
IL (3) | IL153567A0 (es) |
MX (1) | MXPA02012867A (es) |
NO (1) | NO20026239L (es) |
NZ (1) | NZ523080A (es) |
PE (1) | PE20020132A1 (es) |
PL (1) | PL208069B1 (es) |
SK (1) | SK1152003A3 (es) |
TW (2) | TWI307716B (es) |
UY (1) | UY26807A1 (es) |
WO (1) | WO2002002773A2 (es) |
ZA (1) | ZA200210109B (es) |
Families Citing this family (172)
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US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
DE60237282D1 (de) * | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
GB0115841D0 (en) | 2001-06-28 | 2001-08-22 | Medical Res Council | Ligand |
US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
ES2368733T3 (es) | 2002-07-18 | 2011-11-21 | Merus B.V. | Producción recombinante de mezclas de anticuerpos. |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
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US20110223168A1 (en) * | 2002-12-27 | 2011-09-15 | Greg Winter | Ligand that has binding specificity for il-4 and/or il-13 |
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CA2527694C (en) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Fab library for the preparation of anti vegf and anti rabies virus fabs |
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CA2659745A1 (en) * | 2006-08-02 | 2008-02-07 | California Institute Of Technology | Methods and systems for detecting and/or sorting targets |
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CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
RU2010153578A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойными вариабельными доменами и их применение |
RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
KR101705911B1 (ko) | 2008-09-03 | 2017-02-10 | 제넨테크, 인크. | 다중특이적 항체 |
US8377429B2 (en) * | 2008-09-05 | 2013-02-19 | Xoma Technology Ltd. | Methods for improvement of beta cell function with anti-IL-1β antibodies or fragments thereof |
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2001
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- 2001-06-28 PL PL359995A patent/PL208069B1/pl not_active IP Right Cessation
- 2001-06-28 EP EP10182393A patent/EP2386575A3/en not_active Withdrawn
- 2001-06-28 CN CN2010105838125A patent/CN102120773B/zh not_active Expired - Fee Related
- 2001-06-28 AT AT01950668T patent/ATE420958T1/de not_active IP Right Cessation
- 2001-06-28 EP EP15154039.0A patent/EP2899210A3/en not_active Withdrawn
- 2001-06-28 NZ NZ523080A patent/NZ523080A/en not_active IP Right Cessation
- 2001-06-28 MX MXPA02012867A patent/MXPA02012867A/es active IP Right Grant
- 2001-06-28 BR BR0112026-3A patent/BR0112026A/pt not_active IP Right Cessation
- 2001-06-28 CZ CZ2003291A patent/CZ2003291A3/cs unknown
- 2001-06-28 AU AU2001271636A patent/AU2001271636A1/en not_active Abandoned
- 2001-06-28 CN CN01814818A patent/CN1451043A/zh active Pending
- 2001-06-28 IL IL15356701A patent/IL153567A0/xx unknown
- 2001-06-28 SK SK115-2003A patent/SK1152003A3/sk not_active Application Discontinuation
- 2001-06-28 EP EP01950668A patent/EP1297142B1/en not_active Expired - Lifetime
- 2001-06-28 WO PCT/US2001/020755 patent/WO2002002773A2/en active Application Filing
- 2001-06-28 US US09/894,550 patent/US7491516B2/en not_active Expired - Fee Related
- 2001-06-28 KR KR1020087018593A patent/KR20080074231A/ko not_active Application Discontinuation
- 2001-06-28 PE PE2001000641A patent/PE20020132A1/es not_active Application Discontinuation
- 2001-06-28 HU HU0301002A patent/HUP0301002A3/hu unknown
- 2001-06-28 CN CNA2009101351381A patent/CN101525384A/zh active Pending
- 2001-06-28 UY UY26807A patent/UY26807A1/es not_active Application Discontinuation
- 2001-06-28 KR KR1020027017916A patent/KR100919593B1/ko not_active IP Right Cessation
- 2001-06-28 JP JP2002508013A patent/JP4955185B2/ja not_active Expired - Fee Related
- 2001-06-28 EP EP09150437A patent/EP2042518A3/en not_active Withdrawn
- 2001-06-28 CA CA2411374A patent/CA2411374C/en not_active Expired - Fee Related
- 2001-06-28 ES ES01950668T patent/ES2319866T3/es not_active Expired - Lifetime
- 2001-06-29 TW TW090115948A patent/TWI307716B/zh not_active IP Right Cessation
- 2001-06-29 TW TW094102248A patent/TW200516083A/zh unknown
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2002
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- 2002-12-20 IL IL153567A patent/IL153567A/en not_active IP Right Cessation
- 2002-12-27 NO NO20026239A patent/NO20026239L/no not_active Application Discontinuation
- 2002-12-27 EC EC2002004409A patent/ECSP024409A/es unknown
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2003
- 2003-01-21 BG BG107483A patent/BG66209B1/bg unknown
- 2003-08-27 HK HK03106152.8A patent/HK1055316A1/xx unknown
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2008
- 2008-12-11 US US12/316,340 patent/US8475766B2/en not_active Expired - Lifetime
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2010
- 2010-02-14 IL IL203955A patent/IL203955A/en not_active IP Right Cessation
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2011
- 2011-08-31 JP JP2011188635A patent/JP2012031178A/ja active Pending
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2013
- 2013-05-23 US US13/900,841 patent/US20140155579A1/en not_active Abandoned
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2014
- 2014-08-26 US US14/469,122 patent/US20140378666A1/en not_active Abandoned
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2015
- 2015-03-05 US US14/639,985 patent/US20150175694A1/en not_active Abandoned
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