MXPA02007756A - Anticuerpos que aglutinan interleuqina-18 humana y metodos de fabricacion y uso. - Google Patents

Anticuerpos que aglutinan interleuqina-18 humana y metodos de fabricacion y uso.

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Publication number
MXPA02007756A
MXPA02007756A MXPA02007756A MXPA02007756A MXPA02007756A MX PA02007756 A MXPA02007756 A MX PA02007756A MX PA02007756 A MXPA02007756 A MX PA02007756A MX PA02007756 A MXPA02007756 A MX PA02007756A MX PA02007756 A MXPA02007756 A MX PA02007756A
Authority
MX
Mexico
Prior art keywords
antibodies
hil
making
human
human interleukin
Prior art date
Application number
MXPA02007756A
Other languages
English (en)
Inventor
John Mankovich
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22665007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02007756(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MXPA02007756A publication Critical patent/MXPA02007756A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Se proporcionan anticuerpos que aglutinan interleuquina-18 humana (hlL-18), en particular anticuerpos que aglutinan epitope(s) de IL-18 humana. Los anticuerpos pueden ser, por ejemplo, anticuerpos completamente humanos, anticuerpos recombinantes, o anticuerpos monoclonales. Los anticuerpos preferidos tienen una gran afinidad por hlL-18 y neutralizan la actividad de hlL-18 in vitro e in vivo. Un anticuerpo de la invencion puede ser un anticuerpo de tamano natural o una porcion de aglutinacion de antigeno del mismo. Se proporcionan tambien el metodo para fabricar y el metodo para utilizar los anticuerpos de la invencion. Los anticuerpos, o porciones de anticuerpo, de la invencion son utiles para detectar hlL-8 y para inhibir la actividad de hL-18, por ejemplo, en un paciente humano que sufre un padecimiento en el que es perjudicial la actividad de hlL-18.
MXPA02007756A 2000-02-10 2001-02-09 Anticuerpos que aglutinan interleuqina-18 humana y metodos de fabricacion y uso. MXPA02007756A (es)

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JP2004500086A (ja) 2004-01-08
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KR20120011898A (ko) 2012-02-08
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