BRPI0308663B8 - uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas - Google Patents

uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas

Info

Publication number
BRPI0308663B8
BRPI0308663B8 BRPI0308663A BR0308663A BRPI0308663B8 BR PI0308663 B8 BRPI0308663 B8 BR PI0308663B8 BR PI0308663 A BRPI0308663 A BR PI0308663A BR 0308663 A BR0308663 A BR 0308663A BR PI0308663 B8 BRPI0308663 B8 BR PI0308663B8
Authority
BR
Brazil
Prior art keywords
prevention
treatment
peripheral vascular
vascular diseases
inhibitors
Prior art date
Application number
BRPI0308663A
Other languages
English (en)
Other versions
BR0308663A (pt
BRPI0308663B1 (pt
Inventor
Tedgui Alain
Chavatchko Yolande
Mallat Ziad
Original Assignee
Applied Res Systems Ars Holding N V
Inst Nat Sante Rech Med
Laboratoires Serono S A
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Res Systems Ars Holding N V, Inst Nat Sante Rech Med, Laboratoires Serono S A, Merck Serono Sa filed Critical Applied Res Systems Ars Holding N V
Publication of BR0308663A publication Critical patent/BR0308663A/pt
Publication of BRPI0308663B1 publication Critical patent/BRPI0308663B1/pt
Publication of BRPI0308663B8 publication Critical patent/BRPI0308663B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

"uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas". a presente invenção refere-se ao uso de um inibidor de il-18 na preparação de um medicamento para o tratamento e/ou prevenção de doenças vasculares periféricas. a presente invenção refere-se ainda ao uso de um inibidor de il-18 para prevenção de amputação de membros.
BRPI0308663A 2002-03-22 2003-03-13 uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas BRPI0308663B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02100290.2 2002-03-22
EP02100290 2002-03-22
PCT/EP2003/050061 WO2003080104A2 (en) 2002-03-22 2003-03-13 Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases

Publications (3)

Publication Number Publication Date
BR0308663A BR0308663A (pt) 2005-01-25
BRPI0308663B1 BRPI0308663B1 (pt) 2019-07-16
BRPI0308663B8 true BRPI0308663B8 (pt) 2021-05-25

Family

ID=28051827

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308663A BRPI0308663B8 (pt) 2002-03-22 2003-03-13 uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas

Country Status (28)

Country Link
US (2) US9592267B2 (pt)
EP (1) EP1487541B1 (pt)
JP (1) JP4885424B2 (pt)
KR (1) KR20050004809A (pt)
CN (1) CN100540058C (pt)
AR (1) AR039103A1 (pt)
AT (1) ATE414556T1 (pt)
AU (1) AU2003219162B2 (pt)
BR (1) BRPI0308663B8 (pt)
CA (1) CA2478855C (pt)
CY (1) CY1108748T1 (pt)
DE (1) DE60324777D1 (pt)
DK (1) DK1487541T3 (pt)
EA (1) EA008495B1 (pt)
ES (1) ES2314191T3 (pt)
HK (1) HK1075422A1 (pt)
HR (1) HRP20040758B1 (pt)
IL (2) IL164211A0 (pt)
ME (1) ME00548B (pt)
MX (1) MXPA04009135A (pt)
NO (1) NO336226B1 (pt)
PL (1) PL207303B1 (pt)
PT (1) PT1487541E (pt)
RS (1) RS51755B (pt)
SI (1) SI1487541T1 (pt)
UA (1) UA80275C2 (pt)
WO (1) WO2003080104A2 (pt)
ZA (1) ZA200407022B (pt)

Families Citing this family (31)

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US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
EP2338515A3 (en) * 2000-02-10 2011-11-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
ME00548B (me) 2002-03-22 2011-10-10 Serono Lab Korišćenje inhibitora il-18 za liječenje i/ili prevenciju perifernih vaskularnih bolesti
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
CA2563678A1 (en) * 2004-04-19 2005-11-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
EP2267024B1 (en) 2005-06-03 2012-05-09 Ares Trading S.A. Production of recombinant Il-18 binding protein
WO2006131550A1 (en) 2005-06-10 2006-12-14 Ares Trading S.A. Process for the purification of il-18 binding protein
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US10106587B2 (en) 2008-02-27 2018-10-23 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
EP2445492B1 (en) 2009-06-24 2016-09-28 Strategic Science & Technologies, LLC Topical composition containing ibuprofen
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
EP2445493A1 (en) 2009-06-24 2012-05-02 Strategic Science & Technologies, LLC Topical composition containing naproxen
AU2010292486B2 (en) 2009-08-27 2014-08-07 Biomet Biologics, Llc Implantable device for production of interleukin-1 receptor antagonist
EP2483407A2 (en) 2009-09-30 2012-08-08 President and Fellows of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
TW201215405A (en) 2010-08-25 2012-04-16 Hoffmann La Roche Antibodies against IL-18R1 and uses thereof
EP2658551B1 (en) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
CN105878172A (zh) 2010-12-29 2016-08-24 战略科学与技术有限责任公司 治疗变态反应和其它适应症的系统和方法
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9833474B2 (en) 2013-11-26 2017-12-05 Biomet Biologies, LLC Methods of mediating macrophage phenotypes
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions
AU2016227644B2 (en) 2015-03-05 2022-06-16 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases
US9763800B2 (en) 2015-03-18 2017-09-19 Biomet C. V. Implant configured for hammertoe and small bone fixation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) * 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18 BINDING PROTEIN
CA2324168A1 (en) * 1999-11-16 2001-05-16 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
BRPI0110506B8 (pt) * 2000-05-05 2021-05-25 Applied Res Systems Ars Holding N V uso de inibidores de il-18 para o tratamento e/ou prevenção da aterosclerose
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
ME00548B (me) 2002-03-22 2011-10-10 Serono Lab Korišćenje inhibitora il-18 za liječenje i/ili prevenciju perifernih vaskularnih bolesti

Also Published As

Publication number Publication date
BR0308663A (pt) 2005-01-25
US9592267B2 (en) 2017-03-14
ATE414556T1 (de) 2008-12-15
AU2003219162B2 (en) 2008-01-03
WO2003080104A2 (en) 2003-10-02
WO2003080104A3 (en) 2004-03-04
HRP20040758A2 (en) 2005-02-28
EA200401240A1 (ru) 2005-02-24
RS81504A (en) 2006-12-15
JP2005520852A (ja) 2005-07-14
IL164211A0 (en) 2005-12-18
DE60324777D1 (de) 2009-01-02
EP1487541B1 (en) 2008-11-19
JP4885424B2 (ja) 2012-02-29
US9566313B2 (en) 2017-02-14
SI1487541T1 (sl) 2009-02-28
CN1655845A (zh) 2005-08-17
ME00548B (me) 2011-10-10
NO336226B1 (no) 2015-06-22
EA008495B1 (ru) 2007-06-29
IL164211A (en) 2011-07-31
AR039103A1 (es) 2005-02-09
PT1487541E (pt) 2008-12-10
ZA200407022B (en) 2006-06-28
PL372398A1 (en) 2005-07-25
US20060233799A1 (en) 2006-10-19
AU2003219162A1 (en) 2003-10-08
HK1075422A1 (en) 2005-12-16
CN100540058C (zh) 2009-09-16
HRP20040758B1 (hr) 2012-10-31
PL207303B1 (pl) 2010-11-30
DK1487541T3 (da) 2009-01-19
BRPI0308663B1 (pt) 2019-07-16
US20100291028A1 (en) 2010-11-18
CA2478855C (en) 2013-12-17
RS51755B (en) 2011-12-31
UA80275C2 (en) 2007-09-10
ES2314191T3 (es) 2009-03-16
NO20044459L (no) 2004-10-20
CA2478855A1 (en) 2003-10-02
CY1108748T1 (el) 2014-04-09
KR20050004809A (ko) 2005-01-12
MXPA04009135A (es) 2004-12-07
EP1487541A2 (en) 2004-12-22

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Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M

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