BR0308663A - Uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas - Google Patents

Uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas

Info

Publication number
BR0308663A
BR0308663A BR0308663-1A BR0308663A BR0308663A BR 0308663 A BR0308663 A BR 0308663A BR 0308663 A BR0308663 A BR 0308663A BR 0308663 A BR0308663 A BR 0308663A
Authority
BR
Brazil
Prior art keywords
prevention
treatment
peripheral vascular
vascular diseases
inhibitors
Prior art date
Application number
BR0308663-1A
Other languages
English (en)
Other versions
BRPI0308663B8 (pt
BRPI0308663B1 (pt
Inventor
Yolande Chavatchko
Alain Tedgui
Ziad Mallat
Original Assignee
Applied Research Systems
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems, Inst Nat Sante Rech Med filed Critical Applied Research Systems
Publication of BR0308663A publication Critical patent/BR0308663A/pt
Publication of BRPI0308663B1 publication Critical patent/BRPI0308663B1/pt
Publication of BRPI0308663B8 publication Critical patent/BRPI0308663B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"USO DE INIBIDORES DE IL-18 PARA O TRATAMENTO E/OU PREVENçãO DE DOENçAS VASCULARES PERIFéRICAS". A presente invenção refere-se ao uso de um inibidor de IL-18 na preparação de um medicamento para o tratamento e/ou prevenção de doenças vasculares periféricas. A presente invenção refere-se ainda ao uso de um inibidor de IL-18 para prevenção de amputação de membros.
BRPI0308663A 2002-03-22 2003-03-13 uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas BRPI0308663B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02100290 2002-03-22
EP02100290.2 2002-03-22
PCT/EP2003/050061 WO2003080104A2 (en) 2002-03-22 2003-03-13 Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases

Publications (3)

Publication Number Publication Date
BR0308663A true BR0308663A (pt) 2005-01-25
BRPI0308663B1 BRPI0308663B1 (pt) 2019-07-16
BRPI0308663B8 BRPI0308663B8 (pt) 2021-05-25

Family

ID=28051827

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308663A BRPI0308663B8 (pt) 2002-03-22 2003-03-13 uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas

Country Status (28)

Country Link
US (2) US9592267B2 (pt)
EP (1) EP1487541B1 (pt)
JP (1) JP4885424B2 (pt)
KR (1) KR20050004809A (pt)
CN (1) CN100540058C (pt)
AR (1) AR039103A1 (pt)
AT (1) ATE414556T1 (pt)
AU (1) AU2003219162B2 (pt)
BR (1) BRPI0308663B8 (pt)
CA (1) CA2478855C (pt)
CY (1) CY1108748T1 (pt)
DE (1) DE60324777D1 (pt)
DK (1) DK1487541T3 (pt)
EA (1) EA008495B1 (pt)
ES (1) ES2314191T3 (pt)
HK (1) HK1075422A1 (pt)
HR (1) HRP20040758B1 (pt)
IL (2) IL164211A0 (pt)
ME (1) ME00548B (pt)
MX (1) MXPA04009135A (pt)
NO (1) NO336226B1 (pt)
PL (1) PL207303B1 (pt)
PT (1) PT1487541E (pt)
RS (1) RS51755B (pt)
SI (1) SI1487541T1 (pt)
UA (1) UA80275C2 (pt)
WO (1) WO2003080104A2 (pt)
ZA (1) ZA200407022B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
KR101111103B1 (ko) * 2000-02-10 2012-02-13 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
DE60324777D1 (de) 2002-03-22 2009-01-02 Inst Nat Sante Rech Med Verwendung von il-18-inhibitoren zur behandlung und/oder prävention von peripheren gefässkrankheiten
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
ES2429443T3 (es) * 2004-04-19 2013-11-14 Strategic Science & Technologies, Llc Suministro transdérmico de sustancias beneficiosas efectuado mediante un entorno de fuerza iónica elevada
US7691611B2 (en) 2005-06-03 2010-04-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
EP2259774B1 (en) 2008-02-27 2012-12-12 Biomet Biologics, LLC Methods and compositions for delivering interleukin-1 receptor antagonist
US9072659B2 (en) 2009-06-24 2015-07-07 Strategic Science & Technologies, Llc Topical composition containing naproxen
KR101643797B1 (ko) 2009-06-24 2016-07-28 스트러티직 사이언스 앤드 테크놀로지스, 엘엘씨 이부프로펜을 함유하는 국소 조성물
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
EP2470162B1 (en) 2009-08-27 2019-03-27 Biomet Biologics, LLC Implantable device for production of interleukin-1 receptor antagonist
CN102639700A (zh) 2009-09-30 2012-08-15 哈佛大学校长及研究员协会 通过调节自噬增强基因产物调节自噬的方法
WO2012025536A1 (en) 2010-08-25 2012-03-01 F. Hoffmann-La Roche Ag Antibodies against il-18r1 and uses thereof
JP2014504592A (ja) 2010-12-29 2014-02-24 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー 勃起不全および他の適応症の処置
JP2014501283A (ja) 2010-12-29 2014-01-20 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー アレルギーおよび他の適応症の処置のためのシステムおよび方法
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
EP3074507B1 (en) 2013-11-26 2022-01-05 Biomet Biologics, LLC Methods of mediating macrophage phenotypes
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions
US10882905B2 (en) 2015-03-05 2021-01-05 Ab2 Bio Sa IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases
US9763800B2 (en) 2015-03-18 2017-09-19 Biomet C. V. Implant configured for hammertoe and small bone fixation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18 BINDING PROTEIN
EP1101772B1 (en) * 1999-11-16 2009-01-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
CN1250286C (zh) * 2000-05-05 2006-04-12 应用研究系统Ars股份公司 Il－18抑制剂在治疗和/或预防动脉粥样硬化中的应用
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
DE60324777D1 (de) 2002-03-22 2009-01-02 Inst Nat Sante Rech Med Verwendung von il-18-inhibitoren zur behandlung und/oder prävention von peripheren gefässkrankheiten

Also Published As

Publication number Publication date
RS51755B (en) 2011-12-31
IL164211A (en) 2011-07-31
US9592267B2 (en) 2017-03-14
IL164211A0 (en) 2005-12-18
NO20044459L (no) 2004-10-20
PL207303B1 (pl) 2010-11-30
EP1487541B1 (en) 2008-11-19
HRP20040758B1 (hr) 2012-10-31
ME00548B (me) 2011-10-10
NO336226B1 (no) 2015-06-22
WO2003080104A3 (en) 2004-03-04
ES2314191T3 (es) 2009-03-16
CA2478855C (en) 2013-12-17
CA2478855A1 (en) 2003-10-02
CN100540058C (zh) 2009-09-16
HK1075422A1 (en) 2005-12-16
CN1655845A (zh) 2005-08-17
JP4885424B2 (ja) 2012-02-29
EA200401240A1 (ru) 2005-02-24
SI1487541T1 (sl) 2009-02-28
HRP20040758A2 (en) 2005-02-28
CY1108748T1 (el) 2014-04-09
UA80275C2 (en) 2007-09-10
ATE414556T1 (de) 2008-12-15
US20100291028A1 (en) 2010-11-18
PL372398A1 (en) 2005-07-25
DE60324777D1 (de) 2009-01-02
AU2003219162A1 (en) 2003-10-08
MXPA04009135A (es) 2004-12-07
US9566313B2 (en) 2017-02-14
RS81504A (en) 2006-12-15
EP1487541A2 (en) 2004-12-22
JP2005520852A (ja) 2005-07-14
WO2003080104A2 (en) 2003-10-02
US20060233799A1 (en) 2006-10-19
DK1487541T3 (da) 2009-01-19
EA008495B1 (ru) 2007-06-29
KR20050004809A (ko) 2005-01-12
BRPI0308663B8 (pt) 2021-05-25
PT1487541E (pt) 2008-12-10
AU2003219162B2 (en) 2008-01-03
ZA200407022B (en) 2006-06-28
AR039103A1 (es) 2005-02-09
BRPI0308663B1 (pt) 2019-07-16

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