EA200401240A1 - Применение ингибиторов il-18 для лечения и/или профилактики заболеваний периферических сосудов - Google Patents

Применение ингибиторов il-18 для лечения и/или профилактики заболеваний периферических сосудов

Info

Publication number
EA200401240A1
EA200401240A1 EA200401240A EA200401240A EA200401240A1 EA 200401240 A1 EA200401240 A1 EA 200401240A1 EA 200401240 A EA200401240 A EA 200401240A EA 200401240 A EA200401240 A EA 200401240A EA 200401240 A1 EA200401240 A1 EA 200401240A1
Authority
EA
Eurasian Patent Office
Prior art keywords
prevention
treatment
inhibitors
application
peripheral vessel
Prior art date
Application number
EA200401240A
Other languages
English (en)
Other versions
EA008495B1 (ru
Inventor
Йоланд Шватшко
Алан Тедги
Зиад Маллат
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н. В.
Энститю Насьональ Де Ля Санте Э Де Ля Решерш Медикаль
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н. В., Энститю Насьональ Де Ля Санте Э Де Ля Решерш Медикаль filed Critical Апплайд Резеч Системз Арс Холдинг Н. В.
Publication of EA200401240A1 publication Critical patent/EA200401240A1/ru
Publication of EA008495B1 publication Critical patent/EA008495B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение относится к применению ингибитора IL-18 для получения лекарства для лечения и/или профилактики заболеваний периферических сосудов. Изобретение дополнительно относится к применению ингибитора IL-18 для предотвращения ампутации конечности.Отчет о международном поиске был опубликован 2004.03.04.
EA200401240A 2002-03-22 2003-03-13 Применение ингибиторов il-18 для лечения и/или профилактики заболеваний периферических сосудов EA008495B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100290 2002-03-22
PCT/EP2003/050061 WO2003080104A2 (en) 2002-03-22 2003-03-13 Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases

Publications (2)

Publication Number Publication Date
EA200401240A1 true EA200401240A1 (ru) 2005-02-24
EA008495B1 EA008495B1 (ru) 2007-06-29

Family

ID=28051827

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401240A EA008495B1 (ru) 2002-03-22 2003-03-13 Применение ингибиторов il-18 для лечения и/или профилактики заболеваний периферических сосудов

Country Status (28)

Country Link
US (2) US9592267B2 (ru)
EP (1) EP1487541B1 (ru)
JP (1) JP4885424B2 (ru)
KR (1) KR20050004809A (ru)
CN (1) CN100540058C (ru)
AR (1) AR039103A1 (ru)
AT (1) ATE414556T1 (ru)
AU (1) AU2003219162B2 (ru)
BR (1) BRPI0308663B8 (ru)
CA (1) CA2478855C (ru)
CY (1) CY1108748T1 (ru)
DE (1) DE60324777D1 (ru)
DK (1) DK1487541T3 (ru)
EA (1) EA008495B1 (ru)
ES (1) ES2314191T3 (ru)
HK (1) HK1075422A1 (ru)
HR (1) HRP20040758B1 (ru)
IL (2) IL164211A0 (ru)
ME (1) ME00548B (ru)
MX (1) MXPA04009135A (ru)
NO (1) NO336226B1 (ru)
PL (1) PL207303B1 (ru)
PT (1) PT1487541E (ru)
RS (1) RS51755B (ru)
SI (1) SI1487541T1 (ru)
UA (1) UA80275C2 (ru)
WO (1) WO2003080104A2 (ru)
ZA (1) ZA200407022B (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
KR101111103B1 (ko) * 2000-02-10 2012-02-13 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
UA80275C2 (en) 2002-03-22 2007-09-10 Applied Research Systems Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases (variants)
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
ES2429443T3 (es) * 2004-04-19 2013-11-14 Strategic Science & Technologies, Llc Suministro transdérmico de sustancias beneficiosas efectuado mediante un entorno de fuerza iónica elevada
ES2370417T3 (es) 2005-06-03 2011-12-15 Ares Trading S.A. Producción de una proteína de unión a il-18 recombinante.
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
EP2445493A1 (en) 2009-06-24 2012-05-02 Strategic Science & Technologies, LLC Topical composition containing naproxen
MX337166B (es) 2009-06-24 2016-02-15 Composicion topica que contiene ibuoprofeno.
AU2010292486B2 (en) 2009-08-27 2014-08-07 Biomet Biologics, Llc Implantable device for production of interleukin-1 receptor antagonist
MX2012003770A (es) 2009-09-30 2012-08-03 Harvard College Metodos para la modulacion de autofagia a traves de la modulacion de productos de genes que aumentan la autofagia.
RU2013110874A (ru) 2010-08-25 2014-09-27 Ф.Хоффманн-Ля Рош Аг Антитела против il-18r1 и их применения
EP2658551B1 (en) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
WO2012092523A1 (en) 2010-12-29 2012-07-05 Strategic Science & Technologies, Llc Systems and methods for treatment of allergies and other indications
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
US9895418B2 (en) * 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
EP3074507B1 (en) 2013-11-26 2022-01-05 Biomet Biologics, LLC Methods of mediating macrophage phenotypes
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions
CA2972689A1 (en) * 2015-03-05 2016-09-09 Ab2 Bio Sa Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
US9763800B2 (en) 2015-03-18 2017-09-19 Biomet C. V. Implant configured for hammertoe and small bone fixation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) * 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18 BINDING PROTEIN
CA2324168A1 (en) * 1999-11-16 2001-05-16 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
KR100798545B1 (ko) * 2000-05-05 2008-01-28 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 죽상경화증의 치료 또는 예방을 위한 ｉｌ-18 저해물질의용도
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
UA80275C2 (en) 2002-03-22 2007-09-10 Applied Research Systems Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases (variants)

Also Published As

Publication number Publication date
HRP20040758B1 (hr) 2012-10-31
WO2003080104A2 (en) 2003-10-02
US9566313B2 (en) 2017-02-14
UA80275C2 (en) 2007-09-10
BR0308663A (pt) 2005-01-25
IL164211A0 (en) 2005-12-18
PL372398A1 (en) 2005-07-25
RS81504A (en) 2006-12-15
NO336226B1 (no) 2015-06-22
AR039103A1 (es) 2005-02-09
WO2003080104A3 (en) 2004-03-04
IL164211A (en) 2011-07-31
AU2003219162B2 (en) 2008-01-03
US20060233799A1 (en) 2006-10-19
AU2003219162A1 (en) 2003-10-08
JP4885424B2 (ja) 2012-02-29
CN1655845A (zh) 2005-08-17
CY1108748T1 (el) 2014-04-09
EA008495B1 (ru) 2007-06-29
ME00548B (me) 2011-10-10
BRPI0308663B1 (pt) 2019-07-16
US9592267B2 (en) 2017-03-14
PL207303B1 (pl) 2010-11-30
HRP20040758A2 (en) 2005-02-28
ES2314191T3 (es) 2009-03-16
KR20050004809A (ko) 2005-01-12
EP1487541B1 (en) 2008-11-19
SI1487541T1 (sl) 2009-02-28
CN100540058C (zh) 2009-09-16
DE60324777D1 (de) 2009-01-02
CA2478855C (en) 2013-12-17
ZA200407022B (en) 2006-06-28
MXPA04009135A (es) 2004-12-07
NO20044459L (no) 2004-10-20
US20100291028A1 (en) 2010-11-18
CA2478855A1 (en) 2003-10-02
JP2005520852A (ja) 2005-07-14
ATE414556T1 (de) 2008-12-15
RS51755B (en) 2011-12-31
DK1487541T3 (da) 2009-01-19
HK1075422A1 (en) 2005-12-16
PT1487541E (pt) 2008-12-10
EP1487541A2 (en) 2004-12-22
BRPI0308663B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
EA200401240A1 (ru) Применение ингибиторов il-18 для лечения и/или профилактики заболеваний периферических сосудов
DE60236413D1 (de) Inhibitoren von hmgb1 zur behandlung von gewebekrankheiten
EA200300953A1 (ru) Терапевтические комбинации для применения при сердечно-сосудистых и воспалительных заболеваниях
EA200401183A1 (ru) Применение ингибиторов il-18 в качестве диагностического маркера
IN2005KO00312A (ru)
EA200301253A1 (ru) Применение остеопонтина для лечения и/или профилактики неврологических заболеваний
HUP0401501A2 (hu) Érrendszeri gyulladás kezelése vagy megelőzése szterin-felszívódást gátló anyagokat tartalmazó gyógyszerkészítmények alkalmazásával
ATE323490T1 (de) Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung
EA200300844A1 (ru) Использование ингибиторов il-18 для лечения и/или профилактики заболевания сердца
DE60309887D1 (de) Kombination von einem aromatasehemmer mit einem bisphosphonat
ATE550039T1 (de) Mittel zur behandlung von glomerulären erkrankungen
WO2001070233A3 (en) Apoptosis inhibiting composition comprising a 15-keto-prostaglandin or derivative thereof
SE0004827D0 (sv) Therapeutic compounds
TNSN05154A1 (en) Use of levocetirizine for the treatment of persistent allergic rhinitis
DE60330233D1 (de) Arsentherapie zur behandlung von autoimmunerkrankungen
EA200400296A1 (ru) Применение ингибиторов il-18 при расстройствах в виде гиперчувствительности
DE60305018D1 (de) Citalopram zur behandlung von bluthochdruck
ATE288254T1 (de) Methode zur behandlung von schlaganfall
WO2002089732A3 (en) Therapeutic compisitions and methods for the inhibition of angiogenesis
ECSP993018A (es) Nuevos inhibidores de proteasas, particularmente inhibidores de cisteina y serina proteasas
MXPA04005310A (es) Inhibidores de fosfolipasa a2 citosolica.
DE60118924D1 (de) Verwendung des riluzols oder dessen salzen zur phophylaxe und behandlung der adrenoleukodystrophie

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM