ATE323490T1 - Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung - Google Patents
Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankungInfo
- Publication number
- ATE323490T1 ATE323490T1 AT01998349T AT01998349T ATE323490T1 AT E323490 T1 ATE323490 T1 AT E323490T1 AT 01998349 T AT01998349 T AT 01998349T AT 01998349 T AT01998349 T AT 01998349T AT E323490 T1 ATE323490 T1 AT E323490T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- inhibitors
- transfera
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 2
- JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25334600P | 2000-11-28 | 2000-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323490T1 true ATE323490T1 (de) | 2006-05-15 |
Family
ID=22959893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01998349T ATE323490T1 (de) | 2000-11-28 | 2001-11-20 | Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040044032A1 (de) |
| EP (1) | EP1339407B1 (de) |
| JP (1) | JP4231691B2 (de) |
| AT (1) | ATE323490T1 (de) |
| AU (1) | AU2002218311A1 (de) |
| CY (1) | CY1106122T1 (de) |
| DE (1) | DE60118953T2 (de) |
| DK (1) | DK1339407T3 (de) |
| ES (1) | ES2261523T3 (de) |
| PT (1) | PT1339407E (de) |
| WO (1) | WO2002043733A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516258A (ja) | 2003-12-12 | 2007-06-21 | ワイス | 心臓血管の疾患治療に有用なキノリン誘導体 |
| WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| CA2559285A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20050288298A1 (en) * | 2004-03-18 | 2005-12-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| CA2559221A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| PT1815247E (pt) | 2004-11-05 | 2013-04-23 | Janssen Pharmaceutica Nv | Uso terapêutico de inibidores de farnesiltransferase e métodos para monitorizar a eficácia do mesmo |
| AU2006331542A1 (en) | 2005-12-23 | 2007-07-05 | Link Medicine Corporation | Treatment of synucleinopathies |
| WO2009151683A2 (en) * | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| AU2009313927A1 (en) * | 2008-11-13 | 2010-05-20 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| HK1213887A1 (zh) | 2012-10-16 | 2016-07-15 | Janssen Pharmaceutica N.V. | RORγt的苯基连接的喹啉基调节剂 |
| WO2014062655A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt |
| MY189505A (en) | 2012-10-16 | 2022-02-16 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of roryt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| CA2926339A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of roryt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| CA2927182A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Quinolinyl modulators of ror.gamma.t |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US10471055B2 (en) | 2015-08-17 | 2019-11-12 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| HRP20210544T1 (hr) | 2016-11-03 | 2021-08-20 | Kura Oncology, Inc. | Inhibitori farneziltransferaze za uporabu u liječenju raka |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2146126A1 (en) * | 1992-10-07 | 1994-04-14 | Sumitomo Pharmaceuticals Company, Limited | Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor |
| US5470832A (en) * | 1994-01-31 | 1995-11-28 | Merck & Co., Inc. | Inhibitors of geranylgeranyl-protein transferase |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| TW316902B (de) * | 1994-12-28 | 1997-10-01 | Janssen Pharmaceutica Nv | |
| TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| DE69635966T2 (de) * | 1995-12-08 | 2006-11-30 | Janssen Pharmaceutica N.V. | (Imidazol-5-yl)Methyl-2-Chinolinonderivate als Farnesyl Protein transferase Inhibitoren |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US5929077A (en) * | 1996-11-08 | 1999-07-27 | Leftheris; Katerina | Thioproline-containing inhibitors of farnesyl protein transferase |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| GB2323783A (en) * | 1997-04-02 | 1998-10-07 | Ferring Bv Group Holdings | Inhibitors of farnesyl protein transferase |
| SK146199A3 (en) * | 1997-04-25 | 2000-06-12 | Janssen Pharmaceutica Nv | Farnesyltransferase inhibiting quinazolinones |
| TW527355B (en) * | 1997-07-02 | 2003-04-11 | Bristol Myers Squibb Co | Inhibitors of farnesyl protein transferase |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| PT1140935E (pt) * | 1998-12-23 | 2003-10-31 | Janssen Pharmaceutica Nv | Derivados da quinolina 1,2-ciclizada |
-
2001
- 2001-11-20 AT AT01998349T patent/ATE323490T1/de active
- 2001-11-20 ES ES01998349T patent/ES2261523T3/es not_active Expired - Lifetime
- 2001-11-20 EP EP01998349A patent/EP1339407B1/de not_active Expired - Lifetime
- 2001-11-20 US US10/433,243 patent/US20040044032A1/en not_active Abandoned
- 2001-11-20 JP JP2002545703A patent/JP4231691B2/ja not_active Expired - Lifetime
- 2001-11-20 DE DE60118953T patent/DE60118953T2/de not_active Expired - Lifetime
- 2001-11-20 WO PCT/EP2001/013540 patent/WO2002043733A1/en not_active Ceased
- 2001-11-20 AU AU2002218311A patent/AU2002218311A1/en not_active Abandoned
- 2001-11-20 DK DK01998349T patent/DK1339407T3/da active
- 2001-11-20 PT PT01998349T patent/PT1339407E/pt unknown
-
2006
- 2006-07-18 CY CY20061100996T patent/CY1106122T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004514695A (ja) | 2004-05-20 |
| CY1106122T1 (el) | 2011-06-08 |
| PT1339407E (pt) | 2006-08-31 |
| US20040044032A1 (en) | 2004-03-04 |
| WO2002043733A1 (en) | 2002-06-06 |
| AU2002218311A1 (en) | 2002-06-11 |
| DK1339407T3 (da) | 2006-08-14 |
| DE60118953T2 (de) | 2007-01-11 |
| ES2261523T3 (es) | 2006-11-16 |
| EP1339407B1 (de) | 2006-04-19 |
| EP1339407A1 (de) | 2003-09-03 |
| DE60118953D1 (de) | 2006-05-24 |
| JP4231691B2 (ja) | 2009-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60118953D1 (de) | Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung | |
| CY1105477T1 (el) | Αναστολεις τρανσφepασης φαρνεσυλ πρωτεϊνης για τη θepαπευτικη αντιμετωπιση του καρκινου του μαστου | |
| DE60124302D1 (de) | Thiazolderivate zur behandlung von ppar-lierte krankheiten | |
| DE60123238D1 (de) | Zusammensetzungen zur behandlung von autoimmunkrankheiten | |
| ATE345331T1 (de) | Verbindungen verwendbar für die behandlung von entzündungskrankheiten | |
| ATE390407T1 (de) | Phenethanolamin-derivate zur behandlung von atemwegserkrankungen | |
| ATE417606T1 (de) | Phenethanolamin-derivate zur behandlung von erkrankungen der atemwege | |
| HRP20040758B1 (hr) | Uporaba il-18 inhibitora za lijeäśenje i/ili prevenciju perifernih krvožilnih bolesti | |
| ATE384522T1 (de) | Medikamente zur chemotherapeutischen behandlung von erkrankungen | |
| ATE338036T1 (de) | Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate | |
| DE602004016729D1 (de) | 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen | |
| DE50013843D1 (de) | Arzneimittel zur behandlung von darmerkrankungen | |
| DE60236743D1 (de) | Zur behandlung androgenabhängiger krankheiten | |
| ATE522218T1 (de) | Dosierungseinheit enthaltend prostaglandin-analog zur behandlung von darmverstopfung | |
| TNSN06138A1 (fr) | Inhibitors of the mutant form of kit | |
| ATE290384T1 (de) | Etherlysophospholipide zur behandlung von chronischen entzündlichen erkrankungen | |
| EP1594435A4 (de) | Hemmung der hiv-1-replikation durch störung der verarbeitung des viralen capsid-spacer peptid 1 proteins | |
| DE60042161D1 (de) | Ppar delta-inhibitoren zur behandlung kardiovasculärer erkrankungen | |
| DE60120990D1 (de) | Verwendung von 3-bezoylphenylessigsäure-derivaten zur behandlung von netzhauterkrankungen | |
| ATE374197T1 (de) | Indolderivate zur behandlung von erkrankungen des zentralnervensystems | |
| ATE536874T1 (de) | Dreifache monoamin-wiederaufnahmehemmer zur behandlung von chronischen schmerzen | |
| ATE330938T1 (de) | Disulfid-derivate verwendbar zur behandlung von allergischen erkrankungen | |
| ATE267194T1 (de) | Medikamente geeignet zur behandlung von proliferativen erkrankungen | |
| ATE272619T1 (de) | Anilin-disulfid-derivate zur behandlung allergischer erkrankungen | |
| DE60220825D1 (de) | Verwendung von norepinephrinwiederaufnahmehemmern zur behandlung von ticks |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1339407 Country of ref document: EP |