DE60042161D1 - Ppar delta-inhibitoren zur behandlung kardiovasculärer erkrankungen - Google Patents
Ppar delta-inhibitoren zur behandlung kardiovasculärer erkrankungenInfo
- Publication number
- DE60042161D1 DE60042161D1 DE60042161T DE60042161T DE60042161D1 DE 60042161 D1 DE60042161 D1 DE 60042161D1 DE 60042161 T DE60042161 T DE 60042161T DE 60042161 T DE60042161 T DE 60042161T DE 60042161 D1 DE60042161 D1 DE 60042161D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- cardiovascular diseases
- ppar delta
- delta inhibitors
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5055—Cells of the immune system involving macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9917405.4A GB9917405D0 (en) | 1999-07-23 | 1999-07-23 | Methods of treatment and drug screening methods |
PCT/EP2000/006986 WO2001007066A2 (en) | 1999-07-23 | 2000-07-19 | Ppar delta inhibitors for the treatment of cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60042161D1 true DE60042161D1 (de) | 2009-06-18 |
Family
ID=10857874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60042161T Expired - Lifetime DE60042161D1 (de) | 1999-07-23 | 2000-07-19 | Ppar delta-inhibitoren zur behandlung kardiovasculärer erkrankungen |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1200114B1 (de) |
JP (1) | JP2003505058A (de) |
KR (1) | KR20020012323A (de) |
CN (1) | CN1364087A (de) |
AR (1) | AR027832A1 (de) |
AT (1) | ATE430577T1 (de) |
AU (1) | AU6825900A (de) |
BR (1) | BR0012661A (de) |
CA (1) | CA2378462A1 (de) |
CO (1) | CO5280202A1 (de) |
CY (1) | CY1109255T1 (de) |
CZ (1) | CZ2002247A3 (de) |
DE (1) | DE60042161D1 (de) |
DK (1) | DK1200114T3 (de) |
ES (1) | ES2326785T3 (de) |
GB (1) | GB9917405D0 (de) |
HK (1) | HK1046094B (de) |
HU (1) | HUP0201966A3 (de) |
IL (1) | IL147363A0 (de) |
MX (1) | MXPA02000880A (de) |
MY (1) | MY140626A (de) |
NO (1) | NO20020326L (de) |
NZ (1) | NZ573856A (de) |
PL (1) | PL205747B1 (de) |
PT (1) | PT1200114E (de) |
SI (1) | SI1200114T1 (de) |
TR (2) | TR200501763T1 (de) |
WO (1) | WO2001007066A2 (de) |
ZA (1) | ZA200200542B (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6677298B2 (en) | 2000-07-20 | 2004-01-13 | Bristol-Myers Squibb Company | Regulators of PPARδ (β) and their use in the treatment of obesity and insulin resistance |
AU2002243778A1 (en) * | 2001-02-02 | 2002-09-19 | Smithkline Beecham Corporation | Treatment of ppar mediated diseases |
GB0103809D0 (en) | 2001-02-16 | 2001-04-04 | Univ Dundee | Methods |
AU2003220521A1 (en) * | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Methods of treatment with lxr modulators |
GB0302446D0 (en) * | 2003-02-03 | 2003-03-05 | Imp College Innovations Ltd | Screening for modulators of fat storage |
JPWO2004093910A1 (ja) * | 2003-04-22 | 2006-07-13 | アステラス製薬株式会社 | PPARδアゴニストによる脳神経変性疾患治療剤 |
EP1804813A4 (de) * | 2004-09-27 | 2011-09-07 | Vical Inc | Formulierungen und verfahren zur behandlung von entzündlichen erkrankungen |
DE102006033394A1 (de) * | 2006-07-13 | 2008-01-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Verfahren zum Auffinden von antiatherosklerotischen Substanzen |
US8236831B2 (en) * | 2007-01-08 | 2012-08-07 | Seoul National University Industry Foundation | Thiazole compound (as PPARδ) ligand and pharmaceutical, cosmetic and health food comprised thereof |
CN112168820B (zh) * | 2019-07-05 | 2023-09-29 | 中国科学院生物物理研究所 | SRCAP ATPase抑制剂在结直肠癌治疗中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5157025A (en) * | 1991-04-01 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug |
US5939442A (en) * | 1995-06-07 | 1999-08-17 | The Salk Institute For Biological Studies | Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof |
AU1856997A (en) * | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
WO1998008836A1 (fr) * | 1996-08-27 | 1998-03-05 | Shionogi & Co., Ltd. | Derives de chromene-3-carboxylate |
EP1410799B1 (de) * | 1996-12-11 | 2010-03-31 | Dana-Farber Cancer Institute, Inc. | Methoden und pharmazeutische Zusammensetzungen zur Inhibition des Tumorwachstums |
AU6773598A (en) * | 1997-03-26 | 1998-10-20 | Institut Pasteur | Treatment of gastrointestinal disease with ppar modulators |
WO1999000491A1 (fr) * | 1997-06-27 | 1999-01-07 | Ono Pharmaceutical Co., Ltd. | Nouvel adn plasmidique contenant de l'adn de gene reporter et utilisation associee |
JP4427825B2 (ja) * | 1997-07-24 | 2010-03-10 | アステラス製薬株式会社 | コレステロール低下作用を有する医薬組成物 |
US6191154B1 (en) * | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
-
1999
- 1999-07-23 GB GBGB9917405.4A patent/GB9917405D0/en not_active Ceased
-
2000
- 2000-07-19 IL IL14736300A patent/IL147363A0/xx unknown
- 2000-07-19 NZ NZ573856A patent/NZ573856A/en unknown
- 2000-07-19 MX MXPA02000880A patent/MXPA02000880A/es unknown
- 2000-07-19 ES ES00956238T patent/ES2326785T3/es not_active Expired - Lifetime
- 2000-07-19 DK DK00956238T patent/DK1200114T3/da active
- 2000-07-19 PT PT00956238T patent/PT1200114E/pt unknown
- 2000-07-19 TR TR2005/01763T patent/TR200501763T1/xx unknown
- 2000-07-19 KR KR1020027000942A patent/KR20020012323A/ko not_active Application Discontinuation
- 2000-07-19 HU HU0201966A patent/HUP0201966A3/hu not_active Application Discontinuation
- 2000-07-19 EP EP00956238A patent/EP1200114B1/de not_active Expired - Lifetime
- 2000-07-19 AU AU68259/00A patent/AU6825900A/en not_active Abandoned
- 2000-07-19 SI SI200031033T patent/SI1200114T1/sl unknown
- 2000-07-19 AT AT00956238T patent/ATE430577T1/de active
- 2000-07-19 DE DE60042161T patent/DE60042161D1/de not_active Expired - Lifetime
- 2000-07-19 CZ CZ2002247A patent/CZ2002247A3/cs unknown
- 2000-07-19 JP JP2001511949A patent/JP2003505058A/ja active Pending
- 2000-07-19 CN CN00810779A patent/CN1364087A/zh active Pending
- 2000-07-19 PL PL364749A patent/PL205747B1/pl not_active IP Right Cessation
- 2000-07-19 WO PCT/EP2000/006986 patent/WO2001007066A2/en not_active Application Discontinuation
- 2000-07-19 BR BR0012661-6A patent/BR0012661A/pt not_active Application Discontinuation
- 2000-07-19 TR TR2002/00211T patent/TR200200211T2/xx unknown
- 2000-07-19 CA CA002378462A patent/CA2378462A1/en not_active Abandoned
- 2000-07-21 CO CO00054777A patent/CO5280202A1/es not_active Application Discontinuation
- 2000-07-21 MY MYPI20003340A patent/MY140626A/en unknown
- 2000-07-21 AR ARP000103776A patent/AR027832A1/es unknown
-
2002
- 2002-01-22 NO NO20020326A patent/NO20020326L/no not_active Application Discontinuation
- 2002-01-22 ZA ZA200200542A patent/ZA200200542B/en unknown
- 2002-10-22 HK HK02107665.7A patent/HK1046094B/zh not_active IP Right Cessation
-
2009
- 2009-07-15 CY CY20091100754T patent/CY1109255T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |