NO178789C - Fremgangsmåte for fremstilling av gamma-interferonpolypeptid med forbedret stabilitet, ekspresjonsvektor samt DNA-sekvens kodende for polypeptidene - Google Patents
Fremgangsmåte for fremstilling av gamma-interferonpolypeptid med forbedret stabilitet, ekspresjonsvektor samt DNA-sekvens kodende for polypeptideneInfo
- Publication number
- NO178789C NO178789C NO845042A NO845042A NO178789C NO 178789 C NO178789 C NO 178789C NO 845042 A NO845042 A NO 845042A NO 845042 A NO845042 A NO 845042A NO 178789 C NO178789 C NO 178789C
- Authority
- NO
- Norway
- Prior art keywords
- polypeptides
- preparation
- expression vector
- sequence encoding
- dna sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56200983A | 1983-12-16 | 1983-12-16 | |
US06/584,217 US4855238A (en) | 1983-12-16 | 1984-02-27 | Recombinant gamma interferons having enhanced stability and methods therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
NO845042L NO845042L (no) | 1985-06-17 |
NO178789B NO178789B (no) | 1996-02-26 |
NO178789C true NO178789C (no) | 1996-06-05 |
Family
ID=27072811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO845042A NO178789C (no) | 1983-12-16 | 1984-12-14 | Fremgangsmåte for fremstilling av gamma-interferonpolypeptid med forbedret stabilitet, ekspresjonsvektor samt DNA-sekvens kodende for polypeptidene |
Country Status (23)
Country | Link |
---|---|
US (4) | US4855238A (no) |
EP (1) | EP0146354B2 (no) |
JP (6) | JPH0789935B2 (no) |
KR (1) | KR940008978B1 (no) |
AT (1) | ATE135405T1 (no) |
AU (1) | AU597872B2 (no) |
CA (1) | CA1341573C (no) |
CY (1) | CY1945A (no) |
DE (1) | DE3486424T3 (no) |
DK (1) | DK166832B1 (no) |
ES (1) | ES8801553A1 (no) |
FI (1) | FI91884C (no) |
GR (1) | GR82468B (no) |
HK (1) | HK175996A (no) |
HU (1) | HU202278B (no) |
IE (1) | IE72494B1 (no) |
IL (1) | IL73803A (no) |
LV (1) | LV11633B (no) |
MY (1) | MY102899A (no) |
NO (1) | NO178789C (no) |
OA (1) | OA07902A (no) |
PH (1) | PH24790A (no) |
PT (1) | PT79691A (no) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
GB8406910D0 (en) * | 1984-03-16 | 1984-04-18 | Biogen Nv | Gamma interferon |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
ZA846554B (en) * | 1983-09-20 | 1985-04-24 | Hoffmann La Roche | Immune interferon and method for its purification |
MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
JPS60172999A (ja) * | 1983-12-20 | 1985-09-06 | Suntory Ltd | 新規な塩基性ポリペプチドおよびその製造法 |
US4758656A (en) * | 1983-12-26 | 1988-07-19 | Kyowa Hakko Kogyo Co., Ltd. | Novel human interferon-gamma polypeptide derivative |
DE3582542D1 (de) * | 1984-03-16 | 1991-05-23 | Biogen Nv | Verfahren zur expressionsverbesserung und mittel hierfuer. |
DE3414831A1 (de) * | 1984-04-19 | 1985-10-31 | Hoechst Ag, 6230 Frankfurt | Herstellung von polypeptiden mit human-gammainterferon-aktivitaet |
IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
CA1302320C (en) * | 1984-06-11 | 1992-06-02 | Hideo Niwa | Expression of human cromosomal interferon-_ in animal cells |
JPS61108397A (ja) * | 1984-10-31 | 1986-05-27 | Green Cross Corp:The | インタ−フエロン−γ蛋白質の製造法 |
JPS6156195A (ja) * | 1985-03-01 | 1986-03-20 | Asahi Chem Ind Co Ltd | 新規生理活性ペプチド |
US4873312A (en) * | 1985-04-25 | 1989-10-10 | Amgen | Method for purifying interferon and composition of matter produced thereby |
EP0200417B1 (en) * | 1985-04-30 | 1992-10-21 | Takeda Chemical Industries, Ltd. | Production of protein |
DE3532134A1 (de) * | 1985-09-10 | 1987-03-12 | Basf Ag | Verfahren zur herstellung von proteinen bestimmter n-terminaler struktur mit hilfe von prokaryonten |
DE3536939A1 (de) * | 1985-10-17 | 1987-04-23 | Hoechst Ag | Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten |
DE3751664T2 (de) * | 1986-08-01 | 1996-06-05 | Commw Scient Ind Res Org | Rekombinanter impfstoff |
GB8619725D0 (en) * | 1986-08-13 | 1986-09-24 | Hoffmann La Roche | Homogenous interferon fragments |
US5157004A (en) * | 1986-12-27 | 1992-10-20 | Takeda Chemical Industries, Ltd. | Polypeptides and production thereof |
JP2653061B2 (ja) * | 1986-12-27 | 1997-09-10 | 武田薬品工業株式会社 | 新規ポリペプチドおよびその製造法 |
DE3730331A1 (de) * | 1987-09-10 | 1989-03-30 | Basf Ag | Neue polypeptide, verfahren zur herstellung, die vektoren dafuer und arzneimittel daraus |
AT393690B (de) * | 1987-10-08 | 1991-11-25 | Hoffmann La Roche | Homogene, rekombinante immun-interferonfragmente |
US5151265A (en) * | 1987-11-03 | 1992-09-29 | Genentech, Inc. | Gamma interferon formulation |
EP0355460B1 (en) * | 1988-08-24 | 2000-12-27 | American Cyanamid Company | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization |
US5198212A (en) * | 1988-10-31 | 1993-03-30 | University Of Lousville Research Foundation Incorporated | Method and compositions for treatment of trauma-associated sepsis with gamma interferon |
US6068994A (en) * | 1989-08-07 | 2000-05-30 | Chiron Corporation | Ubiquitin expression system |
BG52073B2 (en) * | 1990-01-24 | 1996-04-30 | Inst Molekuljarna Biolog | Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine |
CA2090478A1 (en) * | 1990-08-31 | 1992-03-01 | Satwant K. Narula | Human interferon- 4-134, functional equivalents thereof and methods of using and compositions employing these materials |
DE4036856C1 (no) * | 1990-11-19 | 1992-05-27 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
US5227158A (en) * | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
US5328989A (en) * | 1993-03-05 | 1994-07-12 | Schering-Plough | Purification of human interleukin-10 from a cell culture medium |
AU7116394A (en) * | 1993-07-01 | 1995-01-24 | Merck & Co., Inc. | Culture medium for recombinant yeasts |
TW249202B (no) * | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
ES2297889T3 (es) | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
US7153943B2 (en) * | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
JP5030329B2 (ja) | 1998-04-02 | 2012-09-19 | ジェネンテック, インコーポレイテッド | 心臓肥大の処置 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
RU2140285C1 (ru) * | 1999-01-25 | 1999-10-27 | Гапонюк Петр Яковлевич | Противовирусное средство - капли в нос "гриппферон" |
US6475796B1 (en) * | 1999-05-20 | 2002-11-05 | Scios, Inc. | Vascular endothelial growth factor variants |
AU5026100A (en) * | 1999-05-20 | 2000-12-12 | Scios Inc. | Vascular endothelial growth factor dimers |
YU32402A (sh) | 1999-11-12 | 2005-03-15 | Maxygen Holdings Ltd. | Konjugati gama interferona |
PL356007A1 (en) * | 1999-11-12 | 2004-05-31 | Maxygen Holdings Ltd | Interferon gamma conjugates |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2408851C (en) * | 2000-05-16 | 2011-07-12 | Bolder Biotechnology, Inc. | Methods for refolding proteins containing free cysteine residues |
IL155730A0 (en) * | 2000-11-03 | 2003-11-23 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
EP1351707B9 (en) * | 2001-01-09 | 2012-01-25 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
US7038015B2 (en) * | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
IL161630A0 (en) * | 2001-11-06 | 2004-09-27 | Applied Research Systems | Methods of treating endometreosis |
IL161762A0 (en) * | 2001-11-06 | 2005-11-20 | Applied Research Systems | Estradiol inhibiting agents in breast cancer |
NZ532779A (en) * | 2001-11-09 | 2008-04-30 | Intarcia Therapeutics Inc | Method for treating diseases with omega interferon |
US20050095224A1 (en) * | 2001-12-07 | 2005-05-05 | Ramachandran Radhakrishnan | Compositions and method for treating hepatitis virus infection |
EP2990417A1 (en) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin insulin fusion protein |
WO2004005341A2 (en) * | 2002-07-03 | 2004-01-15 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
US20070092488A1 (en) * | 2003-05-16 | 2007-04-26 | Intermune Inc. | Methods of treating idiopathic pulmonary fibrosis |
CN102020697B (zh) | 2003-10-14 | 2014-10-29 | F·霍夫曼-罗须公司 | 作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺 |
US7407973B2 (en) * | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
MXPA06008507A (es) | 2004-02-02 | 2008-02-13 | Ambrx Inc | Cuatro polipeptidos en haz helicoidal humanos modificados y sus usos. |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
JP2006141263A (ja) * | 2004-11-18 | 2006-06-08 | Kyoto Univ | (r)−ヒドロキシニトリルリアーゼの製造方法 |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
CA2607806A1 (en) * | 2005-05-04 | 2006-11-16 | Nautilus Biotech, S.A. | Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides |
MX2008014870A (es) | 2006-05-30 | 2009-02-12 | Intarcia Therapeutics Inc | Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas. |
KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
EP2486938B1 (en) | 2006-09-26 | 2018-05-09 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
US8617531B2 (en) * | 2006-12-14 | 2013-12-31 | Bolder Biotechnology, Inc. | Methods of making proteins and peptides containing a single free cysteine |
CN101715340A (zh) | 2007-04-23 | 2010-05-26 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
US8114630B2 (en) | 2007-05-02 | 2012-02-14 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
JP5702150B2 (ja) | 2008-02-08 | 2015-04-15 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾されているレプチンポリペプチドおよびそれらの使用 |
WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US8243103B2 (en) * | 2009-05-29 | 2012-08-14 | Exelis, Inc. | Laser aiming spot distinguishing methods and apparatus |
CA2764374C (en) * | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
PT2462246T (pt) | 2009-09-28 | 2017-12-11 | Intarcia Therapeutics Inc | Estabelecimento rápido e/ou terminação de entrega de fármaco em estado estável substancial |
KR101858598B1 (ko) * | 2010-02-01 | 2018-05-16 | 디그나 비오테크, 에스.엘. | 인터페론 알파 5의 제조방법 |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
JP6054942B2 (ja) | 2011-04-08 | 2016-12-27 | イミューン デザイン コーポレイション | 免疫原性組成物、ならびに体液性および細胞性免疫応答を誘発するための該組成物の使用方法 |
WO2013024156A2 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection |
WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
DK2811981T3 (da) | 2012-02-07 | 2019-06-11 | Infectious Disease Res Inst | Forbedrede adjuvansformuleringer, der omfatter tlr4-agonister, og fremgangsmåder til anvendelse heraf |
JP6619648B2 (ja) | 2012-05-16 | 2019-12-11 | イミューン デザイン コーポレイション | Hsv−2のためのワクチン |
WO2014033266A1 (en) | 2012-08-31 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection |
CN105209047B (zh) | 2013-04-18 | 2020-08-18 | 免疫设计股份有限公司 | 用于癌症治疗的gla单一疗法 |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
ES2968262T3 (es) | 2015-06-03 | 2024-05-08 | I2O Therapeutics Inc | Sistemas de colocación de implantes |
HUE059605T2 (hu) | 2016-05-16 | 2022-11-28 | Access To Advanced Health Inst | TLR agonista tartalmú készítmény és használati eljárások |
AU2017268161B2 (en) | 2016-05-16 | 2020-03-12 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
MX2018014399A (es) | 2016-06-01 | 2019-06-06 | Infectious Disease Res Inst | Particulas de nanoalumbre que contienen un agente de dimensionamiento. |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
EP3529264B1 (en) | 2016-10-24 | 2022-03-09 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
IL267736B2 (en) | 2017-01-03 | 2024-03-01 | Intarcia Therapeutics Inc | Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
EP3672488A4 (en) | 2017-08-23 | 2021-07-14 | Wayne State University | IN VIVO IMMUNOIMAGING OF INTERFERON GAMMA |
CN111315406A (zh) | 2017-09-08 | 2020-06-19 | 传染病研究所 | 包括皂苷的脂质体调配物及其使用方法 |
IL296520A (en) | 2020-03-19 | 2022-11-01 | Trizell Ltd | A virus storage system that responds to temperature |
WO2021198777A1 (en) | 2020-03-30 | 2021-10-07 | Trizell Ltd. | Compositions and methods for treating cancer |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7404589A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het stabiliseren van interferon. |
NL7404590A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het reactiveren van interferon. |
US4332892A (en) * | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
JPS5598118A (en) * | 1979-01-18 | 1980-07-25 | Hayashibara Takeshi | Preparation of type-2 interferon and drug containing the same |
AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
GB2068970B (en) * | 1980-02-06 | 1983-06-22 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
DE3005897A1 (de) * | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
US4460685A (en) * | 1980-05-29 | 1984-07-17 | New York University | Method of enhancing the production of human γ Interferon |
US4341761A (en) * | 1980-07-25 | 1982-07-27 | E. I. Du Pont De Nemours And Company | Antibodies to immunogenic peptides and their use to purify human fibroblast interferon |
US4311639A (en) * | 1980-07-25 | 1982-01-19 | E. I. Du Pont De Nemours And Company | Immunogenic interferon peptides |
FI64813C (fi) * | 1980-12-31 | 1984-01-10 | Ilkka Antero Palva | Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer |
US4382027A (en) * | 1981-08-18 | 1983-05-03 | Meloy Laboratories, Inc. | Purification of human immune interferon |
IL65475A0 (en) * | 1981-04-17 | 1982-07-30 | Meloy Lab | Production of immune interferon and its mrna |
US4404188A (en) * | 1981-07-29 | 1983-09-13 | Massachusetts General Hospital | Purified Mullerian Inhibiting Substance and method of purification |
US5582824A (en) * | 1981-10-19 | 1996-12-10 | Genentech, Inc. | Recombinant DES-CYS-TYR-CYS human immune interferon |
US5096705A (en) * | 1981-10-19 | 1992-03-17 | Genentech, Inc. | Human immune interferon |
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
US4388234A (en) * | 1981-12-28 | 1983-06-14 | Hoffmann-La Roche Inc. | Peptide isolation |
EP0088540A3 (en) * | 1982-02-22 | 1984-10-17 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides |
US5004689A (en) * | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
ZA83768B (en) * | 1982-03-01 | 1983-10-26 | Hoffmann La Roche | Homogeneous human immune interferon and process therefor |
IL68100A0 (en) * | 1982-03-24 | 1983-06-15 | Takeda Chemical Industries Ltd | Novel dna and use thereof |
US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
JPH0787797B2 (ja) * | 1982-05-20 | 1995-09-27 | サントリー株式会社 | ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法 |
US4681848A (en) * | 1982-09-22 | 1987-07-21 | Takeda Chemical Industries, Ltd. | Novel peptide and use thereof |
IL69851A0 (en) * | 1982-09-30 | 1983-12-30 | Japan Found Cancer | Novel dna and recombinant plasmid containing the same |
WO1984002129A1 (en) * | 1982-11-22 | 1984-06-07 | Takeda Chemical Industries Ltd | Human immune interferon protein and process for its preparation |
US4432895A (en) * | 1982-11-24 | 1984-02-21 | Hoffmann-La Roche Inc. | Monomeric interferons |
US4485017A (en) * | 1982-12-22 | 1984-11-27 | Cetus Corporation | Isolation of human interferon by immunosorbent and high performance liquid chromatography |
JPH0740925B2 (ja) * | 1983-03-14 | 1995-05-10 | 協和醗酵工業株式会社 | 新規ヒトインタ−フエロン−γポリペプチド |
JPS59169494A (ja) * | 1983-03-17 | 1984-09-25 | Takeda Chem Ind Ltd | 新規組み換えdnaおよびその用途 |
US4599306A (en) * | 1983-04-15 | 1986-07-08 | Amgen | Monoclonal antibodies which specifically bind to human immune interferon |
DK265384A (da) * | 1983-06-01 | 1984-12-02 | Hoffmann La Roche | Polypeptider med interferonaktivitet |
IL72773A0 (en) * | 1983-08-29 | 1984-11-30 | Meloy Lab | Production of immune interferon and its mrna |
US4681930A (en) * | 1983-09-20 | 1987-07-21 | Hoffmann-La Roche Inc. | Immune interferon and a method for its extraction and purification |
US4604284A (en) * | 1983-09-20 | 1986-08-05 | Hoffmann-La Roche Inc. | Homogeneous immune interferon fragment |
US4476049A (en) * | 1983-09-20 | 1984-10-09 | Hoffmann-La Roche Inc. | Method for the extraction of immune interferon |
JPS6079000A (ja) * | 1983-10-04 | 1985-05-04 | Takeda Chem Ind Ltd | ヒトγ型インタ−フエロン単量体の製造法 |
JPH0788398B2 (ja) * | 1983-10-17 | 1995-09-27 | サントリー株式会社 | 新規生理活性ポリペプチドおよびその製造法 |
JPS60118196A (ja) * | 1983-11-30 | 1985-06-25 | Takeda Chem Ind Ltd | インタ−フェロンの製造法 |
FR2556365B1 (fr) * | 1983-12-09 | 1987-07-31 | Transgene Sa | Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
JP2653061B2 (ja) | 1986-12-27 | 1997-09-10 | 武田薬品工業株式会社 | 新規ポリペプチドおよびその製造法 |
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1984
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- 1984-12-14 NO NO845042A patent/NO178789C/no not_active IP Right Cessation
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- 1984-12-14 DE DE3486424T patent/DE3486424T3/de not_active Expired - Lifetime
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- 1984-12-14 DK DK600984A patent/DK166832B1/da not_active IP Right Cessation
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1987
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1990
- 1990-09-10 JP JP2239776A patent/JPH0794477B2/ja not_active Expired - Lifetime
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1994
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1995
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