DE68929273T2 - Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung - Google Patents
Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische DerivatisierungInfo
- Publication number
- DE68929273T2 DE68929273T2 DE68929273T DE68929273T DE68929273T2 DE 68929273 T2 DE68929273 T2 DE 68929273T2 DE 68929273 T DE68929273 T DE 68929273T DE 68929273 T DE68929273 T DE 68929273T DE 68929273 T2 DE68929273 T2 DE 68929273T2
- Authority
- DE
- Germany
- Prior art keywords
- somatotropins
- stabilization
- site
- modification
- cysteine residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23606088A | 1988-08-24 | 1988-08-24 | |
US37269989A | 1989-07-03 | 1989-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929273D1 DE68929273D1 (de) | 2001-02-01 |
DE68929273T2 true DE68929273T2 (de) | 2001-07-05 |
Family
ID=26929421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929273T Expired - Fee Related DE68929273T2 (de) | 1988-08-24 | 1989-07-27 | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
Country Status (18)
Country | Link |
---|---|
US (1) | US5891840A (de) |
EP (1) | EP0355460B1 (de) |
JP (1) | JP2894355B2 (de) |
AR (1) | AR245138A1 (de) |
AT (1) | ATE198353T1 (de) |
AU (1) | AU630105B2 (de) |
DE (1) | DE68929273T2 (de) |
DK (1) | DK416589A (de) |
ES (1) | ES2154627T3 (de) |
FI (1) | FI104908B (de) |
GR (1) | GR3035608T3 (de) |
HU (1) | HU217095B (de) |
IE (1) | IE892706A1 (de) |
IL (1) | IL91156A (de) |
NO (1) | NO893387L (de) |
NZ (1) | NZ230342A (de) |
PT (1) | PT91512B (de) |
YU (1) | YU163289A (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2580303B2 (ja) * | 1987-02-19 | 1997-02-12 | ジ・アップジョン・カンパニー | 異種蛋白をコ−ド付けするcDNA類、発現ベクタ−類および宿主類 |
US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
EP0458064B1 (de) * | 1990-05-04 | 1998-02-25 | American Cyanamid Company | Stabilisierung von Somatotropin durch Modifizierung von Cysteinsresten |
US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
DK168790D0 (de) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US6894023B1 (en) | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
US5310882A (en) * | 1990-11-30 | 1994-05-10 | American Cyanamid Company | Somatotropins with alterations in the α-helix 3 region |
NZ260103A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin with alterations in the alpha-helix-1 region |
GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
FR2671554A1 (fr) * | 1991-01-11 | 1992-07-17 | Clonatec Sa | Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b. |
AU654563B2 (en) * | 1991-07-24 | 1994-11-10 | Imperial Chemical Industries Plc | Proteins |
ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
EP1881005B1 (de) | 1997-07-14 | 2013-04-03 | Bolder Biotechnology, Inc. | Derivate von G-CSF und damit zusammenhängende Proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
EP1284987B1 (de) * | 2000-05-16 | 2007-07-18 | Bolder Biotechnology, Inc. | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
WO2007041614A2 (en) | 2005-10-03 | 2007-04-12 | Bolder Biotechnology, Inc. | Long acting vegf inhibitors and methods of use |
US20090269358A1 (en) | 2005-10-07 | 2009-10-29 | Shone Clifford C | Proteins with Improved Solubility and Methods for Producing and Using Same |
WO2008076933A2 (en) | 2006-12-14 | 2008-06-26 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
CA2733200A1 (en) * | 2008-08-06 | 2010-02-11 | Novo Nordisk Health Care Ag | Conjugated proteins with prolonged in vivo efficacy |
CN102292349B (zh) | 2009-01-22 | 2016-04-13 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
CN102612376A (zh) | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
CN107674121A (zh) * | 2009-12-21 | 2018-02-09 | Ambrx 公司 | 经过修饰的牛促生长素多肽和其用途 |
CN106139158A (zh) | 2010-01-22 | 2016-11-23 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
EP2525833A2 (de) | 2010-01-22 | 2012-11-28 | Novo Nordisk Health Care AG | Stabile wachstumshormonverbindungen |
PL2890394T3 (pl) | 2012-08-31 | 2019-12-31 | Glaxosmithkline Biologicals Sa | Stabilizowane białka do immunizacji przeciw staphylococcus aureus |
US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
KR20180003677A (ko) * | 2016-06-30 | 2018-01-10 | 주식회사 크레아플래닛 | 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
AU634517B2 (en) * | 1989-01-19 | 1993-02-25 | Pharmacia & Upjohn Company | Somatotropin analogs |
JP3207416B2 (ja) * | 1989-01-31 | 2001-09-10 | ファルマシア・アンド・アップジョン・カンパニー | ソマトトロピン・アナログ類 |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
-
1989
- 1989-07-27 EP EP89113852A patent/EP0355460B1/de not_active Expired - Lifetime
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
-
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
-
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI893963A0 (fi) | 1989-08-23 |
IE892706L (en) | 1990-02-24 |
PT91512A (pt) | 1990-03-08 |
HU217095B (hu) | 1999-11-29 |
EP0355460B1 (de) | 2000-12-27 |
ATE198353T1 (de) | 2001-01-15 |
HUT51331A (en) | 1990-04-28 |
ES2154627T3 (es) | 2001-04-16 |
DK416589A (da) | 1990-02-25 |
AU4020289A (en) | 1990-03-15 |
YU163289A (en) | 1992-05-28 |
FI893963A (fi) | 1990-02-25 |
JPH034797A (ja) | 1991-01-10 |
US5891840A (en) | 1999-04-06 |
IL91156A0 (en) | 1990-03-19 |
NO893387L (no) | 1990-02-26 |
DE68929273D1 (de) | 2001-02-01 |
FI104908B (fi) | 2000-04-28 |
NO893387D0 (no) | 1989-08-23 |
EP0355460A3 (de) | 1991-04-03 |
PT91512B (pt) | 1995-05-31 |
NZ230342A (en) | 1992-08-26 |
AR245138A1 (es) | 1993-12-30 |
DK416589D0 (da) | 1989-08-23 |
IE892706A1 (en) | 1991-01-16 |
AU630105B2 (en) | 1992-10-22 |
GR3035608T3 (en) | 2001-06-29 |
IL91156A (en) | 1995-05-26 |
JP2894355B2 (ja) | 1999-05-24 |
EP0355460A2 (de) | 1990-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |