AR245138A1 - Metodo para inhibir la agregacion de una somatotropina animal recombinante. - Google Patents

Metodo para inhibir la agregacion de una somatotropina animal recombinante.

Info

Publication number
AR245138A1
AR245138A1 AR89314728A AR31472889A AR245138A1 AR 245138 A1 AR245138 A1 AR 245138A1 AR 89314728 A AR89314728 A AR 89314728A AR 31472889 A AR31472889 A AR 31472889A AR 245138 A1 AR245138 A1 AR 245138A1
Authority
AR
Argentina
Prior art keywords
somatotropins
stabilization
modification
directed mutagenesis
cysteine residues
Prior art date
Application number
AR89314728A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of AR245138A1 publication Critical patent/AR245138A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AR89314728A 1988-08-24 1989-08-23 Metodo para inhibir la agregacion de una somatotropina animal recombinante. AR245138A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23606088A 1988-08-24 1988-08-24
US37269989A 1989-07-03 1989-07-03

Publications (1)

Publication Number Publication Date
AR245138A1 true AR245138A1 (es) 1993-12-30

Family

ID=26929421

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89314728A AR245138A1 (es) 1988-08-24 1989-08-23 Metodo para inhibir la agregacion de una somatotropina animal recombinante.

Country Status (18)

Country Link
US (1) US5891840A (es)
EP (1) EP0355460B1 (es)
JP (1) JP2894355B2 (es)
AR (1) AR245138A1 (es)
AT (1) ATE198353T1 (es)
AU (1) AU630105B2 (es)
DE (1) DE68929273T2 (es)
DK (1) DK416589A (es)
ES (1) ES2154627T3 (es)
FI (1) FI104908B (es)
GR (1) GR3035608T3 (es)
HU (1) HU217095B (es)
IE (1) IE892706A1 (es)
IL (1) IL91156A (es)
NO (1) NO893387L (es)
NZ (1) NZ230342A (es)
PT (1) PT91512B (es)
YU (1) YU163289A (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2580303B2 (ja) * 1987-02-19 1997-02-12 ジ・アップジョン・カンパニー 異種蛋白をコ−ド付けするｃＤＮＡ類、発現ベクタ−類および宿主類
US5089473A (en) * 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
ATE163431T1 (de) * 1990-05-04 1998-03-15 American Cyanamid Co Stabilisierung von somatotropin durch modifizierung von cysteinsresten
US5951972A (en) * 1990-05-04 1999-09-14 American Cyanamid Company Stabilization of somatotropins and other proteins by modification of cysteine residues
DK168790D0 (es) * 1990-07-13 1990-07-13 Novo Nordisk As
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals
US6894023B1 (en) 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
NZ260103A (en) * 1990-11-30 1996-10-28 Bio Technology General Corp Somatotropin with alterations in the alpha-helix-1 region
US5310882A (en) * 1990-11-30 1994-05-10 American Cyanamid Company Somatotropins with alterations in the α-helix 3 region
GB9100381D0 (en) * 1991-01-09 1991-02-20 Erba Carlo Spa Human bfgf derivatives,their analogs and process for their production
FR2671554A1 (fr) * 1991-01-11 1992-07-17 Clonatec Sa Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b.
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7306931B2 (en) 2000-05-16 2007-12-11 Bolder Biotechnology, Inc. Method for refolding proteins containing free cysteine residues
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US7270809B2 (en) 1997-07-14 2007-09-18 Bolder Biotechnology, Inc. Cysteine variants of alpha interferon-2
DE69838552T2 (de) 1997-07-14 2008-05-21 Bolder Biotechnology, Inc., Louisville Derivate des wachstumshormons und verwandte proteine
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
ES2343518T3 (es) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8329866B2 (en) 2005-10-03 2012-12-11 Bolder Biotechnology, Inc. Long acting VEGF inhibitors and methods of use
WO2007044382A2 (en) 2005-10-07 2007-04-19 Health Protection Agency Proteins with improved solubility and methods for producing and using same
EP2102355B1 (en) 2006-12-14 2016-03-02 Bolder Biotechnology, Inc. Long acting proteins and peptides and methods of making and using the same
MX2011000847A (es) * 2008-08-06 2011-02-25 Novo Nordisk Healthcare Ag Proteinas conjugadas con eficacia prolongada in vivo.
JP5816097B2 (ja) 2009-01-22 2015-11-18 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
US8841249B2 (en) 2009-08-06 2014-09-23 Novo Nordisk A/S Growth hormones with prolonged in-vivo efficacy
CN102753573A (zh) * 2009-12-21 2012-10-24 Ambrx公司 经过修饰的牛促生长素多肽和其用途
EP2525834B1 (en) 2010-01-22 2019-07-17 Novo Nordisk Health Care AG Growth hormones with prolonged in-vivo efficacy
JP5980689B2 (ja) 2010-01-22 2016-08-31 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
ES2737024T3 (es) 2012-08-31 2020-01-09 Glaxosmithkline Biologicals Sa Proteínas estabilizadas para inmunización contra Staphylococcus aureus
EP2981282B1 (en) 2013-04-05 2020-11-04 Novo Nordisk Health Care AG Growth hormone compound formulation
KR20180003677A (ko) * 2016-06-30 2018-01-10 주식회사 크레아플래닛 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4774091A (en) * 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
EP0454730A1 (en) * 1989-01-19 1991-11-06 The Upjohn Company Somatotropin analogs
WO1990008823A1 (en) * 1989-01-31 1990-08-09 The Upjohn Company Somatotropin analogs
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
NO893387D0 (no) 1989-08-23
PT91512A (pt) 1990-03-08
IL91156A0 (en) 1990-03-19
JP2894355B2 (ja) 1999-05-24
EP0355460A3 (en) 1991-04-03
NO893387L (no) 1990-02-26
ATE198353T1 (de) 2001-01-15
IE892706A1 (en) 1991-01-16
DK416589A (da) 1990-02-25
EP0355460A2 (en) 1990-02-28
ES2154627T3 (es) 2001-04-16
GR3035608T3 (en) 2001-06-29
IE892706L (en) 1990-02-24
NZ230342A (en) 1992-08-26
HU217095B (hu) 1999-11-29
FI104908B (fi) 2000-04-28
DE68929273T2 (de) 2001-07-05
DE68929273D1 (de) 2001-02-01
AU4020289A (en) 1990-03-15
PT91512B (pt) 1995-05-31
DK416589D0 (da) 1989-08-23
HUT51331A (en) 1990-04-28
AU630105B2 (en) 1992-10-22
YU163289A (en) 1992-05-28
IL91156A (en) 1995-05-26
FI893963A0 (fi) 1989-08-23
FI893963A (fi) 1990-02-25
EP0355460B1 (en) 2000-12-27
US5891840A (en) 1999-04-06
JPH034797A (ja) 1991-01-10

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