DK416589A - Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende dem - Google Patents
Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende demInfo
- Publication number
- DK416589A DK416589A DK416589A DK416589A DK416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A
- Authority
- DK
- Denmark
- Prior art keywords
- somatotropines
- aggregation
- inhibiting
- procedure
- recombinant animal
- Prior art date
Links
- 238000004220 aggregation Methods 0.000 title 1
- 230000002776 aggregation Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23606088A | 1988-08-24 | 1988-08-24 | |
US37269989A | 1989-07-03 | 1989-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK416589D0 DK416589D0 (da) | 1989-08-23 |
DK416589A true DK416589A (da) | 1990-02-25 |
Family
ID=26929421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK416589A DK416589A (da) | 1988-08-24 | 1989-08-23 | Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende dem |
Country Status (18)
Country | Link |
---|---|
US (1) | US5891840A (da) |
EP (1) | EP0355460B1 (da) |
JP (1) | JP2894355B2 (da) |
AR (1) | AR245138A1 (da) |
AT (1) | ATE198353T1 (da) |
AU (1) | AU630105B2 (da) |
DE (1) | DE68929273T2 (da) |
DK (1) | DK416589A (da) |
ES (1) | ES2154627T3 (da) |
FI (1) | FI104908B (da) |
GR (1) | GR3035608T3 (da) |
HU (1) | HU217095B (da) |
IE (1) | IE892706A1 (da) |
IL (1) | IL91156A (da) |
NO (1) | NO893387L (da) |
NZ (1) | NZ230342A (da) |
PT (1) | PT91512B (da) |
YU (1) | YU163289A (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2580303B2 (ja) * | 1987-02-19 | 1997-02-12 | ジ・アップジョン・カンパニー | 異種蛋白をコ−ド付けするcDNA類、発現ベクタ−類および宿主類 |
US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
ATE163431T1 (de) * | 1990-05-04 | 1998-03-15 | American Cyanamid Co | Stabilisierung von somatotropin durch modifizierung von cysteinsresten |
US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
DK168790D0 (da) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
US6894023B1 (en) | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
NZ260103A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin with alterations in the alpha-helix-1 region |
US5310882A (en) * | 1990-11-30 | 1994-05-10 | American Cyanamid Company | Somatotropins with alterations in the α-helix 3 region |
GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
FR2671554A1 (fr) * | 1991-01-11 | 1992-07-17 | Clonatec Sa | Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b. |
AU654563B2 (en) * | 1991-07-24 | 1994-11-10 | Imperial Chemical Industries Plc | Proteins |
ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7306931B2 (en) | 2000-05-16 | 2007-12-11 | Bolder Biotechnology, Inc. | Method for refolding proteins containing free cysteine residues |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
US8329866B2 (en) | 2005-10-03 | 2012-12-11 | Bolder Biotechnology, Inc. | Long acting VEGF inhibitors and methods of use |
WO2007044382A2 (en) | 2005-10-07 | 2007-04-19 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
EP2102355B1 (en) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
MX2011000847A (es) * | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Proteinas conjugadas con eficacia prolongada in vivo. |
JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
CN102753573A (zh) * | 2009-12-21 | 2012-10-24 | Ambrx公司 | 经过修饰的牛促生长素多肽和其用途 |
EP2525834B1 (en) | 2010-01-22 | 2019-07-17 | Novo Nordisk Health Care AG | Growth hormones with prolonged in-vivo efficacy |
JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
ES2737024T3 (es) | 2012-08-31 | 2020-01-09 | Glaxosmithkline Biologicals Sa | Proteínas estabilizadas para inmunización contra Staphylococcus aureus |
EP2981282B1 (en) | 2013-04-05 | 2020-11-04 | Novo Nordisk Health Care AG | Growth hormone compound formulation |
KR20180003677A (ko) * | 2016-06-30 | 2018-01-10 | 주식회사 크레아플래닛 | 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
IE56026B1 (en) * | 1982-10-19 | 1991-03-27 | Cetus Corp | Cysteine-depleted muteins of biologically active proteins |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
EP0454730A1 (en) * | 1989-01-19 | 1991-11-06 | The Upjohn Company | Somatotropin analogs |
WO1990008823A1 (en) * | 1989-01-31 | 1990-08-09 | The Upjohn Company | Somatotropin analogs |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
-
1989
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-27 EP EP89113852A patent/EP0355460B1/en not_active Expired - Lifetime
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
-
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
-
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO893387D0 (no) | 1989-08-23 |
PT91512A (pt) | 1990-03-08 |
IL91156A0 (en) | 1990-03-19 |
JP2894355B2 (ja) | 1999-05-24 |
EP0355460A3 (en) | 1991-04-03 |
NO893387L (no) | 1990-02-26 |
ATE198353T1 (de) | 2001-01-15 |
IE892706A1 (en) | 1991-01-16 |
AR245138A1 (es) | 1993-12-30 |
EP0355460A2 (en) | 1990-02-28 |
ES2154627T3 (es) | 2001-04-16 |
GR3035608T3 (en) | 2001-06-29 |
IE892706L (en) | 1990-02-24 |
NZ230342A (en) | 1992-08-26 |
HU217095B (hu) | 1999-11-29 |
FI104908B (fi) | 2000-04-28 |
DE68929273T2 (de) | 2001-07-05 |
DE68929273D1 (de) | 2001-02-01 |
AU4020289A (en) | 1990-03-15 |
PT91512B (pt) | 1995-05-31 |
DK416589D0 (da) | 1989-08-23 |
HUT51331A (en) | 1990-04-28 |
AU630105B2 (en) | 1992-10-22 |
YU163289A (en) | 1992-05-28 |
IL91156A (en) | 1995-05-26 |
FI893963A0 (fi) | 1989-08-23 |
FI893963A (fi) | 1990-02-25 |
EP0355460B1 (en) | 2000-12-27 |
US5891840A (en) | 1999-04-06 |
JPH034797A (ja) | 1991-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK416589A (da) | Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende dem | |
NO922940D0 (no) | Fem-leddete heterocykliske forbindelser, fremgangsmaate for deres fremstilling og legemidler inneholdende dem | |
NO871111L (no) | Tertiaere hydroksyalkylxantiner, fremgangsmaate til deres fremstilling, legemidler som inneholder dem og deres anvendelse. | |
DK56086A (da) | 11beta-phenylgonaner, deres fremstilling og farmaceutiske indeholdende dem | |
DK328586A (da) | Phenylethanolaminotetraliner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem | |
DK362787D0 (da) | Benzensulfonamido-indanylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling | |
DK273689D0 (da) | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler | |
DK605989D0 (da) | Propenonoximethere og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem | |
NO932120D0 (no) | Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling | |
DK518687D0 (da) | Imidazo-benzoxazinoner, deres fremstilling og laegemidler indholdende forbindelserne | |
DK218985A (da) | Aminocyklopentylaetere, farmaceutiske praeparater indeholdende dem og fremgangsmaade til fremstilling af dem | |
DK438788D0 (da) | Alkylaminoalkoxyphenylderivater, fremgangsmaade til deres fremstilling og midler indeholdende dem | |
NO893886D0 (no) | Nye aminokinolinforbindelser og fremgangsmaate for deres fremstilling. | |
DK504986D0 (da) | 7-acylbenzoxazinoner og deres derivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem | |
DK530689A (da) | Adenylcyclasederivater, fremgangsmaade til fremstilling deraf og deres anvendelse | |
NO883047D0 (no) | Substituerte benzimidazoler, fremgangsmaate til deres fremstilling, farmasoeytise tilberedninger inneholdende dem og deres anvendelse. | |
DK572785D0 (da) | Imidazolderivater, laegemidler indeholdende disse forbindelser og fremgangsmaader til deres fremstilling | |
DK457787A (da) | Sulfonamidoethylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling | |
DK374089D0 (da) | Il-1alfa-derivater og medkiament til behandling af thrombocytopenia | |
DK484989A (da) | Herbicide sulfonanilider, fremgangsmaader til deres fremstilling og midler, der indeholder dem | |
DK187989D0 (da) | Substituerede propanaminer, fremgangsmaade til fremstilling heraf og laegemidler indeholdende saadanne forbindelser | |
NO871745D0 (no) | Benzotiazinonderivater, fremgangsmaate til deres fremstilling, legemidler inneholdende dem og deres anvendelse. | |
DK103889A (da) | Benzimidazooe1,2-caachinazoliner og fremgangsmaade til fremstilling heraf | |
NO893756D0 (no) | Basiske 4-aryl-dhp-amider, fremgangsmaate til deres fremstilling og deres anvendelse i legemidler. | |
DK142682A (da) | 1-benzoyl-3-(6-oxopyridazinyl)-urinstoffer,fremgangsmaade til deres fremstilling og insekticide praeparater indeholdende dem |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A0 | Application filed | ||
AHB | Application shelved due to non-payment |