FI893963A0 - Stabilisering av somatotropiner genom att modifiera cysteingrupper med punktmutagenes eller kemisk derivatisering. - Google Patents
Stabilisering av somatotropiner genom att modifiera cysteingrupper med punktmutagenes eller kemisk derivatisering.Info
- Publication number
- FI893963A0 FI893963A0 FI893963A FI893963A FI893963A0 FI 893963 A0 FI893963 A0 FI 893963A0 FI 893963 A FI893963 A FI 893963A FI 893963 A FI893963 A FI 893963A FI 893963 A0 FI893963 A0 FI 893963A0
- Authority
- FI
- Finland
- Prior art keywords
- somatotropiner
- punktmutagenes
- derivatisering
- cysteingrupper
- kemisk
- Prior art date
Links
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23606088A | 1988-08-24 | 1988-08-24 | |
US23606088 | 1988-08-24 | ||
US37269989A | 1989-07-03 | 1989-07-03 | |
US37269989 | 1989-07-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI893963A0 true FI893963A0 (fi) | 1989-08-23 |
FI893963A FI893963A (fi) | 1990-02-25 |
FI104908B FI104908B (fi) | 2000-04-28 |
Family
ID=26929421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI893963A FI104908B (fi) | 1988-08-24 | 1989-08-23 | Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus |
Country Status (18)
Country | Link |
---|---|
US (1) | US5891840A (fi) |
EP (1) | EP0355460B1 (fi) |
JP (1) | JP2894355B2 (fi) |
AR (1) | AR245138A1 (fi) |
AT (1) | ATE198353T1 (fi) |
AU (1) | AU630105B2 (fi) |
DE (1) | DE68929273T2 (fi) |
DK (1) | DK416589A (fi) |
ES (1) | ES2154627T3 (fi) |
FI (1) | FI104908B (fi) |
GR (1) | GR3035608T3 (fi) |
HU (1) | HU217095B (fi) |
IE (1) | IE892706A1 (fi) |
IL (1) | IL91156A (fi) |
NO (1) | NO893387L (fi) |
NZ (1) | NZ230342A (fi) |
PT (1) | PT91512B (fi) |
YU (1) | YU163289A (fi) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2580303B2 (ja) * | 1987-02-19 | 1997-02-12 | ジ・アップジョン・カンパニー | 異種蛋白をコ−ド付けするcDNA類、発現ベクタ−類および宿主類 |
US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
DK0458064T3 (da) * | 1990-05-04 | 1998-04-27 | American Cyanamid Co | Stabilisering af somatotropiner ved modificering af cysteinrester |
DK168790D0 (fi) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
US6894023B1 (en) | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
NZ240718A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin analogues carrying mutations in the alpha-helix-1 region |
US5310882A (en) * | 1990-11-30 | 1994-05-10 | American Cyanamid Company | Somatotropins with alterations in the α-helix 3 region |
GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
FR2671554A1 (fr) * | 1991-01-11 | 1992-07-17 | Clonatec Sa | Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b. |
AU654563B2 (en) * | 1991-07-24 | 1994-11-10 | Imperial Chemical Industries Plc | Proteins |
ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
ATE367398T1 (de) | 2000-05-16 | 2007-08-15 | Bolder Biotechnology Inc | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
WO2007041614A2 (en) | 2005-10-03 | 2007-04-12 | Bolder Biotechnology, Inc. | Long acting vegf inhibitors and methods of use |
DK1931379T3 (da) | 2005-10-07 | 2013-08-19 | Sec Dep For Health | Proteiner med forbedret opløselighed samt fremgangsmåder til frembringelse og anvendelse af samme |
EP2102355B1 (en) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
RU2526804C2 (ru) * | 2008-08-06 | 2014-08-27 | Ново Нордиск Хелс Кеа Аг | Конъюгированные белки с пролонгированным действием in vivo |
RU2539797C2 (ru) * | 2009-01-22 | 2015-01-27 | Ново Нордиск Хелс Кеа Аг | Производное гормона роста человека с повышенной стабильностью к протеолитическому разрушению, способ получения такого производного, его применение, способ лечения и фармацевтическая композиция |
CN102612376A (zh) | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
EA201290541A1 (ru) * | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
SI2525834T1 (sl) | 2010-01-22 | 2019-10-30 | Novo Nordisk Healthcare Ag | Rastni hormoni s podaljšano in vivo učinkovitostjo |
EP2525833A2 (en) | 2010-01-22 | 2012-11-28 | Novo Nordisk Health Care AG | Stable growth hormone compounds |
US9926344B2 (en) * | 2012-08-31 | 2018-03-27 | Glaxosmithkline Biologicals Sa | Stabilised proteins for immunising against Staphylococcus aureus |
JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
KR20180003677A (ko) * | 2016-06-30 | 2018-01-10 | 주식회사 크레아플래닛 | 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
KR910700264A (ko) * | 1989-01-19 | 1991-03-14 | 로버트 에이. 아미테이지 | 소마토트로핀 유사물 |
WO1990008823A1 (en) * | 1989-01-31 | 1990-08-09 | The Upjohn Company | Somatotropin analogs |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
-
1989
- 1989-07-27 EP EP89113852A patent/EP0355460B1/en not_active Expired - Lifetime
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
-
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
-
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE892706L (en) | 1990-02-24 |
AR245138A1 (es) | 1993-12-30 |
GR3035608T3 (en) | 2001-06-29 |
EP0355460A3 (en) | 1991-04-03 |
FI893963A (fi) | 1990-02-25 |
HU217095B (hu) | 1999-11-29 |
AU4020289A (en) | 1990-03-15 |
EP0355460B1 (en) | 2000-12-27 |
EP0355460A2 (en) | 1990-02-28 |
NO893387L (no) | 1990-02-26 |
DK416589A (da) | 1990-02-25 |
PT91512A (pt) | 1990-03-08 |
DK416589D0 (da) | 1989-08-23 |
NO893387D0 (no) | 1989-08-23 |
IE892706A1 (en) | 1991-01-16 |
ATE198353T1 (de) | 2001-01-15 |
NZ230342A (en) | 1992-08-26 |
PT91512B (pt) | 1995-05-31 |
JPH034797A (ja) | 1991-01-10 |
DE68929273T2 (de) | 2001-07-05 |
YU163289A (en) | 1992-05-28 |
JP2894355B2 (ja) | 1999-05-24 |
IL91156A (en) | 1995-05-26 |
HUT51331A (en) | 1990-04-28 |
US5891840A (en) | 1999-04-06 |
FI104908B (fi) | 2000-04-28 |
ES2154627T3 (es) | 2001-04-16 |
DE68929273D1 (de) | 2001-02-01 |
AU630105B2 (en) | 1992-10-22 |
IL91156A0 (en) | 1990-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI893963A0 (fi) | Stabilisering av somatotropiner genom att modifiera cysteingrupper med punktmutagenes eller kemisk derivatisering. | |
FI891348A (fi) | Foerfarande foer tillverkning av papper eller kartong av aoterfoerbrukade, med entzymer behandlade fibrer. | |
FI895778A0 (fi) | Anlaeggning foer foerstoering av aerosol- och/eller frysmedel. | |
FI870010A0 (fi) | Foerfarande foer framnstaellning av genom fotopolymerisation tvaerbundna reliefformar. | |
FI911220A0 (fi) | Genom inverkan av ultraviolettljus haerdbara katjoniska vinyleterpolyuretanbelaeggningsblandningar. | |
FI882604A (fi) | Foerbaettrande av utnyttjande av foer vaexter anvaendbart kvaeve genom bringande av odlingsvaexter att uttrycka glutaminsyntetas i oeverskott. | |
FI894042A0 (fi) | Stabilisering av foerpackad jodofor och minimering av jodlaeckage genom foerpackningen. | |
FI905830A0 (fi) | Anordning foer reglering av luftfloedet genom en luftkanal i en kemisk regeneringsugn. | |
FI921318A0 (fi) | Kopplingsanordning foer oemsesidig oeverfoering av data- och/eller styrsignaler. | |
FI881045A0 (fi) | Foerfartande foer neutralisering av flytande avfall genom foerbraenning. | |
FI911957A0 (fi) | Foerfarande foer behandling av kabelmaterial eller liknande. | |
FI882949A (fi) | Foerfarande foer xerografisk tryckning av textilmaterial eller dylikt. | |
FI870231A0 (fi) | Anordning foer behandling av en genom aotminstone tvao aendloesa viror eller motsvarande transportanordningar foerd material- eller aemnesbana. | |
FI884996A0 (fi) | Maetningsprocedur foer att fraon nmr-signaler avlaegsna stoerningar genom jaemfoerelse av i olika riktningar roterande rf-faeltkomponenter. | |
FI884507A (fi) | Foerminskning av faerg i pappersfabriksavfallsvatten genom oxidering med klordioxid. | |
FI872162A0 (fi) | Anordning foer angivande av stroemimpulser vilka flyter genom oeverspaenningsavlaeggningsmekanismer i hoegspaenningsnaet. | |
FI872031A0 (fi) | Producering av streptokinas med jaest erhaollen genom dna-teknik. | |
FI883103A0 (fi) | Foerfarande foer framstaellning eller reparering av en kulventil. | |
FI894260A (fi) | Foerfarande foer mesofil eller termofil aerobisk-enzymatisk luftning av vaetskeformiga organiska aemnen. | |
FI901567A0 (fi) | Foerfarande foer reglering av spaenning i papper i tryck- och/eller utstansningmaskiner foer att framstaella kommersiella aendloesa blanketter. | |
FI923350A0 (fi) | Foerfarande foer maerkning av substanser med teknetium eller renium. | |
FI880093A0 (fi) | Brandsaeker skaop av modultyp foer skydd av ritnings-, arkiv-, haengmapps- och olika skyddskaop eller att anvaendas saom saodan. | |
FI913083A0 (fi) | Foerfarande foer anpassning av en radiotelefon i radiotelefonsystem med tvao eller flera operatoerer. | |
FI910876A0 (fi) | Foerfarande foer punktvist eller streckvist faestande av plattor med plattsaettningssilikon. | |
FI911672A0 (fi) | Anordning foer maskinell foerpackning av korv, speciellt laenk-, grill- eller motsvarande korv med konstgjort skal eller skal naturtarm. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: AMERICAN CYANAMID COMPANY |