NO173502C - Analogifremgangsmaate for fremstilling av terapeutisk aktive xantin-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive xantin-derivater

Info

Publication number
NO173502C
NO173502C NO895168A NO895168A NO173502C NO 173502 C NO173502 C NO 173502C NO 895168 A NO895168 A NO 895168A NO 895168 A NO895168 A NO 895168A NO 173502 C NO173502 C NO 173502C
Authority
NO
Norway
Prior art keywords
substd
opt
alkyl
cycloalkyl
alkenyl
Prior art date
Application number
NO895168A
Other languages
English (en)
Norwegian (no)
Other versions
NO173502B (no
NO895168L (no
NO895168D0 (no
Inventor
Ulrike Kuefner-Muehl
Karl Heinz Weber
Gerhard Walther
Werner Stransky
Helmut Ensinger
Guenter Schingnitz
Franz Josef Kuhn
Erich Lehr
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of NO895168D0 publication Critical patent/NO895168D0/no
Publication of NO895168L publication Critical patent/NO895168L/no
Publication of NO173502B publication Critical patent/NO173502B/no
Publication of NO173502C publication Critical patent/NO173502C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO895168A 1988-12-22 1989-12-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive xantin-derivater NO173502C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3843117A DE3843117A1 (de) 1988-12-22 1988-12-22 Neue xanthinderivate mit adenosin-antagonistischer wirkung

Publications (4)

Publication Number Publication Date
NO895168D0 NO895168D0 (no) 1989-12-21
NO895168L NO895168L (no) 1990-06-25
NO173502B NO173502B (no) 1993-09-13
NO173502C true NO173502C (no) 1993-12-22

Family

ID=6369764

Family Applications (1)

Application Number Title Priority Date Filing Date
NO895168A NO173502C (no) 1988-12-22 1989-12-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive xantin-derivater

Country Status (32)

Country Link
US (4) US5175291A (fr)
EP (1) EP0374808B1 (fr)
JP (1) JP2565576B2 (fr)
KR (1) KR0165666B1 (fr)
AT (1) ATE136897T1 (fr)
BG (1) BG61669B2 (fr)
BR (1) BR1100527A (fr)
CA (1) CA2006387C (fr)
CZ (1) CZ286230B6 (fr)
DD (1) DD290421A5 (fr)
DE (3) DE3843117A1 (fr)
DK (1) DK652689A (fr)
ES (1) ES2086313T3 (fr)
FI (1) FI96513C (fr)
GR (1) GR3019733T3 (fr)
HR (1) HRP940724A2 (fr)
HU (1) HU218674B (fr)
IE (1) IE74205B1 (fr)
IL (1) IL92829A (fr)
MX (1) MX9203618A (fr)
NO (1) NO173502C (fr)
NZ (1) NZ231901A (fr)
PH (2) PH31107A (fr)
PL (1) PL162877B1 (fr)
PT (1) PT92658B (fr)
RU (1) RU2057752C1 (fr)
SG (1) SG46380A1 (fr)
SI (1) SI8912423B (fr)
SK (1) SK719789A3 (fr)
UA (1) UA26427A (fr)
YU (1) YU47934B (fr)
ZA (1) ZA899881B (fr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (fr) * 1991-02-25 1992-08-26 Fumio Suzuki Composes de la xanthine
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
ATE180482T1 (de) * 1991-11-08 1999-06-15 Kyowa Hakko Kogyo Kk Xanthinderivate zur behandlung der demenz
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
JPH05294966A (ja) * 1992-02-17 1993-11-09 Kyowa Hakko Kogyo Co Ltd キサンチン誘導体
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
CA2093403C (fr) * 1992-04-08 1999-08-10 Fumio Suzuki Agent de traitement de la maladie de parkinson
WO1994003173A1 (fr) * 1992-08-01 1994-02-17 Boehringer Ingelheim Kg Utilisation de 8-(3-oxocyclopentyle)-1,3-dipropyle-7h-purine-2,6-dione pour le traitement symptomatique de la fibrose cystique
TW252044B (fr) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
US5877179A (en) * 1992-09-29 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
AU6087894A (en) * 1993-01-14 1994-08-15 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
US5840729A (en) * 1993-02-26 1998-11-24 Merrell Pharmaceuticals Inc. Xanthine derivatives as adenosine A1 receptor antagonists
WO1994025462A1 (fr) * 1993-05-03 1994-11-10 The United States Of America, Represented By The Derives de 1,3,7-trialkyl-xanthine substitues en position 8 utiles comme antagonistes de recepteurs d'adenosine a2 a selectivite
DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
JP3769737B2 (ja) * 1994-03-30 2006-04-26 味の素株式会社 シクロプロパン誘導体及びその製造法
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
WO1996018399A1 (fr) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryle thioxanthines
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
WO1999012546A1 (fr) * 1997-09-05 1999-03-18 Kyowa Hakko Kogyo Co., Ltd. Remede contre la degenerescence neurale
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
DE19816857A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1084710B1 (fr) * 1998-06-01 2006-10-18 Astellas Pharma Inc. Antagonistes de l'adenosine a1 contre la sterilite masculine
WO2000002861A1 (fr) 1998-07-10 2000-01-20 The United States Of America, Represented By Secretary, Department Of Health And Human Services Antagonistes du recepteur de l'adenosine a¿3?
US6025362A (en) * 1998-08-31 2000-02-15 Fukunaga; Atsuo F. Uses of xanthine compounds
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6545002B1 (en) * 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
SI1230243T1 (sl) 1999-11-12 2009-08-31 Biogen Idec Inc Policikloalkilpurini kot antagonisti adenozinskega receptorja
JP2003513976A (ja) * 1999-11-12 2003-04-15 バイオジェン インコーポレイテッド アデノシンレセプターアンタゴニストおよびこれを作製し使用する方法
ATE336492T1 (de) 2000-01-14 2006-09-15 Us Gov Health & Human Serv Methonocarbacycloalkylanaloga von nucleosiden
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
US7125993B2 (en) * 2001-11-09 2006-10-24 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US20080318983A1 (en) * 2001-11-09 2008-12-25 Rao Kalla A2b adenosine receptor antagonists
US7317017B2 (en) 2002-11-08 2008-01-08 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
PL370207A1 (en) 2001-11-09 2005-05-16 Cv Therapeutics, Inc. A2b adenosine receptor antagonists
US6977300B2 (en) * 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
AU2003261206A1 (en) * 2002-07-19 2004-02-09 Aryx Therapeutics Xanthine derivatives having adenosine a1-receptor antagonist properties
WO2004074247A2 (fr) * 2003-02-19 2004-09-02 Endacea, Inc. Antagonistes du recepteur de l'adenosine a1
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
US20060293312A1 (en) * 2003-04-25 2006-12-28 Howard Dittrich Method of improved diuresis in individuals with impaired renal function
BRPI0409699A (pt) * 2003-04-25 2006-04-18 Novacardia Inc métodos de indução do efeito diurético, de indução, manutenção ou restauração do efeito diurético de diurético não modificador de adenosina, de manutenção, restauração ou melhoria da função renal em paciente, de indução de diurese, de prevenção do inìcio de deficiência renal em paciente com sobrecarga de fluidos ou chf, de tratamento de paciente que sofre de chf e de melhoria dos resultados globais da saúde, composição farmacêutica e seus usos
ES2311759T3 (es) * 2003-05-06 2009-02-16 Cv Therapeutics, Inc. Derivados de xantina como antagonistas del receptor a2b de adenosina.
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
CA2528367A1 (fr) * 2003-06-09 2004-12-23 Endacea, Inc. Antagonistes de recepteur d'adenosine a1
TW200507882A (en) * 2003-07-17 2005-03-01 Kyowa Hakko Kogyo Kk Solid formulations
US6847249B1 (en) * 2003-10-09 2005-01-25 Analog Devices, Inc. Highest available voltage selector circuit
BRPI0509753A (pt) * 2004-04-16 2007-10-16 Novacardia Inc composição farmacêutica e método de tratamento de doença cardiovascular
DK1789053T3 (da) * 2004-09-01 2012-08-06 Gilead Sciences Inc Fremgangsmåde til sårheling under anvendelse af a2b-adenosinreceptor-antagonister
CN101466383A (zh) * 2006-06-16 2009-06-24 美国诺华卡迪亚公司 包含低频率投与aa1ra的肾功能延长改善
US8193200B2 (en) 2007-01-04 2012-06-05 University Of Virginia Patent Foundation Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease
WO2008121882A1 (fr) * 2007-03-29 2008-10-09 Novacardia, Inc. Procédés améliorés d'administration d'antagonistes de récepteur d'adénosine a1
WO2008121893A1 (fr) * 2007-03-29 2008-10-09 Novacardia, Inc. Procédés de traitement d'insuffisance cardiaque et de dysfonctionnement rénal chez des individus avec un antagoniste de récepteur a1 de l'adénosine
CA2718983C (fr) * 2008-03-26 2015-12-08 Advinus Therapeutics Pvt. Ltd. Composes heterocycliques utiles comme antagonistes des recepteurs adenosiniques
US8129862B2 (en) * 2009-10-23 2012-03-06 Analog Devices, Inc. Scalable highest available voltage selector circuit
EP2499142B1 (fr) * 2009-11-09 2016-09-21 Advinus Therapeutics Limited Composés pyrimidine fusionnés substitués, leur préparation et leurs utilisations
US8518957B2 (en) 2009-12-02 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1201997A (en) * 1967-08-04 1970-08-12 Yissum Res Dev Co New substituted purines and purine derivatives
US3624215A (en) * 1970-06-25 1971-11-30 Abbott Lab 8-substituted theophyllines as anti-anxiety agents
US3624216A (en) * 1970-06-25 1971-11-30 Abbott Lab 8-substituted theophyllines as anti-inflammatory agents
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
ES8401072A1 (es) * 1982-11-23 1983-12-16 Faes Procedimiento de preparacion de un nuevo espirodecano.
US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4755517A (en) * 1986-07-31 1988-07-05 Warner-Lambert Company Derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US5175290A (en) * 1988-09-16 1992-12-29 Marion Merrell Dow Inc. 8-(oxo-substituted cycloalkyl)xanthines
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US4957921A (en) * 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
ATE180482T1 (de) * 1991-11-08 1999-06-15 Kyowa Hakko Kogyo Kk Xanthinderivate zur behandlung der demenz

Also Published As

Publication number Publication date
CZ286230B6 (cs) 2000-02-16
UA26427A (uk) 1999-08-30
DE58909657D1 (de) 1996-05-23
CA2006387C (fr) 2000-02-08
US5175291A (en) 1992-12-29
SI8912423B (sl) 1998-12-31
AU4707289A (en) 1990-06-28
KR0165666B1 (ko) 1999-01-15
BG61669B2 (bg) 1998-02-27
PL162877B1 (pl) 1994-01-31
NO173502B (no) 1993-09-13
DK652689A (da) 1990-06-23
EP0374808A3 (fr) 1991-05-15
MX9203618A (es) 1992-09-01
PH31111A (en) 1998-02-23
PL282878A1 (en) 1992-03-09
HRP940724A2 (en) 1997-06-30
IE894147L (en) 1990-06-22
SK279525B6 (sk) 1998-12-02
RU2057752C1 (ru) 1996-04-10
PT92658B (pt) 1995-09-12
CA2006387A1 (fr) 1990-06-22
DE3843117A1 (de) 1990-06-28
FI96513B (fi) 1996-03-29
HU896736D0 (en) 1990-02-28
US5696124A (en) 1997-12-09
AU637990B2 (en) 1993-06-17
CZ719789A3 (cs) 1999-10-13
YU242389A (en) 1991-10-31
PH31107A (en) 1998-02-23
US5532368A (en) 1996-07-02
IE74205B1 (en) 1997-07-16
DE8817122U1 (de) 1993-02-04
GR3019733T3 (en) 1996-07-31
NO895168L (no) 1990-06-25
US5688802A (en) 1997-11-18
EP0374808B1 (fr) 1996-04-17
SG46380A1 (en) 1998-02-20
HU218674B (hu) 2000-10-28
FI896117A0 (fi) 1989-12-20
IL92829A (en) 1995-12-31
NZ231901A (en) 1993-12-23
DD290421A5 (de) 1991-05-29
BR1100527A (pt) 2000-08-01
SI8912423A (sl) 1998-04-30
KR900009646A (ko) 1990-07-05
ZA899881B (en) 1991-08-28
EP0374808A2 (fr) 1990-06-27
FI96513C (fi) 1996-07-10
PT92658A (pt) 1990-06-29
ES2086313T3 (es) 1996-07-01
SK719789A3 (en) 1998-12-02
JP2565576B2 (ja) 1996-12-18
HUT52503A (en) 1990-07-28
YU47934B (sh) 1996-05-20
NO895168D0 (no) 1989-12-21
DK652689D0 (da) 1989-12-21
JPH02247180A (ja) 1990-10-02
IL92829A0 (en) 1990-09-17
ATE136897T1 (de) 1996-05-15

Similar Documents

Publication Publication Date Title
NO173502C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive xantin-derivater
DK148279C (da) Analogifremgangsmaade til fremstilling af 9-substituerede guaninderivater eller fysiologisk acceptable salte eller optiske isomerer deraf
ES2090507T3 (es) Procedimiento para la preparacion de simvastatina.
KR850003533A (ko) 1,3-디옥산 유도체의 제조방법
FR2671349B1 (fr) Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
YU47973B (sh) S-enantiomerni glutaramidi i postupak za njihovo dobijanje
KR860002508A (ko) 푸로(3,2-c)피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물
GB8330097D0 (en) Cyclic ethers
SE7607856L (sv) Forfarande for framstellning av 2-bensopyranonderivat och deras anvendning som lekemedel
GB1108538A (en) New oxazolidine derivatives and process for their manufacture
GB1525687A (en) Cephalosporin derivatives
Christensen et al. Strategy in the total synthesis of β-lactam antibiotics
DE68917491D1 (de) Triazolo[1,5-c]pyrimido[1,4]azine als Bronchodilatatoren.
FI894458A0 (fi) Substituerade imidazo /2,1-b/ kinazolin -5 (3h)-oner och andra liknande tricykliska foereningar.
GB1494758A (en) Prostaglandin intermediates

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2001