ES2134345T3 - Derivados de 2-aciloxicefem como inhibidores de elastasa. - Google Patents

Derivados de 2-aciloxicefem como inhibidores de elastasa.

Info

Publication number
ES2134345T3
ES2134345T3 ES94909042T ES94909042T ES2134345T3 ES 2134345 T3 ES2134345 T3 ES 2134345T3 ES 94909042 T ES94909042 T ES 94909042T ES 94909042 T ES94909042 T ES 94909042T ES 2134345 T3 ES2134345 T3 ES 2134345T3
Authority
ES
Spain
Prior art keywords
aciloxicefem
derivatives
elastase inhibitors
ch2nh
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909042T
Other languages
English (en)
Inventor
Marco Alpegiani
Pierluigi Bissolino
Ettore Perrone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2134345T3 publication Critical patent/ES2134345T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SUMINISTRA SULFONAS DE LA CEFALOSPORINA DE LA FORMULA (I) Y LAS SALES FARMACEUTICA Y VETERINARIAMENTE ACEPTABLES DE LAS MISMAS, EN DONDE M ES 1 O 2; A Y B SON AMBAS O CADA UNA INDEPENDIENTEMENTE HIDROGENO O UN RADICAL ORGANICO; R1 REPRESENTA HALOGENO, A, OA, -S(O)MA EN DONDE M ES 0-2, -OC(O)A, -OS(O)2A, NHC(O)A O -NH-Z EN DONDE Z ES UN MONO, DI O TRIPEPTIDO Y A ES SEGUN SE HA DEFINIDO ANTERIORMENTE; R2 REPRESENTA HALOGENO, A, -S(O),A, -OA, -C(O)A, -C(O)OA, -CH2S(O)MA, -CH2OC(O)A, -CH2O-Z, -CH2SC(O)A, CH2-N(A)A'', -CH2N+(A)(A'')A", -CH2NH-C(O)A O -CH2NH-Z EN DONDE A Y Z SON SEGUN SE DEFINIERON ANTERIORMENTE. LOS COMPUESTOS DE LA FORMULA (I) Y SUS SALES SON INHIBIDORES DE LA ELASTASA.
ES94909042T 1993-03-04 1994-02-24 Derivados de 2-aciloxicefem como inhibidores de elastasa. Expired - Lifetime ES2134345T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939304440A GB9304440D0 (en) 1993-03-04 1993-03-04 2-acyloxycephem derivatives

Publications (1)

Publication Number Publication Date
ES2134345T3 true ES2134345T3 (es) 1999-10-01

Family

ID=10731476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909042T Expired - Lifetime ES2134345T3 (es) 1993-03-04 1994-02-24 Derivados de 2-aciloxicefem como inhibidores de elastasa.

Country Status (9)

Country Link
US (1) US5587373A (es)
EP (1) EP0639195B1 (es)
JP (1) JPH07506841A (es)
AU (1) AU671202B2 (es)
CA (1) CA2118422A1 (es)
DE (1) DE69418656T2 (es)
ES (1) ES2134345T3 (es)
GB (1) GB9304440D0 (es)
WO (1) WO1994020504A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513818D0 (en) * 1995-07-06 1995-09-06 Pharmacia Spa 7,7-Disubstituted cephem-4-ketones
GB9525697D0 (en) * 1995-12-15 1996-02-14 Pharmacia Spa Cephem derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3578660A (en) * 1968-10-07 1971-05-11 Lilly Co Eli 2-acyloxycephalosporin compounds
US3852282A (en) * 1969-04-01 1974-12-03 Squibb & Sons Inc Certain 2-substituted cephalosporins
JPS5834184A (ja) * 1981-08-25 1983-02-28 Otsuka Chem Co Ltd ２−オキシセフアロスポリン誘導体の製造方法
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
GB9207715D0 (en) * 1992-04-08 1992-05-27 Erba Carlo Spa 2,2-disubstituted cephem sulphones

Also Published As

Publication number Publication date
AU671202B2 (en) 1996-08-15
WO1994020504A1 (en) 1994-09-15
JPH07506841A (ja) 1995-07-27
DE69418656D1 (de) 1999-07-01
AU6205594A (en) 1994-09-26
EP0639195A1 (en) 1995-02-22
DE69418656T2 (de) 1999-12-30
EP0639195B1 (en) 1999-05-26
GB9304440D0 (en) 1993-04-21
US5587373A (en) 1996-12-24
CA2118422A1 (en) 1994-09-15

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