ES2048090B1 - Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina. - Google Patents

Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.

Info

Publication number
ES2048090B1
ES2048090B1 ES9200196A ES9200196A ES2048090B1 ES 2048090 B1 ES2048090 B1 ES 2048090B1 ES 9200196 A ES9200196 A ES 9200196A ES 9200196 A ES9200196 A ES 9200196A ES 2048090 B1 ES2048090 B1 ES 2048090B1
Authority
ES
Spain
Prior art keywords
procedure
cumarina
antitromboticos
derived
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9200196A
Other languages
English (en)
Other versions
ES2048090A1 (es
Inventor
Belmonte Lorenzo Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Priority to ES9200196A priority Critical patent/ES2048090B1/es
Priority to DE69220201T priority patent/DE69220201D1/de
Priority to EP19920500036 priority patent/EP0553590B1/en
Publication of ES2048090A1 publication Critical patent/ES2048090A1/es
Application granted granted Critical
Publication of ES2048090B1 publication Critical patent/ES2048090B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS ANTITROMBOTICOS DERIVADOS DE LA CUMARINA. DICHOS DERIVADOS RESPONDEN A LA FORMULA (I) EN DONDE Z Y R SE DEFINEN COMO SE INDICA EN LA DESCRIPCION. EL PROCEDIMIENTO COMPRENDE ACILAR 4-HIDROXI-CUMARINA CON UN CLORURO DE ACIDO DE FORMULA (II). LOS COMPUESTOS OBTENIDOS SON DE UTILIDAD COMO AGENTES ANTITROMBOTICOS EN LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES TROMBOLITICAS Y CORONARIAS. OJO OJO FORMULA
ES9200196A 1992-01-31 1992-01-31 Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina. Expired - Lifetime ES2048090B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9200196A ES2048090B1 (es) 1992-01-31 1992-01-31 Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.
DE69220201T DE69220201D1 (de) 1992-01-31 1992-04-07 Antithrombotika, die sich von Cumarin ableiten, und Verfahren zu ihrer Herstellung
EP19920500036 EP0553590B1 (en) 1992-01-31 1992-04-07 Antithrombotics derived from coumarin and process for obtaining them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200196A ES2048090B1 (es) 1992-01-31 1992-01-31 Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.

Publications (2)

Publication Number Publication Date
ES2048090A1 ES2048090A1 (es) 1994-03-01
ES2048090B1 true ES2048090B1 (es) 1994-10-01

Family

ID=8275898

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200196A Expired - Lifetime ES2048090B1 (es) 1992-01-31 1992-01-31 Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.

Country Status (3)

Country Link
EP (1) EP0553590B1 (es)
DE (1) DE69220201D1 (es)
ES (1) ES2048090B1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1306669B1 (it) * 1999-06-14 2001-10-02 Fidia Spa Composizioni farmaceutiche comprendenti 8-cloro-3 (beta-dietilaminoetil) -4-metil-7-etossicarbonilmetossi cumarina base e
CN105111176A (zh) * 2015-10-16 2015-12-02 南开大学 3-苯氧乙酰基-4-羟基香豆素衍生物与合成方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2427578A (en) * 1945-04-02 1947-09-16 Wisconsin Alumni Res Found 3-substituted 4-hydroxycoumarin and process of making it
FR1559595A (es) * 1966-12-13 1969-03-14
FR6928M (es) * 1967-11-24 1969-05-05
HU177497B (en) * 1979-08-01 1981-10-28 Reanal Finomvegyszergyar Acaricide preparation further process for preparing the active materials
ES8106719A1 (es) * 1980-09-11 1981-09-01 Ind Farma Especial Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina
JPH0546666A (ja) * 1991-08-16 1993-02-26 Tokyo Electric Co Ltd 情報検索装置

Also Published As

Publication number Publication date
EP0553590A1 (en) 1993-08-04
ES2048090A1 (es) 1994-03-01
DE69220201D1 (de) 1997-07-10
EP0553590B1 (en) 1997-06-04

Similar Documents

Publication Publication Date Title
DE69429440T2 (de) Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen
ES2080900T3 (es) Derivados piranicos utiles como inhibidores de 5-lipoxigenasa.
ES2065881T3 (es) Nuevos inhibidores de dopamina beta-hidroxilasa.
PT97047A (pt) Processo de preparacao de compostos de 1-carboxialquilquinoxalina-2,3(1h,4h)-diona e de composicoes farmaceuticas que os contem
ES2132609T3 (es) Derivados del acido arilacetico y su empleo como fungicidas.
DK516684D0 (da) Purinderivater
ES2131313T3 (es) Derivados de acido nipecotico como compuestos antitromboticos.
CA2023089A1 (en) Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia
ES2139669T3 (es) Nuevos derivados triciclicos de indan-2-mercaptoacetilamida 2-substituidos utiles como inhibidores de la encefalinasa.
ES2048090B1 (es) Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.
ES2093666T3 (es) Derivados de los acidos 7-(2,7-diazabiciclo(3,3.0)octil)-3-quinolon- y -naftiridon carboxilicos.
ES2032317T3 (es) Derivados de quinazolina tetraciclicos, obtencion y empleo.
ES2061556T3 (es) Derivados amida y su produccion y fungicidas agricolas que los contienen.
GR1000887B (el) Νεα παραγωγα σπιροφουρανης.
ATE118209T1 (de) Pyridin-3-percarboxylsäure monopersulfat.
ES2187656T3 (es) Derivados de acido fosfinico con actividad inhibidora de metalopeptidasa.
ATE10370T1 (de) Benzothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung.
ES2147316T3 (es) 1-cicloalqueniltetrazolinonas.
ES2055440T3 (es) Derivados del acido quinurenico, su preparacion y composiciones farmaceuticas que los contienen.
DK0551844T3 (da) Svovlholdige galdesyrederivater
ES2073919T3 (es) Derivados de piperidina 1,3,4-trisubstituidos, su obtencion y empleo.
ES8506720A1 (es) Un procedimiento para la preparacion de un compuesto
DK305182A (da) Biologisk aktive heterobicycliske hydroximidater og thiolhydroximidater samt carbamatesterderivater deraf
SV1995000024A (es) Derivado de oxalilamino-benzofurano y benzotienilo ref. lea 30118-sv
FR2387034A1 (fr) Compose 1,4,4a-trimethyle-1,2,4a,4b,9a,10a-hexahydro-10h-benzo(b) thieno(2',3': 4'3) cyclopenta(1,2-b)piridine et son procede de fabrication