ES8106719A1 - Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina - Google Patents

Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina

Info

Publication number
ES8106719A1
ES8106719A1 ES494942A ES494942A ES8106719A1 ES 8106719 A1 ES8106719 A1 ES 8106719A1 ES 494942 A ES494942 A ES 494942A ES 494942 A ES494942 A ES 494942A ES 8106719 A1 ES8106719 A1 ES 8106719A1
Authority
ES
Spain
Prior art keywords
hydroxycumarine
ethylbencil
alpha
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494942A
Other languages
English (en)
Other versions
ES494942A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industrial Farmaceutica y de Especialidades SA
Original Assignee
Industrial Farmaceutica y de Especialidades SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Farmaceutica y de Especialidades SA filed Critical Industrial Farmaceutica y de Especialidades SA
Priority to ES494942A priority Critical patent/ES494942A0/es
Publication of ES8106719A1 publication Critical patent/ES8106719A1/es
Publication of ES494942A0 publication Critical patent/ES494942A0/es
Granted legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 3(ALFA-ETILBENCIL)-4-HIDROXICUMARINA, COMUNMENTE CONOCIDA COMO FENPROCUMONE, DE FORMULA (I). COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE HACE REACCIONAR ORTONITROXIACETOFENONA, DE FORMULA (II), EN SOLUCION ACUOSA DE NAOH O KOH, CON UN HALOGENCARBONATO: XCOOET, EN DONDE X ES HALOGENO, DE PREFERENCIA CL; SEGUNDA, EL PRODUCTO DE LA PRIMERA REACCION, UNA VEZ SEPARADO, SE HACE REACCIONAR, EN UN DISOLVENTE APROTICO ANHIDRO, CON BENZALDEHIDO, EN PRESENCIA DE LITIO DIISOPROPILAMIDA; Y POR ULTIMO, EL PRODUCTO DE LA SEGUNDA REACCION, UNA VEZ SEPARADO, SE HACE REACCIONAR, EN UN DISOLVENTE APROTICO ANHIDRO, CON REACTIVO DE "GRIGNARD"; ETMGX, EN PRESENCIA DE HALOGENURO CUPROSO, EN DONDE X ES HALOGENO, DE PREFERENCIA BR O I. DE USO EN LA TERAPIA HUMANA COMO FLUIDIFICANTE DE LA SANGRE. *FORMULA*
ES494942A 1980-09-11 1980-09-11 Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina Granted ES494942A0 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES494942A ES494942A0 (es) 1980-09-11 1980-09-11 Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES494942A ES494942A0 (es) 1980-09-11 1980-09-11 Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina

Publications (2)

Publication Number Publication Date
ES8106719A1 true ES8106719A1 (es) 1981-09-01
ES494942A0 ES494942A0 (es) 1981-09-01

Family

ID=8481059

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494942A Granted ES494942A0 (es) 1980-09-11 1980-09-11 Procedimiento para la preparacion de 3(alfa-etilbencil)-4- hidroxicumarina

Country Status (1)

Country Link
ES (1) ES494942A0 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048090A1 (es) * 1992-01-31 1994-03-01 Rovi Lab Farmaceut Sa Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048090A1 (es) * 1992-01-31 1994-03-01 Rovi Lab Farmaceut Sa Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.

Also Published As

Publication number Publication date
ES494942A0 (es) 1981-09-01

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