NL1000566C2 - Complex van een analoog van menselijk insuline, alsmede een dergelijk complex omvattende formulering. - Google Patents
Complex van een analoog van menselijk insuline, alsmede een dergelijk complex omvattende formulering.Info
- Publication number
- NL1000566C2 NL1000566C2 NL1000566A NL1000566A NL1000566C2 NL 1000566 C2 NL1000566 C2 NL 1000566C2 NL 1000566 A NL1000566 A NL 1000566A NL 1000566 A NL1000566 A NL 1000566A NL 1000566 C2 NL1000566 C2 NL 1000566C2
- Authority
- NL
- Netherlands
- Prior art keywords
- complex
- analogue
- formulation
- well
- human insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/260,634 US5474978A (en) | 1994-06-16 | 1994-06-16 | Insulin analog formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
NL1000566A1 NL1000566A1 (nl) | 1995-12-18 |
NL1000566C2 true NL1000566C2 (nl) | 1996-12-03 |
Family
ID=22989969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL1000566A NL1000566C2 (nl) | 1994-06-16 | 1995-06-14 | Complex van een analoog van menselijk insuline, alsmede een dergelijk complex omvattende formulering. |
Country Status (39)
Country | Link |
---|---|
US (1) | US5474978A (cs) |
JP (2) | JP3171541B2 (cs) |
KR (1) | KR100382326B1 (cs) |
CN (1) | CN1105576C (cs) |
AT (1) | AT408720B (cs) |
BE (1) | BE1009408A5 (cs) |
BR (1) | BR9502795A (cs) |
CA (1) | CA2151560C (cs) |
CH (2) | CH689250A5 (cs) |
CO (1) | CO4410203A1 (cs) |
CZ (1) | CZ287484B6 (cs) |
DE (1) | DE19521720B4 (cs) |
DK (1) | DK173015B1 (cs) |
ES (1) | ES2091727B1 (cs) |
FI (1) | FI118207B (cs) |
FR (2) | FR2721214B1 (cs) |
GB (1) | GB2291427B (cs) |
GR (1) | GR1003004B (cs) |
HK (1) | HK1015138A1 (cs) |
HU (1) | HU227240B1 (cs) |
IE (1) | IE68853B1 (cs) |
IL (1) | IL114151A (cs) |
IT (1) | IT1276723B1 (cs) |
LU (1) | LU88626A1 (cs) |
MY (1) | MY115631A (cs) |
NL (1) | NL1000566C2 (cs) |
NO (1) | NO322128B1 (cs) |
NZ (1) | NZ272359A (cs) |
PE (1) | PE19496A1 (cs) |
PL (1) | PL181310B1 (cs) |
PT (1) | PT101722B (cs) |
RO (1) | RO113530B1 (cs) |
RS (1) | RS49577B (cs) |
RU (1) | RU2152399C2 (cs) |
SE (1) | SE509052C2 (cs) |
SI (1) | SI9500200A (cs) |
TW (1) | TW421596B (cs) |
UA (1) | UA26874C2 (cs) |
ZA (1) | ZA954943B (cs) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5836705A (en) * | 1992-07-27 | 1998-11-17 | Choate; John I. M. | Keyboard arrangement to maximize typing speed and data entry and to ease transition from a qwerty keyboard |
US5352050A (en) * | 1992-07-27 | 1994-10-04 | Choate John I M | Keyboard arrangement to maximize typing speed and ease of transition from a QWERTY keyboard |
US5498088A (en) * | 1992-07-27 | 1996-03-12 | Choate; John I. M. | Keyboard arrangement to maximize typing speed and ease of transition from a qwerty keyboard |
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
AR002976A1 (es) * | 1995-03-31 | 1998-05-27 | Lilly Co Eli | Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas |
AU6299596A (en) * | 1995-06-30 | 1997-02-05 | Novo Nordisk A/S | Prevention of a disease having the characteristics of diabetes |
ATE208208T1 (de) * | 1996-06-20 | 2001-11-15 | Novo Nordisk As | Halogenid-enthaltende insulinzubereitungen |
PE79099A1 (es) * | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
IL134901A0 (en) | 1997-10-24 | 2001-05-20 | Lilly Co Eli | Insoluble insulin compositions |
CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
DE69924232D1 (de) * | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
US6211144B1 (en) | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
KR100617286B1 (ko) * | 1998-10-16 | 2006-08-30 | 노보 노르디스크 에이/에스 | 폐 송달을 위한 안정한 농축 인슐린 조제물 |
EP1121145B1 (en) * | 1998-10-16 | 2002-04-17 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US6489292B1 (en) | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
EP1131089B1 (en) * | 1998-11-18 | 2004-02-18 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
WO2001052937A1 (en) | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
JP2004536018A (ja) * | 2000-07-31 | 2004-12-02 | バル・イラン・ユニバーシティ | 創傷治療のための方法および薬学的組成物 |
DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
ES2664189T3 (es) | 2002-01-09 | 2018-04-18 | Emisphere Technologies, Inc. | Polimorfos de 4-(4-cloro-2-hidroxibenzoil)aminobutanoato de sodio |
US20030211976A1 (en) * | 2002-03-07 | 2003-11-13 | Andreasen Kasper Huus | Polyamino acid-based particle insulin formulation |
US20040005999A1 (en) * | 2002-03-07 | 2004-01-08 | Andreasen Kasper Huus | Polyamino acid-based particle insulin preparation |
DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
ES2313018T3 (es) | 2003-06-17 | 2009-03-01 | Sembiosys Genetics Inc. | Procedimiento de produccion de insulina en plantas. |
ES2328579T3 (es) * | 2003-07-25 | 2009-11-16 | Conjuchem Biotechnologies Inc. | Derivados de insulina de larga duracion y procedimientos asociados. |
EP1711220A1 (en) * | 2004-01-16 | 2006-10-18 | Biodel, Inc. | Sublingual drug delivery device |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
AU2005240213B8 (en) | 2004-05-06 | 2011-10-20 | Emisphere Technologies, Inc. | Crystalline polymorphic forms of monosodium n-[8-(2-hydroxybenzoyl)amino]caprylate |
MXPA06013251A (es) * | 2004-05-14 | 2007-02-28 | Emisphere Tech Inc | Compuestos y composiciones de aril-cetona para suministrar agentes activos. |
EP1750674A4 (en) * | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
UA91512C2 (ru) | 2004-07-19 | 2010-08-10 | Биокон Лимитед | Коньюгати олигомеров инсулина, их композиция (варианты) и применение |
CN101014360A (zh) * | 2004-08-03 | 2007-08-08 | 埃米斯菲尔技术公司 | 抗糖尿病口服胰岛素-双胍组合物 |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
US20060078623A1 (en) * | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
SI2918286T1 (sl) * | 2004-10-05 | 2020-06-30 | Novo Nordisk A/S | Farmacevtski pripravek, ki vsebuje inzulin v kristalni obliki in tudi v obliki raztopine |
ES2391776T3 (es) | 2004-11-22 | 2012-11-29 | Novo Nordisk A/S | Formulaciones solubles, estables conteniendo insulina con una sal de protamina |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
JPWO2006093222A1 (ja) * | 2005-03-02 | 2008-08-07 | 味の素株式会社 | インスリンの多量体形成阻害剤 |
CA2625674C (en) | 2005-08-29 | 2015-04-14 | Healor Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
AR058053A1 (es) * | 2005-09-19 | 2008-01-23 | Toole Doris C O | Formas cristalinas polimorficas de la sal de di- sodio del acido n- (5 -clorosaliciloil)-8- aminocaprilico |
US7713929B2 (en) * | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
EP1991575A1 (en) * | 2006-02-21 | 2008-11-19 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
MX2008013165A (es) | 2006-04-12 | 2009-01-29 | Biodel Inc | Formulaciones de combinacion de insulina de accion rapida y accion larga. |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
PL2134351T3 (pl) | 2007-03-13 | 2017-10-31 | Jds Therapeutics Llc | Sposoby i kompozycje do przedłużonego uwalniania chromu |
JP5526018B2 (ja) * | 2007-03-21 | 2014-06-18 | エミスフェアー・テクノロジーズ・インク | アリルオキシおよびアルキルオキシ安息香酸送達薬剤 |
EP2514412A1 (en) * | 2007-04-30 | 2012-10-24 | Novo Nordisk A/S | Highly Concentrated Insulin Solutions and Compositions |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
US9241908B2 (en) | 2007-10-16 | 2016-01-26 | Biocon Limited | Orally administrable solid pharmaceutical composition and a process thereof |
MX2010004716A (es) | 2007-11-02 | 2010-12-17 | Emisphere Tech Inc | Metodo para tratar la deficiencia de vitamina b12. |
BRPI0916560A2 (pt) | 2008-07-31 | 2015-11-10 | Univ Case Western Reserve | análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. |
ES2477552T3 (es) | 2008-09-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos |
KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
KR20110082180A (ko) | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
MA33064B1 (fr) | 2009-01-28 | 2012-02-01 | Smartcells Inc | Systemes à base de conjugués pour administration contrôlée de médicaments |
WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
WO2010092218A2 (es) | 2009-02-12 | 2010-08-19 | Proyecto De Biomedicina Cima, S.L. | Uso de la cardiotrofina-1 para el tratamiento de enfermedades metabólicas |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
AU2010226243A1 (en) | 2009-03-20 | 2011-09-22 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
EP3345593B1 (de) | 2009-11-13 | 2023-09-06 | Sanofi-Aventis Deutschland GmbH | Pharmazeutische zusammensetzung umfassend despro36exendin-4(1-39)-lys6-nh2 und methionin |
TR201809460T4 (tr) | 2009-11-13 | 2018-07-23 | Sanofi Aventis Deutschland | Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim. |
EP2523677A2 (en) | 2010-01-11 | 2012-11-21 | Healor Ltd. | Method for treatment of inflammatory disease and disorder |
WO2011106378A2 (en) * | 2010-02-24 | 2011-09-01 | Emisphere Technologies, Inc. | Oral b12 therapy |
ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
CN103261181A (zh) | 2010-09-30 | 2013-08-21 | 索尔维公司 | 天然来源的环氧氯丙烷的衍生物 |
WO2012115641A1 (en) | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom |
CN105749253A (zh) | 2011-03-01 | 2016-07-13 | Jds治疗有限公司 | 用于预防和治疗糖尿病、低血糖症及相关病症的胰岛素和铬组合物 |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
TWI608847B (zh) | 2011-08-29 | 2017-12-21 | 賽諾菲阿凡提斯德意志有限公司 | 用於控制糖尿病二型病患血糖的醫藥組合物 |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
BR112014010139A2 (pt) | 2011-10-27 | 2017-04-25 | Univ Case Western Reserve | formulação farmacêutica, método de redução do nível de açúcar no sangue de um paciente e polipeptídeo |
US10159735B2 (en) * | 2012-06-26 | 2018-12-25 | The Curators Of The University Of Missouri | Photocleavable drug conjugates |
WO2014015078A1 (en) | 2012-07-17 | 2014-01-23 | Michael Weiss | O-linked carbohydrate-modified insulin analogues |
KR20150082640A (ko) | 2012-11-13 | 2015-07-15 | 아도시아 | 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형 |
US9707276B2 (en) | 2012-12-03 | 2017-07-18 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues |
JP6111475B2 (ja) | 2012-12-19 | 2017-04-12 | ウォックハート リミテッド | ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物 |
CN104870469A (zh) | 2012-12-26 | 2015-08-26 | 沃克哈特有限公司 | 药物组合物 |
JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法 |
TW201605489A (zh) | 2013-10-25 | 2016-02-16 | 賽諾菲公司 | 賴谷胰島素(insulin glulisine)的穩定調配物 |
WO2016032869A1 (en) | 2014-08-26 | 2016-03-03 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin or insulin analog compositions |
PE20171622A1 (es) | 2014-12-12 | 2017-11-02 | Sanofi Aventis Deutschland | Formulacion de relacion fija de insulina glargina/lixisenatida |
AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
US11865121B2 (en) | 2016-02-11 | 2024-01-09 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
MA50496A (fr) | 2017-06-01 | 2020-09-09 | Lilly Co Eli | Compositions d'insuline à action rapide |
EP3727424A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE |
EP3740212A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY |
CA3157995A1 (en) | 2019-10-25 | 2021-04-29 | Cercacor Laboratories, Inc. | Indicator compounds, devices comprising indicator compounds, and methods of making and using the same |
BR112022019687A2 (pt) | 2020-03-31 | 2022-12-20 | Protomer Tech Inc | Conjugados para responsividade seletiva a dióis vicinais |
JP2024500284A (ja) | 2020-11-19 | 2024-01-09 | プロトマー・テクノロジーズ・インコーポレイテッド | 芳香族ホウ素含有化合物及びインスリン類似体 |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2114573A (en) * | 1982-02-05 | 1983-08-24 | Novo Industri As | Stabilized insulin solutions and methods for their production |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3060093A (en) * | 1957-07-18 | 1962-10-23 | Nordisk Insulinlab | Slowly acting insulin preparation in crystalline form and method of preparation |
US4608634A (en) * | 1982-02-22 | 1986-08-26 | Texas Instruments Incorporated | Microcomputer with offset in store-accumulator operations |
DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
JPH03506023A (ja) * | 1988-07-20 | 1991-12-26 | ノボ ノルデイスク アクツイエセルスカプ | ポリペプチド |
HUT56857A (en) * | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
PT93057B (pt) * | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
DE69416409T2 (de) * | 1993-06-21 | 1999-09-16 | Novo Nordisk A/S, Bagsvaerd | Asp-b28-insulinkristalle |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
-
1994
- 1994-06-16 US US08/260,634 patent/US5474978A/en not_active Expired - Lifetime
- 1994-06-24 TW TW083105767A patent/TW421596B/zh not_active IP Right Cessation
-
1995
- 1995-06-12 CA CA002151560A patent/CA2151560C/en not_active Expired - Lifetime
- 1995-06-13 RS YUP-396/95A patent/RS49577B/sr unknown
- 1995-06-13 HU HU9501716A patent/HU227240B1/hu unknown
- 1995-06-14 CH CH01763/95A patent/CH689250A5/de not_active IP Right Cessation
- 1995-06-14 AT AT0101695A patent/AT408720B/de not_active IP Right Cessation
- 1995-06-14 SE SE9502167A patent/SE509052C2/sv not_active IP Right Cessation
- 1995-06-14 KR KR1019950015782A patent/KR100382326B1/ko active IP Right Grant
- 1995-06-14 GR GR950100229A patent/GR1003004B/el not_active IP Right Cessation
- 1995-06-14 NO NO19952357A patent/NO322128B1/no not_active IP Right Cessation
- 1995-06-14 IT IT95MI001278A patent/IT1276723B1/it active IP Right Grant
- 1995-06-14 CO CO95026235A patent/CO4410203A1/es unknown
- 1995-06-14 IE IE950436A patent/IE68853B1/en not_active IP Right Cessation
- 1995-06-14 CZ CZ19951542A patent/CZ287484B6/cs not_active IP Right Cessation
- 1995-06-14 SI SI9500200A patent/SI9500200A/sl not_active IP Right Cessation
- 1995-06-14 LU LU88626A patent/LU88626A1/fr unknown
- 1995-06-14 BR BR9502795A patent/BR9502795A/pt not_active IP Right Cessation
- 1995-06-14 IL IL11415195A patent/IL114151A/xx not_active IP Right Cessation
- 1995-06-14 PL PL95309098A patent/PL181310B1/pl unknown
- 1995-06-14 ZA ZA9504943A patent/ZA954943B/xx unknown
- 1995-06-14 NZ NZ272359A patent/NZ272359A/en not_active IP Right Cessation
- 1995-06-14 NL NL1000566A patent/NL1000566C2/xx not_active IP Right Cessation
- 1995-06-14 PE PE1995271263A patent/PE19496A1/es not_active IP Right Cessation
- 1995-06-14 PT PT101722A patent/PT101722B/pt not_active IP Right Cessation
- 1995-06-14 MY MYPI95001593A patent/MY115631A/en unknown
- 1995-06-14 CN CN95106568A patent/CN1105576C/zh not_active Ceased
- 1995-06-14 FR FR9507094A patent/FR2721214B1/fr not_active Expired - Lifetime
- 1995-06-14 RO RO95-01140A patent/RO113530B1/ro unknown
- 1995-06-14 DE DE19521720A patent/DE19521720B4/de not_active Expired - Lifetime
- 1995-06-14 DK DK199500677A patent/DK173015B1/da not_active IP Right Cessation
- 1995-06-14 GB GB9512038A patent/GB2291427B/en not_active Expired - Lifetime
- 1995-06-14 JP JP14732195A patent/JP3171541B2/ja not_active Expired - Lifetime
- 1995-06-14 BE BE9500526A patent/BE1009408A5/fr active
- 1995-06-14 RU RU95110109/04A patent/RU2152399C2/ru active
- 1995-06-14 CH CH02040/98A patent/CH689935A5/de not_active IP Right Cessation
- 1995-06-14 UA UA95062794A patent/UA26874C2/uk unknown
- 1995-06-14 FI FI952931A patent/FI118207B/fi not_active IP Right Cessation
- 1995-06-14 ES ES09501195A patent/ES2091727B1/es not_active Expired - Fee Related
-
1997
- 1997-01-09 FR FR9700156A patent/FR2741078B1/fr not_active Expired - Lifetime
-
1998
- 1998-12-23 HK HK98115200A patent/HK1015138A1/xx not_active IP Right Cessation
-
2001
- 2001-01-18 JP JP2001010342A patent/JP2001199899A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2114573A (en) * | 1982-02-05 | 1983-08-24 | Novo Industri As | Stabilized insulin solutions and methods for their production |
Non-Patent Citations (3)
Title |
---|
D.N. BREMS ET AL.: "ALTERING THE ASSOCIATION PROPERTIES OF INSULIN BY AMINO ACID REPLACEMENT.", PROTEIN ENGINEERING, vol. 5, no. 6, September 1992 (1992-09-01), OXFORD, GB, pages 527 - 533, XP000306022 * |
E. CISZAK ET AL.: "ROLE OF C-TERMINAL B-CHAIN RESIDUES IN INSULIN ASSEMBLY: THE STRUCTURE OF HEXAMERIC LYS(B28) PRO(B29)-HUMAN INSULIN.", STRUCTURE, vol. 3, no. 6, 15 June 1995 (1995-06-15), LONDON, GB, pages 615 - 622, XP000574929 * |
U. DEREWENDA ET AL.: "PHENOL STABILIZES MORE HELIX IN A NEW SYMMETRICAL ZINC INSULIN HEXAMER.", NATURE, vol. 338, 13 April 1989 (1989-04-13), LONDON GB, pages 594 - 596, XP002007532 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL1000566C2 (nl) | Complex van een analoog van menselijk insuline, alsmede een dergelijk complex omvattende formulering. | |
NL1000565C2 (nl) | Complex van een insuline-analoog en protamine, dit complex bevattende farmaceutische formuleringen en bereidingswerkwijzen daarvan. | |
TR199501420A2 (tr) | Acillenmis ensülin benzerleri. | |
NO944526D0 (no) | Medisinsk aerosolformulering | |
PT1283051E (pt) | Formulacoes de insulina estaveis | |
DE69827328D1 (de) | Vormontierte Spritze | |
DZ1862A1 (fr) | Acides 5-vinyl-et 5-éthinyl-quinolone et -naphtyridone-carboxyliques. | |
TR199501082A2 (tr) | Farmasötik formülasyonlar. | |
FR2716375B3 (fr) | Injecteur médical. | |
ID23928A (id) | Formulasi mengandung insektisida | |
FR2683353B1 (fr) | Multiplicateur analogique mosfet. | |
DE69522857D1 (de) | Insulinstandardlösung | |
NL1002937A1 (nl) | Gerede infusie-set. | |
ITBO930181A1 (it) | Siringa odontoiatrica. | |
ES1027238Y (es) | Calzado perfeccionado. | |
SE9702793D0 (sv) | Novel formulation | |
FR2704759B1 (fr) | Aspirateur médical - mouche bébé. | |
ES1038353Y (es) | Jeringuilla perfeccionada. | |
IT1267343B1 (it) | Composizione insetticida. | |
ES1037951Y (es) | Cosechadora de ajos. | |
ZA9810587B (en) | Anaesthetic formulation. | |
ES1027406Y (es) | Calzado perfeccionado. | |
ES1026307Y (es) | Calzado perfeccionado. | |
NL1004176A1 (nl) | Deelbare lijkkist. | |
ES1025314Y (es) | Sandalia perfeccionada. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AD1A | A request for search or an international type search has been filed | ||
RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 19960731 |
|
PD2B | A search report has been drawn up | ||
RD1A | Patents in respect of which a request for advice has been filed [in relation to nullification] | ||
RD2A | Patents in respect of which a decision has been taken or a report has been made (for advice) | ||
VD1 | Lapsed due to non-payment of the annual fee |
Effective date: 20090101 |