MX9604942A - Preparacion de purina. - Google Patents
Preparacion de purina.Info
- Publication number
- MX9604942A MX9604942A MX9604942A MX9604942A MX9604942A MX 9604942 A MX9604942 A MX 9604942A MX 9604942 A MX9604942 A MX 9604942A MX 9604942 A MX9604942 A MX 9604942A MX 9604942 A MX9604942 A MX 9604942A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- alkoxy
- phenyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Treatment Of Metals (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un proceso para la preparacion de un compuesto de la formula (A), en donde: X es hidrogeno, hidroxi, cloro, alcoxi de 1 a 6 átomos de carbono, o fenilalcoxi de 1 a 6 átomos de carbono; y Ra y Rb son hidrogeno, o derivados de acilo o fosfato del mismo, cuyo proceso comprende: (i) la preparacion de un compuesto de la formula de carbono, o fenilalquilo de 1 a 6 átomos de carbono, en donde el grupo fenilo está opcionalmente sustituido; R2 es hidrogeno, hidroxi, cloro, alcoxi de 1 a 6 átomos de carbono, fenilalcoxi de 1 a 6 átomos de carbono, fenilalcoxi de 1 a 6 átomos de carbono, o amino; y R3 es halogeno, tioalquilo de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono-sulfonilo, ácido, un grupo amino, o un grupo amino protegido, cuya preparacion comprende la reaccion de un compuesto de la formula (II), en donde R1 y R3 son como se definen para la formula (I), con un compuesto de la formula (V) en donde L es un grupo de salida y R1 es como se define para la formula (I), para dar un compuesto de la formula (VI), y posteriormente convertir el compuesto intermediario de la formula (VI) es un compuesto de la formula (I) mediante descarboxilacion, y como sea necesario o deseado, interconvertir las variables R1, R2, y R3 en otros valores de R1, R2 y R3; (ii) la conversion del compuesto resultante de la formula (I) en un compuesto de la formula (A) mediante la conversion de la variable R3, cuando sea diferente de amino, en amino, reducir los grupos éster CO2R1 a CH2OH y opcionalmente formar los derivados de acilo o fosfato de los mismos, y como sea necesario o deseado, convertir la variable R2 del compuesto de la formula (A); caracterizado porque R2 es cloro en la formula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9407698A GB9407698D0 (en) | 1994-04-19 | 1994-04-19 | Pharmaceuticals |
PCT/EP1995/001840 WO1995028402A2 (en) | 1994-04-19 | 1995-04-19 | Preparation of purines |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9604942A true MX9604942A (es) | 1998-05-31 |
Family
ID=10753741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604942A MX9604942A (es) | 1994-04-19 | 1995-04-19 | Preparacion de purina. |
Country Status (40)
Country | Link |
---|---|
US (2) | US6846927B1 (es) |
EP (1) | EP0756597B1 (es) |
JP (1) | JP3936734B2 (es) |
KR (1) | KR100327147B1 (es) |
CN (1) | CN1045963C (es) |
AP (2) | AP582A (es) |
AT (1) | ATE201209T1 (es) |
AU (1) | AU691000B2 (es) |
BG (1) | BG63464B1 (es) |
BR (1) | BR9507494A (es) |
CA (1) | CA2188181C (es) |
CZ (1) | CZ287674B6 (es) |
DE (1) | DE69520945T2 (es) |
DK (1) | DK0756597T3 (es) |
DZ (1) | DZ1872A1 (es) |
EG (1) | EG20938A (es) |
ES (1) | ES2158948T3 (es) |
FI (1) | FI119691B (es) |
GB (1) | GB9407698D0 (es) |
GR (1) | GR3036338T3 (es) |
HK (1) | HK1012348A1 (es) |
HU (1) | HU226209B1 (es) |
IL (1) | IL113409A (es) |
IN (1) | IN183830B (es) |
MA (1) | MA23518A1 (es) |
MX (1) | MX9604942A (es) |
MY (1) | MY128846A (es) |
NO (1) | NO315000B1 (es) |
NZ (1) | NZ287858A (es) |
OA (1) | OA10376A (es) |
PL (1) | PL181219B1 (es) |
PT (1) | PT756597E (es) |
RO (1) | RO118950B1 (es) |
RU (1) | RU2158266C2 (es) |
SA (1) | SA95150619B1 (es) |
SK (1) | SK283193B6 (es) |
TW (1) | TW311138B (es) |
UA (1) | UA47401C2 (es) |
WO (1) | WO1995028402A2 (es) |
ZA (1) | ZA953110B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9615253D0 (en) * | 1996-07-20 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
GB9615276D0 (en) * | 1996-07-20 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
GB9807116D0 (en) | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
GB9807114D0 (en) * | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
US20040097528A1 (en) * | 2002-08-26 | 2004-05-20 | Ben-Zion Dolitzky | Crystalline solid famciclovir forms I, II, III and preparation thereof |
TW200510415A (en) * | 2003-04-30 | 2005-03-16 | Teva Pharma | Process for the preparation of famciclovir |
US20050143400A1 (en) * | 2003-09-04 | 2005-06-30 | Genny Shamai | Process for preparing famciclovir |
US7458839B2 (en) * | 2006-02-21 | 2008-12-02 | Fci Americas Technology, Inc. | Electrical connectors having power contacts with alignment and/or restraining features |
US20050215787A1 (en) * | 2004-03-26 | 2005-09-29 | Joshi Ramesh A | An improved process for the preparation of purines |
TW200613304A (en) * | 2004-05-18 | 2006-05-01 | Teva Pharma | Drying process for preparing crystalline solid famciclovir |
GB2426247A (en) * | 2005-05-20 | 2006-11-22 | Arrow Int Ltd | Methods of preparing purine derivatives such as famciclovir |
CN102070636B (zh) * | 2011-01-17 | 2012-05-23 | 浙江大学 | 喷昔洛韦的制备方法 |
CN104086552B (zh) * | 2014-07-31 | 2016-01-13 | 济南兆康医药科技有限公司 | 一种喷昔洛韦的精制方法 |
CN104496991A (zh) * | 2014-11-04 | 2015-04-08 | 常州康丽制药有限公司 | 高品质2-氨基-6-氯-9-(4-羟基-3–羟甲基丁基)嘌呤的制备方法 |
CN104744472A (zh) * | 2015-03-12 | 2015-07-01 | 常州康丽制药有限公司 | 高品质2-氨基-6-氯-9-(4-羟基-3-羟甲基丁基)嘌呤的制备方法 |
CN108314685B (zh) * | 2018-03-16 | 2020-08-25 | 上药康丽(常州)药业有限公司 | 一种2-氨基-6-氯-9-(4-乙酰氧基-3-乙酰氧甲基丁基)嘌呤的制备方法 |
CN110713490A (zh) * | 2018-07-12 | 2020-01-21 | 浙江医药股份有限公司新昌制药厂 | 一种喷昔洛韦的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0141927B1 (en) * | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Antiviral guanine derivatives |
EP0182024B1 (en) * | 1984-09-20 | 1991-04-03 | Beecham Group Plc | Purine derivatives and their pharmaceutical use |
DE3855774T2 (de) * | 1987-08-01 | 1997-06-12 | Beecham Group Plc | Purinverbindungen und ihre Herstellung |
GB8817607D0 (en) * | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
GB8822236D0 (en) * | 1988-09-21 | 1988-10-26 | Beecham Group Plc | Chemical process |
-
1994
- 1994-04-19 GB GB9407698A patent/GB9407698D0/en active Pending
-
1995
- 1995-04-12 DZ DZ950040A patent/DZ1872A1/fr active
- 1995-04-13 AP APAP/P/1995/000730A patent/AP582A/en active
- 1995-04-17 TW TW084103750A patent/TW311138B/zh not_active IP Right Cessation
- 1995-04-17 MA MA23846A patent/MA23518A1/fr unknown
- 1995-04-17 MY MYPI95000990A patent/MY128846A/en unknown
- 1995-04-18 IL IL11340995A patent/IL113409A/xx not_active IP Right Cessation
- 1995-04-18 IN IN705DE1995 patent/IN183830B/en unknown
- 1995-04-18 ZA ZA953110A patent/ZA953110B/xx unknown
- 1995-04-19 MX MX9604942A patent/MX9604942A/es active IP Right Grant
- 1995-04-19 UA UA96103899A patent/UA47401C2/uk unknown
- 1995-04-19 RU RU96121936/04A patent/RU2158266C2/ru active
- 1995-04-19 PT PT95921751T patent/PT756597E/pt unknown
- 1995-04-19 CA CA002188181A patent/CA2188181C/en not_active Expired - Lifetime
- 1995-04-19 PL PL95316943A patent/PL181219B1/pl unknown
- 1995-04-19 KR KR1019960705948A patent/KR100327147B1/ko not_active IP Right Cessation
- 1995-04-19 BR BR9507494A patent/BR9507494A/pt unknown
- 1995-04-19 DK DK95921751T patent/DK0756597T3/da active
- 1995-04-19 ES ES95921751T patent/ES2158948T3/es not_active Expired - Lifetime
- 1995-04-19 JP JP52673895A patent/JP3936734B2/ja not_active Expired - Lifetime
- 1995-04-19 DE DE69520945T patent/DE69520945T2/de not_active Expired - Lifetime
- 1995-04-19 CZ CZ19963053A patent/CZ287674B6/cs not_active IP Right Cessation
- 1995-04-19 AP APAP/P/1996/000870A patent/AP703A/en active
- 1995-04-19 SK SK1332-96A patent/SK283193B6/sk not_active IP Right Cessation
- 1995-04-19 HU HU9602891A patent/HU226209B1/hu unknown
- 1995-04-19 RO RO96-02001A patent/RO118950B1/ro unknown
- 1995-04-19 EG EG32695A patent/EG20938A/xx active
- 1995-04-19 WO PCT/EP1995/001840 patent/WO1995028402A2/en active IP Right Grant
- 1995-04-19 AU AU26706/95A patent/AU691000B2/en not_active Expired
- 1995-04-19 NZ NZ287858A patent/NZ287858A/en not_active IP Right Cessation
- 1995-04-19 EP EP95921751A patent/EP0756597B1/en not_active Expired - Lifetime
- 1995-04-19 CN CN95193489A patent/CN1045963C/zh not_active Expired - Lifetime
- 1995-04-19 AT AT95921751T patent/ATE201209T1/de active
- 1995-04-26 SA SA95150619A patent/SA95150619B1/ar unknown
-
1996
- 1996-10-15 NO NO19964395A patent/NO315000B1/no not_active IP Right Cessation
- 1996-10-18 BG BG100926A patent/BG63464B1/bg unknown
- 1996-10-18 OA OA60905A patent/OA10376A/en unknown
- 1996-10-18 FI FI964193A patent/FI119691B/fi not_active IP Right Cessation
-
1998
- 1998-12-15 HK HK98113459A patent/HK1012348A1/xx not_active IP Right Cessation
-
1999
- 1999-03-11 US US09/265,926 patent/US6846927B1/en not_active Expired - Fee Related
-
2001
- 2001-08-07 GR GR20010401190T patent/GR3036338T3/el unknown
-
2004
- 2004-12-14 US US11/011,352 patent/US7355043B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. |