MX378808B - Secuencias 3´ utr para estabilización de arn - Google Patents

Secuencias 3´ utr para estabilización de arn

Info

Publication number
MX378808B
MX378808B MX2018004160A MX2018004160A MX378808B MX 378808 B MX378808 B MX 378808B MX 2018004160 A MX2018004160 A MX 2018004160A MX 2018004160 A MX2018004160 A MX 2018004160A MX 378808 B MX378808 B MX 378808B
Authority
MX
Mexico
Prior art keywords
rna
utr sequences
rna stabilization
present
stabilization
Prior art date
Application number
MX2018004160A
Other languages
English (en)
Other versions
MX2018004160A (es
Inventor
Von Niessen Alexandra Orlandini
Andreas Kuhn
Britta Vallazza
Marco Alexander Poleganov
Stephanie Fesser
Tim Beissert
Ugur Sahin
Original Assignee
BioNTech SE
Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNTech SE, Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh filed Critical BioNTech SE
Publication of MX2018004160A publication Critical patent/MX2018004160A/es
Publication of MX378808B publication Critical patent/MX378808B/es

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    • A—HUMAN NECESSITIES
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    • A47B3/002—Folding or stowable tables with foldable underframe
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60B—VEHICLE WHEELS; CASTORS; AXLES FOR WHEELS OR CASTORS; INCREASING WHEEL ADHESION
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • E—FIXED CONSTRUCTIONS
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    • E04H1/125—Small buildings, arranged in other buildings
    • E04H1/1266—Cubicles for dressing; Toilets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C11/00—Pivots; Pivotal connections
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    • A47B2200/00—General construction of tables or desks
    • A47B2200/0011—Underframes
    • A47B2200/0017—Nodal leg assembly for table
    • A47B2200/0018—Nodal leg assembly for table in two parts
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

La presente invención se refiere a la estabilización de ARN, en particular ARNm, y un incremento en la traducción de ARNm. La presente invención se refiere en particular a una modificación de ARN, en particular ARN transcrito in vitro, que da por resultado estabilidad incrementada de transcripto y/o eficiencia incrementada de traducción. De acuerdo a la invención, se demostró que ciertas secuencias en la región 3'-no traducida (UTR) de una molécula de ARN mejora la estabilidad y eficiencia de traducción.
MX2018004160A 2015-10-07 2016-10-05 Secuencias 3´ utr para estabilización de arn MX378808B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/073180 WO2017059902A1 (en) 2015-10-07 2015-10-07 3' utr sequences for stabilization of rna
PCT/EP2016/073814 WO2017060314A2 (en) 2015-10-07 2016-10-05 3' utr sequences for stabilization of rna

Publications (2)

Publication Number Publication Date
MX2018004160A MX2018004160A (es) 2018-08-01
MX378808B true MX378808B (es) 2025-03-10

Family

ID=54293227

Family Applications (2)

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MX2018004160A MX378808B (es) 2015-10-07 2016-10-05 Secuencias 3´ utr para estabilización de arn
MX2021000250A MX2021000250A (es) 2015-10-07 2018-04-05 Secuencias 3 utr para estabilizacion de arn.

Family Applications After (1)

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MX2021000250A MX2021000250A (es) 2015-10-07 2018-04-05 Secuencias 3 utr para estabilizacion de arn.

Country Status (26)

Country Link
US (2) US11492628B2 (es)
EP (3) EP3337902B1 (es)
JP (6) JP7084302B2 (es)
KR (4) KR102688535B1 (es)
CN (1) CN108291230B (es)
AU (3) AU2016335029B2 (es)
BR (2) BR122021025194B1 (es)
CA (2) CA2998554C (es)
CY (2) CY1122347T1 (es)
DK (2) DK3636764T3 (es)
ES (2) ES2753201T3 (es)
HR (2) HRP20191907T1 (es)
HU (2) HUE055152T2 (es)
IL (3) IL293020A (es)
LT (2) LT3337902T (es)
MX (2) MX378808B (es)
NZ (1) NZ740946A (es)
PL (2) PL3337902T3 (es)
PT (2) PT3337902T (es)
RS (2) RS59538B1 (es)
RU (1) RU2720934C2 (es)
SG (1) SG10201912558YA (es)
SI (2) SI3337902T1 (es)
SM (2) SMT202100157T1 (es)
WO (2) WO2017059902A1 (es)
ZA (1) ZA201800835B (es)

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WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
US11253601B2 (en) 2016-07-11 2022-02-22 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
EP3526332B1 (en) * 2016-10-17 2024-06-26 Janssen Pharmaceuticals, Inc. Recombinant virus replicon systems and uses thereof
KR102740888B1 (ko) * 2017-08-15 2024-12-13 인텔리아 테라퓨틱스, 인크. 메신저 리보핵산(mRNA)을 암호화하는 안정화된 핵산
US12178855B2 (en) 2018-01-10 2024-12-31 Translate Bio Ma, Inc. Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
MX2020008394A (es) 2018-02-12 2020-09-21 Biontech Rna Pharmaceuticals Gmbh Tratamiento que usa arn que codifica citoquinas.
US12398182B2 (en) * 2018-05-01 2025-08-26 Wake Forest University Health Sciences Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
JP7550745B2 (ja) 2018-07-24 2024-09-13 バイオエヌテック エスエー Ｉｌ２アゴニスト
MX2021008434A (es) * 2019-01-14 2021-09-23 Genentech Inc Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.
MX2021009506A (es) 2019-02-08 2021-09-08 Biontech Cell & Gene Therapies Gmbh Tratamiento que implica celulas t modificadas con car y citoquinas.
CA3133414A1 (en) 2019-03-18 2020-09-24 Biontech Cell & Gene Therapies Gmbh Interleukin-2 receptor (il2r) and interleukin-2 (il2) variants for specific activation of immune effector cells
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