BR122021025194A8 - Molécula de ácido nucleico, método para obter rna, rna, método para obter um peptídeo ou proteína e usos in vitro ou ex vivo do rna - Google Patents

Molécula de ácido nucleico, método para obter rna, rna, método para obter um peptídeo ou proteína e usos in vitro ou ex vivo do rna

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Publication number
BR122021025194A8
BR122021025194A8 BR122021025194A BR122021025194A BR122021025194A8 BR 122021025194 A8 BR122021025194 A8 BR 122021025194A8 BR 122021025194 A BR122021025194 A BR 122021025194A BR 122021025194 A BR122021025194 A BR 122021025194A BR 122021025194 A8 BR122021025194 A8 BR 122021025194A8
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BR
Brazil
Prior art keywords
rna
vitro
peptide
protein
nucleic acid
Prior art date
Application number
BR122021025194A
Other languages
English (en)
Other versions
BR122021025194A2 (pt
BR122021025194B1 (pt
Inventor
Orlandini Von Niessen Alexandra
Fesser Stephanie
Vallazza Britta
Beissert Tim
Kuhn Andreas
Sahin Ugur
Alexander Poleganov Marco
Original Assignee
Biontech Rna Pharmaceuticals Gmbh
BioNTech SE
Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biontech Rna Pharmaceuticals Gmbh, BioNTech SE, Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh filed Critical Biontech Rna Pharmaceuticals Gmbh
Publication of BR122021025194A2 publication Critical patent/BR122021025194A2/pt
Publication of BR122021025194A8 publication Critical patent/BR122021025194A8/pt
Publication of BR122021025194B1 publication Critical patent/BR122021025194B1/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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Abstract

A presente invenção refere-se à estabilização de RNA, em particular mRNA, e um aumento na tradução de mRNA. A presente invenção particularmente refere-se a uma modificação de RNA, em particular RNA transcrito in vitro, resultando em estabilidade de transcrito aumentada e/ou eficiência de tradução. De acordo com a invenção, demonstrou-se que determinadas sequências na região não traduzida 3? (UTR) de uma molécula de RNA melhora a estabilidade e eficiência de tradução.
BR122021025194-0A 2015-10-07 2016-10-05 Molécula de ácido nucleico, método para obter rna, rna, método para obter um peptídeo ou proteína e usos in vitro ou ex vivo do rna BR122021025194B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPPCT/EP2015/073180 2015-10-07
PCT/EP2015/073180 WO2017059902A1 (en) 2015-10-07 2015-10-07 3' utr sequences for stabilization of rna
PCT/EP2016/073814 WO2017060314A2 (en) 2015-10-07 2016-10-05 3' utr sequences for stabilization of rna
BR112018003486-0A BR112018003486B1 (pt) 2015-10-07 2016-10-05 Molécula de ácido nucleico, rnas, métodos para obter rna, métodos para obter um peptídeo ou proteína, métodos para obter rna, usos in vitro ou ex vivo do rna e usos do rna

Publications (3)

Publication Number Publication Date
BR122021025194A2 BR122021025194A2 (pt) 2018-09-25
BR122021025194A8 true BR122021025194A8 (pt) 2023-01-31
BR122021025194B1 BR122021025194B1 (pt) 2023-09-26

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BR122021025194-0A BR122021025194B1 (pt) 2015-10-07 2016-10-05 Molécula de ácido nucleico, método para obter rna, rna, método para obter um peptídeo ou proteína e usos in vitro ou ex vivo do rna
BR112018003486-0A BR112018003486B1 (pt) 2015-10-07 2016-10-05 Molécula de ácido nucleico, rnas, métodos para obter rna, métodos para obter um peptídeo ou proteína, métodos para obter rna, usos in vitro ou ex vivo do rna e usos do rna

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US (2) US11492628B2 (pt)
EP (3) EP3636764B1 (pt)
JP (5) JP7084302B2 (pt)
KR (3) KR102363368B1 (pt)
CN (1) CN108291230B (pt)
AU (3) AU2016335029B2 (pt)
BR (2) BR122021025194B1 (pt)
CA (2) CA2998554C (pt)
CY (2) CY1122347T1 (pt)
DK (2) DK3337902T3 (pt)
ES (2) ES2866224T3 (pt)
HK (2) HK1256701A1 (pt)
HR (2) HRP20191907T1 (pt)
HU (2) HUE055152T2 (pt)
IL (3) IL293020A (pt)
LT (2) LT3636764T (pt)
MX (2) MX2018004160A (pt)
NZ (1) NZ740946A (pt)
PL (2) PL3636764T3 (pt)
PT (2) PT3337902T (pt)
RS (2) RS59538B1 (pt)
RU (1) RU2720934C2 (pt)
SG (1) SG10201912558YA (pt)
SI (2) SI3337902T1 (pt)
WO (2) WO2017059902A1 (pt)
ZA (1) ZA201800835B (pt)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
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